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Early complete surgical treatment of a patient after multiple trauma using intramedullary nail and LCP system from Medgal company Medgal公司髓内钉与LCP系统的早期完整手术治疗一例多发外伤患者
Medical and Biological Sciences Pub Date : 2016-05-06 DOI: 10.12775/MBS.2016.005
M. Weiss, Tomasz Dolata, W. Weiss
{"title":"Early complete surgical treatment of a patient after multiple trauma using intramedullary nail and LCP system from Medgal company","authors":"M. Weiss, Tomasz Dolata, W. Weiss","doi":"10.12775/MBS.2016.005","DOIUrl":"https://doi.org/10.12775/MBS.2016.005","url":null,"abstract":"The study presents a case of a 44-year old patient admitted to the Department of Orthopaedics as an emergency to treat a multiple fractures of lower limbs. Successful, several-stages surgical treatment and rehabilitation was performed providing very satisfactory result. A case shows how important is the individual approach to the patient after multiple trauma.","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"32 1","pages":"41-44"},"PeriodicalIF":0.0,"publicationDate":"2016-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84173480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thoracoscopic lung biopsy in diagnosis of malignancy in children 胸腔镜肺活检在儿童恶性肿瘤诊断中的价值
Medical and Biological Sciences Pub Date : 2016-05-05 DOI: 10.12775/MBS.2016.006
Krzysztof Dymek, Estera Rodziewicz, Paulina Szymańska, Konrad Kamiński, Irena Daniluk-Matraś, P. Gałązka
{"title":"Thoracoscopic lung biopsy in diagnosis of malignancy in children","authors":"Krzysztof Dymek, Estera Rodziewicz, Paulina Szymańska, Konrad Kamiński, Irena Daniluk-Matraś, P. Gałązka","doi":"10.12775/MBS.2016.006","DOIUrl":"https://doi.org/10.12775/MBS.2016.006","url":null,"abstract":"W s t e p Torakoskopowa biopsja pluc jest wazną metodą w diagnostyce i leczeniu dzieci ze zmianami chorobowymi miązszu pluc w celu uzyskania wyniku histopatologicznego. Celem pracy jest ocena przydatności torakoskopowej biopsji pluc w procesie diagnostycznym wykrywania chorob pluc u dzieci, wplywu na modyfikacje procesu leczenia i wystepowanie ewentualnych powiklan. M a t e r i a l  i  m e t o d y . Klinową resekcje pluc wykonano 12-krotnie (w tym u 2 dzieci dwukrotnie) u 10 dzieci (5 chlopcow, 5 dziewczynek). W analizowanej grupie pacjentow mediana wieku wyniosla 9 lat (zakres 2-17 lat). Wy n i k i . W 11 na 12 wykonanych biopsji udalo sie potwierdzic rozpoznanie i uzyskac wynik histopatologiczny, co mialo wplyw na dalsze postepowanie terapeutyczne. W 5 przypadkach biopsja miala na celu pierwotne rozpoznanie choroby (potwierdzono Hodgkin lymphoma, non-Hodgkin lymphoma oraz soft tissue sarcoma), a w 7 rozpoznanie nawrotu choroby nowotworowej. W 3 przypadkach potwierdzono wznowe choroby nowotworowej (Ewing sarcoma lub neuroblastoma), a w 4 przypadkach wykluczono. U zadnego pacjenta u ktorego nie potwierdzono choroby nowotworowej, nie zdiagnozowano jej w okresie 2-letniej obserwacji. Po zabiegu operacyjnym tylko w jednym przypadku pacjent wymagal krotkotrwalej terapii w OIT z powodu niewydolności oddechowej, w 5 przypadkach wystąpily powiklania zaliczane do malych (w tym 4-krotnie do powstania niewielkiej odmy podskornej). Mediana czasu utrzymania drenazu jamy oplucnej wyniosla 2 dni (zakres 0-5 dni). Nie odnotowano zgonow w okresie środ- i pooperacyjnym. Wn i o s k i . Biopsja pluc odgrywa wazną role w diagnostyce chorob pluc u dzieci i jest metodą bezpieczną z niską ilością powiklan. W analizowanym materiale stwierdzono wysoki odsetek rozpoznan zgodnych ze stanem klinicznym.","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"22 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2016-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78798162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social suport received by primiparae and multiparae in the perinatal period 初产和多产在围产期获得的社会支持
Medical and Biological Sciences Pub Date : 2016-05-05 DOI: 10.12775/MBS.2016.003
Grażyna Gebuza, Marzena Kaźmierczak, Estera Mieczkowska, Małgorzata Gierszewska
