Malawi Medical Journal最新文献

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Exploring the cultural appropriateness of a psychosocial intervention, the Thinking Healthy Programme-Peer delivered (THPP), for perinatal depression in Lilongwe, Malawi. 探索马拉维利隆圭围产期抑郁症心理社会干预的文化适宜性,即同伴提供的健康思考方案(THPP)。
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-06-01 DOI: 10.4314/mmj.v34i2.3
Mwawi Ng'oma, Najia Atif, Samantha Meltzer-Brody, Robert C Stewart, Ellen Chirwa
{"title":"Exploring the cultural appropriateness of a psychosocial intervention, the Thinking Healthy Programme-Peer delivered (THPP), for perinatal depression in Lilongwe, Malawi.","authors":"Mwawi Ng'oma,&nbsp;Najia Atif,&nbsp;Samantha Meltzer-Brody,&nbsp;Robert C Stewart,&nbsp;Ellen Chirwa","doi":"10.4314/mmj.v34i2.3","DOIUrl":"https://doi.org/10.4314/mmj.v34i2.3","url":null,"abstract":"<p><strong>Background: </strong>Perinatal depression is a common and disabling mental health problem in Malawi and other Low- and middle-income countries. There is evidence for effective psychosocial interventions for perinatal depression, but no such intervention has been developed for use in Malawi. The broad aim of this study was to explore the cultural appropriateness of a psychosocial intervention for perinatal depression called the Thinking Healthy Programme-Peer delivered for adaptation and use in Lilongwe, Malawi.</p><p><strong>Methods: </strong>A qualitative exploratory design was used. Data were collected through conducting five Focus Group Discussions, involving thirty-eight purposefully selected participants including pregnant women, community volunteers and their supervisors, the Health Surveillance Assistants and maternal health care workers at implementation and policy level following observations of video recorded role plays of the Thinking Healthy Programme-Peer delivered sessions in theatre testing. A content analysis approach was used to analyse data.</p><p><strong>Results: </strong>Six main themes were generated regarding the appropriateness of the content and delivery of the Thinking Healthy Programme-Peer delivered intervention, including: 1) Focus of the intervention; 2) Cultural appropriateness of the content; 3) Language used; 4) Context; 5) Provider of the intervention; and 6) Flexibility in the delivery of the intervention. The Thinking Healthy Programme-Peer delivered intervention was deemed appropriate for the target population, though with recommendations to: review illustrations to enhance clarity, use culturally appropriate stories and idioms, use daily spoken language, and adapt the number and duration of sessions to meet the needs of individual clients.</p><p><strong>Conclusions: </strong>These findings highlight important areas to inform adaptation of the Thinking Healthy Programme-Peer delivered and add to the growing evidence of cultural adaptation of psychosocial interventions for perinatal depression.</p>","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":"34 2","pages":"87-94"},"PeriodicalIF":0.8,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/e6/MMJ3402-0087.PMC9356516.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10663362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sufficient informed consent to medical treatment of adults: legal and ethical perspectives from Malawi. 对成年人医疗的充分知情同意:马拉维的法律和伦理观点。
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-06-01 DOI: 10.4314/mmj.v34i2.11
Eva Maria Mfutso Bengo, Adamson Muula, Joseph Mfutso Bengo
{"title":"Sufficient informed consent to medical treatment of adults: legal and ethical perspectives from Malawi.","authors":"Eva Maria Mfutso Bengo,&nbsp;Adamson Muula,&nbsp;Joseph Mfutso Bengo","doi":"10.4314/mmj.v34i2.11","DOIUrl":"https://doi.org/10.4314/mmj.v34i2.11","url":null,"abstract":"<p><p>This special communication discusses the current legal and ethical requirements for informed consent to medical treatment of adults in Malawi. It analyzes the scope of the laws and code of ethics on professional discipline, including criminal privilege for surgeries and clarifies when insufficient disclosures entitle patients to compensation under civil law. Inconsistencies and uncertainties in the law are made apparent. It evaluates to which degree disclosure standards of other Commonwealth jurisdictions (e.g. the case of <i>Montgomery</i>) would be suitable for the health care setting of a country like Malawi that is characterized by shortages of resources, high illiteracy rates and a communitarian cultural context. Doctor-patient communication is not alien to African culture and part of sufficient informed consent. In order to balance the need for efficiency in health care delivery, accountability for quality care, fairness and effective patient-doctor communication the authors suggest to adopt the reasonable patient test only, if a defence of heavy workload on case-to-case basis is introduced at the same time. This does not dispense the need for organisational diligence on part of the institutional health care provider within its capacity.