Medical Science Monitor Basic Research最新文献_第3页

Degree of Myopia and Reduced Physical Activity in 3600 College Students in China 3600名中国大学生近视程度与体育活动减少

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-02-14 DOI: 10.12659/MSMBR.934807

Xiangyu Zhao, Yanan Zhang

{"title":"Degree of Myopia and Reduced Physical Activity in 3600 College Students in China","authors":"Xiangyu Zhao, Yanan Zhang","doi":"10.12659/MSMBR.934807","DOIUrl":"https://doi.org/10.12659/MSMBR.934807","url":null,"abstract":"Background This study aimed to evaluate the degree of myopia and reduced physical activity in 3600 college students in China between 2018 and 2020. Material/Methods The study included 3600 participants (1742 men and 1858 women) aged 19 to 23 years from a Chinese college. The distribution of the levels of eyesight associated with physical exercise was assessed using the Early Treatment Diabetic Retinopathy Study chart measurement method. Results The rates of myopia of students enrolled students in 2018, 2019, and 2020 were 84.31%, 87.22%, and 89.17%, respectively, which showed an increasing trend (P<0.01). For the students starting in 2018, the rate of myopia showed an upward trend in their 3 years of college (P<0.01). The incidence of myopia was significantly different during the academic year between students who participated and did not participate in sports clubs (P<0.01). Conclusions The findings from this study showed that between 2018 and 2020 there was a high prevalence of myopia in college students in China, which increased annually and was associated with reduced physical activity while at college. These findings may have public health implications for improving physical activity in this population. Physical exercise could effectively prevent the occurrence of myopia, improve the visual status of students, and alleviate the decline of vision.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"211 1","pages":"e934807-1 - e934807-6"},"PeriodicalIF":2.8,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75582525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anodal Transcranial Direct Current Stimulation (tDCS) Over the Primary Motor Cortex (M1) Enhances Motor Response Inhibition and Visual Recognition Memory 经颅阳极直流电刺激(tDCS)对初级运动皮层(M1)增强运动反应抑制和视觉识别记忆

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-01-17 DOI: 10.12659/MSMBR.934180

S. Bashir, Azzam Bamugaddam, Muath Alasheikh, Tariq Alhassan, Saud M Alhaidar, Abdulelah Khalaf Almutairi, Mohammed Alfaleh, K. Al-Regaiey, Sultan S. Al Zahrani, Bassam Ali Albaiji, T. Abualait

{"title":"Anodal Transcranial Direct Current Stimulation (tDCS) Over the Primary Motor Cortex (M1) Enhances Motor Response Inhibition and Visual Recognition Memory","authors":"S. Bashir, Azzam Bamugaddam, Muath Alasheikh, Tariq Alhassan, Saud M Alhaidar, Abdulelah Khalaf Almutairi, Mohammed Alfaleh, K. Al-Regaiey, Sultan S. Al Zahrani, Bassam Ali Albaiji, T. Abualait","doi":"10.12659/MSMBR.934180","DOIUrl":"https://doi.org/10.12659/MSMBR.934180","url":null,"abstract":"Background Transcranial direct current stimulation (tDCS) is a non-invasive brain modulatory technique that can boost cognitive processes and alter performance in cognitive tasks. The effect of anodal-tDCS on cognitive functions following a single session has been repeatedly reported. However, results are varied, mixed, and confounded by several factors, including differences in tDCS current intensity and sham conditions used. Therefore, we assessed the effect of a single session of anodal-tDCS over the primary motor cortex (M1) on cognitive functions, particularly response inhibitory control and visual recognition memory, in healthy adults. Material/Methods Thirty healthy male subjects participated in a randomized, double-blind, sham-controlled tDCS study (2 mA, for 20 min). In the sham stimulation, subjects received the same intensity (2 mA, for 30 s, ramped up, then ramped down). We assessed the cognitive functions response inhibitory control and visual recognition memory using the stop signal task (SST) and pattern recognition memory (PRM) task before and after the stimulation. Results There was a statistically significant difference in cognitive function as assessed by the stop signal task go trial (SST) (P=0.019) and SST correct response time on go trials (P=0.04) after real stimulation only. There was no significant effect observed in sham condition. Conclusions The findings suggest that anodal-tDCS applied over M1 improves inhibitory control and visual recognition memory compared to sham stimulation. Thus, application of anodal-tDCS to the M1, as an integral node in inhibitory motor control, might be a promising adjuvant therapeutic intervention for modulation of motor response inhibition.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"89 1","pages":"e934180-1 - e934180-7"},"PeriodicalIF":2.8,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80386544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020 科索沃共和国关于批量质量保证抽样(LQAS)评估2018年至2020年12至24月龄儿童疫苗接种状况的全国横断面研究

