Mechanisms of Ageing and Development最新文献_第4页

Human astrocytes from healthy individuals and Alzheimer’s patients respond differently to Aβ1–42 oligomers, triggering distinct paths of reactivity and senescence 健康个体和阿尔茨海默病患者的人类星形胶质细胞对Aβ1-42寡聚物的反应不同，引发不同的反应性和衰老途径。

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-12-01 Epub Date: 2025-09-24 DOI: 10.1016/j.mad.2025.112116

Sara Ristori , Gianmarco Bertoni , Alessandra Bigi , Cristina Cecchi , Manuela Sollazzo , Luisa Iommarini , Daniela Monti , Elisa Bientinesi

{"title":"Human astrocytes from healthy individuals and Alzheimer’s patients respond differently to Aβ1–42 oligomers, triggering distinct paths of reactivity and senescence","authors":"Sara Ristori , Gianmarco Bertoni , Alessandra Bigi , Cristina Cecchi , Manuela Sollazzo , Luisa Iommarini , Daniela Monti , Elisa Bientinesi","doi":"10.1016/j.mad.2025.112116","DOIUrl":"10.1016/j.mad.2025.112116","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is a neurodegenerative disorder characterised by cognitive decline, amyloid-β (Aβ) plaques, and neurofibrillary tangles. Aβ<sub>1–42</sub> oligomers exert neurotoxic and pro-inflammatory effects. Astrocytes maintain brain homeostasis, and their dysfunction contributes to AD progression. This study investigates the impact of Aβ<sub>1–42</sub> oligomers on primary human astrocytes from healthy individuals and AD patients. Our findings show that astrocytes from both groups internalise Aβ<sub>1–42</sub> oligomers. In healthy astrocytes, internalisation enhances proteasome activity, whereas in AD astrocytes, it reduces it. Aβ<sub>1–42</sub> oligomers induce calcium dyshomeostasis and mitochondrial membrane potential alterations in both groups. Interestingly, oligomers induce apoptosis in a subset of healthy astrocytes, while surviving ones become reactive and hyperproliferative, releasing neuroinflammatory and neurotrophic molecules. Conversely, Aβ<sub>1–42</sub> drives AD astrocytes into senescence, characterised by increased β-galactosidase activity, p14<sup>ARF</sup> expression, senescence-associated secretory phenotype (SASP), and heterochromatin foci. Importantly, conditioned media from Aβ<sub>1–42</sub>-treated AD astrocytes, but not from healthy ones, cause death of differentiated SH-SY5Y neuron-like cells, suggesting that senescent astrocytes contribute to neurotoxicity. These findings reveal differential astrocytic responses to Aβ<sub>1–42</sub> oligomers, emphasising the importance of astrocyte senescence in AD pathogenesis. This research offers insight into cellular mechanisms underlying AD and may support the development of innovative therapeutic strategies for neurodegenerative diseases.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"228 ","pages":"Article 112116"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An atlas of age- and sex-related volumetric alterations of grey matter in subcortical regions: The case of 46,111 UK Biobank participants 皮层下区域灰质年龄和性别相关体积变化图谱：46111名英国生物银行参与者的病例。

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-12-01 Epub Date: 2025-11-08 DOI: 10.1016/j.mad.2025.112123

Fatemeh Tabassi Mofrad, Chris Patrick Pflanz, John Gallacher

{"title":"An atlas of age- and sex-related volumetric alterations of grey matter in subcortical regions: The case of 46,111 UK Biobank participants","authors":"Fatemeh Tabassi Mofrad, Chris Patrick Pflanz, John Gallacher","doi":"10.1016/j.mad.2025.112123","DOIUrl":"10.1016/j.mad.2025.112123","url":null,"abstract":"<div><div>Ageing is commonly associated with neuroanatomical changes in brain structure, underscoring the importance of distinguishing normal age-related alterations from those linked to pathological neurodegeneration. Despite this critical need, a standardized benchmark for identifying brain volumetric signatures of ageing remains lacking, and the influence of biological sex on age-related changes in brain volume is not yet fully understood. To address the above-mentioned gaps, we employed T1-weighted MRI images of 46,111 cognitively healthy individuals aged 44–83 from the UK Biobank cohort, and generated comprehensive maps of all the linear and non-linear trajectories of alterations in the grey matter volumes (GMVs) of subcortical regions across males and females. According to our findings, Brainstem, bilateral Amygdala and Hippocampus are the most susceptible subcortical regions to age-related atrophy, with males being generally more prone to such alterations. However, ageing proves to have a dual function as we also observed age-related inflammation in GMVs of Pallidum and Caudate which accelerates during older age and remains consistent across males and females. Our findings guide regenerative strategies and therapeutic interventions by locating subcortical regions most vulnerable to age-related atrophy and inflammation and establish a benchmark for sex-specific typical patterns of subcortical grey matter alterations due to ageing.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"228 ","pages":"Article 112123"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diminished CEACAM1 level plays a critical role in age-related hepatic fibrosis CEACAM1水平降低在年龄相关性肝纤维化中起关键作用。

