Medical Research Journal最新文献_第5页

Semaglutide as a chance for obesity treatment 西马鲁肽作为治疗肥胖的机会

Medical Research Journal Pub Date : 2023-07-27 DOI: 10.5603/mrj.a2023.0034

U. Giordano, Jakub Kobiałka, Justyna Pilch

引用次数: 0

What does the volume of stomach resected during Laparoscopic Sleeve Gastrectomy depend on and what impact does it have on postoperative results? 腹腔镜袖胃切除术切除胃的体积取决于什么?对术后结果有什么影响?

Medical Research Journal Pub Date : 2023-07-27 DOI: 10.5603/mrj.a2023.0033

Patrycja Pawłuszewicz, P. Gołaszewski, Paulina Głuszyńska, Zuzanna Razak Hady, J. Łukaszewicz, J. Ładny, K. Nadolny, H. Razak Hady

引用次数: 0

Brain-derived neurotrophic factor serum concentration and BDNF Val66Met polymorphism in patients with peripheral artery disease: the importance of heart failure 外周动脉疾病患者脑源性神经营养因子血清浓度和BDNF Val66Met多态性:心衰的重要性

Medical Research Journal Pub Date : 2023-07-20 DOI: 10.5603/mrj.a2023.0032

Aleksandra Chyrek-Tomaszewska, A. Popiołek, K. Linkowska, Mariusz Kozakiewicz, Adam Szelągowski, J. Budzyński, M. Bieliński

引用次数: 0

The impact of metformin on the development and course of anaplastic thyroid cancer in comparison to other histologic types of thyroid cancer 与其他组织学类型甲状腺癌相比，二甲双胍对间变性甲状腺癌的发展和病程的影响

Medical Research Journal Pub Date : 2023-07-18 DOI: 10.5603/mrj.a2023.0031

J. Gałązka, Agnieszka Kwiatkowska, Kuba Bieńkowski, Albert Bielaska, A. Filip

引用次数: 0

Short-term efficacy of botulinum neurotoxin for spastic cerebral palsy: A prospective and controlled study with parental feedback 肉毒杆菌神经毒素治疗痉挛性脑瘫的短期疗效:一项有家长反馈的前瞻性对照研究

Medical Research Journal Pub Date : 2023-07-06 DOI: 10.5603/mrj.a2023.0025

Agata Trafalska, Krzysztof Kotecki, Magdalena Kazimierska-Zając, A. Druszcz, M. Miś, Luba Ślósarz

引用次数: 0

Assessment of prognosis of intracerebral haemorrhage with respect to clinical, biochemical and radiological parameters: a study in a tertiary health care centre in Eastern India 在临床、生化和放射参数方面评估脑出血的预后:在印度东部三级保健中心进行的一项研究

Medical Research Journal Pub Date : 2023-07-03 DOI: 10.5603/mrj.a2023.0030

Anasuyak Roy, Rishad Ahmed

引用次数: 0

Coronary slow flow is not an adverse prognostic factor in MINOCA patients in the 5-year follow-up 在5年随访中，冠状动脉慢血流不是MINOCA患者的不良预后因素

