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Toxic principles of hippomane mancinella. II. Structure of Hippomanin A. 曼氏海马的毒性原理。2河马蛋白A的结构。
Lloydia Pub Date : 1977-03-01
K V Rao
{"title":"Toxic principles of hippomane mancinella. II. Structure of Hippomanin A.","authors":"K V Rao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hippomanin A is a pale yellow crystalline toxic principle isolated from the water-soluble portion of the ethanolic extract of Hippomane mancinella. Acid hydrolysis gave glucose, gallic acid and ellagic acid, thus showing that it belonged to the class of \"crystalline tannins\" and was isomeric with corilagin. The presence of free anomeric hydroxyl was shown by methylation and by reduction with sodium borohydride. Mass spectral and chemical evidence showed that the structure was 2-galloyl-4,6-hexahydroxydiphenoyl-D-glucose.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 2","pages":"169-72"},"PeriodicalIF":0.0,"publicationDate":"1977-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12059179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rockogenin formation during the processing of Agave sisalana leaves for hecogenin. 龙舌兰叶加工成龙舌兰素过程中龙舌兰素的形成。
Lloydia Pub Date : 1977-03-01
G Blunden, J A Jaffer, K Jewers, J Barbour
{"title":"Rockogenin formation during the processing of Agave sisalana leaves for hecogenin.","authors":"G Blunden,&nbsp;J A Jaffer,&nbsp;K Jewers,&nbsp;J Barbour","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 2","pages":"218-9"},"PeriodicalIF":0.0,"publicationDate":"1977-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12061526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent studies on bleomycin. 博来霉素的最新研究。
Lloydia Pub Date : 1977-01-01 DOI: 10.1007/978-1-349-05952-2_49
H. Umezawa
{"title":"Recent studies on bleomycin.","authors":"H. Umezawa","doi":"10.1007/978-1-349-05952-2_49","DOIUrl":"https://doi.org/10.1007/978-1-349-05952-2_49","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"98 1","pages":"67-81"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83596104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Recent studies on bleomycin. 博来霉素的最新研究。
Lloydia Pub Date : 1977-01-01
H Umezawa
{"title":"Recent studies on bleomycin.","authors":"H Umezawa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 1","pages":"67-81"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11290633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ergolines as potential prolactin and mammary tumor inhibitors. 麦角碱作为潜在的催乳素和乳腺肿瘤抑制剂。
Lloydia Pub Date : 1977-01-01
J M Cassady, H G Floss
{"title":"Ergolines as potential prolactin and mammary tumor inhibitors.","authors":"J M Cassady,&nbsp;H G Floss","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 1","pages":"90-106"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11540082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental antitumor agents from plants, 1974-76. 实验性植物抗肿瘤药物，1974- 1976。
Lloydia Pub Date : 1977-01-01
G A Cordell, N R Farnsworth
{"title":"Experimental antitumor agents from plants, 1974-76.","authors":"G A Cordell,&nbsp;N R Farnsworth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The published literature in the areas of antitumor agents and cocarcinogens, for the years 1974-6 is reviewed. Some of the chemical classes of compounds discussed include tthe sesquiterpene lactones, diterpenes of the phorbol and simaroubolide types, triterpenes of the withanolide and cucurbitacin types, lignans, monomeric and dimeric indole alkaloids, isoquinoline alkaloids, Cephalotaxus alkaloids, camptothecin and the maytansinoids. Emphasis is placed on the isolation, synthesis, biosynthesis and biological activities of the most promising entities.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 1","pages":"1-44"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11540079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New antitumor anthracyclines. 新型抗肿瘤蒽环类药物。
Lloydia Pub Date : 1977-01-01
F Arcamone
{"title":"New antitumor anthracyclines.","authors":"F Arcamone","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 1","pages":"45-66"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12059174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of the mechanisms of action of VP-16-213 and podophyllotoxin. VP-16-213与鬼臼毒素作用机制的比较。
Lloydia Pub Date : 1977-01-01
S B Horwitz, J D Loike
{"title":"A comparison of the mechanisms of action of VP-16-213 and podophyllotoxin.","authors":"S B Horwitz,&nbsp;J D Loike","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A comparison of the mechanism of action of VP 16-213 and podophyllotoxin has revealed that although both drugs inhibit nucleoside uptake in HeLa cells, they exhibit other biological properties which are quite distinct. Podophyllotoxin inhibits microtubule assembly in vitro while VP-16-213 has no effect in this system. VP-16-213 induces single-stranded breaks in DNA in HeLa cells, an effect which may explain the cytoxicity of VP-16-213. In contrast to VP-16-213-treated cells, cells treated with podophyllotoxin maintain DNA integrity and show no evidence of single-stranded breaks.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 1","pages":"82-9"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12059175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of some biologically active compounds isolated from plants as reported in the 1974-1975 literature. 综述了1974-1975年文献报道的从植物中分离的一些生物活性化合物。
Lloydia Pub Date : 1976-11-01
N R Farnsworth, G A Cordell
{"title":"A review of some biologically active compounds isolated from plants as reported in the 1974-1975 literature.","authors":"N R Farnsworth,&nbsp;G A Cordell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"39 6","pages":"420-55"},"PeriodicalIF":0.0,"publicationDate":"1976-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12207734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alkaloids of Annonaceae. XIV. Identification of canangine and eupolauridine, new alkaloids with a naphthyridine nucleus. 番荔枝科生物碱。十四。具有萘啶核的新生物碱canangine和eupolauridine的鉴定。
Lloydia Pub Date : 1976-11-01
M Leboeuf, A Cavé
{"title":"Alkaloids of Annonaceae. XIV. Identification of canangine and eupolauridine, new alkaloids with a naphthyridine nucleus.","authors":"M Leboeuf,&nbsp;A Cavé","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"39 6","pages":"459-60"},"PeriodicalIF":0.0,"publicationDate":"1976-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12207738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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