Medical Herald of the South of Russia最新文献

{"title":"The spectrum of pollen sensitization in children with allergic diseases living in the Rostov region","authors":"A. Lebedenko, O. Semernik, V. V. Yanchenko, N. S. Alyakhnovich, V. S. Rudyakova","doi":"10.21886/2219-8075-2023-14-1-50-55","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-50-55","url":null,"abstract":"Objective: to investigate the characteristics of pollen sensitization in children with established diagnoses of bronchial asthma (BA) and atopic dermatitis (AD) living in the Rostov region. Materials and methods: patients suffering from BA (n = 53), they made up the first group and patients with AD (n = 65), the second group were examined. All children underwent a comprehensive clinical and laboratory examination. Immunochemiluminescent assay by the Immulight 2000XPi analyzer was used to determine specific IgE. Results: the analysis of the obtained results showed that sensitization to tree pollen was quite often noted - at least a quarter of those examined with BA and about 20% of children with AD had elevated titers of specific IgE to these allergens. The study of the level of specific IgE to meadow grass pollen showed that in the first group an allergic reaction to pollen of bent grass (31.5%), bonfire (33.3%), timothy grass (29.6%) and fescue (28.3%) was noted more often. In the second group, elevated levels of specific IgE were registered in relation to grasses such as bent grass (31.80%), bonfire (27.7%) and timothy grass (21.5%). The highest level of sensitization in patients with respiratory manifestations of allergy was registered in relation to weed pollen: ragweed (40.7%), quinoa (22.2%) and chamomile (14.8%). Conclusion: this study made it possible to identify allergens that play the most important role in the pathogenesis of BA and AD in children living in the Rostov region.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82525355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serological indicators of the presence of antibodies to pathogens of natural focal infections in the population of the Rostov region in 2021","authors":"E. Bereznyak, A. Trishina, N. Aronova, N. Pichurina, L. A. Egiazaryan, A. Anisimova, I. Simonova, N. Pavlovich, E. Kovalev, N. Leonenko, A. I. Novikova, A. Noskov","doi":"10.21886/2219-8075-2023-14-1-75-82","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-75-82","url":null,"abstract":"Objective: to analyze the results of blood sera comprehensive study of the local population of the RR, conducted in 2021 to assess the state of natural and zoonotic focus of CHF, WNF, ITBB, tularemia and risk of possible spread of Haemorrhagic Fever with Renal Syndrome (HFRS). Materials and methods: 424 blood serums obtained in 2021 from healthy donors living in 10 administrative territories of the Russian Federation were tested by enzyme immunoassay. Results: in 2021 the detection rates of specific antibodies in the studied areas were: WNF — 9,9 %, HFRS — 4,5 %, ITBB — 2,6 %, CHF — 0,7 %, tularemia — 22,6 %. When comparing the results obtained in 2020 and 2021, the difference in the proportions of seropositive samples is not statistically significant. Conclusions: the study of the immune layer to NFI in selected population groups confirms the circulation of pathogens in RR territory. The monitoring results demonstrate the extensive, mostly combined nosoareals of NFI of viral and bacterial etiology and the contact of the local population with them.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76977256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical сase of disorder of sex development with karyotype 47XYY","authors":"M. R. Shaydullina, N. R. Akramov, F. Valeeva, Z. R. Alimetova, E. V. Kolbasina","doi":"10.21886/2219-8075-2023-14-1-38-42","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-38-42","url":null,"abstract":"Disorder of sex development (DSD) is a term used to refer to congenital disorders that led to atypical structure of the genitals. The cause of DSD is a disorder of the embryonic development of the reproductive system due to chromosomal, genetic pathology or other adverse effects on pregnancy. DSD entails difficulties with social adaptation of the family, leads to severe psychological disorders in the child and his relatives. Sex of a child with DSD should be established only after a full examination and consultation of specialists in this field. A clinical case is presented to illustrate the complexity of differential diagnosis and choice of passport sex in a child with one of the rare forms of DSD.