MethodsX最新文献

{"title":"Multipronged biobehavioural intervention strategies for prevention and control of hypertension: A protocol for systematic review of education-based community trials","authors":"Martins Nweke ,&nbsp;Nalini Govender ,&nbsp;Innocent Nweke ,&nbsp;Julian Pillay","doi":"10.1016/j.mex.2025.103494","DOIUrl":"10.1016/j.mex.2025.103494","url":null,"abstract":"<div><div>Hypertension is one of the most pressing health challenges in sub-Saharan Africa, particularly South Africa. Evaluation of community-wide biobehavioural, preventative and control strategies for hypertension are necessary for planning and advancing primary prevention in the region. This systematic review aims to assess community-wide biobehavioural intervention strategies for hypertension prevention and control worldwide. This protocol follows the preferred items for reporting systematic reviews and meta-analysis protocols (PRISMA-P). Databases: Medline, PubMed, Scopus, Web of Science, Cochrane Library, Academic Search Complete, Cumulative Index for Allied Health Literature and African Journals (SABINET). Two independent reviewers will conduct article screening and data extraction. Primary data items include multipronged bio-behavioural interventions used for community-wide prevention and control of hypertension, intervention efficacy, and roles of forms and format, modes, and channels of intervention on efficacy. Methodological quality will be assessed using the mixed-method appraisal tool. Findings will be presented using narrative synthesis. Descriptive data will be summarized using frequencies and percentages. Using random-effect meta-analysis, efficacy of interventions will be evaluated. Heterogeneity will be examined using the Cochrane I² statistic. Meta-analysis will be conducted with aid of Comprehensive Meta-analysis version 4. The review will provide insights into preventive and control strategies used in different climes and their efficacy.</div></div>","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103494"},"PeriodicalIF":1.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiation and histological analysis of primary human bronchial epithelial cells cultured on transwell membranes using air-liquid interface culture","authors":"Asha Ashraf,&nbsp;Erica D. Bruce","doi":"10.1016/j.mex.2025.103492","DOIUrl":"10.1016/j.mex.2025.103492","url":null,"abstract":"<div><div>This protocol describes a reproducible and optimized workflow for the differentiation and histological analysis of primary normal human bronchial epithelial cells (NHBECs) cultured on Transwell membranes using air-liquid interface (ALI) culture. The method begins with expansion of early-passage NHBECs under submerged conditions, followed by seeding on collagen-coated Transwell inserts. Upon reaching confluence, cells are transitioned to ALI conditions using PneumaCult™-ALI maintenance medium for 21–28 days, promoting mucociliary differentiation. After differentiation, membranes are fixed, cryoprotected in graded sucrose solutions, embedded in Optimal Cutting Temperature (OCT) compound, and then cryosectioned. Sections are subsequently stained using hematoxylin and eosin (H&amp;E) to assess epithelial morphology, or periodic acid–Schiff (PAS) staining to visualize polysaccharide-containing structures such as mucins. This protocol supports the detailed structural and histological evaluation of NHBEC differentiation on a Transwell model, which is valuable for studies of airway epithelial biology, mucociliary function, and inhalation toxicology.<ul><li><span>•</span><span><div>ALI differentiation of NHBECs on collagen-coated Transwell inserts.</div></span></li><li><span>•</span><span><div>Fixation, sucrose cryoprotection, and OCT embedding for cryosectioning.</div></span></li><li><span>•</span><span><div>H&amp;E and PAS staining for visualization of epithelial cells and mucin.</div></span></li></ul></div></div>","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103492"},"PeriodicalIF":1.