Medical Science Monitor Basic Research最新文献_第3页

Case-Control Study to Evaluate the Oral Hygiene Habits in 31 Children with Hemophilia in Bulgaria Using the Oral Health Impact Profile-14 (OHIP-14) Questionnaire 使用口腔健康影响概况-14 (OHIP-14)问卷评估保加利亚31例血友病儿童口腔卫生习惯的病例-对照研究

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-04-21 DOI: 10.12659/MSMBR.936560

V. Mandova, R. Stefanov

{"title":"Case-Control Study to Evaluate the Oral Hygiene Habits in 31 Children with Hemophilia in Bulgaria Using the Oral Health Impact Profile-14 (OHIP-14) Questionnaire","authors":"V. Mandova, R. Stefanov","doi":"10.12659/MSMBR.936560","DOIUrl":"https://doi.org/10.12659/MSMBR.936560","url":null,"abstract":"Background For patients with hereditary coagulopathies such as hemophilia, the most common dental problem is spontaneous oral bleeding caused by daily oral hygiene habits like tooth brushing. Because of fear of bleeding, children with hemophilia often skip routine oral hygiene procedures, which can lead to dental caries and periodontal diseases. This case control study aimed to evaluate the oral hygiene awareness and hygiene practices of children with hemophilia from 6 to 18 years of age in Bulgaria. Material/Methods This study was conducted over 4 years and included 31 patients (children). A sociological approach was used, with direct individual questionnaires for self-assessment of dental habits. Statistical analyses were performed using SPSS. Results There was no significant difference between groups in methods of oral hygiene. The duration of oral hygiene procedures was 1 min (n=5, 16.13±6.61%) or 2 min (n=13, 41.94±8.86%), which was considered insufficient for proper oral hygiene. Children who had received oral hygiene advice by a dentist brushed their teeth significantly longer (n=9, 69.23±12.80%) than those who had not. There was a considerable difference between the reasons for the last dental visit between the groups of children (χ2=5.18, P<0.05). Conclusions Children with hemophilia have high awareness of oral hygiene methods; however, more attention should be focused on additional individual educational methods at the dental office. Frequent professional and self-assessment of the oral hygiene routine of children with hemophilia could identify the factors compromising dental status in this vulnerable population.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83068260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Case-Control Study to Evaluate the Oral Hygiene Habits in 31 Children with Hemophilia in Bulgaria Using the Oral Health Impact Profile-14 (OHIP-14) Questionnaire. 使用口腔健康影响档案-14 (OHIP-14) 问卷评估保加利亚 31 名血友病患儿口腔卫生习惯的病例对照研究。

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2022-04-21

Viktoriya D Mandova, Rumen S Stefanov

{"title":"Case-Control Study to Evaluate the Oral Hygiene Habits in 31 Children with Hemophilia in Bulgaria Using the Oral Health Impact Profile-14 (OHIP-14) Questionnaire.","authors":"Viktoriya D Mandova, Rumen S Stefanov","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND For patients with hereditary coagulopathies such as hemophilia, the most common dental problem is spontaneous oral bleeding caused by daily oral hygiene habits like tooth brushing. Because of fear of bleeding, children with hemophilia often skip routine oral hygiene procedures, which can lead to dental caries and periodontal diseases. This case control study aimed to evaluate the oral hygiene awareness and hygiene practices of children with hemophilia from 6 to 18 years of age in Bulgaria. MATERIAL AND METHODS This study was conducted over 4 years and included 31 patients (children). A sociological approach was used, with direct individual questionnaires for self-assessment of dental habits. Statistical analyses were performed using SPSS. RESULTS There was no significant difference between groups in methods of oral hygiene. The duration of oral hygiene procedures was 1 min (n=5, 16.13±6.61%) or 2 min (n=13, 41.94±8.86%), which was considered insufficient for proper oral hygiene. Children who had received oral hygiene advice by a dentist brushed their teeth significantly longer (n=9, 69.23±12.80%) than those who had not. There was a considerable difference between the reasons for the last dental visit between the groups of children (χ²=5.18, P.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141862063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production of Inflammatory Mediators in Conditioned Medium of Adipose Tissue-Derived Mesenchymal Stem Cells (ATMSC)-Treated Fresh Frozen Plasma. 脂肪组织源性间充质干细胞(ATMSC)处理的新鲜冷冻血浆条件培养基中炎症介质的产生。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-03-23 DOI: 10.12659/MSMBR.933726