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80055800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing mental health disorders in healthcare workers during the COVID-19 pandemic","authors":"L. Strizhakov, S. A. Babanov, D. Vinnikov, N. Ostryakova, A. Agarkova","doi":"10.21886/2219-8075-2023-14-1-112-118","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-112-118","url":null,"abstract":"Objective: based on a comprehensive assessment of the levels of anxiety and burnout syndrome among medical workers of COVID hospitals, develop measures to prevent mental health disorders. Materials and methods: examined: group 1 — medical workers of COVID hospitals (n=201); group 2 — medical workers of multidisciplinary hospitals (n=195); group 3 — medical workers of the outpatient clinic link (n=186). Control group (n=190) — employees of engineering, technical and economic specialties (healthy). Methods: psychological (“integrative anxiety test”, authors: A.P. Bizyuk, L.I. Wasserman, B.V. Iovlev (2005); method for diagnosing professional burnout according to V.V. Boyko). During statistical processing, the significance of differences was determined using one-way analysis of variance (ANOVA) followed by intergroup comparisons according to Dunnet’s test. The obtained data were processed using the statistical package “Statistica” from StatSoft (USA). Results: in the study of the phases of emotional burnout, it was revealed that medical workers in COVID hospitals had significantly higher scores of the phase of stress, phases of resistance compared to medical workers in multidisciplinary hospitals and outpatient services. At the same time, the total score of the exhaustion phase was significantly increased in medical workers in COVID hospitals compared to medical workers in multidisciplinary hospitals, but there were no significant differences in this indicator when compared with medical workers in outpatient services. It has been established that among medical workers of COVID hospitals, the indicator “alarming assessment of prospects” prevails; in medical workers of multidisciplinary hospitals — “asthenic component”; among medical workers of the outpatient clinic link — a «phobic component». Conclusions: among medical workers of COVID hospitals, there is a high level of formation of phases of emotional burnout and anxiety. Measures to prevent mental health disorders of medical workers in COVID hospitals include: socio-psychological, professional and organizational.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79849652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenicity factors of Acinetobacter baumannii","authors":"E. Gudueva, O. Chemisova","doi":"10.21886/2219-8075-2023-14-1-66-74","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-66-74","url":null,"abstract":"Acinetobacter baumannii is a gram–negative, aerobic, oxidase-negative microorganism, a pathogen that causes serious nosocomial infections, as well as community-acquired pneumonia, especially in people with weakened immunity and multiple organ diseases, all over the world. A. baumannii survives for a long time on various surfaces, medical equipment. According to the World Health Organization (WHO), this microorganism is classified as a threat to human health. The review describes the main factors of pathogenicity of A. baumannii: outer membrane proteins, pili, LPS, capsule, siderophores, biofilm formation, secretion systems. The literature search was carried out using databases “Scopus”, “Web of Science”, “RSCI”, “MedLine”, in the period from 1992 to 2022. The selection of literature sources was carried out based on the availability of information on the study of pathogenicity factors of Acinetobacter baumannii. 60 literature sources were selected that meet the necessary criteria. The search was carried out using keywords and phrases, such as “A. baumannii”, “pathogenicity factors”, “outer membrane proteins”, “pili”, “LPS”, “capsule”, “siderophores”, “biofilm formation”, “secretion systems”. The review presents the latest achievements obtained by foreign and domestic authors. A. baumannii, like other pathogens, requires the coordinated work of various pathogenicity factors for the occurrence of infection. Together, pathogenicity factors enable the microorganism to survive in hospital conditions. Scientific research data indicate a high degree of heterogeneity of A. baumannii strains. Further research should be aimed at molecular genetic studies of the mechanisms of pathogenicity, the emergence of resistance to antimicrobial drugs. Understanding what mechanisms and factors contribute to the virulence of strains is necessary for the development of new methods of combating A. baumannii.