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Influence of verapamil on central and peripheral effects of prostacyclin on circulatory system in rats. 维拉帕米对前列环素循环系统中枢和外周作用的影响。
Medical biology Pub Date : 1987-01-01
T Krzemiński, A Kurcok, Z Juraszczyk, W Kozik, J Kapustecki, M Kryj, R Brus
{"title":"Influence of verapamil on central and peripheral effects of prostacyclin on circulatory system in rats.","authors":"T Krzemiński,&nbsp;A Kurcok,&nbsp;Z Juraszczyk,&nbsp;W Kozik,&nbsp;J Kapustecki,&nbsp;M Kryj,&nbsp;R Brus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of verapamil on cardiovascular effects of prostacyclin (PGI2) in rats was examined. PGI2 administered into the lateral brain ventricle (i.c.v.) or intravenously (i.v.) in a dose of 2.7 x 10(-8)mol evoked hypotension and tachycardia. Pretreatment with verapamil in a dose of 2.0 x 10(-5)mol/kg given intraperitoneally (i.p.) diminished hypotensive effect of PGI2 i.c.v. as well as inhibiting the influence of PGI2 i.c.v. and i.v. upon the heart rate. Bolus injection of PGI2 in a dose of 2.7 x 10(-10), 2.7 x 10(-9) or 2.7 x 10(-8)mol evoked biphasic inotropic and chronotropic effects on isolated rat heart. Short-term increase of the contractile force together with bradycardia and afterwards long-lasting decrease of contractility with sustained, slight tachycardia were observed. Verapamil in a concentration of 1.0 x 10(-6)M blocked biphasic inotropic effect and bradycardia after PGI2 administration. Because some central and peripheral cardiovascular effects of PGI2 were inhibited by verapamil, it is concluded that PGI2 may participate in transmembrane calcium ions movements.</p>","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 5-6","pages":"249-53"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14456943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental changes in the level of glucocorticoid receptors in chick-embryo tissues. 鸡胚组织糖皮质激素受体水平的发育变化。
Medical biology Pub Date : 1987-01-01
A Oikarinen
{"title":"Developmental changes in the level of glucocorticoid receptors in chick-embryo tissues.","authors":"A Oikarinen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The concentrations of glucocorticoid receptors were assayed in various chick embryo tissues by a cytosol charcoal-dextran method using [3H]dexamethasone as ligand. The highest levels of receptors were found in muscle on developmental day 15-16. The order of maximum binding of dexamethasone in various tissues was muscle greater than heart greater than skin greater than tendon greater than kidney greater than cartilage greater than liver. However, marked variation in the level of receptors was found even in the same tissue during development of the chick-embryo. The highest levels of receptors were generally found on days 15-17. For example, in tendon the difference between the highest and lowest level of receptors was about 6-7 fold. Thus the results show that specific glucocorticoid receptors may be found in various tissues of developing chick-embryos.</p>","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 4","pages":"199-202"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14562750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphocyte-endothelial cell interactions. 淋巴细胞-内皮细胞相互作用。
Medical biology Pub Date : 1987-01-01
S Jalkanen
{"title":"Lymphocyte-endothelial cell interactions.","authors":"S Jalkanen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphocyte-high endothelial venule (HEV) cell interaction that is mediated by specific receptors is fundamentally important during normal and malignant lymphocyte traffic. Putative human lymphocyte homing receptors to peripheral lymph node, mucosal (Peyer's patch, appendix) and inflamed joint tissue (synovium) HEV appear to be functionally distinct, but structurally closely related 90 kDa glycoproteins that are highly conserved during evolution. These receptors regulate lymphocyte traffic in an organ-specific manner throughout the body, thus determining the characteristics of local immune responses and possibly also the patterns of dissemination of lymphoid malignancies.</p>","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 5-6","pages":"223-7"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13975209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical neurotransmission in the parkinsonian brain. 帕金森大脑中的化学神经传递。
Medical biology Pub Date : 1987-01-01
U K Rinne, J O Rinne, J K Rinne, K Laakso
