Mechanisms of Ageing and Development最新文献_第9页

The role of the LINC complex in ageing and microgravity LINC复合物在衰老和微重力中的作用。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-01-14 DOI: 10.1016/j.mad.2025.112028

Ivana Lansweers , Sharon van Rijthoven , Jack J.W.A. van Loon

{"title":"The role of the LINC complex in ageing and microgravity","authors":"Ivana Lansweers , Sharon van Rijthoven , Jack J.W.A. van Loon","doi":"10.1016/j.mad.2025.112028","DOIUrl":"10.1016/j.mad.2025.112028","url":null,"abstract":"<div><div>The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex plays a crucial role in connecting the nuclear envelope to the cytoskeleton, providing structural support to the nucleus and facilitating mechanical signaling between the extracellular environment and the nucleus. Research in mechanobiology onboard the International Space Station (ISS) and in simulated microgravity (SMG) highlight the importance of gravity in functional mechanotransduction. Although the altered gravity research regarding mechanobiology has been greatly focused on the cytoskeleton and the extracellular matrix (ECM), recent research demonstrates that SMG also induces changes in nuclear mechanics and gene expression patterns, which have been shown to be LINC complex dependent. Additionally, dysregulation of the LINC complex disrupts nuclear integrity which leads to nuclear shape abnormalities in both Hutchinson-Gilford Progeria Syndrome (HGPS) and aged cells, which highlights the significance of the LINC complex and related proteins in ageing and age-related disorders. Interestingly, as the effects of spaceflight closely resemble those found in the elderly, the microgravity environment seems to induce an accelerated ageing phenotype in astronauts. Therefore, this review will explore the role of the LINC complex and related proteins in ageing and in microgravity, to further elucidate the interplay between loss of gravitational loading and ageing.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"224 ","pages":"Article 112028"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients 转矩病毒（TTV）感染对慢性阻塞性肺病患者临床结局、基因组完整性和死亡率的影响

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-01-14 DOI: 10.1016/j.mad.2024.112024

Patrizia Russo , Francesca Milani , Dolores Limongi , Carla Prezioso , Federica Novazzi , Francesca Drago Ferrante , Fabrizio Maggi , Guido Antonelli , Stefano Bonassi

{"title":"The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients","authors":"Patrizia Russo , Francesca Milani , Dolores Limongi , Carla Prezioso , Federica Novazzi , Francesca Drago Ferrante , Fabrizio Maggi , Guido Antonelli , Stefano Bonassi","doi":"10.1016/j.mad.2024.112024","DOIUrl":"10.1016/j.mad.2024.112024","url":null,"abstract":"<div><h3>Introduction</h3><div>Torque Teno Virus (TTV), an \"orphan\" virus with unclear pathology, has been associated with various diseases and immune dysfunctions. This study investigates the link between TTV viremia and clinical markers in patients with severe to very severe COPD undergoing respiratory rehabilitation.</div></div><div><h3>Methods</h3><div>We analyzed 102 elderly COPD patients, stratified by TTV viremia levels (< or ≥ 4 log10 copies/mL). Clinical markers—including mortality, inflammatory-oxidative parameters (Lymphocyte/Monocyte, Neutrophil/Lymphocyte, and Platelet/Lymphocyte ratios), IL-6 (measured via ELISA assay), and DNA damage (assessed via comet assay)—were evaluated.</div></div><div><h3>Results</h3><div>Of the patients, 62.75 % had TTV viremia levels > 4 log<sub>10</sub> copies/mL. No associations were found between TTV levels and sex or obesity. However, higher TTV viremia correlated with increased DNA damage and significantly lower 5-year survival probability.</div></div><div><h3>Conclusion</h3><div>Patients with TTV levels ≥ 4 log<sub>10</sub> copies/mL exhibited the lowest survival probability, though DNA damage emerged as a stronger determinant of outcomes. This study raises key scientific questions on the role of TTV in COPD. Specifically, it explores whether TTV may serve as a potential marker for poor prognosis in COPD and whether rehabilitation strategies for these patients could be customized based on DNA damage and/or viremia.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"224 ","pages":"Article 112024"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses 衰老肺泡上皮细胞中的IRF1-RIG-I信号缺陷可能导致肺部抗病毒免疫反应下降。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-01-26 DOI: 10.1016/j.mad.2025.112037

Shan Li , Qianqian Lu , Jiao Lu , Xiaotong Song , Yang Gu , Xuefeng Duan , Wei Jiang , Guanglei Gu , Mengli Zheng , Lixin Xie , Min Fang