Dian Ratih Laksmitawati, Wahyu Widowati, Rachmawati Noverina, Wireni Ayuningtyas, Dedy Kurniawan, Hanna Sari Widya Kusuma, Ervi Afifah, Ratih Rinendyaputri, Rilianawati Rilianawati, Ahmad Faried, Ni Ketut Susilarini

{"title":"Production of Inflammatory Mediators in Conditioned Medium of Adipose Tissue-Derived Mesenchymal Stem Cells (ATMSC)-Treated Fresh Frozen Plasma.","authors":"Dian Ratih Laksmitawati, Wahyu Widowati, Rachmawati Noverina, Wireni Ayuningtyas, Dedy Kurniawan, Hanna Sari Widya Kusuma, Ervi Afifah, Ratih Rinendyaputri, Rilianawati Rilianawati, Ahmad Faried, Ni Ketut Susilarini","doi":"10.12659/MSMBR.933726","DOIUrl":"https://doi.org/10.12659/MSMBR.933726","url":null,"abstract":"BACKGROUND Inflammation is the body's first response to an illness that causes irritation or infection. Inflammation is tightly correlated with aging, which is a progressive degenerative process. Conditioned medium (CM) from adipose tissue-derived mesenchymal stem cells (CM-ATMSCs) has been shown to stimulate collagen synthesis and dermal fibroblast migration, as well as reduce wrinkles and improve wound healing. This study aimed to observe the production of inflammatory modulators - interleukin (IL)-1alpha, IL-6, IL-10, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) - in CM-ATMSCs treated with fresh frozen plasma (FFP) at passages 3 (P3), 7, 11, and 15. MATERIAL AND METHODS ATMSCs P3 were obtained from liposuction of female donors, and the CM from ATMSCs was collected. Measurement of these cytokines was performed with ELISA. RESULTS At many passages, IL-6, a proinflammatory modulator, was discovered to be the most powerful modulator among FFP- and non-FFP-treated cells. However, CM-ATMSCs treated with FFP and in the late passage have significant differences (P<0.05) compared to non-FFP treatments and in other passages in their effects on secretion of inflammatory modulators. CONCLUSIONS In conclusion, CM-ATMSC has the potential to secrete proinflammatory modulators.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/82/medscimonitbasicres-28-e933726.PMC8958862.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40315844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Degree of Myopia and Reduced Physical Activity in 3600 College Students in China. 中国 3600 名大学生的近视程度和体育锻炼减少情况。

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2022-02-14

Xiangyu Zhao, Yanan Zhang

{"title":"Degree of Myopia and Reduced Physical Activity in 3600 College Students in China.","authors":"Xiangyu Zhao, Yanan Zhang","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND This study aimed to evaluate the degree of myopia and reduced physical activity in 3600 college students in China between 2018 and 2020. MATERIAL AND METHODS The study included 3600 participants (1742 men and 1858 women) aged 19 to 23 years from a Chinese college. The distribution of the levels of eyesight associated with physical exercise was assessed using the Early Treatment Diabetic Retinopathy Study chart measurement method. RESULTS The rates of myopia of students enrolled students in 2018, 2019, and 2020 were 84.31%, 87.22%, and 89.17%, respectively, which showed an increasing trend (P<0.01). For the students starting in 2018, the rate of myopia showed an upward trend in their 3 years of college (P<0.01). The incidence of myopia was significantly different during the academic year between students who participated and did not participate in sports clubs (P<0.01). CONCLUSIONS The findings from this study showed that between 2018 and 2020 there was a high prevalence of myopia in college students in China, which increased annually and was associated with reduced physical activity while at college. These findings may have public health implications for improving physical activity in this population. Physical exercise could effectively prevent the occurrence of myopia, improve the visual status of students, and alleviate the decline of vision.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39914069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degree of Myopia and Reduced Physical Activity in 3600 College Students in China 3600名中国大学生近视程度与体育活动减少

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-02-14 DOI: 10.12659/MSMBR.934807