{"title":"Social suport received by primiparae and multiparae in the perinatal period","authors":"Grażyna Gebuza, Marzena Kaźmierczak, Estera Mieczkowska, Małgorzata Gierszewska","doi":"10.12775/MBS.2016.003","DOIUrl":"https://doi.org/10.12775/MBS.2016.003","url":null,"abstract":"O b j e c t i v e s . The aim of the study was to establish if the social support received by primiparae in the 3rd trimester of pregnancy and in the postpartum period differs significantly from the social support received by multiparae, and if there are any differences in the satisfaction with life among the women involved in the study. M e t h o d s . The Berlin Social Support Scales (BSSS) as well as the Satisfaction with Life Scale (SWLS) were used in the study. A total of 199 women in the third trimester of pregnancy and after physiological birth or caesarean section (only 188) took part in the study. R e s u l t s . In the 3rd trimester of pregnancy the primiparae received significantly more emotional and instrumental support than the multiparae. In the postpartum period no difference was found between the social support received by the primiparae and the one received by the multiparae. There is no difference in life satisfaction between primiparae and multiparae in the gestation and postpartum period. C o n c l u s i o n s . Study of received social support and life satisfaction is necessary in order to define what assistance programmes should be created for women and their families while they are in the perinatal period.","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"13 1","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2016-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77266262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Cardiopulmonary efficeincy evaluation in women between 50 and 80 years of age in Kujawsko-Pomorskie Voivodeship, Poland 波兰库贾维斯科-波莫尔斯基省50 ~ 80岁妇女心肺功能评价
Medical and Biological Sciences Pub Date : 2016-05-05 DOI: 10.12775/MBS.2016.007
Andrzej Chęsy, G. Chęsy, W. Sikorski, A. Rakowski, Paweł Rakowski, Tomasz Zegarski, K. Dmitruk, M. Tafil-Klawe
{"title":"Cardiopulmonary efficeincy evaluation in women between 50 and 80 years of age in Kujawsko-Pomorskie Voivodeship, Poland","authors":"Andrzej Chęsy, G. Chęsy, W. Sikorski, A. Rakowski, Paweł Rakowski, Tomasz Zegarski, K. Dmitruk, M. Tafil-Klawe","doi":"10.12775/MBS.2016.007","DOIUrl":"https://doi.org/10.12775/MBS.2016.007","url":null,"abstract":"One of major obstacles in social activity routines is aging and all impairments generated by this inevitable process. Thus, in order to facilitate the effective functioning of elderly people within a society, our attention should be drawn to the quickly advancing consequences of aging. The purpose of this study is to evaluate cardiopulmonary efficiency in a chosen group of women above 50 years of age in Kujawsko- Pomorskie Voivodeship. 3413 women, aged 50-80 years participated in the study. Subjects were divided into six age groups. The BMI was calculated for each participant. All women were subjected to a 2-minute step test. All participants completed the study. The results of the ‘2-minute Step’ tests showed a decrease of cardiopulmonary efficiency in women. The downslide was correlated with age. Test results indicate unmistakably that cardiopulmonary efficiency diminishes with age. Secondly, bigger cardiopulmonary efficiency will make it easier for women to cope with everyday work. Finally, cardiopulmonary efficiency is shown here to be a parameter worth improving while creating special health programs for seniors.","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"96 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2016-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86607114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of health behaviour of school-age youth 对学龄青年健康行为的评估
Medical and Biological Sciences Pub Date : 2016-05-05 DOI: 10.12775/MBS.2016.001
J. Siminska, K. Pietkun, Piotr Porzych, I. Głowacka, Krystyna Nowacka, Małgorzata Banaszkiewicz, W. Hagner