</p>","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":"34 2","pages":"143-150"},"PeriodicalIF":0.8,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/51/MMJ3402-0143.PMC9356522.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10604177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic assessment of complications after laparoscopic colorectal surgery for advanced colorectal cancer: A retrospective study using Clavien-Dindo classification, 5-year experience. 腹腔镜结直肠癌手术后并发症的系统评估:Clavien-Dindo分类回顾性研究,5年经验。
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-03-01 DOI: 10.4314/mmj.v34i1.9
Mahmut Said Degerli, Alp Omer Canturk, Hilmi Bozkurt, Orcun Alpay, Muzaffer Akinci, Yusuf Emre Altundal, Turgay Yildiz, Dogan Yildirim
{"title":"Systematic assessment of complications after laparoscopic colorectal surgery for advanced colorectal cancer: A retrospective study using Clavien-Dindo classification, 5-year experience.","authors":"Mahmut Said Degerli,&nbsp;Alp Omer Canturk,&nbsp;Hilmi Bozkurt,&nbsp;Orcun Alpay,&nbsp;Muzaffer Akinci,&nbsp;Yusuf Emre Altundal,&nbsp;Turgay Yildiz,&nbsp;Dogan Yildirim","doi":"10.4314/mmj.v34i1.9","DOIUrl":"https://doi.org/10.4314/mmj.v34i1.9","url":null,"abstract":"<p><strong>Aim: </strong>The presence and frequency of surgical complications indicate the quality of the surgery performed. However, a standard classification system should specify, describe, and compare complications. Clavien Dindo classification is an easily applicable classification in the evaluation of complications. Our study aimed to reveal the severity of complications and the factors affecting them by using the Clavien Dindo classification in patients undergoing laparoscopic colorectal surgery.</p><p><strong>Methods: </strong>Between January 2015 and December 2020, we retrospectively collected the laparoscopic colorectal surgery complications using Clavien Dindo grading in patients in our colorectal surgery unit in the database. The outcome variables studied were age, gender, BMI, ASA score, postoperative length of hospital stay, operation procedure, cancer size, postoperative mortality.</p><p><strong>Results: </strong>There were 53 males and 17 female patients, with a mean age of 56,9±13,4.(19-81). Seventy patients, 32 (45%), had at least one postoperative complication. About complications; 58.6% were rated as Clavien I, 22.9% as Clavien II, 8.6% as Clavien IIIa, 4.3% as Clavien IIIb, 2.9% as Clavien IVa, and 2.9% as Clavien V. There was no Clavien grade IVb complication in any of the patients. Length of hospital stays was significantly higher in patients with had major complex surgery and had higher scores. Clavien Dindo classification was positively statistically significantly related to the day of hospitalization in male and female sex (p<0.001 for all). In addition, positively significantly related to Clavien Dindo classation and tumor diameter in the female sex (p=0.014) detected.</p><p><strong>Conclusions: </strong>In laparoscopic colorectal surgery, the Clavien-Dindo classification can be easily applied and used safely to determine complication rates. The reason for this statistical difference that we detected in our study and that occurs in women may be due to anatomical differences or the surgeon's experience.</p>","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":"34 1","pages":"49-52"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/10/MMJ3401-0049.PMC10230576.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The burden of surgical complications from unsafe abortion treated at the John F. Kennedy Maternity Center (JFKMC), Monrovia, Liberia. 利比里亚蒙罗维亚约翰·肯尼迪妇产中心(JFKMC)治疗不安全堕胎手术并发症的负担。
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-03-01 DOI: 10.4314/mmj.v34i1.8
Williams O Odunvbun, Jewel T Kollie