Xiangyu Zhao, Yanan Zhang

{"title":"Degree of Myopia and Reduced Physical Activity in 3600 College Students in China","authors":"Xiangyu Zhao, Yanan Zhang","doi":"10.12659/MSMBR.934807","DOIUrl":"https://doi.org/10.12659/MSMBR.934807","url":null,"abstract":"Background This study aimed to evaluate the degree of myopia and reduced physical activity in 3600 college students in China between 2018 and 2020. Material/Methods The study included 3600 participants (1742 men and 1858 women) aged 19 to 23 years from a Chinese college. The distribution of the levels of eyesight associated with physical exercise was assessed using the Early Treatment Diabetic Retinopathy Study chart measurement method. Results The rates of myopia of students enrolled students in 2018, 2019, and 2020 were 84.31%, 87.22%, and 89.17%, respectively, which showed an increasing trend (P<0.01). For the students starting in 2018, the rate of myopia showed an upward trend in their 3 years of college (P<0.01). The incidence of myopia was significantly different during the academic year between students who participated and did not participate in sports clubs (P<0.01). Conclusions The findings from this study showed that between 2018 and 2020 there was a high prevalence of myopia in college students in China, which increased annually and was associated with reduced physical activity while at college. These findings may have public health implications for improving physical activity in this population. Physical exercise could effectively prevent the occurrence of myopia, improve the visual status of students, and alleviate the decline of vision.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75582525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anodal Transcranial Direct Current Stimulation (tDCS) Over the Primary Motor Cortex (M1) Enhances Motor Response Inhibition and Visual Recognition Memory 经颅阳极直流电刺激(tDCS)对初级运动皮层(M1)增强运动反应抑制和视觉识别记忆

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-01-17 DOI: 10.12659/MSMBR.934180

S. Bashir, Azzam Bamugaddam, Muath Alasheikh, Tariq Alhassan, Saud M Alhaidar, Abdulelah Khalaf Almutairi, Mohammed Alfaleh, K. Al-Regaiey, Sultan S. Al Zahrani, Bassam Ali Albaiji, T. Abualait

{"title":"Anodal Transcranial Direct Current Stimulation (tDCS) Over the Primary Motor Cortex (M1) Enhances Motor Response Inhibition and Visual Recognition Memory","authors":"S. Bashir, Azzam Bamugaddam, Muath Alasheikh, Tariq Alhassan, Saud M Alhaidar, Abdulelah Khalaf Almutairi, Mohammed Alfaleh, K. Al-Regaiey, Sultan S. Al Zahrani, Bassam Ali Albaiji, T. Abualait","doi":"10.12659/MSMBR.934180","DOIUrl":"https://doi.org/10.12659/MSMBR.934180","url":null,"abstract":"Background Transcranial direct current stimulation (tDCS) is a non-invasive brain modulatory technique that can boost cognitive processes and alter performance in cognitive tasks. The effect of anodal-tDCS on cognitive functions following a single session has been repeatedly reported. However, results are varied, mixed, and confounded by several factors, including differences in tDCS current intensity and sham conditions used. Therefore, we assessed the effect of a single session of anodal-tDCS over the primary motor cortex (M1) on cognitive functions, particularly response inhibitory control and visual recognition memory, in healthy adults. Material/Methods Thirty healthy male subjects participated in a randomized, double-blind, sham-controlled tDCS study (2 mA, for 20 min). In the sham stimulation, subjects received the same intensity (2 mA, for 30 s, ramped up, then ramped down). We assessed the cognitive functions response inhibitory control and visual recognition memory using the stop signal task (SST) and pattern recognition memory (PRM) task before and after the stimulation. Results There was a statistically significant difference in cognitive function as assessed by the stop signal task go trial (SST) (P=0.019) and SST correct response time on go trials (P=0.04) after real stimulation only. There was no significant effect observed in sham condition. Conclusions The findings suggest that anodal-tDCS applied over M1 improves inhibitory control and visual recognition memory compared to sham stimulation. Thus, application of anodal-tDCS to the M1, as an integral node in inhibitory motor control, might be a promising adjuvant therapeutic intervention for modulation of motor response inhibition.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80386544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anodal Transcranial Direct Current Stimulation (tDCS) Over the Primary Motor Cortex (M1) Enhances Motor Response Inhibition and Visual Recognition Memory. 初级运动皮层（M1）上的阳极经颅直流电刺激（tDCS）可增强运动反应抑制和视觉识别记忆。