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2021-12-27 DOI: 10.12659/MSMBR.934194

Bashkim Gllareva, Isme Humolli, I. Rudhani, X. Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi

{"title":"A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020","authors":"Bashkim Gllareva, Isme Humolli, I. Rudhani, X. Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi","doi":"10.12659/MSMBR.934194","DOIUrl":"https://doi.org/10.12659/MSMBR.934194","url":null,"abstract":"Background In the Republic of Kosovo, full vaccination status in children under age 2 years includes: 1 dose of Bacillus Calmette-Guérin (BCG) hepatitis B virus (HBV) vaccine; 3 doses of diphtheria, tetanus, pertussis, hepatitis B, polio, and Haemophilus influenzae type b (DTaP-HB-IPV-Hib) vaccine; 3 doses of inactivated polio vaccine (IPV); and 1 dose of measles, mumps, and rubella (MMR) vaccine. Lot quality assurance sampling (LQAS) is a method used to assess the performance of health quality indicators. Material/Methods A national cross-sectional study with children aged between 12 and 24 months from Kosovo was performed between 2018 and 2020. The vaccination status of children was assessed with lot quality assurance sampling (LQAS) using randomized samples. Results Among 430 children, more than 90% had completed the full immunization schedule. Delays in children’s immunizations were observed. Most vaccinations showed short delays of less than 1 month, followed by delays of up to 3 months. The main reason for vaccination delay was the COVID-19 pandemic, following by child’s illness at the scheduled time of vaccination or the parents were too busy to take the child to the vaccination site. Meanwhile, child age was the only parameter that showed difference among non-vaccinated and fully vaccinated (P<0.001). Conclusions LQAS analysis showed that between 2018 and 2020 lack of full immunization was due to delay caused by the parent not taking the child to the vaccination site, which may be prevented by improving information given to parents and the use of vaccination reminders.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"22 1","pages":"e934194-1 - e934194-9"},"PeriodicalIF":2.8,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84609719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020. 科索沃共和国关于批量质量保证抽样（LQAS）的全国横断面研究，以评估 2018 年至 2020 年期间 12 至 24 个月大儿童的疫苗接种情况。

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2021-12-27

Bashkim Bejtë Gllareva, Isme Humolli, Ibrahim Rudhani, Xhevat Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi

{"title":"A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020.","authors":"Bashkim Bejtë Gllareva, Isme Humolli, Ibrahim Rudhani, Xhevat Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND In the Republic of Kosovo, full vaccination status in children under age 2 years includes: 1 dose of Bacillus Calmette-Guerin (BCG) hepatitis B virus (HBV) vaccine; 3 doses of diphtheria, tetanus, pertussis, hepatitis B, polio, and Haemophilus influenzae type b (DTaP-HB-IPV-Hib) vaccine; 3 doses of inactivated polio vaccine (IPV); and 1 dose of measles, mumps, and rubella (MMR) vaccine. Lot quality assurance sampling (LQAS) is a method used to assess the performance of health quality indicators. MATERIAL AND METHODS A national cross-sectional study with children aged between 12 and 24 months from Kosovo was performed between 2018 and 2020. The vaccination status of children was assessed with lot quality assurance sampling (LQAS) using randomized samples. RESULTS Among 430 children, more than 90% had completed the full immunization schedule. Delays in children's immunizations were observed. Most vaccinations showed short delays of less than 1 month, followed by delays of up to 3 months. The main reason for vaccination delay was the COVID-19 pandemic, following by child's illness at the scheduled time of vaccination or the parents were too busy to take the child to the vaccination site. Meanwhile, child age was the only parameter that showed difference among non-vaccinated and fully vaccinated (P<0.001). CONCLUSIONS LQAS analysis showed that between 2018 and 2020 lack of full immunization was due to delay caused by the parent not taking the child to the vaccination site, which may be prevented by improving information given to parents and the use of vaccination reminders.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"27 ","pages":"e934194"},"PeriodicalIF":1.5,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39876138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Hepatitis B and C Virus Infections: Influence of National Health Care Policies and Local Clinical Practices 乙型和丙型肝炎病毒感染的流行:国家卫生保健政策和地方临床实践的影响