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an explainable machine learning model for Alzheimer’s disease prediction using clinical and behavioural features","authors":"Rajkumar Govindarajan ,&nbsp;K. Thirunadanasikamani ,&nbsp;Komal Kumar Napa ,&nbsp;S. Sathya ,&nbsp;J. Senthil Murugan ,&nbsp;K. G. Chandi Priya","doi":"10.1016/j.mex.2025.103491","DOIUrl":"10.1016/j.mex.2025.103491","url":null,"abstract":"<div><div>This article presents a reproducible machine learning methodology for the early prediction of Alzheimer’s disease (AD) using clinical and behavioural data. A comparative analysis of multiple classification algorithms was conducted, with the Gradient Boosting classifier yielding the best performance (accuracy: 93.9 %, F1-score: 91.8 %). To improve interpretability, SHapley Additive exPlanations (SHAP) were integrated into the workflow to quantify feature contributions at both global and individual levels. Key predictive variables such as Mini-Mental State Examination (MMSE), Activities of Daily Living (ADL), cholesterol levels, and functional assessment scores were identified and visualized using SHAP-based insights. A user-friendly, interactive web application was developed using Streamlit, allowing real-time patient data input and transparent model output visualization. This method offers a practical tool for clinicians and researchers to support early diagnosis and personalized risk assessment of AD, thus aiding in timely and informed clinical decision-making.</div><div>Accurate Prediction: Gradient Boosting model achieved 93.9 % accuracy for early Alzheimer’s detection.</div><div>Explainability: SHAP values provided interpretable insights into key clinical features.</div><div>Clinical Tool: A Streamlit-based web app enabled real-time, explainable predictions for users.</div></div>","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103491"},"PeriodicalIF":1.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an alternative method for ergosterol determination in alder leaves using liquid-liquid extraction and LC-MS/MS after saponification","authors":"Björn Kusebauch,&nbsp;Stefan Bader,&nbsp;Steffen Carl","doi":"10.1016/j.mex.2025.103495","DOIUrl":"10.1016/j.mex.2025.103495","url":null,"abstract":"<div><div>Ergosterol is widely used as proxy for the estimation of leaf litter associated fungal biomass. According to a common textbook method, ergosterol can be extracted from plant tissue with methanolic potassium hydroxide followed by purification with solid-phase extraction (SPE) and detection via high-performance liquid chromatography-ultraviolet (HPLC-UV). As an alternative, we developed a method using liquid-liquid extraction (LLE) of the methanolic extract with cyclohexane instead of time consuming and error prone SPE. For ergosterol detection, HPLC-UV was replaced by the more sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method was validated for alder leaves at 10 µg/g dw (LOQ) and 500 µg/g dw with mean recoveries between 95.1 and 100.2 % (relative standard deviations &lt; 10 %) and has been successfully applied for the measurement of fungicide effects on leaf litter associated aquatic fungi.<ul><li><span>•</span><span><div>Selective and flexible analytical method for ergosterol quantification in alder leaves using LLE and LC-MS/MS instead of SPE and HPLC-UV</div></span></li><li><span>•</span><span><div>Optional use of 7-dehydrocholesterol as internal standard to allow for compensation of volumetric variations during sample preparation and signal drift in LC-MS/MS</div></span></li><li><span>•</span><span><div>Method validation for three mass transitions according to guidance document SANTE/2020/12830 including matrix effect evaluation and stability investigations</div></span></li></ul></div></div>","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103495"},"PeriodicalIF":1.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toeplitz and Hankel determinants of logarithmic coefficients for r-valent q-starlike and r-valent q-convex functions","authors":"Pishtiwan Othman Sabir,&nbsp;Awara Ahmed Ali","doi":"10.1016/j.mex.2025.103463","DOIUrl":"10.1016/j.mex.2025.103463","url":null,"abstract":"&lt;div&gt;&lt;div&gt;The aim of the present paper is to extend the notions of &lt;span&gt;&lt;math&gt;&lt;mi&gt;q&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;-starlikeness and &lt;span&gt;&lt;math&gt;&lt;mi&gt;q&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;-convexity to encompass multivalent &lt;span&gt;&lt;math&gt;&lt;mi&gt;q&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;-starlikeness and multivalent &lt;span&gt;&lt;math&gt;&lt;mi&gt;q&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;-convexity. We systematically introduce and examine subfamilies of &lt;span&gt;&lt;math&gt;&lt;mi&gt;r&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;-valently holomorphic functions within the open unit disk &lt;span&gt;&lt;math&gt;&lt;mi&gt;D&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt; by employing the fractional &lt;span&gt;&lt;math&gt;&lt;mi&gt;q&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;-derivative operator, along with the principle of subordination between holomorphic functions.