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-12-01 Epub Date: 2025-11-04 DOI: 10.1016/j.mad.2025.112122

Sobia Zaidi , Suman Asalla , Raziyeh Abdolahipour , Agnes O. Portuphy , Marziyeh S. Jahromi , Harrison T. Muturi , Getachew D. Belew , Ramiro Malgor , Sivarajan Kumarasamy , Sonia M. Najjar

{"title":"Diminished CEACAM1 level plays a critical role in age-related hepatic fibrosis","authors":"Sobia Zaidi , Suman Asalla , Raziyeh Abdolahipour , Agnes O. Portuphy , Marziyeh S. Jahromi , Harrison T. Muturi , Getachew D. Belew , Ramiro Malgor , Sivarajan Kumarasamy , Sonia M. Najjar","doi":"10.1016/j.mad.2025.112122","DOIUrl":"10.1016/j.mad.2025.112122","url":null,"abstract":"<div><h3>Background</h3><div>Hepatic fibrosis increases with aging, but its physiological progression and underlying mechanisms remain poorly defined. Given that CEACAM1 repression causes metabolic dysfunction and liver injury, the current studies investigated whether it mediates age-related hepatic fibrosis.</div></div><div><h3>Materials and methods</h3><div>The metabolic phenotype, histological, immunochemical and Western blot analyses were performed in male C57BL6/J wild-type and LCC1 mice with liver-specific CEACAM1 overexpression at 2–17 months of age.</div></div><div><h3>Results</h3><div>Progression of metabolic dysfunction during physiological aging began with increased lipolysis-derived fatty acids, followed by hepatic insulin resistance with compensatory increase in insulin secretion and a decline in hepatic insulin clearance mediated initially by compromised CEACAM1 phosphorylation and then expression. Resultant hyperinsulinemia drove hepatic steatosis, followed by Th1 inflammatory response and subsequently, hepatic fibrosis at 17 months of age. These histological abnormalities regressed in LCC1 mice with protected hepatic CEACAM1 levels. Accordingly, LCC1 mice exhibited survival advantage.</div></div><div><h3>Discussion</h3><div>This age-related mapping demonstrated that early metabolic alterations impaired insulin clearance with a progressive loss of CEACAM1. Resultant hyperinsulinemia drove hepatic steatosis followed by inflammation and ultimately, hepatic fibrosis in wild-type but not LCC1 mice. Together with survival benefit of LCC1, these observations propose that protecting hepatic CEACAM1 prevents age-related hepatic fibrosis and bestows longevity.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"228 ","pages":"Article 112122"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The stress-responsive cytokine GDF-15 and sarcopenia: A systematic review and meta-analysis on aging muscle decline 应激反应细胞因子GDF-15和肌肉减少症：衰老肌肉衰退的系统回顾和荟萃分析。

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-12-01 Epub Date: 2025-09-26 DOI: 10.1016/j.mad.2025.112117

Mario Virgilio Papa , Chiara Ceolin , Francesco Boschele , Raffaele Pagliuca , Giuseppe Sergi , Marina De Rui

