MethodsX最新文献_第10页

Microbiological contamination in home continuous positive airway pressure (CPAP) devices. Study protocol. 家用持续气道正压通气（CPAP）设备的微生物污染。研究协议。

IF 2.9

MethodsX Pub Date : 2026-05-23 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103968

Verónica López-García, David Peña-Otero, Gregoria Megías-Lobón, Luis Carlos Rodríguez-Pascual, Natalia García-Ruíz, Ledicia Álvarez-Paredes, Piedad Gómez-Torres, Sergio Glarreta-Aperte

{"title":"Microbiological contamination in home continuous positive airway pressure (CPAP) devices. Study protocol.","authors":"Verónica López-García, David Peña-Otero, Gregoria Megías-Lobón, Luis Carlos Rodríguez-Pascual, Natalia García-Ruíz, Ledicia Álvarez-Paredes, Piedad Gómez-Torres, Sergio Glarreta-Aperte","doi":"10.1016/j.mex.2026.103968","DOIUrl":"10.1016/j.mex.2026.103968","url":null,"abstract":"Home mechanical ventilation is crucial for treating conditions such as obstructive sleep apnea, and its use has increased exponentially. A possible link exists between poor equipment hygiene and the risk of respiratory infections, due to healthcare-related practices; however, the exact effect is unknown. The aim of this study is to determine the level of bacterial and fungal contamination in home continuous positive airway pressure (CPAP) devices. This prospective, cross-sectional study will be conducted at the Burgos University Hospital Complex (CAUBU), Spain. Twenty-five patients undergoing home CPAP treatment for at least six months will be recruited. Microbiological samples will be taken from each patient at critical points of the CPAP device: CPAP housing, tubing, internal filter, interface, and humidifier. Analyses will be performed at the CAUBU Microbiology Department, which is certified under UNE-EN ISO 9001:2015. In addition to microbiological analysis, clinical variables and determinants of patient health will be collected to study potential factors associated with contamination. It is known that 30% of healthcare-associated infections are preventable, so this study aims to improve prevention strategies, health education, and nursing care to reduce the risk of pathogenic contamination related to home respiratory therapy.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103968"},"PeriodicalIF":2.9,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13251800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated microwave-assisted acetic acid pretreatment and endoglucanase-xylanase hydrolysis for nanocrystalline cellulose preparation. 微波辅助醋酸预处理和内切葡聚糖酶-木聚糖酶水解制备纳米纤维素。

IF 2.9

MethodsX Pub Date : 2026-05-20 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103961

K Y Lim, K Y Foo

{"title":"Integrated microwave-assisted acetic acid pretreatment and endoglucanase-xylanase hydrolysis for nanocrystalline cellulose preparation.","authors":"K Y Lim, K Y Foo","doi":"10.1016/j.mex.2026.103961","DOIUrl":"10.1016/j.mex.2026.103961","url":null,"abstract":"This study presents a high-efficiency extraction strategy for nanocrystalline cellulose (NCC) from tangerine peel as a model lignocellulosic biomass, using sequential microwave (MW)-assisted acetic acid (AA) pretreatment and dual-enzyme (endoglucanase and xylanase) hydrolysis. MW-assisted AA pretreatment (50 % AA, 100 °C, 10 min) achieves rapid volumetric heating and enhanced solvent penetration, and selective removal of hemicellulose, lignin and pectin components, while preserving crystalline cellulose domains, generating a highly accessible substrate for enzymatic processing. Subsequent hydrolysis with endoglucanase and xylanase (25 U/g substrate (TP-CFs) for endoglucanase and 50 U/g substrate (TP-CFs) for xylanase, 50 °C, 5 h, pH 4.8) depolymerizes amorphous cellulose regions and residual hemicellulosic barriers under mild conditions, resulting in NCC with uniform nano-fibrillar morphology (length 603.48 nm, diameter 9.23 nm, aspect ratio 65.36), high crystallinity (64.35 %), enhanced thermal stability (Tmax 338.9 °C), colloidal stability (-30.2 mV) and high production yield (70.8 %). The MW-AA and dual-enzyme platform reduces chemical usage, lowers energy demand and enables selective biomass fractionation, establishing a simple, scalable and environmentally friendly pathway for high-performance nanocellulose preparation. • Microwave-assisted acetic acid pretreatment promotes rapid, selective biomass fractionation and cellulose preservation • Dual endoglucanase-xylanase synergy drives efficient amorphous cellulose removal under mild reaction conditions • The hybrid platform delivers high-yield nanocellulose production and structural integrity.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103961"},"PeriodicalIF":2.9,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A method description for developing critical reading skills through a digital platform based on Barrett's taxonomy. 通过基于巴雷特分类法的数字平台开发批判性阅读技能的方法描述。