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2021-11-01 DOI: 10.12659/MSMBR.933692

V. Lekskulchai

{"title":"Prevalence of Hepatitis B and C Virus Infections: Influence of National Health Care Policies and Local Clinical Practices","authors":"V. Lekskulchai","doi":"10.12659/MSMBR.933692","DOIUrl":"https://doi.org/10.12659/MSMBR.933692","url":null,"abstract":"Background : Because reliable epidemiological data are necessary to eliminate hepatitis B and C virus (HBV and HCV) infections, factors influencing their prevalence should be determined. This study aimed to disclose practical issues that affect the prevalence of these viral infections. Material/Methods All medical records with laboratory findings during 2016 to 2018 were reviewed, and all relevant data were extracted. All HBV and HCV infections were followed within these 3 years and investigated in detail. Results The total number of records was 103 197, with a male to female ratio of 1: 1.4. Hepatitis B surface antigen (HBsAg) was tested in 12 934 cases, with a male to female ratio of 1: 2.6. Anti-HCV antibody (anti-HCV Ab) testing was done in 475 cases (53% male). The seroprevalence of HBV and HCV was 5.2% and 4.4%, respectively. Chronic HBV and HCV infections and their life-threatening complication, liver cancer, were highly detected in men aged 41–60 years. Conclusions HBsAg was highly screened in women owing to the nationwide implementation of the universal HBsAg screening in pregnant women to prevent vertical transmission. Screening for anti-HCV Ab was neglected, probably due to lack of vaccine and high costs of anti-HCV drugs, which most people in low- to middle-income countries generally cannot afford. Local practices under national health care policies and limited budget and resources can cause underestimation of the prevalence of the HBV and HCV infections and persistent transmission of these viruses owing to unidentified cases.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"85 1","pages":"e933692-1 - e933692-9"},"PeriodicalIF":2.8,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84036983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Hepatitis B and C Virus Infections: Influence of National Health Care Policies and Local Clinical Practices. 乙型肝炎和丙型肝炎病毒感染的流行情况：国家医疗保健政策和地方临床实践的影响。

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2021-11-01

Veeravan Lekskulchai

{"title":"Prevalence of Hepatitis B and C Virus Infections: Influence of National Health Care Policies and Local Clinical Practices.","authors":"Veeravan Lekskulchai","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND Because reliable epidemiological data are necessary to eliminate hepatitis B and C virus (HBV and HCV) infections, factors influencing their prevalence should be determined. This study aimed to disclose practical issues that affect the prevalence of these viral infections. MATERIAL AND METHODS All medical records with laboratory findings during 2016 to 2018 were reviewed, and all relevant data were extracted. All HBV and HCV infections were followed within these 3 years and investigated in detail. RESULTS The total number of records was 103 197, with a male to female ratio of 1: 1.4. Hepatitis B surface antigen (HBsAg) was tested in 12 934 cases, with a male to female ratio of 1: 2.6. Anti-HCV antibody (anti-HCV Ab) testing was done in 475 cases (53% male). The seroprevalence of HBV and HCV was 5.2% and 4.4%, respectively. Chronic HBV and HCV infections and their life-threatening complication, liver cancer, were highly detected in men aged 41-60 years. CONCLUSIONS HBsAg was highly screened in women owing to the nationwide implementation of the universal HBsAg screening in pregnant women to prevent vertical transmission. Screening for anti-HCV Ab was neglected, probably due to lack of vaccine and high costs of anti-HCV drugs, which most people in low- to middle-income countries generally cannot afford. Local practices under national health care policies and limited budget and resources can cause underestimation of the prevalence of the HBV and HCV infections and persistent transmission of these viruses owing to unidentified cases.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"27 ","pages":"e933692"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39681637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroacupuncture Inhibits Myelin Sheath Injury in the Internal Capsule After Focal Cerebral Infarction in Rats Through the Nogo-A/NgR Signaling Pathway. 电针通过Nogo-A/NgR信号通路抑制大鼠局灶性脑梗死后内囊髓鞘损伤