&lt;ul&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;div&gt;The families we define in this paper constitute a generalization of numerous established classes available in existing literature.&lt;/div&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;div&gt;We derive the Fekete-Szegö inequalities for these newly introduced families.&lt;/div&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;div&gt;As a result, we apply these findings to establish bounds for the Toeplitz and Hankel determinants &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;T&lt;/mi&gt;&lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mi&gt;u&lt;/mi&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;T&lt;/mi&gt;&lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mi&gt;u&lt;/mi&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt; and &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;H&lt;/mi&gt;&lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mrow&gt;&lt;mi&gt;u&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;, defined as follows:&lt;span&gt;&lt;span&gt;&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;T&lt;/mi&gt;&lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mi&gt;u&lt;/mi&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mrow&gt;&lt;mo&gt;|&lt;/mo&gt;&lt;mtable&gt;&lt;mtr&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;/mtr&gt;&lt;mtr&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;/mtr&gt;&lt;/mtable&gt;&lt;mo&gt;|&lt;/mo&gt;&lt;/mrow&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mspace&gt;&lt;/mspace&gt;&lt;msub&gt;&lt;mi&gt;T&lt;/mi&gt;&lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mi&gt;u&lt;/mi&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mrow&gt;&lt;mo&gt;|&lt;/mo&gt;&lt;mtable&gt;&lt;mtr&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;3&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;/mtr&gt;&lt;mtr&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;3&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;/mtr&gt;&lt;/mtable&gt;&lt;mo&gt;|&lt;/mo&gt;&lt;/mrow&gt;&lt;mspace&gt;&lt;/mspace&gt;&lt;mspace&gt;&lt;/mspace&gt;&lt;mtext&gt;and&lt;/mtext&gt;&lt;mspace&gt;&lt;/mspace&gt;&lt;mspace&gt;&lt;/mspace&gt;&lt;msub&gt;&lt;mi&gt;H&lt;/mi&gt;&lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mi&gt;u&lt;/mi&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mrow&gt;&lt;mo&gt;|&lt;/mo&gt;&lt;mtable&gt;&lt;mtr&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;/mtr&gt;&lt;mtr&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;mtd&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;3&lt;/mn&gt;&lt;/msub&gt;&lt;/mtd&gt;&lt;/mtr&gt;&lt;/mtable&gt;&lt;mo&gt;|&lt;/mo&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;where &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;γ&lt;/mi&gt;&lt;mn&gt;1&lt;/","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103463"},"PeriodicalIF":1.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stepwise approach to designing and delivering the SCHeLTI trial community-family-mother-child obesity prevention intervention","authors":"Olivia De-Jongh González ,&nbsp;Jianxia Fan ,&nbsp;Isabelle Marc ,&nbsp;Hong Jiang ,&nbsp;Andraea Van Hulst ,&nbsp;Claire N. Tugault-Lafleur ,&nbsp;Yanting Wu ,&nbsp;Yanhui Hao ,&nbsp;Liping Wang ,&nbsp;Xiaoyu Hu ,&nbsp;Caifeng Wang ,&nbsp;Wenguang Sun ,&nbsp;Sonia Semenic ,&nbsp;Yamei Yu ,&nbsp;Lei Chen ,&nbsp;Weibin Wu ,&nbsp;Yulai Zhou ,&nbsp;Ting Li ,&nbsp;Wenli Fang ,&nbsp;Yinan Liu ,&nbsp;Louise C. Mâsse","doi":"10.1016/j.mex.2025.103493","DOIUrl":"10.1016/j.mex.2025.103493","url":null,"abstract":"<div><div>This paper describes the methods for the development and implementation of the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI) intervention, part of a World Health Organization-supported effort to prevent childhood obesity through four international randomized controlled trials. SCHeLTI is a multi-center, cluster-randomized trial in Shanghai, supporting 4500 families from preconception through the child’s fifth year. This Community-Family-Mother-Child