Mechanisms of Ageing and Development最新文献_第9页

Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology 针对慢性破坏性tnf驱动的关节病理衰老和炎症

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI: 10.1016/j.mad.2023.111856

Nikolaos I. Vlachogiannis , Konstantinos Evangelou , Lydia Ntari , Christoforos Nikolaou , Maria C. Denis , Niki Karagianni , Dimitris Veroutis , Vassilis Gorgoulis , George Kollias , Petros P. Sfikakis

{"title":"Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology","authors":"Nikolaos I. Vlachogiannis , Konstantinos Evangelou , Lydia Ntari , Christoforos Nikolaou , Maria C. Denis , Niki Karagianni , Dimitris Veroutis , Vassilis Gorgoulis , George Kollias , Petros P. Sfikakis","doi":"10.1016/j.mad.2023.111856","DOIUrl":"10.1016/j.mad.2023.111856","url":null,"abstract":"<div><p><span><span><span>We had shown that administration of the senolytic Dasatinib<span> abolishes arthritis in the human TNF </span></span>transgenic mouse<span> model of chronic destructive arthritis when given in combination with a sub-therapeutic dose of the anti-TNF mAb </span></span>Infliximab<span> (1 mg/kg). Herein, we found that while the number of senescent chondrocytes (GL13</span></span><sup>+</sup>/Ki67<sup>-</sup>), assessed according to guideline algorithmic approaches, was not affected by either Dasatinib or sub-therapeutic Infliximab monotherapies, their combination reduced senescent chondrocytes by 50 %, which was comparable to levels observed with therapeutic Infliximab monotherapy (10 mg/kg). This combination therapy also reduced the expression of multiple factors of senescence-associated secretory phenotype in arthritic joints. Studies to elucidate the interplay of inflammation and senescence may help in optimizing treatment strategies also for age-related pathologies characterized by chronic low-grade joint inflammation.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10179117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ageing-associated phenotypes in mice 小鼠衰老相关表型

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI: 10.1016/j.mad.2023.111852

Kan Xie, Dan Ehninger

引用次数: 0

Role of cytokines and reactive oxygen species in brain aging 细胞因子和活性氧在大脑衰老中的作用。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI: 10.1016/j.mad.2023.111855

Sheba M.J. MohanKumar, Abarna Murugan, Arunkumar Palaniyappan, Puliyur S. MohanKumar

引用次数: 1

Improving intestinal inflammaging to delay aging? A new perspective 改善肠道炎症延缓衰老?一个新的视角

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI: 10.1016/j.mad.2023.111841

Lan Zhang , Junbin Yan , Chi Zhang , Shuyan Feng , Zheli Zhan , Yang Bao , Shuo Zhang , Guanqun Chao

{"title":"Improving intestinal inflammaging to delay aging? A new perspective","authors":"Lan Zhang , Junbin Yan , Chi Zhang , Shuyan Feng , Zheli Zhan , Yang Bao , Shuo Zhang , Guanqun Chao","doi":"10.1016/j.mad.2023.111841","DOIUrl":"10.1016/j.mad.2023.111841","url":null,"abstract":"<div><p>Greying population is becoming an increasingly critical issue for social development. In advanced aging context, organismal multiple tissues and organs experience a progressive deterioration, initially presenting with functional decline, followed by structural disruption and eventually organ failure. The aging of the gut is one of the key links. Decreased gut function leads to reduced nutrient absorption and can perturb systemic metabolic rates. The degeneration of the intestinal structure causes the migration of harmful components such as pathogens and toxins, inducing pathophysiological changes in other organs through the \"brain-gut axis\" and \"liver-gut axis\". There is no accepted singular underlying mechanism of aged gut. While the inflamm-aging theory was first proposed in 2000, the mutual promotion of chronic inflammation and aging has attracted much attention. Numerous studies have established that gut microbiome<span> composition, gut immune function, and gut barrier integrity are involved in the formation of inflammaging<span> in the aging gut. Remarkably, inflammaging additionally drives the development of aging-like phenotypes, such as microbiota<span> dysbiosis and impaired intestinal barrier, via a broad array of inflammatory mediators. Here we demonstrate the mechanisms of inflammaging in the gut and explore whether aging-like phenotypes in the gut can be negated by improving gut inflammaging.</span></span></span></p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10233389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