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2021-10-01

Wenqing Dong, Huachun Miao, Huaibin Li, Feng Wu

{"title":"Electroacupuncture Inhibits Myelin Sheath Injury in the Internal Capsule After Focal Cerebral Infarction in Rats Through the Nogo-A/NgR Signaling Pathway.","authors":"Wenqing Dong, Huachun Miao, Huaibin Li, Feng Wu","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND Ischemic stroke is usually accompanied by white matter damage. The effect of electroacupuncture (EA) on ameliorating white matter damage is still unclear. The purpose of this study was to explore the precise mechanism of EA in treating ischemic white matter. MATERIAL AND METHODS In this study, 40 Sprague-Dawley rats were randomly divided into 4 groups: normal group, the sham-operated group, model group, and EA group. The stroke model was established by right middle cerebral artery occlusion, and EA was performed 24 h after the operation for 30 min per day. After 14 days of treatment, brain tissue samples were collected. Hematoxylin and eosin and Luxol fast blue staining were used to observe the changes of white matter damage in the internal capsule (IC). The expression levels of myelin basic protein (MBP), Nogo-A, and Nogo-A receptor (NgR) were detected by immunohistochemistry and western blot. RESULTS Compared with the sham-operated group, the model group had decreased expression of MBP and significantly increased expression of Nogo-A and NgR (P<0.05). Compared with the model group, the IC damage was alleviated in the EA group. Immunohistochemistry and western blot analysis showed that EA significantly increased the expression of MBP in white matter (P<0.05) and downregulated the expression levels of Nogo-A and NgR (P<0.05). CONCLUSIONS The results of this study indicate that EA can inhibit the expression of Nogo-A/NgR and promote myelin sheath regeneration.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"27 ","pages":"e933253"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39498324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroacupuncture Inhibits Myelin Sheath Injury in the Internal Capsule After Focal Cerebral Infarction in Rats Through the Nogo-A/NgR Signaling Pathway 电针通过Nogo-A/NgR信号通路抑制局灶性脑梗死后大鼠内胶囊髓鞘损伤

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2021-10-01 DOI: 10.12659/MSMBR.933253

W. Dong, Hua-chun Miao, Huai-bin Li, Feng Wu

{"title":"Electroacupuncture Inhibits Myelin Sheath Injury in the Internal Capsule After Focal Cerebral Infarction in Rats Through the Nogo-A/NgR Signaling Pathway","authors":"W. Dong, Hua-chun Miao, Huai-bin Li, Feng Wu","doi":"10.12659/MSMBR.933253","DOIUrl":"https://doi.org/10.12659/MSMBR.933253","url":null,"abstract":"Background Ischemic stroke is usually accompanied by white matter damage. The effect of electroacupuncture (EA) on ameliorating white matter damage is still unclear. The purpose of this study was to explore the precise mechanism of EA in treating ischemic white matter. Material/Methods In this study, 40 Sprague-Dawley rats were randomly divided into 4 groups: normal group, the sham-operated group, model group, and EA group. The stroke model was established by right middle cerebral artery occlusion, and EA was performed 24 h after the operation for 30 min per day. After 14 days of treatment, brain tissue samples were collected. Hematoxylin and eosin and Luxol fast blue staining were used to observe the changes of white matter damage in the internal capsule (IC). The expression levels of myelin basic protein (MBP), Nogo-A, and Nogo-A receptor (NgR) were detected by immunohistochemistry and western blot. Results Compared with the sham-operated group, the model group had decreased expression of MBP and significantly increased expression of Nogo-A and NgR (P<0.05). Compared with the model group, the IC damage was alleviated in the EA group. Immunohistochemistry and western blot analysis showed that EA significantly increased the expression of MBP in white matter (P<0.05) and downregulated the expression levels of Nogo-A and NgR (P<0.05). Conclusions The results of this study indicate that EA can inhibit the expression of Nogo-A/NgR and promote myelin sheath regeneration.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"36 1","pages":"e933253-1 - e933253-8"},"PeriodicalIF":2.8,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81064932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size of Acute Myocardial Infarction Correlates with Earlier Time of Initiation of Reperfusion Therapy with Cardiac Perfusion Scintigraphy: A National Single-Center Study. 急性心肌梗死的大小与较早开始使用心脏灌注闪烁成像进行再灌注治疗有关：全国单中心研究