IF 2.9

MethodsX Pub Date : 2026-05-19 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103963

Bakhtiniso Turakulova, Barnokhon Samatova, Munirabonu Raxmonova, Dilorom Rahmonova, Gulnozakhon Ganiyeva, Umida Jumamurodova, Dildora Norkuziyeva

{"title":"A method description for developing critical reading skills through a digital platform based on Barrett's taxonomy.","authors":"Bakhtiniso Turakulova, Barnokhon Samatova, Munirabonu Raxmonova, Dilorom Rahmonova, Gulnozakhon Ganiyeva, Umida Jumamurodova, Dildora Norkuziyeva","doi":"10.1016/j.mex.2026.103963","DOIUrl":"10.1016/j.mex.2026.103963","url":null,"abstract":"The article outlines a method for developing, assessing critical reading skills using a digital learning platform based on Barrett's taxonomy of Reading Comprehension. A taxonomy-based task design is integrated with an automated assessment. The level of questions is categorized into two types: lower-level questions, comprising literal and reorganization levels, and higher-level questions, including inferential, evaluative, and appreciative types. Lower-level comprehension is automatically evaluated with objective questions on the platform. Whereas, higher-level comprehension is assessed through a specifically designed assessment rubric, integrated into the platform. Educators can use the platform architecture for these functions: design and share reading tasks, gather student responses, and define the students' performance through integrated learning analytics. A pilot demonstration with a sample dataset shows the disparities in the students' levels of understanding. Students face challenges in performing high level tasks. The proposed framework illustrates how teaching critical reading can be conducted with the integration of digital platform, Which allows for reproducible implementation A Barrett's taxonomy grounded methodological framework for developing multilevel reading comprehension tasks A digital assessment platform, integrated with automated evaluation of objective questions and rubric-based assessment of open-ended questions An evaluation system supported analytically, informing teachers about students' performance across comprehension levels.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103963"},"PeriodicalIF":2.9,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13213629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The experiment of the Mozart effect revisited: Modulations of the functional network according to EEG correlations. 莫扎特效应实验重访：根据脑电图相关性调节功能网络。

IF 2.9

MethodsX Pub Date : 2026-05-19 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103964

Dulce María Guerrero-Tánori, Antonieta Martínez-Guerrero, Markus F Müller, Paola V Olguín-Rodríguez

{"title":"The experiment of the Mozart effect revisited: Modulations of the functional network according to EEG correlations.","authors":"Dulce María Guerrero-Tánori, Antonieta Martínez-Guerrero, Markus F Müller, Paola V Olguín-Rodríguez","doi":"10.1016/j.mex.2026.103964","DOIUrl":"10.1016/j.mex.2026.103964","url":null,"abstract":"The Mozart effect has been the subject of lively but also controversial debate in literature during the last decades. Positive as well as negative results have been reported, using different musical stimuli as well as cognitive tasks. In addition, only a few studies included EEG recordings in the experimental design, and when they did, they focused exclusively on spectral power densities. A more complete experimental design is presented considering different stimuli as well as three different cognitive tasks including EEG measurements. Furthermore, we propose a novel strategy for the analysis of the functional network of brain dynamics, based on deviations from a universal stationary cross-correlation pattern.•An experimental design of the Mozart effect is presented, considering different cognitive tasks and two different musical stimuli, besides a control group•The presence of a stationary cross-correlation pattern that is nearly independent of the physilogical brain state is illustrated.•It is demostrasted that that deviations from the stationary pattern serve much better for the distinction of different task settings.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103964"},"PeriodicalIF":2.9,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming financial documents into credit decisions using explainable artificial intelligence and optical character recognition. 使用可解释的人工智能和光学字符识别将财务文件转换为信用决策。

IF 2.9

MethodsX Pub Date : 2026-05-18 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103962

Sachin Malave, Bharti Khemani, Hrishit Patil, Sanket Nandurkar, Om Nandurkar, Ayush Nayak