{"title":"Assessment of health behaviour of school-age youth","authors":"J. Siminska, K. Pietkun, Piotr Porzych, I. Głowacka, Krystyna Nowacka, Małgorzata Banaszkiewicz, W. Hagner","doi":"10.12775/MBS.2016.001","DOIUrl":"https://doi.org/10.12775/MBS.2016.001","url":null,"abstract":"I n t r o d u c t i o n . Adolescence is a very important period for young people as it is the time when the patterns of health behaviour stabilize and in such form may be adopted for the rest of one’s life. This age group is also most prone to behaviour posing a risk to health and lacking behaviour good for health. The period of education is the most suitable to make teenagers aware of how much depends on themselves. Adolescence is often the time of rebellion and independent decision making which influence both the diet, way of spending fee time, personal and mental hygiene as well as abusing dangerous substance. The aim of the study was to assess the health behaviour of lower secondary school attendees in the scope of diet and physical activity by means of a questionnaire. The materials were based on research regarding health behaviour. The study group consisted of 90 students (60% male, 40% female). A questionnaire was chosen as the study method. The study was performed in 2012, from May until September. The results were comparable with HBSC results from 2006 in which 64.4% of the adolescents did not achieve the recommended physical activity minimum. The research has shown that adolescents prefer passive ways of spending their free time. Studies which monitor the state of behaviour linked with the health of the youth are carried out both internationally, nationally and locally. Poland achieves poor results in comparison to other countries when it comes to level of physical activity and amount of time spent on passive leisure.","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"5 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2016-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83756405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomical Study of the Water Cells Area in the Dromedary Camels Rumen (Camelus dromedarius) 单峰骆驼瘤胃水细胞区解剖学研究
Medical and Biological Sciences Pub Date : 2016-03-20 DOI: 10.20286/NOVA-JMBS-050285
N. Pirbonyeh, Mitra Zardosht, A. Emami, S. Rostampour, A. Moattari, Abdolkhalegh Keshavarzi
{"title":"Anatomical Study of the Water Cells Area in the Dromedary Camels Rumen (Camelus dromedarius)","authors":"N. Pirbonyeh, Mitra Zardosht, A. Emami, S. Rostampour, A. Moattari, Abdolkhalegh Keshavarzi","doi":"10.20286/NOVA-JMBS-050285","DOIUrl":"https://doi.org/10.20286/NOVA-JMBS-050285","url":null,"abstract":"","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88679301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Falls in the elderly – risk assessment and procedding 老年人跌倒-风险评估和处理
Medical and Biological Sciences Pub Date : 2016-02-15 DOI: 10.12775/MBS.2015.037
Marta Podhorecka, K. Kędziora–Kornatowska, Jadwiga Główczewska, Dominika Gębka, Marta Sucharska-Szymkowiak, Natalia Ciesielska, Remigiusz Sokołowski, Magdalena Weber-Rajek
{"title":"Falls in the elderly – risk assessment and procedding","authors":"Marta Podhorecka, K. Kędziora–Kornatowska, Jadwiga Główczewska, Dominika Gębka, Marta Sucharska-Szymkowiak, Natalia Ciesielska, Remigiusz Sokołowski, Magdalena Weber-Rajek","doi":"10.12775/MBS.2015.037","DOIUrl":"https://doi.org/10.12775/MBS.2015.037","url":null,"abstract":"The aging of society was an incentive to the development of many fields of medicine including geriatric physiotherapy. Rehabilitation in geriatrics involves a range of issues connected with the involutional and/or disease related changes in the organism of an elderly person. To highlight the most important ones, so called ‘great geriatric problems’ were distinguished. One of them are falls. The risk of falls rises significantly after the age of 65. Among people older than 65 the chances of falls are 40% higher than among younger people. The article aims at showing the issues connected with the role of physiotherapy in falls prophylaxis in the elderly. The problem of falls in the elderly is mainly connected with the consequences of falls. Falls may lead to injuries, disability and even death. Falls prophylaxis should start with complex geriatric assessment. To assess the risk of falls a physiotherapist may use special scales: the stand up and go and the Tinetti test. After thorough analysis of the state