{"title":"The stress-responsive cytokine GDF-15 and sarcopenia: A systematic review and meta-analysis on aging muscle decline","authors":"Mario Virgilio Papa , Chiara Ceolin , Francesco Boschele , Raffaele Pagliuca , Giuseppe Sergi , Marina De Rui","doi":"10.1016/j.mad.2025.112117","DOIUrl":"10.1016/j.mad.2025.112117","url":null,"abstract":"<div><h3>Background</h3><div>Given the increasing interest for Growth Differentiation Factor-15 (GDF-15) in muscle decline, this study aims to evaluate the association between circulating levels of GDF-15 and muscle mass and sarcopenia through a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>The research, in accordance with PRISMA and MOOSE guidelines, involved PubMed, Embase, and Cochrane Libraries. Two meta-analyses were performed: (1) comparison of GDF-15 levels in sarcopenic vs non-sarcopenic individuals; (2) correlation between GDF-15 and muscle mass.</div></div><div><h3>Results</h3><div>A total of 7 studies met the inclusion criteria (total n = 2344) enrolling both adults aged ≥ 60 years (6/7 studies) and a younger cohort (42 years [IQR 31.8–51]). The first meta-analysis, based on 4 studies (n = 1393), showed significantly higher levels of GDF-15 in sarcopenic individuals (r = 0.482). The second meta-analysis, involving 4 studies (n = 1400), found a significant inverse correlation between GDF-15 and muscle mass (r = -0.221).</div></div><div><h3>Conclusions</h3><div>Sarcopenic individuals had higher circulating GDF-15. Together with the inverse correlation between GDF-15 and muscle mass observed, these findings show a small-to-moderate association between elevated GDF-15 and sarcopenic phenotypes in older adults. However, the limited number of studies and high heterogeneity for the sarcopenia comparison warrant cautious interpretation and underscore the need for larger, longitudinal investigations.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"228 ","pages":"Article 112117"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DKK3, regulated by FOXF1-EZH2 axis, takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis DKK3受FOXF1-EZH2轴调控，作用于小管上皮细胞衰老，触发肾小球内皮细胞铁上沉，参与肾纤维化。

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-12-01 Epub Date: 2025-08-28 DOI: 10.1016/j.mad.2025.112103

Huiling Cao , Yanxia Chen , Jinjing Huang, Weiping Tu, Ben Ke, Xiangdong Fang

{"title":"DKK3, regulated by FOXF1-EZH2 axis, takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis","authors":"Huiling Cao , Yanxia Chen , Jinjing Huang, Weiping Tu, Ben Ke, Xiangdong Fang","doi":"10.1016/j.mad.2025.112103","DOIUrl":"10.1016/j.mad.2025.112103","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) can be accelerated by renal fibrosis. Dickkopf-3 (DKK3) plays a role in regulating renal fibrosis, while tubular cell senescence contributes to fibrosis development. Here, the role and mechanism of DKK3 on senescence and renal fibrosis were evaluated. We demonstrated that in CKD patients and Unilateral Ureteral Obstruction (UUO) mice, downregulation of FOXF1 and upregulation of DDK3 was observed, of which expression patterns exhibited negative association. Reinforced FOXF1 protected against H<sub>2</sub>O<sub>2</sub>-triggered tubular cell damage, fibrosis, and senescence, which was reversed by DKK3 overexpression. In UUO mice, FOXF1 depletion worsened renal fibrosis and senescence. Mechanistically, FOXF1 was identified to be a transcriptional activator of EZH2 to mediated epigenetic silence of DKK3 via H3K27me3 levels. Moreover, exosomal DKK3 from tubular cells controlled Endothelial to Mesenchymal Transition, oxidative stress and ferroptosis in MRGECs. Overall, our data reveal that the FOXF1-EZH2-DKK3 axis controls tubular cell senescence. Exosome-borne DKK3 influences lipid peroxidation in glomerular endothelial cells, inducing ferroptosis and advancing renal fibrosis, which provides new therapeutic targets for CKD treatment.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"228 ","pages":"Article 112103"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased mTOR signaling secondary to a human ILK missense variant inhibits nephrogenesis with decreased metabolism 继发于人类ILK错义变异的mTOR信号增加抑制代谢降低的肾发生。

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.mad.2025.112115

Xiangyue Hu , Dana Kablawi , Wout F.J. Feitz , Kirsten Y. Renkema , Nine V.A.M. Knoers , Norman D. Rosenblum