{"title":"Transforming financial documents into credit decisions using explainable artificial intelligence and optical character recognition.","authors":"Sachin Malave, Bharti Khemani, Hrishit Patil, Sanket Nandurkar, Om Nandurkar, Ayush Nayak","doi":"10.1016/j.mex.2026.103962","DOIUrl":"10.1016/j.mex.2026.103962","url":null,"abstract":"The increasing use of digital technology in banking and financial services has accelerated the adoption of Artificial Intelligence and Machine Learning in lending and credit scoring. While advanced ensemble models offer higher predictive accuracy than traditional statistical approaches, they are often difficult to interpret. This lack of transparency raises concerns related to fairness, regulatory compliance, and borrower trust. This study proposes an integrated Explainable Artificial Intelligence framework for automated credit scoring and lending decisions. The framework utilizes Optical Character Recognition through EasyOCR, PyPDF2, and PdfPlumber to extract financial and identity data from applicant documents, followed by data cleaning, normalization, and structured feature engineering. SHAP and LIME are applied to generate global and local explanations, enhancing interpretability. Experimental evaluation shows that XGBoost achieves 92.5% accuracy, outperforming LightGBM (90.8%), Random Forest (87%), Logistic Regression (91%), and LSTM (81%).•The methodology integrates document-based data extraction with supervised learning models to generate accurate credit scores and lending decisions.•Performance metrics including accuracy, precision, recall, F1-score, MAE, RMSE, and R² confirm the superior performance of XGBoost in credit risk prediction.•The results highlight that combining structured financial features with explainable models improves transparency, supports regulatory compliance, and enhances decision-making reliability.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103962"},"PeriodicalIF":2.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recovery of ferrous sulfate from basic oxygen furnace sludge using waste sulfuric acid. 利用废硫酸从碱性氧炉污泥中回收硫酸亚铁。

IF 2.9

MethodsX Pub Date : 2026-05-15 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103960

Bilguun Mend, Jang-Ho-Jay Kim, Yong-Sik Chu

{"title":"Recovery of ferrous sulfate from basic oxygen furnace sludge using waste sulfuric acid.","authors":"Bilguun Mend, Jang-Ho-Jay Kim, Yong-Sik Chu","doi":"10.1016/j.mex.2026.103960","DOIUrl":"10.1016/j.mex.2026.103960","url":null,"abstract":"Basic oxygen furnace (BOF) sludge and waste sulfuric acid are industrial waste streams that require effective management due to environmental and disposal concerns. In this study, a laboratory-scale hydrometallurgical method was developed to recover ferrous sulfate from BOF sludge using waste sulfuric acid (50% purity). The method integrates controlled acid leaching, low-temperature crystallization, and cyclic reuse of the recovered filtrate. The key features of the protocol are:•Selective acid leaching of Fe-bearing phases from BOF sludge using waste sulfuric acid at 70 °C•Low-temperature crystallization of hydrated ferrous sulfate phases at 5 °C•Cyclic reuse of the recovered filtrate to improve solution efficiencyThe protocol was validated through repeated leaching-crystallization cycles. X-ray diffraction analysis confirmed the dissolution of Fe-bearing phases from the BOF sludge and the formation of hydrated ferrous sulfate phases, including melanterite, rozenite, and szomolnokite, in the recovered products. Average ferrous sulfate yields of 8.86 ± 0.22 g, 10.10 ± 0.18 g, and 10.60 ± 0.26 g were obtained for Cycles A, B, and C, respectively, corresponding to estimated Fe recovery efficiencies of 40.2%, 46.8%, and 51.4%. These results demonstrate that the proposed method provides a reproducible route for converting BOF sludge and waste sulfuric acid into value-added ferrous sulfate while enabling filtrate reuse.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103960"},"PeriodicalIF":2.9,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Confidence interval construction for multivariable truncated spline logistic model (MTSLM). 多变量截断样条逻辑模型（MTSLM）的置信区间构造。

IF 2.9

MethodsX Pub Date : 2026-05-15 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103959