{"title":"Chemical neurotransmission in the parkinsonian brain.","authors":"U K Rinne,&nbsp;J O Rinne,&nbsp;J K Rinne,&nbsp;K Laakso","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In Parkinson's disease the progressive loss of nigrostriatal dopamine neurons leads to striatal dopamine deficiency and correlates with the severity of parkinsonian disability. The findings concerning dopamine receptors both in vitro and in vivo are not consistent, possibly reflecting differences in patient populations, but the presynaptic defect in dopaminergic neurotransmission is greater than that seen in postsynaptic receptor binding studies. The cholinergic neurons in the extrapyramidal nuclei are relatively well preserved, but subcortico-cortical and -hippocampal cholinergic neurons degenerate in relation to the degree of dementia. The decreased GABA receptor binding in the parkinsonian substantia nigra possibly reflects the loss of nigral dopamine neurons, since nigral GABA receptors are located on these neurons. Of the various neuropeptides, the concentration of met- and leu-enkephalin seems to be reduced in the striatum. In the substantia nigra the concentration of substance P decreases, together with the met-enkephalin and cholecystokinin levels. The concentration of somatostatin decreases in the frontal cortex and hippocampus of demented patients. With the exception of the association between cortical somatostatin deficiency and intellectual deterioration, the role of the neuropeptides in the pathophysiology and clinical features of Parkinson's disease are not yet fully understood.</p>","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 2-3","pages":"75-81"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13959152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time relationships and reversal by two indoleamines of the pinealectomy-inhibited thyrotropin secretion in male rats. 两种吲哚胺对松果体切除抑制雄性大鼠促甲状腺激素分泌的时间关系及逆转作用。
Medical biology Pub Date : 1987-01-01
P T Männistö, M Toivonen, R Tuominen
{"title":"Time relationships and reversal by two indoleamines of the pinealectomy-inhibited thyrotropin secretion in male rats.","authors":"P T Männistö,&nbsp;M Toivonen,&nbsp;R Tuominen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Time relationships and mediators of the inhibitory effect of pinealectomy on cold-induced TSH secretion were studied in male Sprague-Dawley rats. Pinealectomy but not sham operation significantly reduced the TSH cold-response (30 min at +4 degrees C) in 6-8 week-old rats on the 3rd postoperative day. Longer postoperative periods resulted in gradual attenuation of the effect of pinealectomy. Pinealectomy did not modify basal TSH levels on the 3rd or 7th postoperative day. Melatonin, arginine vasotocin and crude pineal extracts failed to antagonise the suppressed cold-response in pinealectomised rats. 5-Hydroxytryptamine and 6-methoxy-tetrahydro-beta-carboline, however, antagonised partially but significantly the pinealectomy-induced reduction in TSH cold-response. Although transient, the suppression of cold-stimulated TSH secretion by pinealectomy may be caused by lack of two pineal indoleamines 5-hydroxytryptamine and/or 6-methoxy-tetrahydro-beta-carboline.</p>","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 5-6","pages":"267-72"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14577014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormonal regulation of lymphocyte functions. 淋巴细胞功能的激素调节。
Medical biology Pub Date : 1987-01-01
T Paavonen
{"title":"Hormonal regulation of lymphocyte functions.","authors":"T Paavonen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The role of hormones in regulating the complex network of immune responses has lately been emphasized. In particular, glucocorticoids and sex hormones have been shown to modulate both cellular and humoral immunity. Reports concerning the mechanisms of hormonal action are still somewhat conflicting, and there are reports of both inhibitory and stimulatory effects on various phases of the immune response.</p>","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 5-6","pages":"229-40"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14457181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between tryptophan and serotonin concentrations in postmortem human brain. 人类死后大脑中色氨酸和血清素浓度的关系。
Medical biology Pub Date : 1987-01-01
E R Korpi, S I Goodman, J E Kleinman, R J Wyatt