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2021-09-13

Hajdin Çitaku, Ramë Miftari, David Stubljar, Xhevdet Krasniqi

{"title":"Size of Acute Myocardial Infarction Correlates with Earlier Time of Initiation of Reperfusion Therapy with Cardiac Perfusion Scintigraphy: A National Single-Center Study.","authors":"Hajdin Çitaku, Ramë Miftari, David Stubljar, Xhevdet Krasniqi","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND The aim of this study was to determine the correlation between the size of acute myocardial infarction (AMI) and the time of initiation of reperfusion therapy with cardiac perfusion scintigraphy. MATERIAL AND METHODS Overall, 80 patients with acute ST elevation myocardial infarction (STEMI) were examined. All patients were treated with primary percutaneous coronary intervention (pPCI). Data on patient and system delay expressed in minutes were recorded and compared with recommended timelines. Cardiac scintigraphy was performed with 99m Tc-sestamibi single-photon emission computed tomography (SPECT). The median time of cardiac scintigraphy was 20 days. The correlation between the size of infarction and the time of initiation of reperfusion therapy was evaluated. RESULTS The mean age of patients was 60.5±11.5 years, and 72.5% were male. The average system delay was 348 min, and the average patient delay was 173 min. The mean total ischemic time was 800 min. There was a correlation between time delays of reperfusion therapy and infarct size. Patients with a shorter time delay to patent artery after FMC showed smaller infarct size when compared to the patients with longer delay times. Multiple linear regression analysis showed that FMC, being male, and smokers had statistical significance when predicting infarct size. CONCLUSIONS There is a correlation between the size of myocardial infarction and the time of initiation of reperfusion therapy determined by perfusion myocardial scintigraphy. The study showed that there are time delays in starting the treatment of AMI with pPCI when compared to the recommended time, which requires an action plan in the near future to ensure earlier treatment for our patients.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"27 ","pages":"e933214"},"PeriodicalIF":1.5,"publicationDate":"2021-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39408015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size of Acute Myocardial Infarction Correlates with Earlier Time of Initiation of Reperfusion Therapy with Cardiac Perfusion Scintigraphy: A National Single-Center Study 急性心肌梗死的大小与心脏灌注显像开始再灌注治疗的早期时间相关:一项国家单中心研究

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2021-09-13 DOI: 10.12659/MSMBR.933214

Hajdin Çitaku, R. Miftari, D. Štubljar, X. Krasniqi

{"title":"Size of Acute Myocardial Infarction Correlates with Earlier Time of Initiation of Reperfusion Therapy with Cardiac Perfusion Scintigraphy: A National Single-Center Study","authors":"Hajdin Çitaku, R. Miftari, D. Štubljar, X. Krasniqi","doi":"10.12659/MSMBR.933214","DOIUrl":"https://doi.org/10.12659/MSMBR.933214","url":null,"abstract":"Background The aim of this study was to determine the correlation between the size of acute myocardial infarction (AMI) and the time of initiation of reperfusion therapy with cardiac perfusion scintigraphy. Material/Methods Overall, 80 patients with acute ST elevation myocardial infarction (STEMI) were examined. All patients were treated with primary percutaneous coronary intervention (pPCI). Data on patient and system delay expressed in minutes were recorded and compared with recommended timelines. Cardiac scintigraphy was performed with 99m Tc-sestamibi single-photon emission computed tomography (SPECT). The median time of cardiac scintigraphy was 20 days. The correlation between the size of infarction and the time of initiation of reperfusion therapy was evaluated. Results The mean age of patients was 60.5±11.5 years, and 72.5% were male. The average system delay was 348 min, and the average patient delay was 173 min. The mean total ischemic time was 800 min. There was a correlation between time delays of reperfusion therapy and infarct size. Patients with a shorter time delay to patent artery after FMC showed smaller infarct size when compared to the patients with longer delay times. Multiple linear regression analysis showed that FMC, being male, and smokers had statistical significance when predicting infarct size. Conclusions There is a correlation between the size of myocardial infarction and the time of initiation of reperfusion therapy determined by perfusion myocardial scintigraphy. The study showed that there are time delays in starting the treatment of AMI with pPCI when compared to the recommended time, which requires an action plan in the near future to ensure earlier treatment for our patients.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"109 48","pages":"e933214-1 - e933214-6"},"PeriodicalIF":2.8,"publicationDate":"2021-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72376969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1