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79868566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of combined antioxidant and photodynamic therapy on the emotional state of patients with vulvar craurosis","authors":"E. Kiseleva, A. Makhmutkhodzhaev, G. A. Mikheenko","doi":"10.21886/2219-8075-2023-14-1-5-12","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-5-12","url":null,"abstract":"Objective: studying of the effect of combined antioxidant and photodynamic therapy (PDT) on the emotional state of patients with vulvar kraurosis. Materials and methods: the study involved 90 women with vulvar kraurosis who were randomized into three groups of 30 participants. In the first group, treatment included photodynamic therapy (PDT) followed by administration of the antioxidant Ethylmethylhydroxypyridine succinate for one month. Participants in the second group received only PDT. Patients of the third group underwent a course of laser therapy on the perineal region. The emotional state of the participants was assessed using the Hospital Anxiety and Depression Scale (HADS) before and at the end of treatment, 1, 6 and 12 months after the end of therapy. Results: before treatment, participants from the three groups scored a similar number of HADS scores. In the course of observations, the best result on the scales of anxiety and depression was recorded in patients who received combined antioxidant and photodynamic therapy. After a month of taking Ethylmethylhydroxypyridine succinate, the HADS score in these women was significantly lower than in the comparison groups. Further, these patients continued to show better scores on the depression scale. The total scores on the anxiety scale in this group were comparable to those in patients who received only PDT. Conclusion: combined antioxidant and photodynamic therapy, including Ethylmethylhydroxypyridine succinate, has a more pronounced positive effect on the emotional background of patients with vulvar kraurosis in comparison with PDT and laser therapy.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83389155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of physical development healthy full-term newborns of the Republic of Crimea centile standards INTERGROWTH-21st","authors":"A. I. Balakchina, N. Kaladze","doi":"10.21886/2219-8075-2023-14-1-43-49","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-43-49","url":null,"abstract":"Objective: to determine the feasibility of using INTERGROWTH-21st centile tables in assessing the physical development of full-term newborns in the Republic of Crimea. Materials and methods: a retrospective analysis of 1300 birth histories of full-term newborns whose mothers permanently reside on the territory of the Republic of Crimea was carried out. Mass and length, chest and chest circumference were analyzed. The assessment of the obtained anthropometric indicators was carried out by the centile method according to the INTERGROWTH-21st tables. In the study, we conducted a comparative assessment using the accepted INTERGROWTH-21st standards, comparing them with the accepted domestic assessments of the state of the physical development of newborns. Results: the values of anthropometric indicators of boys in the Republic of Crimea are shifted towards higher estimates. Estimates “below average”, “low”, “very low” are found in no more than 3% of cases. “Above average”, “high”, “very high” are much more common: with 10% — for weight/length ratio, 18% — for weight, 34% — for length, and 51% — for head circumference. The values of anthropometric indicators of girls in the Republic of Crimea are also biased towards higher estimates. Ratings of “below average”, “low”, “very low” are very rare: 6% — for the weight/length ratio, 4% — for the weight rating, less than 1% — for the body length rating and 2% — for the head circumference. “Above average”, “high”, “very high” scores are much more common: 8% — for weight/length ratio, 15% — for weight score, 45% — for length score, and 30%— for OH. Conclusions: we consider the use of centile tables INTERGROWTH-21st in assessing the physical development of full-term newborns of the Republic of Kazakhstan to be inappropriate and we see the need to develop regional standards.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81598019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the health status of medical workers based on the results of mandatory periodic examinations","authors":"E. Golovko, I. A. Nessina, E. Smirnova, E. L. Poteruaeva, N. N. Figurenko, K. O. Demeshko","doi":"10.21886/2219-8075-2022-13-4-22-27","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-4-22-27","url":null,"abstract":"Objective: to analyze the results of periodic medical examinations of employees of a large medical organization in dynamics, according to the final acts. Materials and methods: the research material was the final acts (2019–2021), compiled based on the results of periodic medical examinations of employees of the Novosibirsk Regional Clinical Hospital of War Veterans (Novosibirsk Regional Clinical Hospital of War Veterans). For the analysis, data on the structure of diseases for 2019–2021 were also used, with which medical workers underwent treatment courses in the day hospital of the hospital. Results: in just 3 years, 546 hospital employees under-went periodic medical examination, 489 of them women. The results of the studies have shown that in the dynamics of three-year follow-up, the number of persons subject to additional examination, treatment and dispensary observation has sharply increased, which may indicate a certain effectiveness of PMT. The detectability of chronic somatic diseases according to the results of the PMT has increased by more than 10 times in dynamics. 