{"title":"Increased mTOR signaling secondary to a human ILK missense variant inhibits nephrogenesis with decreased metabolism","authors":"Xiangyue Hu , Dana Kablawi , Wout F.J. Feitz , Kirsten Y. Renkema , Nine V.A.M. Knoers , Norman D. Rosenblum","doi":"10.1016/j.mad.2025.112115","DOIUrl":"10.1016/j.mad.2025.112115","url":null,"abstract":"<div><div>Nephrogenesis is critical to mammalian kidney function throughout life. Decreased nephron formation, an embryonic process dependent on ureteric-mesenchymal tissue interactions, is a fundamental feature of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) and an antecedent to adult-onset cardiovascular and renal disease. Yet, mechanisms controlling the number of nephrons formed during embryogenesis are largely undefined. Here, we elucidated deleterious effects of increased mTOR signaling on murine nephrogenesis. A rare human genetic missense variant (<em>ILK</em><sup><em>T173I</em></sup>) in Integrin-Linked Kinase (<em>ILK</em>) was identified in a human CAKUT cohort. Replacement of the mouse <em>ILK</em><sup><em>WT</em></sup> allele with <em>Ilk</em><sup><em>T173I</em></sup> caused increased kidney mTOR signaling, low nephron number, and decreased ureteric branching, the latter of which was rescued by rapamycin. Transcriptomic analysis of sorted embryonic kidney cells suggested that elevated mTOR signaling is limited to non-ureteric mesenchyme, a finding that was substantiated by immunostaining in situ. Maturation of nephrogenic cells in <em>Ilk</em><sup><em>T173I</em></sup>-knock-in kidneys was decreased as demonstrated by nephrogenic-specific markers, morphologic analysis, and proliferation of nephrogenic progenitors. Metabolic profiling of non-ureteric cells demonstrated decreased oxidative ATP production. Together, our data revealed a deleterious role of excessive mTOR signaling downstream of <em>ILK</em><sup><em>T173I</em></sup> by inhibiting maturation, cell proliferation and metabolism in the nephrogenic cell lineage.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"228 ","pages":"Article 112115"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins 循环microrna和身体功能和虚弱的横断面和纵向测量：一项对大龄双胞胎的探索性研究。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-10-01 Epub Date: 2025-07-16 DOI: 10.1016/j.mad.2025.112099

Rossella La Grotta , Cecilie Agergaard Sørensen , Asmus Cosmos Skovgaard , Mikael Thinggaard , Serena Dato , Giuseppina Rose , Jonas Mengel-From , Mette Soerensen

{"title":"Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins","authors":"Rossella La Grotta , Cecilie Agergaard Sørensen , Asmus Cosmos Skovgaard , Mikael Thinggaard , Serena Dato , Giuseppina Rose , Jonas Mengel-From , Mette Soerensen","doi":"10.1016/j.mad.2025.112099","DOIUrl":"10.1016/j.mad.2025.112099","url":null,"abstract":"<div><div>During aging, physical functioning declines, and disability and frailty increase; phenotypes which are bidirectionally linked. MicroRNAs (miRNAs) are epigenetic regulators of various physiological processes and suggested aging biomarkers. Here we investigate the association between circulating plasma miRNAs and hand grip strength, chair stand, (Rockwood) frailty, and activity of daily living (ADL) in 86 monozygotic twins (73–88 years). In cross-sectional analysis, both individual and twin-pair level analyses were performed, the latter controlling genetic confounding. The majority (74–100 %) of miRNAs identified in the individual-level analysis were validated by twin-pair-level analysis, with 14 miRNAs showing significance (p < 0.05) in both. Longitudinal analysis (up to eight years of follow-up) yielded more significant results (75–93 miRNAs), indicating that miRNAs might be more accurate in predicting functional decline over time. Of these miRNAs, seven showed consistent directions of effects across phenotypes. For all analyses, most (65–79 %) of the observed effect sizes were negative, reflecting reduced functionality with increased miRNA levels. Enrichment analyses revealed pathways of gene expression (incl. p53- and FOXO-mediated transcription), signal transduction, the immune system, metabolism of RNA, among others. Of specific miRNAs, miR-1274a demonstrated negative association in both cross-sectional and longitudinal investigations of ADL. These findings support miRNAs as biomarkers of age-related functional decline.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"227 ","pages":"Article 112099"},"PeriodicalIF":5.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of FTO-mediated m6A demethylation regulation of YAP1 in nucleus pulposus cell senescence fto介导的m6A去甲基化调控YAP1在髓核细胞衰老中的机制