of health of the elderly person appropriate prophylaxis measures may be chosen: removal of the environmental threats, appropriate selection of shoes as well as the assisting equipment, acute and chronic diseases treatment, pharmacotherapy modification, physiotherapy. Anti-fall rehabilitation usually focuses on balance training, expanding the range of motion, gait re-education and analgesic measures. In some medical centres special anti-fall programs are being developed, where physical activities and appropriate assisting equipment play the most important role. Modern physiotherapy methods enable individual anti-fall prophylaxis adjustment to the elderly person’s needs. The use of rehabilitation to diminish the risk of falls in the elderly is more and more common.","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"1 1","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84783432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the quality of life people infected with HCV – proposed research instruments 评估丙型肝炎病毒感染者的生活质量——建议的研究工具
Medical and Biological Sciences Pub Date : 2016-02-15 DOI: 10.12775/MBS.2015.036
L. Sierpińska
{"title":"Evaluation of the quality of life people infected with HCV – proposed research instruments","authors":"L. Sierpińska","doi":"10.12775/MBS.2015.036","DOIUrl":"https://doi.org/10.12775/MBS.2015.036","url":null,"abstract":"I n t r o d u c t i o n. HCV is an important medical and social problem in Poland and worldwide. O b j e c t i ve. Presentation of the instruments for investigating quality of life of patients diagnosed with hepatitis C.  R e s u l t s: The World Health Organization Quality Life Assessment Questionnaire (WHOQOL) evaluates the dimensions of the quality of life: physical, psychological, spiritual, independence, social relations, and the patient’s environment. The WHOQOL-Bref questionnaire assesses the quality of a patient’s life within four spheres: physical, psychological, social and environmental. The following questionnaires may also be used: the Hepatitis Quality of Life Questionnaire (HQLQv2), the Chronic Liver Dise­ase Questionnaire (CLDQ), and the Chronic Liver Disease Questionnaire — Hepatitis C (CLDQ–HCV). For the assessment of coping with the disease, the KMORSZCH scale may be applied ( Brief Method of Assessment of Coping with Disease ). The Nottingham Health Profile ( NHP) allows the evaluation of patient’s functioning in daily life. The Health Behaviour Inventory (IZZ) may be an instrument for evaluation of the level of health behaviours. For assessment of health dimensions in the bio-psych-social sphere the List of Health Criteria (LKZ) may be used. Expectations of patients infected with HCV from a general practitioner may be assessed by the Patient Request Form (PRF). The Satisfaction With Life Scale (SWLS) allows the assessment of the level of satisfaction with life. The degree of acceptance of the disease may be evaluated by the Acceptance of Illness Scale (AIS), whereas the sense of health control may be evaluated by the Multidimensional Health Locus of Control (MHLC). C o n c l u s i o n s. The presented instruments for evaluation of the quality of life of patients with hepatitis C will enable researchers the recognition of specific aspects of functioning of these patients in the bio-psycho-social sphere.","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"78 1","pages":"13-16"},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89241809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Outcome of surgical treatment of proximal humerał fracture 肱骨近端骨折的手术治疗效果
Medical and Biological Sciences Pub Date : 2016-02-15 DOI: 10.12775/MBS.2015.035
Jakub Ohla, D. Mątewski, Marek Jedwabiński
