Medical Science Monitor Basic Research最新文献_第3页

Evaluation of Apical Leakage After Root Canal Obturation with Glass Ionomer, Resin, and Zinc Oxide Eugenol Sealers Combined with Thermafil. 玻璃离子、树脂、氧化锌丁香酚密封剂联合Thermafil对根管封闭后根尖渗漏的评价。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-06-15 DOI: 10.12659/MSMBR.936675

Violeta Vula, Miranda Stavileci, Nexhmije Ajeti, Vegim Vula, Astrit Kuçi, Kastriot Meqa

{"title":"Evaluation of Apical Leakage After Root Canal Obturation with Glass Ionomer, Resin, and Zinc Oxide Eugenol Sealers Combined with Thermafil.","authors":"Violeta Vula, Miranda Stavileci, Nexhmije Ajeti, Vegim Vula, Astrit Kuçi, Kastriot Meqa","doi":"10.12659/MSMBR.936675","DOIUrl":"https://doi.org/10.12659/MSMBR.936675","url":null,"abstract":"BACKGROUND A hermetic seal at the apical terminus is required for healthy periradicular tissue. Root canal obturation sealers that are used in endodontics are based on zinc oxide eugenol, calcium hydroxide, resins, glass ionomers, silicone, or bioceramics, but no optimal sealer material has been identified to date. Therefore, the aim of this in vitro study was to evaluate apical leakage after crown-down preparation and root canal obturation with Endomethasone N, glass ionomer cement, and EndoRez sealers. MATERIAL AND METHODS For this in vitro study, we tested 92 extracted human teeth, which were divided into 3 groups after a preparation technique and obturation with Endomethasone N sealer, glass ionomer cement, and EndoRez sealer in combination with Thermafil obturator. Apical leakage was evaluated and compared among the tested groups using a dye leakage method through a stereomicroscope. The values were measured from the apex to the coronal extent of dye penetration. For statistical analysis, the t test was used for comparison of the arithmetic averages of tested groups. RESULTS After preparation with rotary files, tested groups obturated with Thermafil obturator in combination with Endomethasone sealer showed higher average dye penetration than tested groups obturated with EndoRez and glass ionomer sealer. CONCLUSIONS Although all experimental groups showed dye leakage, the glass ionomer sealer in combination with Thermafil showed the least leakage, compared with EndoRez and Endomethason N.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":" ","pages":"e936675"},"PeriodicalIF":2.8,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/14/medscimonitbasicres-28-e936675.PMC9208302.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40410937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Sealing Abilities Among Zinc Oxide Eugenol Root-Canal Filling Cement, Antibacterial Bioceramic Paste, and Epoxy Resin, using Enterococcus faecalis as a Microbial Tracer. 用粪肠球菌作为微生物示踪剂对氧化锌丁香酚根管充填水泥、抗菌生物陶瓷膏和环氧树脂封堵性能的比较。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-06-01 DOI: 10.12659/MSMBR.936319