{"title":"Relationship between tryptophan and serotonin concentrations in postmortem human brain.","authors":"E R Korpi,&nbsp;S I Goodman,&nbsp;J E Kleinman,&nbsp;R J Wyatt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study was planned to test a recent observation of positive correlation between tryptophan and 5-hydroxyindole concentrations in postmortem human hypothalamic samples. Four other brain areas were studied, but no significant correlations were observed between tryptophan and serotonin or 5-hydroxyindoleacetic acid concentrations, except in the nucleus accumbens samples of a suicide victim group. A possible in vivo correlation may have been obscured by postmortem changes. The use of tryptophan concentrations as an index for normalising postmortem brain serotonin data is not supported by the present results.</p>","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 4","pages":"217-20"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13598111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stimulative effect of somatostatin on cell proliferation in cultured chondrocytes. 生长抑素对培养软骨细胞增殖的促进作用。
Medical biology Pub Date : 1987-01-01
O Johansson, K Madsen
{"title":"Stimulative effect of somatostatin on cell proliferation in cultured chondrocytes.","authors":"O Johansson,&nbsp;K Madsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have earlier demonstrated that human growth hormone stimulates DNA synthesis and proteoglycan production in cultured chondrocytes. The present study is concerned with the effects of somatostatin and other neuropeptides on cell proliferation by cultured rat rib growth plate chondrocytes. Chondrocytes were isolated from the growth plates by collagenase digestion and cultured as monolayers in multiwell plates. The cells were allowed to attach overnight and subsequently incubated for 24 h under serum-free conditions to establish growth arrest. Somatostatin and other peptides were then added and the cultures were incubated for 18 h. Finally, the cultures were labelled for 6 h with tritiated thymidine in the presence of peptide. For screening purposes, the effect on DNA-synthesis was assayed as incorporation of [3H]-thymidine into acid-insoluble material. For a more exact estimate, parallel cultures were prepared for autoradiography and the fraction of labelled nuclei was determined by counting. Among the peptides we tested (somatostatin, GRF, TRH, SP, mENK, PHI, VIP, hCT) only somatostatin had any discernible effect on DNA synthesis, with an apparently optimal effect at 10 fM. This concentration is well within the range found in various tissues in vivo and suggests a physiological role for somatostatin in chondrocyte growth regulation. Further experiments are required, however, to clarify by which mechanism somatostatin influences the cells and whether the peptide interacts with other growth factors such as the IGFs.</p>","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 1","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14023018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical neurotransmission in the central nervous system as a target for drug treatment. Proceedings of a symposium. Helsinki, January 5-6, 1987. 中枢神经系统中的化学神经传递作为药物治疗的靶点。研讨会记录。赫尔辛基，1987年1月5日至6日。
Medical biology Pub Date : 1987-01-01
{"title":"Chemical neurotransmission in the central nervous system as a target for drug treatment. Proceedings of a symposium. Helsinki, January 5-6, 1987.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 2-3","pages":"65-173"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14025007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoamines in autism: an update of neurochemical research on a pervasive developmental disorder. 自闭症中的单胺:一种广泛性发育障碍的神经化学研究进展。
Medical biology Pub Date : 1987-01-01
G M Anderson
{"title":"Monoamines in autism: an update of neurochemical research on a pervasive developmental disorder.","authors":"G M Anderson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent neurochemical studies of norepinephrine (NE), dopamine (DA), and serotonin (5HT) in autism are reviewed. Most studies of the catecholamines, their metabolites, and associated enzymes have not found differences between autistic and normal subjects. However, a robust increase in platelet 5HT has been well replicated and characterized. Studies on the possible causes of the increased platelet 5HT in autism suggest that an alteration in platelet physiology is the cause of the increase. Future directions for research on the platelet are discussed as are other potentially fruitful methods for examining monoamine functioning in autism.</p>","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 2-3","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14437025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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