{"title":"IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses","authors":"Shan Li , Qianqian Lu , Jiao Lu , Xiaotong Song , Yang Gu , Xuefeng Duan , Wei Jiang , Guanglei Gu , Mengli Zheng , Lixin Xie , Min Fang","doi":"10.1016/j.mad.2025.112037","DOIUrl":"10.1016/j.mad.2025.112037","url":null,"abstract":"<div><h3>Background</h3><div>Alveolar epithelial cells (AECs) are the primary targets of many pathogens and play an important role in sensing viruses and regulating immunity. Yet, little is known about the antiviral responses in the aged AECs.</div></div><div><h3>Methods</h3><div>The responses of young or aged AECs after viral infection were analyzed using methods such as flow cytometry, quantitative real-time PCR, Western blot detection, and transwell chemotaxis assay. Deep sequencing and KEGG analysis were used to identify key pathways and genes associated with aged AECs, followed by functional analysis.</div></div><div><h3>Results</h3><div>The retinoic acid-inducible gene I (RIG-I) signaling is defective in aged AECs after influenza A virus (IAV) infection. The interferon regulatory factor 1 (IRF1) binds the promoter of RIG-I gene <em>Ddx58</em> to activate its expression. The regulation of IRF1 is also defective in AECs from aged mice. Fewer NK cells, monocytes, and T cells are recruited by the cell supernatant from PR8-infected aged AECs. Importantly, IRF1-RIG-I signaling is also impaired in the AECs of elderly people after IAV infection.</div></div><div><h3>Conclusion</h3><div>Ageing impairs IRF1-RIG-I signaling in AECs, and the defective responses in AECs may contribute to reduced immune cell recruitment and activation in aged individuals after pulmonary viral infection.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"224 ","pages":"Article 112037"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart of the matter: Mitochondrial dynamics and genome alterations in cardiac aging 问题的核心：线粒体动力学和基因组改变在心脏老化

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1016/j.mad.2025.112044

Claudie Gabillard-Lefort , Théophile Thibault , Guy Lenaers , Rudolf J. Wiesner , Jeanne Mialet-Perez , Olivier R. Baris

{"title":"Heart of the matter: Mitochondrial dynamics and genome alterations in cardiac aging","authors":"Claudie Gabillard-Lefort , Théophile Thibault , Guy Lenaers , Rudolf J. Wiesner , Jeanne Mialet-Perez , Olivier R. Baris","doi":"10.1016/j.mad.2025.112044","DOIUrl":"10.1016/j.mad.2025.112044","url":null,"abstract":"<div><div>Cardiac pathological aging is a serious health issue, with cardiovascular diseases still being a leading cause of deaths worldwide. Therefore, there is an urgent need to identify culprit factors involved in this process. In the last decades, mitochondria, which are crucial for cardiac function, have emerged as major contributors. Mitochondria are organelles involved in a plethora of metabolic pathways and cell processes ranging from ATP production to calcium homeostasis or regulation of apoptotic pathways. This review provides a general overview of the pathomechanisms involving mitochondria during cardiac aging, with a focus on the role of mitochondrial dynamics and mitochondrial DNA (mtDNA). These mechanisms involve imbalanced mitochondrial fusion and fission, loss of mtDNA integrity leading to tissue mosaic of mitochondrial deficiency, as well as mtDNA release in the cytoplasm, promoting inflammation via the NLRP3, cGAS/STING and TLR9 pathways. Potential links between mtDNA, mitochondrial damage and the accumulation of senescent cells in the heart are also discussed. A better understanding of how these factors impact on heart function and accelerate its pathological aging should lead to the development of new therapies to promote healthy aging and restore age-induced cardiac dysfunction.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"224 ","pages":"Article 112044"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation 芒果苷通过激活SIRT1保护间充质干细胞免受DNA损伤和细胞衰老。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-01-26 DOI: 10.1016/j.mad.2025.112038