Medical Research Journal Pub Date : 2023-06-29 DOI: 10.5603/mrj.a2023.0024

P. Buller, Adam Kern, Maciej Tyczyński, Wojciech Rosiak, Wojciech Figatowski, R. Gil, J. Bil

{"title":"Coronary slow flow is not an adverse prognostic factor in MINOCA patients in the 5-year follow-up","authors":"P. Buller, Adam Kern, Maciej Tyczyński, Wojciech Rosiak, Wojciech Figatowski, R. Gil, J. Bil","doi":"10.5603/mrj.a2023.0024","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0024","url":null,"abstract":"Introduction: The research aimed to compare the characteristics and outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) patients with coronary slow flow (CSF) vs. normal coronary flow (no CSF) in a 5-year follow-up. Material and methods: Between 2010–2015 were identified 111 patients as having final MINOCA diagno - sis and available calculated corrected TIMI frame count (cTFC). CSF was defined as cTFC greater than 27 frames per second in any of the three coronary arteries. The primary endpoint was the 5-year major adverse cardiovascular events rate, defined as cardiac death, myocardial infarction, or hospitalization due to angina. Results: The mean cTFC was 28.9 ± 6.1 frames per second (median: 28, IQR 24–33; min-max: 19–58). 62 (55.9%) patients had normal coronary flow, and 49 (44.1%) had CSF. Patients did not differ in sex (fe - males no CSF vs. CSF: 58% vs. 61%, p = 0.7) or age (63 ± 15 years vs. 63 ± 13 years, p = 0.8). Patients with CSF characterized higher rates of chronic kidney disease (0 vs. 8.2%, p = 0.035). No statistically significant difference was observed for any of the analysed points. MACE rates for no CSF vs. CSF were 9.6% vs. 14.3% (HR 0.80, 95% CI 0.28–2.96, p = 0.7), respectively. Conclusions: CSF was not associated with a higher risk of adverse events among MINOCA patients at five years.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82186409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The predictive value of complete blood count-derived indices for major adverse cardiovascular events in MINOCA patients at 5-year follow-up 5年随访中全血细胞计数衍生指标对MINOCA患者主要心血管不良事件的预测价值

Medical Research Journal Pub Date : 2023-06-29 DOI: 10.5603/mrj.a2023.0023

P. Buller, Adam Kern, Maciej Tyczyński, Wojciech Rosiak, Wojciech Figatowski, R. Gil, J. Bil

{"title":"The predictive value of complete blood count-derived indices for major adverse cardiovascular events in MINOCA patients at 5-year follow-up","authors":"P. Buller, Adam Kern, Maciej Tyczyński, Wojciech Rosiak, Wojciech Figatowski, R. Gil, J. Bil","doi":"10.5603/mrj.a2023.0023","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0023","url":null,"abstract":"Introduction: The authors analysed the potential of red blood cell and platelet indices such as red cell distribution width (RDW), mean corpuscular volume (MCV), and mean platelet volume (MPV) as predicting factors in myocardial infarction with non-obstructive coronary arteries (MINOCA) patients of 5-year outcomes. Material and methods: Between 2010–2015 were identified 112 patients who had final MINOCA diagnosis and available laboratory findings. The primary endpoint was the 5-year major adverse cardiovascular events rate, defined as cardiac death, myocardial infarction, or hospitalization due to angina. Results: Only RDW had a significant impact on long-term outcomes. 93 (83%) patients had RDW ≤ 14.5 (group 1), and 19 (17%) patients had RDW > 14.5 (group 2). The mean RDW value was 13.58 ± 1.11%. In group 1 and group 2, mean RDW values were 13.18 ± 0.55%, and 15.54 ± 1.06% (p < 0.001), respectively. Patients with abnormal RDW values (group 2) characterized lower value of left ventricular eject fraction (60 ± 8% vs. 53 ± 13%, p = 0.024), and higher NT-proBNP values (3,170 ± 5,285 pg/mL vs. 6,200 ± 4,223 pg/mL, p = 0.013) as well as troponin levels (501–2500 ng/mL: 31% vs. 53%, p = 0.02). A statistically significant difference was observed only for all-cause death. All-cause death rates for no RDW ≤ 14.5% vs. RDW > 14.5% were 2.2% vs. 21.1% (HR 5.09, 95% CI 1.03–25.2, p = 0.046), respectively. Conclusions: RDW was significantly associated with the increased risk of all-cause mortality in MINOCA patients at 5 years.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"47 2-4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77904703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary artery bypass graft in a patient with Von Willebrand disease type 1 1型血管性血友病患者的冠状动脉旁路移植术

Medical Research Journal Pub Date : 2023-06-29 DOI: 10.5603/mrj.a2023.0028

Sebastian Krych, Katarzyna Krzyżak, Tomasz Styn, Witold Bratkowski, Michał Jamrozik, M. Knapik, Małgorzata Jekiełek, T. Hrapkowicz