Tringa Kelmendi, Ferit Koçani, Arsim Kurti, Blerim Kamberi, Anila Kamberi

{"title":"Comparison of Sealing Abilities Among Zinc Oxide Eugenol Root-Canal Filling Cement, Antibacterial Bioceramic Paste, and Epoxy Resin, using Enterococcus faecalis as a Microbial Tracer.","authors":"Tringa Kelmendi, Ferit Koçani, Arsim Kurti, Blerim Kamberi, Anila Kamberi","doi":"10.12659/MSMBR.936319","DOIUrl":"https://doi.org/10.12659/MSMBR.936319","url":null,"abstract":"BACKGROUND This study aimed to compare sealing abilities among 3 root canal sealers, using Enterococcus faecalis as a microbial tracer. MATERIAL AND METHODS Sixty-six straight single-rooted teeth were subjected to crown removal at the cementoenamel junction. Root canals were instrumented using the crown-down technique. Prepared teeth were randomly divided into 3 groups of 22 teeth each, according to the sealer used: Canason zinc oxide eugenol root-canal filling cement, Well-Root ST antibacterial bioceramic paste, and AH 26 epoxy resin. Root canals were obturated using the lateral condensation technique, then stored at 37°C and 100% humidity for 1 week to allow sealers to set completely. Subsequently, bacterial leakage was tested using a 2-chamber method. Twice weekly, fresh E. faecalis was placed into the coronal portion of the filled root canal. Specimens were monitored at 24-h intervals for 33 days. The number of leaking samples and mean interval until leakage were compared among groups. RESULTS The mean intervals until leakage were 5.8 days in the Canason group, 1.5 days in the Well-Root ST group, and 13.3 days in the AH 26 group. These mean intervals significantly differed between the Canason and Well-Root ST groups (P=0.035) and between the AH 26 and Well-Root ST groups (P=0.012). After 33 days, survival rates were 31.8% in the Canason group, 90.9% in the Well-Root ST group, and 68.2% in the AH 26 group (P.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":" ","pages":"e936319"},"PeriodicalIF":2.8,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/ee/medscimonitbasicres-28-e936319.PMC9169682.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40411284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Calcitriol Inhibits Proliferation and Potentially Induces Apoptosis in B16–F10 Cells 骨化三醇抑制B16-F10细胞增殖并可能诱导凋亡

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-05-05 DOI: 10.12659/MSMBR.935139

Eva Krishna Sutedja, Daniar Amarassaphira, H. Goenawan, Y. Pratiwi, N. Sylviana, B. Setiabudiawan, O. Suwarsa, R. Judistiani, U. Supratman, R. Lesmana

{"title":"Calcitriol Inhibits Proliferation and Potentially Induces Apoptosis in B16–F10 Cells","authors":"Eva Krishna Sutedja, Daniar Amarassaphira, H. Goenawan, Y. Pratiwi, N. Sylviana, B. Setiabudiawan, O. Suwarsa, R. Judistiani, U. Supratman, R. Lesmana","doi":"10.12659/MSMBR.935139","DOIUrl":"https://doi.org/10.12659/MSMBR.935139","url":null,"abstract":"Background Melanoma is one of the most aggressive types of cancer and it has shown a remarkable surge in incidence during the last 50 years. Melanoma has been projected to be continuously rising in the future. Therapy for advanced-type melanoma is still a challenge due to the low response rate and poor 10-year survival. Interestingly, several epidemiological and preclinical studies had reported that vitamin D deficiency was associated with disease progression in several cancer types. In vivo and in vitro studies revealed anti-proliferative, anti-angiogenic, apoptosis, and differentiation induction effects of calcitriol in various cancers. However, information on the effects of calcitriol (1,25(OH)2D3) on melanoma is still limited, and its mechanism remains unclear. Material/Methods In the present study, by utilizing B16–F10 cells, which is a melanoma cell line, we explored the anti-proliferative effect of calcitriol using cell viability assay, near-infrared imaging, expression of apoptosis-related genes using real-time polymerase chain reactions (PCR), and the expression of apoptosis proteins levels using western blot. In addition, we also assessed calcitriol uptake by B16–F10 cells using high-performance liquid chromatography (HPLC). Results We found that calcitriol inhibits melanoma cell proliferation with an IC50 of 93.88 ppm (0.24 μM), as shown by cell viability assay. Additionally, we showed that B16–F10 cells are capable of calcitriol uptake, with a peak uptake time at 60 min after administration. Calcitriol was also able to induce apoptosis-related proteins such as caspase-3, caspase 8, and caspase-9. These effects of calcitriol reflect its potential utility as a potent adjuvant therapy for melanoma. Conclusions Calcitriol inhibits cell proliferation and induces apoptosis in B16–F10 cells.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"82 1","pages":"e935139-1 - e935139-12"},"PeriodicalIF":2.8,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83991964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Case-Control Study to Evaluate the Oral Hygiene Habits in 31 Children with Hemophilia in Bulgaria Using the Oral Health Impact Profile-14 (OHIP-14) Questionnaire 使用口腔健康影响概况-14 (OHIP-14)问卷评估保加利亚31例血友病儿童口腔卫生习惯的病例-对照研究

