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Preparative-Scale Chromatography最新文献

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The Development and Applications of Preparative-Scale Continuous Chromatography 制备规模连续色谱的发展与应用
Preparative-Scale Chromatography Pub Date : 1987-08-01 DOI: 10.1080/01496398708057625
P. Barker, G. Ganetsos
{"title":"The Development and Applications of Preparative-Scale Continuous Chromatography","authors":"P. Barker, G. Ganetsos","doi":"10.1080/01496398708057625","DOIUrl":"https://doi.org/10.1080/01496398708057625","url":null,"abstract":"Abstract The scaling up of continuous chromatography to production scale is considered. The various continuous countercurrent and crosscurrent chromato-graphic techniques have been reviewed and judged according to their merits. The latest developments on a preparative/production scale semicontinuous chroma-tographic refiner (SCCR), consisting of 12 columns each of 5.4 cm i.d. × 75 cm long and packed with calcium charged resin, are reported. When the production of high fructrose corn syrup was carried out using industrial barley syfup, product throughputs of 32.3 kg sugar solids/m3 resin/h were obtained, the fructose-rich product purity was over 90% with a concentration of 12.96% w/v, and glucose-rich product contained only 6.69% fructose and had a concentration of 25.4% w/v. The computer simulation of the SCCR's operation is reported, and a good fit with experimental data was obtained.","PeriodicalId":184327,"journal":{"name":"Preparative-Scale Chromatography","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127845311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Numerical Simulation of Band Propagation in Nonlinear Chromatography 非线性色谱中波段传播的数值模拟
Preparative-Scale Chromatography Pub Date : 1987-08-01 DOI: 10.1080/01496398708057614
P. Rouchon, M. Schonauer, P. Valentin, G. Guiochon
{"title":"Numerical Simulation of Band Propagation in Nonlinear Chromatography","authors":"P. Rouchon, M. Schonauer, P. Valentin, G. Guiochon","doi":"10.1080/01496398708057614","DOIUrl":"https://doi.org/10.1080/01496398708057614","url":null,"abstract":"Abstract A model for the propagation of a finite concentration zone in a chroma-tographic column is discussed for the case of a single component sample. This model is based on the modern theory of nonlinear hyperbolic systems of partial differential equations. It accounts for the nonlinear effects due 1) to the thermodynamics of solute-stationary phase equilibrium (i.e., the nonlinearity of the equilibrium isotherm), 2) to the interaction between radial mass transfer and flow velocity (the sorption effect in gas chromatography), and 3) to the pressure gradient along the column (in gas chromatography). Numerical results are obtained by using the Godunov method. The column is divided into a large","PeriodicalId":184327,"journal":{"name":"Preparative-Scale Chromatography","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123675336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 78
Simple Considerations on Column Design in Preparative-Scale Liquid Chromatography 制备规模液相色谱柱设计的简单考虑
Preparative-Scale Chromatography Pub Date : 1987-08-01 DOI: 10.1080/01496398708057616
H. Colin
{"title":"Simple Considerations on Column Design in Preparative-Scale Liquid Chromatography","authors":"H. Colin","doi":"10.1080/01496398708057616","DOIUrl":"https://doi.org/10.1080/01496398708057616","url":null,"abstract":"Abstract This paper discusses some simple considerations on the design of preparative columns (particle size and column length and diameter). It is shown that the loadability of a column does not depend on the size of the particles for a given efficiency. In order to obtain the maximum efficacity from the pumping system, the design of the column must take into account the characteristics of the pumping system, particularly the flow rate. It is shown that a convenient particle size is in the range 10 to 20 μm. Small particles are associated with shorter and bulkier columns than large particles, while at the same time giving less back pressure (in order to generate a given plate number at a given flow rate). The larger the flow rate generated by the pumping system, the smaller must be the particles.","PeriodicalId":184327,"journal":{"name":"Preparative-Scale Chromatography","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125062516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Investigation of the Influence of Particle Size on the Productivity of Preparative HPLC Columns 粒径对制备型高效液相色谱柱产率影响的研究
Preparative-Scale Chromatography Pub Date : 1987-08-01 DOI: 10.1080/01496398708057621
J. Newburger, L. Liebes, H. Colin, G. Guiochon
{"title":"Investigation of the Influence of Particle Size on the Productivity of Preparative HPLC Columns","authors":"J. Newburger, L. Liebes, H. Colin, G. Guiochon","doi":"10.1080/01496398708057621","DOIUrl":"https://doi.org/10.1080/01496398708057621","url":null,"abstract":"Abstract Changes in band profile, resolution, production, and yield with increasing sample size were determined for 1″ i.d. × 12″ preparative columns packed with 10 or 40 urn silica particles of the same origin. The results for a pure compound and for a mixture are compared. When a pure compound is injected, the efficiency of both columns decreases with increasing sample size. Although the 10-μm particle column is notably more efficient than the 40-μm particle column, for very large samples the plate numbers of both columns eventually become similar. When a binary mixture of isomers is injected, however, the 10-μm particle column provides a much larger yield and production of pure isomers than expected. When the sample size of this mixture is increased, the first eluted peak broadens to a lesser extent than if it were the peak of a pure component. It is better resolved from the more retained isomer than could be predicted on the basis of relative","PeriodicalId":184327,"journal":{"name":"Preparative-Scale Chromatography","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114285469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Cross-Axis Synchronous Flow-Through Coil Planet Centrifuge Free of Rotary Seals for Preparative Countercurrent Chromatography. Part I. Apparatus and Analysis of Acceleration 用于制备逆流色谱的无旋转密封的交叉轴同步流过线圈行星离心机。第一部分:加速度装置与分析
Preparative-Scale Chromatography Pub Date : 1987-08-01 DOI: 10.1080/01496398708057623
Y. Ito
{"title":"Cross-Axis Synchronous Flow-Through Coil Planet Centrifuge Free of Rotary Seals for Preparative Countercurrent Chromatography. Part I. Apparatus and Analysis of Acceleration","authors":"Y. Ito","doi":"10.1080/01496398708057623","DOIUrl":"https://doi.org/10.1080/01496398708057623","url":null,"abstract":"Abstract A novel type of the coil planet centrifuge is introduced. The apparatus holds a coil holder in such a way that the axis of the holder is positioned perpendicular to and at a fixed distance away from the centrifuge axis. In maintaining the above orientation the holder undergoes synchronous planetary motion, i.e., revolution around the central axis-of the centrifuge and rotation about its own axis at the same angular velocity. Mathematical analysis of acceleration generated by this planetary motion revealed a unique distribution pattern of centrifugal force vectors which promises a high performance of the present scheme in counter-current chromatography.","PeriodicalId":184327,"journal":{"name":"Preparative-Scale Chromatography","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130687686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
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