Gyeong Min Lim , Gwang-Won Cho

{"title":"Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation","authors":"Gyeong Min Lim , Gwang-Won Cho","doi":"10.1016/j.mad.2025.112038","DOIUrl":"10.1016/j.mad.2025.112038","url":null,"abstract":"<div><div>The protective effects of mangiferin (MAG) against etoposide- and high glucose (HG)–induced DNA damage and aging were investigated in human bone marrow-mesenchymal stem cells (hBM-MSCs). Etoposide, a topoisomerase II inhibitor, was used to induce double-strand breaks (DSBs) in hBM-MSCs, resulting in increased genotoxicity, elevated levels of the DNA damage sensor ATM and CDKN1A, and decreased levels of the aging markers H3 and H4. MAG activated AMPK and SIRT1, thus protecting against DSB-induced damage. Following long-term exposure to HG, MAG significantly mitigated DNA damage and delayed cellular aging, as evidenced by the preservation of H3, H4, LMNB1, and SIRT1 mRNA levels and reduction in γ-H2AX foci and DSBs. Furthermore, MAG improved genome stability, as indicated by decreased LINE1 expression and increased levels of the heterochromatin marker TRIM28, thereby maintaining H3K9me3 levels. MAG and metformin treatment enhanced cell proliferation, reduced senescence-associated β-galactosidase staining, and lowered the levels of the senescence-associated secretory phenotype factors IL-1A, IL-1B, IL-6, IL-8, CCL2, and CCL20 and senescence marker CDKN1A, CDKN2A and p53. MAG may reduce DNA damage and delay aging in hBM-MSCs under HG conditions, highlighting their potential as therapeutic agents for aging-related diseases.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"224 ","pages":"Article 112038"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The EZH2/MCM Complex/hTERT axis facilitates hepatocellular carcinoma progression by inhibiting cellular senescence EZH2/MCM复合物/hTERT轴通过抑制细胞衰老促进肝细胞癌的进展

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-02-09 DOI: 10.1016/j.mad.2025.112040

Ziyi Shen , Yuanhui Wang , Jie Gao , Wei Gu , Ziyi Ren , Luanqi Xu , Rui Qian , Qinyi Miao , Xiaomeng Hu , Yan Wu , Wei Liu , Yi Cai , Chunpeng (Craig) Wan , Yansong Zhu , Lei Sun , Tingdong Yan

{"title":"The EZH2/MCM Complex/hTERT axis facilitates hepatocellular carcinoma progression by inhibiting cellular senescence","authors":"Ziyi Shen , Yuanhui Wang , Jie Gao , Wei Gu , Ziyi Ren , Luanqi Xu , Rui Qian , Qinyi Miao , Xiaomeng Hu , Yan Wu , Wei Liu , Yi Cai , Chunpeng (Craig) Wan , Yansong Zhu , Lei Sun , Tingdong Yan","doi":"10.1016/j.mad.2025.112040","DOIUrl":"10.1016/j.mad.2025.112040","url":null,"abstract":"<div><div>The complex pathogenesis of hepatocellular carcinoma (HCC) limits the effectiveness of current therapies. Through RNA sequencing of cancerous and adjacent non-cancerous tissues from six HCC patients, we identified a significant upregulation of MCM2–7 genes, which encode proteins that form the MCM complex, a DNA helicase involved in DNA replication and cell cycle progression. We focused on MCM2, MCM3, and MCM7, and observed that knockdown of these proteins inhibited HCC cell proliferation. Further analysis revealed a critical regulatory axis involving EZH2, the MCM complex, and hTERT. EZH2 was found to be highly correlated with MCM complex gene expression and directly bound to the MCM gene promoters, regulating their expression. This EZH2/MCM complex/hTERT axis may play a key role in suppressing cellular senescence, thereby promoting HCC progression. Knocking down MCM complex genes reduced hTERT expression, inducing HCC cell senescence and enhancing the therapeutic efficacy of sorafenib. These findings suggest that the EZH2/MCM complex/hTERT axis could serve as a novel therapeutic target for HCC.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"224 ","pages":"Article 112040"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into age-related osteoporosis from senescence-based preclinical models and human accelerated aging paradigms 从基于衰老的临床前模型和人类加速衰老范式深入了解与年龄相关的骨质疏松症。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-01-11 DOI: 10.1016/j.mad.2025.112025

Robert J. Pignolo , Abhishek Chandra

{"title":"Insights into age-related osteoporosis from senescence-based preclinical models and human accelerated aging paradigms","authors":"Robert J. Pignolo , Abhishek Chandra","doi":"10.1016/j.mad.2025.112025","DOIUrl":"10.1016/j.mad.2025.112025","url":null,"abstract":"<div><div>Preclinical models of age-related osteoporosis have been developed based on the accumulation and clearance of senescent cells. The former include animal models based on telomere dysfunction and focal radiation; the latter based on genetic and pharmacological targeting (i.e., removal) of senescent cells. The weight of evidence using these models suggests that cellular senescence plays a key role in the pathophysiology of aging-onset bone loss with the senescence-associated secretory phenotype (SASP) mediating local and systemic deleterious effects on the skeleton. Mitochondrial dysfunction has also been implicated in senescence and age-related comorbidities, including osteoporosis, and knock-in mutations in the mtDNA polymerase gamma (Polg) gene in mice may recapitulate similar respiratory chain complex defects in aged individual with osteoporosis. This and other contributions to senile osteoporosis may also be identified by the careful evaluation of non-genetic paradigms of human accelerated aging. Premature aging syndromes, especially those with a prominent bone loss phenotype, include clinical scenarios of skeletal unloading, premature ovarian failure and survival from childhood cancers. These non-hereditary progeroid syndromes implicate the involvement of lineage switching to an adipogenic fate, inhibition of Wnt signaling, increased osteoclastogenesis and activation frequency of osteoclasts, as well as the substantial burden of senescent cell accumulation.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"224 ","pages":"Article 112025"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging: A struggle for beneficial to overcome negative factors made by muscle and bone 衰老：克服肌肉和骨骼造成的负面因素的有益斗争