{"title":"Outcome of surgical treatment of proximal humerał fracture","authors":"Jakub Ohla, D. Mątewski, Marek Jedwabiński","doi":"10.12775/MBS.2015.035","DOIUrl":"https://doi.org/10.12775/MBS.2015.035","url":null,"abstract":"Glenohumeral joint movement dysfunction, often caused by proximal humeral fracture, limits daily activity. Proximal fracture of the humerus is a common injury which constitutes 5.7% of all fractures in trauma patients. The aim of the study was the retrospective evaluation of results of surgical treatment of proximal humeral fracture in accordance to fracture type and applied treatment. The study group consisted of 70 patients who had undergone surgery due to proximal humeral fracture. The mean age in the study group was 55.2 years. The patients were classified according to the AO/ASIF system, based on the preoperative X-ray in comparison to the operative X-ray image. The patients were treated with five methods (ORIF – LCP-type plate, ORIF – AO-type plate, ORIF – AO screw(s), CRIF – intramedullary nailing, CRIF – „K” wires). The average time of follow-up amounted to 19.4 months. The function of the glenohumeral joint was assessed after surgery applying the Constant-Murley scale. The analysis of treatment outcomes showed that in patients operated on for proximal humeral fracture type A and B, the percentage of results described as very good and good was comparable and amounted to approximately 50%. In the smallest group of patients with the most complex type C fractures, a good and very good result was observed only in 14.29% of the subjects. The analysis did not show statistically significant differences in treatment results (p>0.05). Multiple comparisons showed that regardless of the fracture type, patients received a similar score on the Constant-Murley scale. Osteosynthesis using LCP plates and angular stabile screws does not improve the treatment outcome in any type of the proximal humeral fracture. However, LCP plates and angular stable screws are used as a standard management for the most severe cases of proximal humeral fracture. Because of a many available treatment techniques, qualification for a particular treatment method should be considered individually for every patient.","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"323 1","pages":"35-38"},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78313112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of arsenic trioxide on the expression of cyclin A in the Jurkat cel line 三氧化二砷对Jurkat细胞系细胞周期蛋白A表达的影响
Medical and Biological Sciences Pub Date : 2016-02-10 DOI: 10.12775/MBS.2015.034
A. Żuryń, Magdalena Czołpińska, Adrian Krajewski, A. Litwiniec, Anna Klimaszewska-Wiśniewska, A. Grzanka
{"title":"Influence of arsenic trioxide on the expression of cyclin A in the Jurkat cel line","authors":"A. Żuryń, Magdalena Czołpińska, Adrian Krajewski, A. Litwiniec, Anna Klimaszewska-Wiśniewska, A. Grzanka","doi":"10.12775/MBS.2015.034","DOIUrl":"https://doi.org/10.12775/MBS.2015.034","url":null,"abstract":"Improper expression of cell cycle regulators is characteristic for most cancer cells. Cyclins are a group of proteins, with concentration changing in time, which control progression through each phase of the cell cycle. Maximum cyclin A expression falls inside S and at the beginning of M phase. In the S phase cyclin A is responsible for a proper run of the replication process, and together with cyclin B conditions transition into the M phase. Arsenic trioxide (ATO) is an efficient drug used in acute promyelocytic leukemia (AML). Numerous reports point that arsenic trioxide can be applied in therapy of other types of cancer as well. The purpose of these study was to evaluate influence of arsenic trioxide on the expression and localization of cyclin A in Jurkat cell line. Additionally, we determined the effect of ATO on morphology and ultrastructure of the Jurkat cells. In order to reach this aim we applied classic light, florescence and electron transmission microscopy. A dose-dependent decrease in the percentage of viable cells was observed. Morphological and ultrastructural alterations suggest that apoptosis and autophagy are induced by ATO. Image-based cytometry showed high extent of necrotic cells after ATO treatment. A decrease in cyclin A level was observed, but without a change in protein nuclear localization.","PeriodicalId":18339,"journal":{"name":"Medical and Biological Sciences","volume":"134 1","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2016-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74701746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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