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-04-21 DOI: 10.12659/MSMBR.936560

V. Mandova, R. Stefanov

{"title":"Case-Control Study to Evaluate the Oral Hygiene Habits in 31 Children with Hemophilia in Bulgaria Using the Oral Health Impact Profile-14 (OHIP-14) Questionnaire","authors":"V. Mandova, R. Stefanov","doi":"10.12659/MSMBR.936560","DOIUrl":"https://doi.org/10.12659/MSMBR.936560","url":null,"abstract":"Background For patients with hereditary coagulopathies such as hemophilia, the most common dental problem is spontaneous oral bleeding caused by daily oral hygiene habits like tooth brushing. Because of fear of bleeding, children with hemophilia often skip routine oral hygiene procedures, which can lead to dental caries and periodontal diseases. This case control study aimed to evaluate the oral hygiene awareness and hygiene practices of children with hemophilia from 6 to 18 years of age in Bulgaria. Material/Methods This study was conducted over 4 years and included 31 patients (children). A sociological approach was used, with direct individual questionnaires for self-assessment of dental habits. Statistical analyses were performed using SPSS. Results There was no significant difference between groups in methods of oral hygiene. The duration of oral hygiene procedures was 1 min (n=5, 16.13±6.61%) or 2 min (n=13, 41.94±8.86%), which was considered insufficient for proper oral hygiene. Children who had received oral hygiene advice by a dentist brushed their teeth significantly longer (n=9, 69.23±12.80%) than those who had not. There was a considerable difference between the reasons for the last dental visit between the groups of children (χ2=5.18, P<0.05). Conclusions Children with hemophilia have high awareness of oral hygiene methods; however, more attention should be focused on additional individual educational methods at the dental office. Frequent professional and self-assessment of the oral hygiene routine of children with hemophilia could identify the factors compromising dental status in this vulnerable population.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"15 1","pages":"e936560-1 - e936560-8"},"PeriodicalIF":2.8,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83068260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Case-Control Study to Evaluate the Oral Hygiene Habits in 31 Children with Hemophilia in Bulgaria Using the Oral Health Impact Profile-14 (OHIP-14) Questionnaire. 使用口腔健康影响档案-14 (OHIP-14) 问卷评估保加利亚 31 名血友病患儿口腔卫生习惯的病例对照研究。

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2022-04-21

Viktoriya D Mandova, Rumen S Stefanov

{"title":"Case-Control Study to Evaluate the Oral Hygiene Habits in 31 Children with Hemophilia in Bulgaria Using the Oral Health Impact Profile-14 (OHIP-14) Questionnaire.","authors":"Viktoriya D Mandova, Rumen S Stefanov","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND For patients with hereditary coagulopathies such as hemophilia, the most common dental problem is spontaneous oral bleeding caused by daily oral hygiene habits like tooth brushing. Because of fear of bleeding, children with hemophilia often skip routine oral hygiene procedures, which can lead to dental caries and periodontal diseases. This case control study aimed to evaluate the oral hygiene awareness and hygiene practices of children with hemophilia from 6 to 18 years of age in Bulgaria. MATERIAL AND METHODS This study was conducted over 4 years and included 31 patients (children). A sociological approach was used, with direct individual questionnaires for self-assessment of dental habits. Statistical analyses were performed using SPSS. RESULTS There was no significant difference between groups in methods of oral hygiene. The duration of oral hygiene procedures was 1 min (n=5, 16.13±6.61%) or 2 min (n=13, 41.94±8.86%), which was considered insufficient for proper oral hygiene. Children who had received oral hygiene advice by a dentist brushed their teeth significantly longer (n=9, 69.23±12.80%) than those who had not. There was a considerable difference between the reasons for the last dental visit between the groups of children (χ²=5.18, P.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"28 ","pages":"e936560"},"PeriodicalIF":1.5,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141862063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production of Inflammatory Mediators in Conditioned Medium of Adipose Tissue-Derived Mesenchymal Stem Cells (ATMSC)-Treated Fresh Frozen Plasma. 脂肪组织源性间充质干细胞(ATMSC)处理的新鲜冷冻血浆条件培养基中炎症介质的产生。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-03-23 DOI: 10.12659/MSMBR.933726