{"title":"Coronary artery bypass graft in a patient with Von Willebrand disease type 1","authors":"Sebastian Krych, Katarzyna Krzyżak, Tomasz Styn, Witold Bratkowski, Michał Jamrozik, M. Knapik, Małgorzata Jekiełek, T. Hrapkowicz","doi":"10.5603/mrj.a2023.0028","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0028","url":null,"abstract":"Von Willebrand disease (VWD), is the most common hereditary bleeding disorder (HBD) and affects ap - proximately 1–2% of the population. Type 1 accounts for 70–80% of all cases and involves partially reduced levels of functional VWF. It is usually manifested by mild to moderate mucocutaneous bleeding. A 63-year-old patient with multivessel coronary artery disease and diagnosed with Von Willebrand’s disease type 1 after a previous NSTEMI infarction (10 days earlier) was admitted to the cardiac surgery department for a planned CABG procedure. The coagulation factor values on admission to the ward were successively (VIII 15%; VWF: Ag 12%). Coronary angiography revealed MV CAD. The patient was consulted with the HEART Team. The decision was made to qualify the patient for CABG using the OPCAB technique. A detailed plan for securing the haemostasis was established. Haemate P 500/1200 and 1000/2400, a lyophilized concentrate of humans VIII and von Willebrand Factors, were secured. During surgery, LITA- LAD and Ao-RCA bridges were performed using Medtronic Starfish® Heart Positioners. In the post-operation period, no complications were noted. Plasma levels of VIII and VW factors were measured daily and antihemorrhagic prophylaxis was given accordingly to measured values. The patient was discharged on the eighth day after surgery in good condition, with the haematological recommendations. Currently, there are no guidelines for the management of patients with Von Willebrand’s disease undergoing cardiac surgery. Incorrectly conducted pharmacotherapy may result in an elevated level of VW factor and additional exposure to the occurrence of acute coronary syndromes and heart attacks.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75459263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The state of the microbiota of the genital tract in women who smoke 吸烟妇女生殖道微生物群的状况

Medical Research Journal Pub Date : 2023-06-29 DOI: 10.5603/mrj.a2023.0027

I. G. Ponomarova, T. Lisyana, Olga Ivanivna Matyashova, Svitlana Urijivna Krishchuk

{"title":"The state of the microbiota of the genital tract in women who smoke","authors":"I. G. Ponomarova, T. Lisyana, Olga Ivanivna Matyashova, Svitlana Urijivna Krishchuk","doi":"10.5603/mrj.a2023.0027","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0027","url":null,"abstract":"Introduction: Tobacco use has a negative effect on the immune system and contributes to a decrease in the protective properties of a woman’s body, which leads to dysbiotic changes in the microbiota of the genital tract. Materials and methods: To assess the species and quantity composition of the microflora of the vagina in women, bacteriological studies were conducted. The research group consisted of women with inflamma - tory diseases of the genital tract who smoke (40 women) and 40 women who do not smoke. The control group consisted of 30 healthy women who did not smoke. Results: The obtained results indicate that the state of the microbiota of the genital organs in women who smoke is characterized by an increase in the spectrum of isolated microflora of enterobacteria and Gram-positive cocci, anaerobic bacteria, an increase in the level of viral infection and a significant decrease in the concentration of protective microflora. The microbiota of the genital tract of women who smoke is characterized by the formation of 2–3 component associations (in 45% of women) of infectious agents in various combinations. In non-smoking women, bacterial associations were found in 17.5% of cases. Conclusions: In women who smoke, there is a significant imbalance of protective and potentially patho - genic flora with active contamination of the genital tract with conditionally pathogenic microorganisms that form multicomponent associations of infectious agents. The obtained data indicate the need for constant monitoring of the causative agents of vaginal dysbiosis in women who smoke, as well as the need for further research to identify the impact of smoking cessation on the vaginal microbiome.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85376195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0