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2022-01-17

Shahid Bashir, Azzam Bamugaddam, Muath Alasheikh, Tariq Alhassan, Saud Alhaidar, Abdulelah Khalaf Almutairi, Mohammed Alfaleh, Khalid Al-Regaiey, Sultan S Al Zahrani, Bassam Ali Albaiji, Turki Abualait

{"title":"Anodal Transcranial Direct Current Stimulation (tDCS) Over the Primary Motor Cortex (M1) Enhances Motor Response Inhibition and Visual Recognition Memory.","authors":"Shahid Bashir, Azzam Bamugaddam, Muath Alasheikh, Tariq Alhassan, Saud Alhaidar, Abdulelah Khalaf Almutairi, Mohammed Alfaleh, Khalid Al-Regaiey, Sultan S Al Zahrani, Bassam Ali Albaiji, Turki Abualait","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND Transcranial direct current stimulation (tDCS) is a non-invasive brain modulatory technique that can boost cognitive processes and alter performance in cognitive tasks. The effect of anodal-tDCS on cognitive functions following a single session has been repeatedly reported. However, results are varied, mixed, and confounded by several factors, including differences in tDCS current intensity and sham conditions used. Therefore, we assessed the effect of a single session of anodal-tDCS over the primary motor cortex (M1) on cognitive functions, particularly response inhibitory control and visual recognition memory, in healthy adults. MATERIAL AND METHODS Thirty healthy male subjects participated in a randomized, double-blind, sham-controlled tDCS study (2 mA, for 20 min). In the sham stimulation, subjects received the same intensity (2 mA, for 30 s, ramped up, then ramped down). We assessed the cognitive functions response inhibitory control and visual recognition memory using the stop signal task (SST) and pattern recognition memory (PRM) task before and after the stimulation. RESULTS There was a statistically significant difference in cognitive function as assessed by the stop signal task go trial (SST) (P=0.019) and SST correct response time on go trials (P=0.04) after real stimulation only. There was no significant effect observed in sham condition. CONCLUSIONS The findings suggest that anodal-tDCS applied over M1 improves inhibitory control and visual recognition memory compared to sham stimulation. Thus, application of anodal-tDCS to the M1, as an integral node in inhibitory motor control, might be a promising adjuvant therapeutic intervention for modulation of motor response inhibition.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39824681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020 科索沃共和国关于批量质量保证抽样(LQAS)评估2018年至2020年12至24月龄儿童疫苗接种状况的全国横断面研究

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2021-12-27 DOI: 10.12659/MSMBR.934194

Bashkim Gllareva, Isme Humolli, I. Rudhani, X. Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi

{"title":"A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020","authors":"Bashkim Gllareva, Isme Humolli, I. Rudhani, X. Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi","doi":"10.12659/MSMBR.934194","DOIUrl":"https://doi.org/10.12659/MSMBR.934194","url":null,"abstract":"Background In the Republic of Kosovo, full vaccination status in children under age 2 years includes: 1 dose of Bacillus Calmette-Guérin (BCG) hepatitis B virus (HBV) vaccine; 3 doses of diphtheria, tetanus, pertussis, hepatitis B, polio, and Haemophilus influenzae type b (DTaP-HB-IPV-Hib) vaccine; 3 doses of inactivated polio vaccine (IPV); and 1 dose of measles, mumps, and rubella (MMR) vaccine. Lot quality assurance sampling (LQAS) is a method used to assess the performance of health quality indicators. Material/Methods A national cross-sectional study with children aged between 12 and 24 months from Kosovo was performed between 2018 and 2020. The vaccination status of children was assessed with lot quality assurance sampling (LQAS) using randomized samples. Results Among 430 children, more than 90% had completed the full immunization schedule. Delays in children’s immunizations were observed. Most vaccinations showed short delays of less than 1 month, followed by delays of up to 3 months. The main reason for vaccination delay was the COVID-19 pandemic, following by child’s illness at the scheduled time of vaccination or the parents were too busy to take the child to the vaccination site. Meanwhile, child age was the only parameter that showed difference among non-vaccinated and fully vaccinated (P<0.001). Conclusions LQAS analysis showed that between 2018 and 2020 lack of full immunization was due to delay caused by the parent not taking the child to the vaccination site, which may be prevented by improving information given to parents and the use of vaccination reminders.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84609719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020. 科索沃共和国关于批量质量保证抽样（LQAS）的全国横断面研究，以评估 2018 年至 2020 年期间 12 至 24 个月大儿童的疫苗接种情况。