Dian Ratih Laksmitawati, Wahyu Widowati, Rachmawati Noverina, Wireni Ayuningtyas, Dedy Kurniawan, Hanna Sari Widya Kusuma, Ervi Afifah, Ratih Rinendyaputri, Rilianawati Rilianawati, Ahmad Faried, Ni Ketut Susilarini

{"title":"Production of Inflammatory Mediators in Conditioned Medium of Adipose Tissue-Derived Mesenchymal Stem Cells (ATMSC)-Treated Fresh Frozen Plasma.","authors":"Dian Ratih Laksmitawati, Wahyu Widowati, Rachmawati Noverina, Wireni Ayuningtyas, Dedy Kurniawan, Hanna Sari Widya Kusuma, Ervi Afifah, Ratih Rinendyaputri, Rilianawati Rilianawati, Ahmad Faried, Ni Ketut Susilarini","doi":"10.12659/MSMBR.933726","DOIUrl":"https://doi.org/10.12659/MSMBR.933726","url":null,"abstract":"BACKGROUND Inflammation is the body's first response to an illness that causes irritation or infection. Inflammation is tightly correlated with aging, which is a progressive degenerative process. Conditioned medium (CM) from adipose tissue-derived mesenchymal stem cells (CM-ATMSCs) has been shown to stimulate collagen synthesis and dermal fibroblast migration, as well as reduce wrinkles and improve wound healing. This study aimed to observe the production of inflammatory modulators - interleukin (IL)-1alpha, IL-6, IL-10, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) - in CM-ATMSCs treated with fresh frozen plasma (FFP) at passages 3 (P3), 7, 11, and 15. MATERIAL AND METHODS ATMSCs P3 were obtained from liposuction of female donors, and the CM from ATMSCs was collected. Measurement of these cytokines was performed with ELISA. RESULTS At many passages, IL-6, a proinflammatory modulator, was discovered to be the most powerful modulator among FFP- and non-FFP-treated cells. However, CM-ATMSCs treated with FFP and in the late passage have significant differences (P<0.05) compared to non-FFP treatments and in other passages in their effects on secretion of inflammatory modulators. CONCLUSIONS In conclusion, CM-ATMSC has the potential to secrete proinflammatory modulators.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":" ","pages":"e933726"},"PeriodicalIF":2.8,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/82/medscimonitbasicres-28-e933726.PMC8958862.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40315844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Degree of Myopia and Reduced Physical Activity in 3600 College Students in China 3600名中国大学生近视程度与体育活动减少

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-02-14 DOI: 10.12659/MSMBR.934807

Xiangyu Zhao, Yanan Zhang

{"title":"Degree of Myopia and Reduced Physical Activity in 3600 College Students in China","authors":"Xiangyu Zhao, Yanan Zhang","doi":"10.12659/MSMBR.934807","DOIUrl":"https://doi.org/10.12659/MSMBR.934807","url":null,"abstract":"Background This study aimed to evaluate the degree of myopia and reduced physical activity in 3600 college students in China between 2018 and 2020. Material/Methods The study included 3600 participants (1742 men and 1858 women) aged 19 to 23 years from a Chinese college. The distribution of the levels of eyesight associated with physical exercise was assessed using the Early Treatment Diabetic Retinopathy Study chart measurement method. Results The rates of myopia of students enrolled students in 2018, 2019, and 2020 were 84.31%, 87.22%, and 89.17%, respectively, which showed an increasing trend (P<0.01). For the students starting in 2018, the rate of myopia showed an upward trend in their 3 years of college (P<0.01). The incidence of myopia was significantly different during the academic year between students who participated and did not participate in sports clubs (P<0.01). Conclusions The findings from this study showed that between 2018 and 2020 there was a high prevalence of myopia in college students in China, which increased annually and was associated with reduced physical activity while at college. These findings may have public health implications for improving physical activity in this population. Physical exercise could effectively prevent the occurrence of myopia, improve the visual status of students, and alleviate the decline of vision.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"211 1","pages":"e934807-1 - e934807-6"},"PeriodicalIF":2.8,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75582525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anodal Transcranial Direct Current Stimulation (tDCS) Over the Primary Motor Cortex (M1) Enhances Motor Response Inhibition and Visual Recognition Memory 经颅阳极直流电刺激(tDCS)对初级运动皮层(M1)增强运动反应抑制和视觉识别记忆