intervention includes coordinated components such as Healthy Conversation sessions, nutrition consultations, breastfeeding support, an obesity clinic, and educational courses tailored to key reproductive and developmental stages and risk profiles. Guided by implementation science principles, SCHeLTI’s development followed four main phases: 1) establishing the conceptual foundation (theoretical framework, outcomes, logic model); 2) building delivery infrastructure and engaging stakeholders in formative research; 3) finalizing the intervention design tailored to families’ needs; and 4) implementing the intervention, including capacity building, adaptation, and process evaluation strategies.<ul><li><span>•</span><span><div>A four-phase development process grounded in implementation science principles guided intervention design and delivery</div></span></li><li><span>•</span><span><div>Tailored components align with reproductive and developmental stages and risk profiles to support family and child needs across the life course</div></span></li><li><span>•</span><span><div>Stakeholder engagement and iterative adaptation ensured contextual relevance and feasibility</div></span></li></ul></div></div>","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103493"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian spatiotemporal stochastic partial differential equation for high-resolution earthquake magnitude mapping: Application to Sumatra Island, Indonesia","authors":"Dila Fitriani Azuri ,&nbsp;I Gede Nyoman Mindra Jaya ,&nbsp;Yudi Rosandi","doi":"10.1016/j.mex.2025.103487","DOIUrl":"10.1016/j.mex.2025.103487","url":null,"abstract":"<div><div>Indonesia’s location at the convergence of the Eurasian, Indo-Australian, and Pacific plates makes it highly susceptible to earthquakes, particularly along the megathrust zone in Sumatra. Given the potential for severe damage and loss of life, spatiotemporal modeling of earthquake risk is crucial, especially in areas without recorded seismic events. One of the key preventive strategies is the development of an Early Warning System, which can help predict potential earthquakes based on seismic activity in specific locations. However, not all areas have recorded earthquake events, making it necessary to estimate seismic activity in unmeasured regions using spatial interpolation technique. This study applies the Stochastic Partial Differential Equation (SPDE) approach to estimate earthquake magnitude potential in unmeasured regions. The SPDE method transforms a continuous Gaussian Field (GF) into a computationally efficient Gaussian Markov Random Field (GMRF) by discretizing the spatial domain using triangulation. This approach overcomes the computational burden of the ‘big n problem’ in traditional GF models. By applying SPDE with a 10 km spatial range and 0.1 standard deviation, we produce high-resolution maps that support the development of early warning systems and inform seismic risk mitigation strategies.</div></div>","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103487"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overconfidence and insider trading with correlated signals","authors":"Wassim Daher ,&nbsp;Sadeq Damrah","doi":"10.1016/j.mex.2025.103476","DOIUrl":"10.1016/j.mex.2025.103476","url":null,"abstract":"<div><div>This study extends the framework of Jain and Mirman (1999) model to the case of overconfident market makers à la Zhou (2011). We characterize the linear equilibrium outcomes and derive explicit formulas for the model parameters. A comparative statics analysis is then conducted with respect to the Jain and Mirman (1999) and Zhou (2011) models.<ul><li><span>•</span><span><div>Insider trading volume is independent of the level of overconfidence.</div></span></li><li><span>•</span><span><div>Key equilibrium outcomes depend on the variances of the underlying variables and the degree of overconfidence.