{"title":"Toxic principles of hippomane mancinella. II. Structure of Hippomanin A.","authors":"K V Rao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hippomanin A is a pale yellow crystalline toxic principle isolated from the water-soluble portion of the ethanolic extract of Hippomane mancinella. Acid hydrolysis gave glucose, gallic acid and ellagic acid, thus showing that it belonged to the class of \"crystalline tannins\" and was isomeric with corilagin. The presence of free anomeric hydroxyl was shown by methylation and by reduction with sodium borohydride. Mass spectral and chemical evidence showed that the structure was 2-galloyl-4,6-hexahydroxydiphenoyl-D-glucose.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 2","pages":"169-72"},"PeriodicalIF":0.0,"publicationDate":"1977-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12059179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rockogenin formation during the processing of Agave sisalana leaves for hecogenin.","authors":"G Blunden, J A Jaffer, K Jewers, J Barbour","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 2","pages":"218-9"},"PeriodicalIF":0.0,"publicationDate":"1977-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12061526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ergolines as potential prolactin and mammary tumor inhibitors.","authors":"J M Cassady, H G Floss","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 1","pages":"90-106"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11540082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Experimental antitumor agents from plants, 1974-76.","authors":"G A Cordell, N R Farnsworth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The published literature in the areas of antitumor agents and cocarcinogens, for the years 1974-6 is reviewed. Some of the chemical classes of compounds discussed include tthe sesquiterpene lactones, diterpenes of the phorbol and simaroubolide types, triterpenes of the withanolide and cucurbitacin types, lignans, monomeric and dimeric indole alkaloids, isoquinoline alkaloids, Cephalotaxus alkaloids, camptothecin and the maytansinoids. Emphasis is placed on the isolation, synthesis, biosynthesis and biological activities of the most promising entities.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 1","pages":"1-44"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11540079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A comparison of the mechanisms of action of VP-16-213 and podophyllotoxin.","authors":"S B Horwitz, J D Loike","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A comparison of the mechanism of action of VP 16-213 and podophyllotoxin has revealed that although both drugs inhibit nucleoside uptake in HeLa cells, they exhibit other biological properties which are quite distinct. Podophyllotoxin inhibits microtubule assembly in vitro while VP-16-213 has no effect in this system. VP-16-213 induces single-stranded breaks in DNA in HeLa cells, an effect which may explain the cytoxicity of VP-16-213. In contrast to VP-16-213-treated cells, cells treated with podophyllotoxin maintain DNA integrity and show no evidence of single-stranded breaks.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 1","pages":"82-9"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12059175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review of some biologically active compounds isolated from plants as reported in the 1974-1975 literature.","authors":"N R Farnsworth, G A Cordell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"39 6","pages":"420-55"},"PeriodicalIF":0.0,"publicationDate":"1976-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12207734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alkaloids of Annonaceae. XIV. Identification of canangine and eupolauridine, new alkaloids with a naphthyridine nucleus.","authors":"M Leboeuf, A Cavé","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"39 6","pages":"459-60"},"PeriodicalIF":0.0,"publicationDate":"1976-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12207738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}