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2021-12-27

Bashkim Bejtë Gllareva, Isme Humolli, Ibrahim Rudhani, Xhevat Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi

{"title":"A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020.","authors":"Bashkim Bejtë Gllareva, Isme Humolli, Ibrahim Rudhani, Xhevat Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND In the Republic of Kosovo, full vaccination status in children under age 2 years includes: 1 dose of Bacillus Calmette-Guerin (BCG) hepatitis B virus (HBV) vaccine; 3 doses of diphtheria, tetanus, pertussis, hepatitis B, polio, and Haemophilus influenzae type b (DTaP-HB-IPV-Hib) vaccine; 3 doses of inactivated polio vaccine (IPV); and 1 dose of measles, mumps, and rubella (MMR) vaccine. Lot quality assurance sampling (LQAS) is a method used to assess the performance of health quality indicators. MATERIAL AND METHODS A national cross-sectional study with children aged between 12 and 24 months from Kosovo was performed between 2018 and 2020. The vaccination status of children was assessed with lot quality assurance sampling (LQAS) using randomized samples. RESULTS Among 430 children, more than 90% had completed the full immunization schedule. Delays in children's immunizations were observed. Most vaccinations showed short delays of less than 1 month, followed by delays of up to 3 months. The main reason for vaccination delay was the COVID-19 pandemic, following by child's illness at the scheduled time of vaccination or the parents were too busy to take the child to the vaccination site. Meanwhile, child age was the only parameter that showed difference among non-vaccinated and fully vaccinated (P<0.001). CONCLUSIONS LQAS analysis showed that between 2018 and 2020 lack of full immunization was due to delay caused by the parent not taking the child to the vaccination site, which may be prevented by improving information given to parents and the use of vaccination reminders.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39876138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Hepatitis B and C Virus Infections: Influence of National Health Care Policies and Local Clinical Practices 乙型和丙型肝炎病毒感染的流行:国家卫生保健政策和地方临床实践的影响

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2021-11-01 DOI: 10.12659/MSMBR.933692

V. Lekskulchai

{"title":"Prevalence of Hepatitis B and C Virus Infections: Influence of National Health Care Policies and Local Clinical Practices","authors":"V. Lekskulchai","doi":"10.12659/MSMBR.933692","DOIUrl":"https://doi.org/10.12659/MSMBR.933692","url":null,"abstract":"Background : Because reliable epidemiological data are necessary to eliminate hepatitis B and C virus (HBV and HCV) infections, factors influencing their prevalence should be determined. This study aimed to disclose practical issues that affect the prevalence of these viral infections. Material/Methods All medical records with laboratory findings during 2016 to 2018 were reviewed, and all relevant data were extracted. All HBV and HCV infections were followed within these 3 years and investigated in detail. Results The total number of records was 103 197, with a male to female ratio of 1: 1.4. Hepatitis B surface antigen (HBsAg) was tested in 12 934 cases, with a male to female ratio of 1: 2.6. Anti-HCV antibody (anti-HCV Ab) testing was done in 475 cases (53% male). The seroprevalence of HBV and HCV was 5.2% and 4.4%, respectively. Chronic HBV and HCV infections and their life-threatening complication, liver cancer, were highly detected in men aged 41–60 years. Conclusions HBsAg was highly screened in women owing to the nationwide implementation of the universal HBsAg screening in pregnant women to prevent vertical transmission. Screening for anti-HCV Ab was neglected, probably due to lack of vaccine and high costs of anti-HCV drugs, which most people in low- to middle-income countries generally cannot afford. Local practices under national health care policies and limited budget and resources can cause underestimation of the prevalence of the HBV and HCV infections and persistent transmission of these viruses owing to unidentified cases.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84036983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0