New frontiers in ageing and longevity: Sex and gender medicine 老龄化和长寿的新领域:性和性别医学

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI: 10.1016/j.mad.2023.111850

Carmela Rita Balistreri

引用次数: 1

Preserving the discreteness of deficits during coding leads to a lower frailty index in individuals living in long-term care 在编码过程中保持缺陷的离散性可以降低长期护理个体的脆弱指数

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI: 10.1016/j.mad.2023.111851

Brian Greeley , Hilary Low , Ronald Kelly , Robert McDermid , Xiaowei Song

{"title":"Preserving the discreteness of deficits during coding leads to a lower frailty index in individuals living in long-term care","authors":"Brian Greeley , Hilary Low , Ronald Kelly , Robert McDermid , Xiaowei Song","doi":"10.1016/j.mad.2023.111851","DOIUrl":"10.1016/j.mad.2023.111851","url":null,"abstract":"<div><p>This study assesses two coding approaches on the frailty index (FI).</p><p>Two FI were calculated using 43 variables from 29,758 older adults (84.6 ± 8 years old; 64 % female) in long-term care. Scores were coded as 0, 0.5, or 1 regardless of the number of levels (grouped), or preserved (e.g., a 4 level variable was coded as 0, 0.33, 0.67, or 1; discrete). Grouped and discrete FI were compared with each ordinal variable removed but all other ordinal variables included. This was repeated until 28 unique (14 grouped, 14 discrete) FI had been constructed each with one ordinal variable removed per FI. FI was correlated to age and mortality separated by sex.</p><p>The median grouped (0.302 (0.221–0.372)) was higher relative to the discrete (0.237 (0.170–0.307)) FI. The discrete (r = 0.91, r = 0.87) and grouped (r = 0.93, r = 0.87) FI showed similar relationships to age and mortality. Removal of any ordinal variable reduced grouped FI by 0.004 or 0.016, whereas removal led to both increases (range: 0.003–0.001) and reductions (range: 0.002–0.008) for discrete FI.</p><p>A grouped approach inflates FI. A discrete approach provides a more accurate measure of frailty.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10233436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials 重新编程iPSCs以研究年龄相关疾病:模型、治疗方法和临床试验

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI: 10.1016/j.mad.2023.111854

Filipa Esteves , David Brito , Ana Teresa Rajado , Nádia Silva , Joana Apolónio , Vânia Palma Roberto , Inês Araújo , Clévio Nóbrega , Pedro Castelo-Branco , José Bragança

{"title":"Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials","authors":"Filipa Esteves , David Brito , Ana Teresa Rajado , Nádia Silva , Joana Apolónio , Vânia Palma Roberto , Inês Araújo , Clévio Nóbrega , Pedro Castelo-Branco , José Bragança","doi":"10.1016/j.mad.2023.111854","DOIUrl":"10.1016/j.mad.2023.111854","url":null,"abstract":"<div><p>The unprecedented rise in life expectancy observed in the last decades is leading to a global increase in the ageing population, and age-associated diseases became an increasing societal, economic, and medical burden. This has boosted major efforts in the scientific and medical research communities to develop and improve therapies to delay ageing and age-associated functional decline and diseases, and to expand health span. The establishment of induced pluripotent stem cells<span><span><span> (iPSCs) by reprogramming human somatic cells has revolutionised the modelling and understanding of human diseases. iPSCs have a major advantage relative to other human pluripotent stem cells as their obtention does not require the destruction of embryos like </span>embryonic stem cells do, and do not have a limited proliferation or differentiation potential as </span>adult stem cells. Besides, iPSCs can be generated from somatic cells from healthy individuals or patients, which makes iPSC technology a promising approach to model and decipher the mechanisms underlying the ageing process and age-associated diseases, study drug effects, and develop new therapeutic approaches. This review discusses the advances made in the last decade using iPSC technology to study the most common age-associated diseases, including age-related macular degeneration (AMD), neurodegenerative and cardiovascular diseases, brain stroke, cancer, diabetes, and osteoarthritis.</span></p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10179142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