69 medical workers underwent treatment courses on the basis of the GNOCGV day hospital for 3 years. Of these, 22 medical workers were treated and rehabilitated in a day hospital with the consequences of a new COVID-19 coronavirus infection. Conclusion: when analyzing the final acts based on the results of the PMOS of GNOCGV employees for the period from 2019 to 2021, it was found that the efficiency and quality of inspections has increased dramatically.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82774737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placenta accreta spectrum. Current diagnostic issues","authors":"A. Volkov, M. A. Rymashevskiy, I. V. Andrusenko","doi":"10.21886/2219-8075-2022-13-4-58-65","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-4-58-65","url":null,"abstract":"In this review of the literature, the issues of diagnosis of abnormal attachment (ingrowth) of the placenta (PAS) are considered: ultrasound scanning (ultrasound), magnetic resonance imaging (MRI), the study of serum markers of the anomaly. A systematic literature search was conducted on the databases PudMed, Scopus and others. The issues of the evolution of views on the causes of this anomaly and its classifications are also discussed. It is noted that currently the main method of diagnosis of placenta accreta is ultrasound. Two-dimensional grayscale scanning in combination with color Doppler mapping (CDK) and three-dimensional echography with the option of energy Doppler is recommended. However, echography remains an absolutely \"operator dependent\" method, therefore, largely subjective, determined by the experience of a specialist in detecting this pathology with an instrument. MRI is recommended as a tool for assessing the depth of invasion in case of suspected placenta percreta and in the diagnosis of complex cases (placenta previa along the posterior wall of the uterus). Ultrasound and MRI have a very high diagnostic potential. It is generally considered that ultrasound is an inexpensive, widely available imaging method, recommended as a priority in the diagnosis of PAS. MRI does not play a primary role in the diagnosis of PAS, but it can be indispensable for detailing the topography of areas that are difficult to assess with ultrasound.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79085801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin microbiota of children with acute urticaria of varying severity","authors":"Y. L. Naboka, A. Lebedenko, A. Posevina, L. A. Averkina, E. Ivannikova, E. V. Kudrya","doi":"10.21886/2219-8075-2022-13-4-100-105","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-4-100-105","url":null,"abstract":"Objective: to evaluate changes in the skin microbiota of the children with acute urticaria of varying severity. Materials and methods: a total of 94 children aged 3 to 14 years old were examined. Four clinical groups were formed. Group I (n=15) included children with mild acute urticaria, group II (n=32) – with moderate course, group III (n=16) – with severe form, and group IV (n=31) – children of the 1 and 2a health group (control group). All patients underwent a comprehensive clinical and laboratory examination, as well as a qualitative and quantitative assessment of the skin microbiota. The sampling of the material for bacteriological examination was carried out from the area of the middle third of the forearm on the affected area of the skin and on a symmetrical unaffected area in patients with acute urticaria. In the control group, the material was taken from the corresponding area of the forearm skin. Results: in the unaffected area of the skin in patients of group I, the rate of detection of Propionibacterium spp. (p<0.05) was increased, in group II, the rate of detection of Bacteroides spp. was increased (p<0.05), and in group III, the rate of detection of S. aigeis was increased and Micrococcus spp. (p<0.05) was reduced in comparison with the microbiota indicators of children in group IV. On the affected area of the skin in children of group II, the detection rate of Bacteroides spp. was significantly increased (p<0.05) and the detection rate of Bacillus spp. (p<0.05) was decreased, in children of group IV, the studied feature was increased for S. aureus (p<0.05). Conclusions: the data obtained during the study indicate differences in microbial patterns of the skin depending on the severity of the course of acute urticaria in children.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80698722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}