Afiqah Saffa Suriaslan, I Nyoman Budiantara, Vita Ratnasari, Dursun Aydin

{"title":"Confidence interval construction for multivariable truncated spline logistic model (MTSLM).","authors":"Afiqah Saffa Suriaslan, I Nyoman Budiantara, Vita Ratnasari, Dursun Aydin","doi":"10.1016/j.mex.2026.103959","DOIUrl":"10.1016/j.mex.2026.103959","url":null,"abstract":"This study highlights the construction of confidence intervals within the Multivariable Truncated Spline Logistic Model (MTSLM). Its truncated spline function allow flexible modeling of nonlinear relationships across sub-intervals that conventional logistic regression cannot capture. A simulation study is conducted to validate the performance of proposed method, and Human Development Index (HDI) data in Indonesia are used as an empirical illustration to demonstrate its practical applicability. The results show that several predictors are statistically significant. For instance, access to clean water has a confidence interval [0.0124, 0.0566], while the percentage of poor population shows interval with range [-0.4039, -0.0341]. Nonlinear effects are evident in the unemployment variable, with both confidence interval [0.5083, 1.2985] and [-1.4760, -0.3656]. Similar patterns are observed for school enrollment rates. The confidence interval analysis result provides insight into the reliability of these predictor effects, emphasizing the role of infrastructure, education, and social-economic factors.The findings demonstrate that MTSLM not only improves accuracy but also provides informative and reliable estimates of predictors influencing HDI. The highlights of this study:•Develop convidence interval for MTSLM to flexibly nonlinear model.•A simulation study and real HDI data are used to validate the proposed method.•The MTSLM model outperforms binary logistic model.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103959"},"PeriodicalIF":2.9,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow cytometry method to identify arginase-1 expressing MDSCs. 流式细胞术鉴定表达精氨酸酶-1的MDSCs。

IF 2.9

MethodsX Pub Date : 2026-05-14 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103957

Pugazhendhi Srinivasan, Misty Bechtel, Dorota Wyczechowska, Augusto C Ochoa, Michael J Fisch, N Lynn Henry, Joseph M Unger, Jill M Hamilton-Reeves

{"title":"Flow cytometry method to identify arginase-1 expressing MDSCs.","authors":"Pugazhendhi Srinivasan, Misty Bechtel, Dorota Wyczechowska, Augusto C Ochoa, Michael J Fisch, N Lynn Henry, Joseph M Unger, Jill M Hamilton-Reeves","doi":"10.1016/j.mex.2026.103957","DOIUrl":"10.1016/j.mex.2026.103957","url":null,"abstract":"Myeloid-derived suppressor cells (MDSCs) contribute to immune suppression in cancer through arginase-1 (ARG1), which limits T-cell activation. Conventional assays such as ELISA or qPCR cannot determine the cellular source of ARG1 in blood. Recognizing the importance of ARG1 in immunosuppression, we developed and validated a standardized flow cytometry method using a commercially available ARG1 antibody to measure intracellular ARG1 in MDSC subsets. This method includes detailed instructions, including experimental optimization using positive and negative controls, to help other researchers perform flow cytometric measurement of ARG1 expressing cells. In this method, peripheral blood mononuclear cells were stained for lymphoid and myeloid markers (CD3, CD20, CD56, HLA-DR, CD33, CD11b, CD14, and CD15), fixed, and permeabilized before intracellular ARG1 staining. Antibody specificity was verified using neutrophils as positive and CD4⁺ T cells as negative controls. The method was applied to blood samples from patients with bladder cancer (n = 23) and healthy volunteers (n = 10), demonstrating reliable detection of intracellular ARG1 in MDSC subpopulations. This accessible protocol provides an adaptable method for quantifying cell-specific ARG1 expression and studying MDSC-mediated immunosuppression.•The flow cytometry method described here was developed by validating the arginase1 antibody binding specificity using cells expressing high and very low levels of arginase-1.•Arginase-1-expressing cells of the peripheral blood monocytes were identified using this method.•This method can be adapted to any cell type and will be a valuable tool in future immunosuppression studies.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103957"},"PeriodicalIF":2.9,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perceptions of undergraduate midwifery students regarding academic self-efficacy at the selected Nursing Education Institutions in Gauteng province. 在豪登省选定的护理教育机构中，助产士本科学生对学业自我效能感的看法。

IF 2.9

MethodsX Pub Date : 2026-05-12 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103954