</div></span></li></ul></div></div>","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103476"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and implementation of a data sharing API for supporting urban governance schemes in environmental and traffic monitoring","authors":"Lasith Niroshan ,&nbsp;Sarbast Moslem ,&nbsp;Francesco Pilla","doi":"10.1016/j.mex.2025.103458","DOIUrl":"10.1016/j.mex.2025.103458","url":null,"abstract":"<div><div>This paper presents the design and implementation of a novel, unified data-sharing API that integrates real-time air quality, noise, and traffic monitoring data to support urban planning and governance. Unlike existing API frameworks for urban data management that often focus on static or delayed datasets, our API uniquely integrates multi-source data with real-time processing capabilities. While prior research often addresses environmental monitoring or traffic analytics separately, our approach provides a single, comprehensive platform, enhancing usability for urban planners. The API provides a unified platform for collecting, processing, and sharing environmental and traffic data from diverse sources, including sensors for air quality, noise levels, and traffic conditions. The system facilitates real-time data integration, enabling urban planners, transport authorities, and policymakers to make informed decisions based on accurate environmental and traffic data. The API supports four key governance schemes in urban planning: User Demand Planning, Transport Planning, Freight and logistics Planning, and City Infrastructure Planning. By integrating environmental and traffic monitoring through a robust API architecture, this project connects technical innovation with real-world applications, supporting smarter urban management. This paper discusses the architecture, functionality, and impact of the API, demonstrating its ability to enhance data-driven decision-making for sustainable and efficient cities.<ul><li><span>•</span><span><div>Developed a unified API that integrates real-time air quality, noise, and traffic data from diverse sensors to support comprehensive urban data-sharing.</div></span></li><li><span>•</span><span><div>Enables four key urban governance schemes—User Demand, Transport, Freight and logistics, and City Infrastructure Planning—through accurate, integrated environmental and traffic data.</div></span></li><li><span>•</span><span><div>Bridges technical innovation and practical application, enhancing data-driven decision-making for sustainable, efficient urban management.</div></span></li></ul></div></div>","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103458"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of a head-controlled wheelchair system for users with severe motor impairments","authors":"Abdelhakim Haddoun ,&nbsp;Dâlel Djabri ,&nbsp;Mallak Saidani ,&nbsp;Mohamed Benbouzid","doi":"10.1016/j.mex.2025.103485","DOIUrl":"10.1016/j.mex.2025.103485","url":null,"abstract":"<div><div>This paper presents an innovative and accessible hands-free wheelchair control system designed for individuals with severe motor impairments, particularly tetraplegic users. Unlike traditional joystick-based systems, which are often unsuitable for users with quadriplegia, our system relies on intuitive head-motion detection to enhance autonomy and ease of use. The system consists of a wearable motion-sensing cap equipped with an MPU-6050 sensor which is a 6-axis Inertial Measurement Unit (IMU) to capture head gestures, processed by an ATmega328 microcontroller (a low-power 8-bit AVR microcontroller widely used in embedded systems) integrated on an Arduino Nano development board. Wireless commands are transmitted via a Bluetooth module (HC-05) to the wheelchair’s control unit consisting of an Arduino Uno microcontroller and BTS7960 motor drivers — high-power H-bridge modules that enable bidirectional control of DC motors. The operational flow, including signal processing, gesture interpretation, and wireless transmission, is structured following a detailed flowchart-based design. Experimental results indicate a high response rate and directional accuracy of over 90 % using a 45° head tilt. The optimal safe speed was determined to be 1.87 km/h with a Pulse Width Modulation (PWM) value of 180. Rather than designing a mechanical chassis from scratch, a commercially available electric wheelchair was modified by removing its joystick interface, allowing seamless integration of the head-controlled system. These findings validate the system’s usability and precision under real-world conditions. By eliminating manual input and emphasizing simplicity, the proposed solution holds strong potential as a scalable and low-cost mobility aid, especially in low-resource environments.</div></div>","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"15 ","pages":"Article 103485"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}