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-02-12 DOI: 10.1016/j.mad.2025.112039

Steven S. Welc , Marco Brotto , Kenneth E. White , Lynda F. Bonewald

引用次数: 0

Deciphering the role of cytokines in aging: Biomarker potential and effective targeting 解读细胞因子在衰老中的作用：生物标志物潜力和有效靶向。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-01-18 DOI: 10.1016/j.mad.2025.112036

Panagiotis Poulios, Stamoulis Skampouras, Christina Piperi

{"title":"Deciphering the role of cytokines in aging: Biomarker potential and effective targeting","authors":"Panagiotis Poulios, Stamoulis Skampouras, Christina Piperi","doi":"10.1016/j.mad.2025.112036","DOIUrl":"10.1016/j.mad.2025.112036","url":null,"abstract":"<div><div>Aging is often characterized by chronic inflammation, immune system dysregulation, and cellular senescence with chronically elevated levels of pro-inflammatory cytokines. These small glycoproteins are mainly secreted by immune cells, mediating intercellular communication and immune system modulation through inflammatory signaling. Their pro- and anti-inflammatory effects make them a noteworthy research topic as well as a promising ally in combating inflammation and the aging process. Cytokines exert a synergistic role in aging and disease and may prove useful biomarkers of tissue-specific dysregulation, disease diagnosis and monitoring, presenting potential therapeutic options as anti-inflammatory and senolytic medications. In this review, we address the cellular and molecular mechanisms implicating cytokines in the aging process and related diseases, highlighting their biomarker potential. We focus on the current therapeutic strategies, including specific pharmaceutical agents, supplements, a balanced diet, and healthy habits such as exercise, stress management, and caloric restriction.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"224 ","pages":"Article 112036"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between physical activity and telomere length in women: A systematic review 女性身体活动与端粒长度的关系：一项系统综述。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1016/j.mad.2025.112042

Jeni Page , Catherine Stephens , Melissa Richard , Elizabeth Lyons , Elizabeth Baumler , M. Terese Verklan , Elizabeth Lorenzo

{"title":"The relationship between physical activity and telomere length in women: A systematic review","authors":"Jeni Page , Catherine Stephens , Melissa Richard , Elizabeth Lyons , Elizabeth Baumler , M. Terese Verklan , Elizabeth Lorenzo","doi":"10.1016/j.mad.2025.112042","DOIUrl":"10.1016/j.mad.2025.112042","url":null,"abstract":"<div><div>Telomere length (TL) is a biomarker of cellular aging with variations observed by sex, age, race, and ethnicity. Prior studies have suggested that physical activity (PA) may positively impact TL by potentially elongating telomeres and slowing cellular aging. However, research examining the optimal type and intensity of PA needed to elicit these changes specific to women remains limited. This systematic review aimed to investigate variations in TL in response to PA among women, exploring how these effects differ by age, race, or ethnicity. Following PRISMA guidelines, searches across five databases identified 17 relevant studies published from 2008 to 2022. A narrative synthesis of study findings indicated PA did not have a significant relationship with TL in women. However, a possible positive relationship was noted between specific types of PA and TL, specific to combined aerobic and strength-training PA and high intensity interval training interventions. The impact of PA on TL appeared to be age-dependent as well, showing significant positive relationships between PA and TL in early and later adulthood but not in middle adulthood. Findings related to race or ethnicity were inconclusive due to limited analyses from the included studies. The studies varied greatly by PA type, intensity, duration, and frequency, which, along with the reliance on self-reported PA measures in the observational studies, impacted the ability to draw firm conclusions. This review underscores the necessity for future research in large cohort studies using objectively measured PA interventions to further clarify the complex associations between PA and TL in women.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"224 ","pages":"Article 112042"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0