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-10-01 Epub Date: 2025-08-26 DOI: 10.1016/j.mad.2025.112101

Rui Sun , Xiao-Tao Wu , Hang Shi , Feng Wang , Jia-Wei Gao , Pei-Yang Wang , Zheng-Yuan Xu , Wen-Wu Gan , Yun-Tao Wang , Cong Zhang

引用次数: 0

Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing 百岁老人的脑电活动：弹性脑老化的神经生理EEG标记。

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-10-01 Epub Date: 2025-08-09 DOI: 10.1016/j.mad.2025.112100

Fabrizio Vecchio , Chiara Pappalettera , Alessia Cacciotti , Federico Frasca , Gabriella Marcon , Paolo Maria Rossini

{"title":"Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing","authors":"Fabrizio Vecchio , Chiara Pappalettera , Alessia Cacciotti , Federico Frasca , Gabriella Marcon , Paolo Maria Rossini","doi":"10.1016/j.mad.2025.112100","DOIUrl":"10.1016/j.mad.2025.112100","url":null,"abstract":"<div><div>Centenarians are an increasing population, in particular in high income countries. Studying cognitively intact Centenarians’ brain becomes fundamental to understand physiological ageing and how it diverges from pathological one. Resting state EEG were recorded using 27 channels in more than 130 subjects (referred to Young, Adults, Elderly, Centenarians and Alzheimer Disease patients), and the power spectral density (PSD) was computed. The paper demonstrates that Centenarians electrical brain activity is more similar to Elderly’s than expected, despite approximately 30 years of age gap, provided they are cognitively intact. Centenarians EEG signal was expected to progressively approach AD one, but surprisingly they seem to slow-down their ageing and maintain non-pathological and resilient EEG patterns, particularly in Alpha bands: occipital region Centenarians PSD has lower values than Young and Adults but not than Elderly, and higher values than AD. These interesting results suggests that Centenarians brain needs to be investigated to extrapolate its characteristics and try to replicate its mechanisms for a widespread healthy ageing.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"227 ","pages":"Article 112100"},"PeriodicalIF":5.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human oral microbiome in aging: A systematic review 人类口腔微生物群与衰老：系统综述

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1016/j.mad.2025.112080

Elena Carbone , Elisa Fabrizi , Roberto Rivabene , Marisa Cappella , Paola Fortini , Lucia Conti , Nicoletta Locuratolo , Patrizia Lorenzini , Eleonora Lacorte , Paola Piscopo

{"title":"Human oral microbiome in aging: A systematic review","authors":"Elena Carbone , Elisa Fabrizi , Roberto Rivabene , Marisa Cappella , Paola Fortini , Lucia Conti , Nicoletta Locuratolo , Patrizia Lorenzini , Eleonora Lacorte , Paola Piscopo","doi":"10.1016/j.mad.2025.112080","DOIUrl":"10.1016/j.mad.2025.112080","url":null,"abstract":"<div><div>Studying aging and risk factors associated with chronic non-communicable diseases is increasingly relevant due to the progressive aging of the global population. Risk factors have focused on diet, physical exercise, cognitive activity, and lifestyle habits; however, recent research has begun to explore how the oral microbiome may influence health and contribute to chronic diseases. The aim of our systematic review is to evaluate the link between human oral microbiome and aging. This SR was carried out using PubMed, Cochrane Library, and Embase, identifying 3490 records, of which 6 met our inclusion/exclusion criteria. These studies were qualitatively assessed using the Revised Risk of Bias Assessment Tool for Nonrandomized Studies of Interventions. Overall, the evidence suggests that while the bacterial and fungal communities remain similar across age groups, there is an increased presence of periodontal pathogens in older subjects. Moreover, bacterial species richness and alpha-diversity decrease with advancing age, though no clear age clustering was observed. Although the reviewed studies offer insights into the association between aging and changes in the oral microbiome, further research is required to address confounding factors, limitations in sample size, and gender differences, in order to better elucidate the role of microbiome alterations in general health.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"226 ","pages":"Article 112080"},"PeriodicalIF":5.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0