RNA-binding proteins in cellular senescence 细胞衰老中的rna结合蛋白

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI: 10.1016/j.mad.2023.111853

Dahyeon Koh , Hyeong Bin Jeon , Chaehwan Oh , Ji Heon Noh , Kyoung Mi Kim

引用次数: 0

Impact of air pollution on cardiovascular aging 空气污染对心血管老化的影响

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI: 10.1016/j.mad.2023.111857

Marin Kuntic , Ivana Kuntic , Omar Hahad , Jos Lelieveld , Thomas Münzel , Andreas Daiber

{"title":"Impact of air pollution on cardiovascular aging","authors":"Marin Kuntic , Ivana Kuntic , Omar Hahad , Jos Lelieveld , Thomas Münzel , Andreas Daiber","doi":"10.1016/j.mad.2023.111857","DOIUrl":"10.1016/j.mad.2023.111857","url":null,"abstract":"<div><p>The world population is aging rapidly, and by some estimates, the number of people older than 60 will double in the next 30 years. With the increase in life expectancy, adverse effects of environmental exposures start playing a more prominent role in human health. Air pollution is now widely considered the most detrimental of all environmental risk factors, with some studies estimating that almost 20% of all deaths globally could be attributed to poor air quality. Cardiovascular diseases are the leading cause of death worldwide and will continue to account for the most significant percentage of non-communicable disease burden. Cardiovascular aging with defined pathomechanisms is a major trigger of cardiovascular disease in old age. Effects of environmental risk factors on cardiovascular aging should be considered in order to increase the health span and reduce the burden of cardiovascular disease in older populations. In this review, we explore the effects of air pollution on cardiovascular aging, from the molecular mechanisms to cardiovascular manifestations of aging and, finally, the age-related cardiovascular outcomes. We also explore the distinction between the effects of air pollution on healthy aging and disease progression. Future efforts should focus on extending the health span rather than the lifespan.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10549130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions 抑制DYRK1B对内皮细胞具有抗衰老作用，可挽救内皮功能障碍

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2023-07-01 DOI: 10.1016/j.mad.2023.111836

Francesca M. Pramotton , Asra Abukar , Chantelle Hudson , James Dunbar , Andrew Potterton , Simone Tonnicchia , Andrea Taddei , Edoardo Mazza , Costanza Giampietro

{"title":"DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions","authors":"Francesca M. Pramotton , Asra Abukar , Chantelle Hudson , James Dunbar , Andrew Potterton , Simone Tonnicchia , Andrea Taddei , Edoardo Mazza , Costanza Giampietro","doi":"10.1016/j.mad.2023.111836","DOIUrl":"10.1016/j.mad.2023.111836","url":null,"abstract":"<div><p>Aging is the major risk factor for chronic disease development. Cellular senescence is a key mechanism that triggers or contributes to age-related phenotypes and pathologies. The endothelium, a single layer of cells lining the inner surface of a blood vessel, is a critical interface between blood and all tissues. Many studies report a link between endothelial cell senescence, inflammation, and diabetic vascular diseases. Here we identify, using combined advanced AI and machine learning, the Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B (DYRK1B) protein as a possible senolytic target for senescent endothelial cells. We demonstrate that upon induction of senescence in vitro DYRK1B expression is increased in endothelial cells and localized at adherens junctions where it impairs their proper organization and functions. <em>DYRK1B</em> knock-down or inhibition restores endothelial barrier properties and collective behavior. DYRK1B is therefore a possible target to counteract diabetes-associated vascular diseases linked to endothelial cell senescence.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10173219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1