抗氧化与光动力联合治疗对外阴硬化患者情绪状态的影响

E. Kiseleva, A. Makhmutkhodzhaev, G. A. Mikheenko
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摘要

目的:探讨抗氧化与光动力联合治疗(PDT)对外阴黑症患者情绪状态的影响。材料和方法:本研究涉及90名患有外阴黑疽的女性,她们被随机分为三组,每组30人。在第一组中,治疗包括光动力治疗(PDT),随后给予抗氧化剂琥珀酸乙基甲基羟吡啶一个月。第二组参与者只接受PDT治疗。第三组患者在会阴部位进行一个疗程的激光治疗。在治疗前、治疗结束时、治疗结束后1个月、6个月和12个月,使用医院焦虑和抑郁量表(HADS)评估参与者的情绪状态。结果:治疗前,三组参与者的HADS得分相近。在观察过程中,接受抗氧化和光动力联合治疗的患者在焦虑和抑郁量表上的效果最好。服用琥珀酸乙基甲基羟吡啶一个月后,这些妇女的HADS评分明显低于对照组。此外,这些患者在抑郁量表上继续表现出更好的得分。该组的焦虑量表总分与仅接受PDT治疗的患者相当。结论:与PDT和激光治疗相比,包括琥珀酸乙甲基羟吡啶在内的抗氧化和光动力联合治疗对外阴黑症患者的情绪背景有更明显的积极作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of combined antioxidant and photodynamic therapy on the emotional state of patients with vulvar craurosis
Objective: studying of the effect of combined antioxidant and photodynamic therapy (PDT) on the emotional state of patients with vulvar kraurosis. Materials and methods: the study involved 90 women with vulvar kraurosis who were randomized into three groups of 30 participants. In the first group, treatment included photodynamic therapy (PDT) followed by administration of the antioxidant Ethylmethylhydroxypyridine succinate for one month. Participants in the second group received only PDT. Patients of the third group underwent a course of laser therapy on the perineal region. The emotional state of the participants was assessed using the Hospital Anxiety and Depression Scale (HADS) before and at the end of treatment, 1, 6 and 12 months after the end of therapy. Results: before treatment, participants from the three groups scored a similar number of HADS scores. In the course of observations, the best result on the scales of anxiety and depression was recorded in patients who received combined antioxidant and photodynamic therapy. After a month of taking Ethylmethylhydroxypyridine succinate, the HADS score in these women was significantly lower than in the comparison groups. Further, these patients continued to show better scores on the depression scale. The total scores on the anxiety scale in this group were comparable to those in patients who received only PDT. Conclusion: combined antioxidant and photodynamic therapy, including Ethylmethylhydroxypyridine succinate, has a more pronounced positive effect on the emotional background of patients with vulvar kraurosis in comparison with PDT and laser therapy.
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