{"title":"The burden of surgical complications from unsafe abortion treated at the John F. Kennedy Maternity Center (JFKMC), Monrovia, Liberia.","authors":"Williams O Odunvbun,&nbsp;Jewel T Kollie","doi":"10.4314/mmj.v34i1.8","DOIUrl":"https://doi.org/10.4314/mmj.v34i1.8","url":null,"abstract":"<p><strong>Background: </strong>The burden of surgical complications from unsafe abortion affects both health facilities and patients in most developing countries. This study aimed to determine the nature of surgical complications from unsafe abortion treated at the JFKMC, Liberia, and the estimated cost burden on facility and patient.</p><p><strong>Method: </strong>This was a retrospective study of the medical records of patients who had exploratory laparotomy for complications of induced abortion and presented at the JFKMC from June 15, 2018, to December 15, 2019.</p><p><strong>Results: </strong>The medical records of 44 out of the 49 patients who had exploratory laparotomy for unsafe abortion were captured and analyzed. Surgical complications from unsafe abortion accounted for 17.8% out of the 276 gynaecological surgeries at the JFKMC, Liberia. The case fatality was 22.4%. The mean age of subjects was 29.00 ±6.06 years. About 1/3 of the subjects were in their teens, over 4/5 were single, and half were students. Almost 60.0% of the subjects terminated their pregnancies in private health facilities. Ten subjects had a hysterectomy for necrotic/septic uterus. The mean cost of managing a patient with surgical complications from unsafe abortion at the JFKMC was $331.50, in contrast with $22.00, for spontaneous or induced abortion with mild complications treated as a day case.</p><p><strong>Conclusion: </strong>This study showed a cost burden on the facility, and patients as a result of surgical complications from induced abortion. A shift in current practice by health facilities in Liberia to medical management of abortion and MVA, training of health personnel on the use of MVA, and a less restrictive abortion law with effective contraceptive services are recommended.</p>","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":"34 1","pages":"43-48"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/54/MMJ3401-0043.PMC10230577.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A rare lesion of breast: Hydatid cyst. 罕见的乳腺病变:包虫囊肿。
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-03-01 DOI: 10.4314/mmj.v34i1.12
Sinan Sozutok, Omer Kaya, Huseyin Akkaya, Bozkurt Gulek
{"title":"A rare lesion of breast: Hydatid cyst.","authors":"Sinan Sozutok,&nbsp;Omer Kaya,&nbsp;Huseyin Akkaya,&nbsp;Bozkurt Gulek","doi":"10.4314/mmj.v34i1.12","DOIUrl":"https://doi.org/10.4314/mmj.v34i1.12","url":null,"abstract":"<p><p>Hydatid cyst (HC) is a lesion most commonly seen in the liver but can occur in many parts of the body. Breast involvement with HC is extremely rare. It can be isolated or accompanied by other organ involvements. In this report, we present a 46-year-old female with isolated HC located in the right breast. In the ultrasonography and MR images of the patient, the lesion was compatible with the HC, and homogenous dens lesion was shown on mammography. Diagnosis of HC was confirmed pathological. With this study, it was aimed to emphasize the radiological findings of isolated breast HC.</p>","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":"34 1","pages":"68-70"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/8b/MMJ3401-0068.PMC10230583.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of a medical doctor in war-thoughts over Russian soldiers and Ukraine. 医生在俄罗斯士兵和乌克兰战争思想中的作用。
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-03-01 DOI: 10.4314/mmj.v34i1.1
Adamson S Muula
{"title":"The role of a medical doctor in war-thoughts over Russian soldiers and Ukraine.","authors":"Adamson S Muula","doi":"10.4314/mmj.v34i1.1","DOIUrl":"https://doi.org/10.4314/mmj.v34i1.1","url":null,"abstract":"In 1992, I interviewed for both medical school and the Malawi Army to join my country’s medical corps in preparation for a military hospital that was soon to be established. From that time many things changed. Although I graduated from medical school, I did not become a military doctor. I have fond images of what it would have been, had my dreams of joining the uniformed forces of my country come to fruition.","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":"34 1","pages":"1-2"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/66/MMJ3401-0001.PMC10230588.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic guideline adherence by Clinicians in medical wards at Queen Elizabeth Central Hospital (QECH), Blantyre Malawi. 马拉维布兰太尔伊丽莎白女王中心医院(QECH)病房临床医生抗生素指南依从性