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2022-01-17 DOI: 10.12659/MSMBR.934180

S. Bashir, Azzam Bamugaddam, Muath Alasheikh, Tariq Alhassan, Saud M Alhaidar, Abdulelah Khalaf Almutairi, Mohammed Alfaleh, K. Al-Regaiey, Sultan S. Al Zahrani, Bassam Ali Albaiji, T. Abualait

{"title":"Anodal Transcranial Direct Current Stimulation (tDCS) Over the Primary Motor Cortex (M1) Enhances Motor Response Inhibition and Visual Recognition Memory","authors":"S. Bashir, Azzam Bamugaddam, Muath Alasheikh, Tariq Alhassan, Saud M Alhaidar, Abdulelah Khalaf Almutairi, Mohammed Alfaleh, K. Al-Regaiey, Sultan S. Al Zahrani, Bassam Ali Albaiji, T. Abualait","doi":"10.12659/MSMBR.934180","DOIUrl":"https://doi.org/10.12659/MSMBR.934180","url":null,"abstract":"Background Transcranial direct current stimulation (tDCS) is a non-invasive brain modulatory technique that can boost cognitive processes and alter performance in cognitive tasks. The effect of anodal-tDCS on cognitive functions following a single session has been repeatedly reported. However, results are varied, mixed, and confounded by several factors, including differences in tDCS current intensity and sham conditions used. Therefore, we assessed the effect of a single session of anodal-tDCS over the primary motor cortex (M1) on cognitive functions, particularly response inhibitory control and visual recognition memory, in healthy adults. Material/Methods Thirty healthy male subjects participated in a randomized, double-blind, sham-controlled tDCS study (2 mA, for 20 min). In the sham stimulation, subjects received the same intensity (2 mA, for 30 s, ramped up, then ramped down). We assessed the cognitive functions response inhibitory control and visual recognition memory using the stop signal task (SST) and pattern recognition memory (PRM) task before and after the stimulation. Results There was a statistically significant difference in cognitive function as assessed by the stop signal task go trial (SST) (P=0.019) and SST correct response time on go trials (P=0.04) after real stimulation only. There was no significant effect observed in sham condition. Conclusions The findings suggest that anodal-tDCS applied over M1 improves inhibitory control and visual recognition memory compared to sham stimulation. Thus, application of anodal-tDCS to the M1, as an integral node in inhibitory motor control, might be a promising adjuvant therapeutic intervention for modulation of motor response inhibition.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"89 1","pages":"e934180-1 - e934180-7"},"PeriodicalIF":2.8,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80386544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020 科索沃共和国关于批量质量保证抽样(LQAS)评估2018年至2020年12至24月龄儿童疫苗接种状况的全国横断面研究

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2021-12-27 DOI: 10.12659/MSMBR.934194

Bashkim Gllareva, Isme Humolli, I. Rudhani, X. Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi

{"title":"A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020","authors":"Bashkim Gllareva, Isme Humolli, I. Rudhani, X. Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi","doi":"10.12659/MSMBR.934194","DOIUrl":"https://doi.org/10.12659/MSMBR.934194","url":null,"abstract":"Background In the Republic of Kosovo, full vaccination status in children under age 2 years includes: 1 dose of Bacillus Calmette-Guérin (BCG) hepatitis B virus (HBV) vaccine; 3 doses of diphtheria, tetanus, pertussis, hepatitis B, polio, and Haemophilus influenzae type b (DTaP-HB-IPV-Hib) vaccine; 3 doses of inactivated polio vaccine (IPV); and 1 dose of measles, mumps, and rubella (MMR) vaccine. Lot quality assurance sampling (LQAS) is a method used to assess the performance of health quality indicators. Material/Methods A national cross-sectional study with children aged between 12 and 24 months from Kosovo was performed between 2018 and 2020. The vaccination status of children was assessed with lot quality assurance sampling (LQAS) using randomized samples. Results Among 430 children, more than 90% had completed the full immunization schedule. Delays in children’s immunizations were observed. Most vaccinations showed short delays of less than 1 month, followed by delays of up to 3 months. The main reason for vaccination delay was the COVID-19 pandemic, following by child’s illness at the scheduled time of vaccination or the parents were too busy to take the child to the vaccination site. Meanwhile, child age was the only parameter that showed difference among non-vaccinated and fully vaccinated (P<0.001). Conclusions LQAS analysis showed that between 2018 and 2020 lack of full immunization was due to delay caused by the parent not taking the child to the vaccination site, which may be prevented by improving information given to parents and the use of vaccination reminders.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"22 1","pages":"e934194-1 - e934194-9"},"PeriodicalIF":2.8,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84609719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020. 科索沃共和国关于批量质量保证抽样（LQAS）的全国横断面研究，以评估 2018 年至 2020 年期间 12 至 24 个月大儿童的疫苗接种情况。

IF 1.5

Medical Science Monitor Basic Research Pub Date : 2021-12-27

Bashkim Bejtë Gllareva, Isme Humolli, Ibrahim Rudhani, Xhevat Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi

{"title":"A National Cross-Sectional Study from the Republic of Kosovo on Lot Quality Assurance Sampling (LQAS) to Evaluate the Vaccination Status of Children Between 12 and 24 Months of Age During 2018 to 2020.","authors":"Bashkim Bejtë Gllareva, Isme Humolli, Ibrahim Rudhani, Xhevat Jakupi, Jon Rexhepi, Tringa Metaj, Ardita Kafexholli, Vlora Sopi","doi":"","DOIUrl":"","url":null,"abstract":"BACKGROUND In the Republic of Kosovo, full vaccination status in children under age 2 years includes: 1 dose of Bacillus Calmette-Guerin (BCG) hepatitis B virus (HBV) vaccine; 3 doses of diphtheria, tetanus, pertussis, hepatitis B, polio, and Haemophilus influenzae type b (DTaP-HB-IPV-Hib) vaccine; 3 doses of inactivated polio vaccine (IPV); and 1 dose of measles, mumps, and rubella (MMR) vaccine. Lot quality assurance sampling (LQAS) is a method used to assess the performance of health quality indicators. MATERIAL AND METHODS A national cross-sectional study with children aged between 12 and 24 months from Kosovo was performed between 2018 and 2020. The vaccination status of children was assessed with lot quality assurance sampling (LQAS) using randomized samples. RESULTS Among 430 children, more than 90% had completed the full immunization schedule. Delays in children's immunizations were observed. Most vaccinations showed short delays of less than 1 month, followed by delays of up to 3 months. The main reason for vaccination delay was the COVID-19 pandemic, following by child's illness at the scheduled time of vaccination or the parents were too busy to take the child to the vaccination site. Meanwhile, child age was the only parameter that showed difference among non-vaccinated and fully vaccinated (P<0.001). CONCLUSIONS LQAS analysis showed that between 2018 and 2020 lack of full immunization was due to delay caused by the parent not taking the child to the vaccination site, which may be prevented by improving information given to parents and the use of vaccination reminders.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"27 ","pages":"e934194"},"PeriodicalIF":1.5,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39876138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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