Nkhensani Florence Mabunda, Dorica Motaung, Yvonne Rambuwani

{"title":"Perceptions of undergraduate midwifery students regarding academic self-efficacy at the selected Nursing Education Institutions in Gauteng province.","authors":"Nkhensani Florence Mabunda, Dorica Motaung, Yvonne Rambuwani","doi":"10.1016/j.mex.2026.103954","DOIUrl":"10.1016/j.mex.2026.103954","url":null,"abstract":"Understanding how undergraduate midwifery students view their academic self-efficacy is crucial for gaining a deeper insight into their learning experiences, levels of confidence, and preparedness to perform competently in clinical settings. Academic self-efficacy not only affects students' motivation and academic performance but also impacts how they manage academic pressures and the emotional demands of midwifery training. By identifying the factors that influence students' perceptions and by implementing targeted, evidence-based strategies to enhance both academic and psychological support, Nursing Education Institutions can improve students' learning outcomes and overall well-being. This qualitative research study aims to gain insights into undergraduate midwives' perceptions of their academic and psychological well-being at the selected Nursing Education Institutions in Gauteng province. The study is grounded in Bandura's Social Cognitive Theory, which offers a comprehensive lens for examining how personal beliefs, environmental conditions, and behavioural factors interact to shape students' learning experiences and coping strategies. The results will help students understand factors influencing their academic journey, develop strategies to overcome challenges and inform policy decisions related to midwifery education and training, and guide institutional policies aimed at strengthening midwifery education and student support systems.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103954"},"PeriodicalIF":2.9,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ECHO-T2D - economic, clinical epidemiologic, and humanistic profiling of diabetic retinopathy, diabetic kidney disease, and painful diabetic peripheral neuropathy in India: A systematic review protocol. ECHO-T2D -印度糖尿病视网膜病变、糖尿病肾病和疼痛性糖尿病周围神经病变的经济、临床流行病学和人文分析：一项系统回顾方案。

IF 2.9

MethodsX Pub Date : 2026-05-12 eCollection Date: 2026-06-01 DOI: 10.1016/j.mex.2026.103953

Muhammad Aaqib Shamim, Krishna Tiwari, Ravindra Shukla, Mukesh Kumar Swami, Shival Srivastav, Seema Meena, Manish Chaturvedy, Samhita Panda, Denny John, Muhammad Aasim Shamim, Shoban Babu Varthya, Surjit Singh, Pradeep Dwivedi

{"title":"ECHO-T2D - economic, clinical epidemiologic, and humanistic profiling of diabetic retinopathy, diabetic kidney disease, and painful diabetic peripheral neuropathy in India: A systematic review protocol.","authors":"Muhammad Aaqib Shamim, Krishna Tiwari, Ravindra Shukla, Mukesh Kumar Swami, Shival Srivastav, Seema Meena, Manish Chaturvedy, Samhita Panda, Denny John, Muhammad Aasim Shamim, Shoban Babu Varthya, Surjit Singh, Pradeep Dwivedi","doi":"10.1016/j.mex.2026.103953","DOIUrl":"10.1016/j.mex.2026.103953","url":null,"abstract":"Microvascular complications of type 2 diabetes (T2D) like diabetic retinopathy (DR), diabetic kidney disease (DKD), and painful diabetic peripheral neuropathy (pDPN) contribute to morbidity, impaired quality of life, and healthcare costs. Evidence describing their clinical course, economic burden, and humanistic impact remains fragmented, limiting its utility for policy and health economic modelling. We aim to carry out an integrated synthesis of the economic, clinical epidemiologic, and humanistic outcomes associated with DR, DKD, and pDPN among individuals with T2D in India. All primary studies on our research question are eligible. Economic outcomes include both costs and resource consumption. Clinical epidemiologic outcomes cover disease staging, severity markers, and progression. Humanistic outcomes include health-related quality of life with utility and disutility values. Our results will provide consolidated and methodologically justified, model-ready estimates of clinical trajectories, economic burden, and health-related quality of life that are specific to a local context and can be adapted elsewhere. These outputs will strengthen health economic evaluations by reducing reliance on non-contextual data. In turn, the evidence generated will support the updating of clinical practice guidance, identify key gaps in the existing evidence base to guide future research, and inform priority setting for resource allocation within constrained healthcare resources.","PeriodicalId":18446,"journal":{"name":"MethodsX","volume":"16 ","pages":"103953"},"PeriodicalIF":2.9,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0