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-03-01 DOI: 10.4314/mmj.v34i1.2
Grace Thandekire Sibande, Ndaziona Peter Kwanjo Banda, Thandizo Moya, Sylvia Siwinda, Rebecca Lester
{"title":"Antibiotic guideline adherence by Clinicians in medical wards at Queen Elizabeth Central Hospital (QECH), Blantyre Malawi.","authors":"Grace Thandekire Sibande,&nbsp;Ndaziona Peter Kwanjo Banda,&nbsp;Thandizo Moya,&nbsp;Sylvia Siwinda,&nbsp;Rebecca Lester","doi":"10.4314/mmj.v34i1.2","DOIUrl":"10.4314/mmj.v34i1.2","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) is a major concern in health care worldwide. In Malawi rates of AMR, in particular third-generation cephalosporin-resistant (3GC-R) Enterobacterales have rapidly increased since 2003. Antibiotic guidelines are a key component of antimicrobial stewardship (AMS). As part of stewardship, Queen Elizabeth Central Hospital (QECH) in Blantyre, Malawi developed an antibiotic guideline in the form of a smart phone application in June 2016.</p><p><strong>Aim: </strong>We conducted a study to assess clinicians adherence to the local antibiotic guideline on the adult medical wards, two years after it was introduced. Specifically assessing choice of antibiotic, time of blood culture collection and 48-hour review.</p><p><strong>Methods: </strong>A cross-sectional study was carried out using purposive sampling method. 230 case files of adult patients were audited against the antibiotic guideline. Adherence to the guideline in terms of indication for antibiotic, choice of antibiotic and antibiotic review time was reviewed. Statistical analysis was done using IBM SPSS and presented with descriptive statistics.</p><p><strong>Results: </strong>194 (84% [95% CI 79.0-88.8]) antibiotic prescriptions were adherent to the guideline, 28 (12% [95% CI 8.2-17.1]) non-adherent and 8 (3.5% [95% CI 1.5-6.7]) antibiotic indication was not clear. The most common indication for antibiotic prescriptions was pneumonia, as documented in 89 (39% [95 % CI 32.4-45.3]) case files. 191(76% [95% CI 70.3-81.2]) of prescriptions were for ceftriaxone. There was evidence of utilising blood culture to adjust therapy as 88/230 (38% [95% CI 32.0-44.9]) had culture taken. 175(76% [95 % CI 70.0-81.4]) of files had antibiotics reviewed within 48 hours.</p><p><strong>Conclusion: </strong>There is still need to work on rational prescribing of antibiotics as ceftriaxone usage was high during this study period. Scheduled audits and point prevalence surveys should be implemented quickly to reduce the impact of antibiotic resistance and improve individual patient care.</p>","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":"34 1","pages":"3-8"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/8d/MMJ3401-0003.PMC10230578.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9594207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Antimicrobial susceptibility profiles of clinically important bacterial pathogens at the Kamuzu Central Hospital in Lilongwe, Malawi. 马拉维利隆圭Kamuzu中心医院临床重要细菌病原体的抗微生物药敏概况
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-03-01 DOI: 10.4314/mmj.v34i1.3
Faheema E Choonara, Bjørg C Haldorsen, Isaac Ndhlovu, Osborne Saulosi, Tarsizio Maida, Fanuel Lampiao, Gunnar S Simonsen, Sabiha Y Essack, Arnfinn Sundsfjord
{"title":"Antimicrobial susceptibility profiles of clinically important bacterial pathogens at the Kamuzu Central Hospital in Lilongwe, Malawi.","authors":"Faheema E Choonara,&nbsp;Bjørg C Haldorsen,&nbsp;Isaac Ndhlovu,&nbsp;Osborne Saulosi,&nbsp;Tarsizio Maida,&nbsp;Fanuel Lampiao,&nbsp;Gunnar S Simonsen,&nbsp;Sabiha Y Essack,&nbsp;Arnfinn Sundsfjord","doi":"10.4314/mmj.v34i1.3","DOIUrl":"https://doi.org/10.4314/mmj.v34i1.3","url":null,"abstract":"<p><strong>Background: </strong>The aim of this prospective study was to ascertain antimicrobial resistance (AMR) in clinical bacterial pathogens from in-hospital adult patients at a tertiary hospital in Lilongwe, Malawi.</p><p><strong>Methods: </strong>Clinical specimens (blood culture, pus, urine and cerebrospinal fluid) collected during June to December 2017 were examined for bacterial growth in standard aerobic conditions. One specimen per patient was included. Antimicrobial susceptibility testing (AST) was performed using the disk diffusion method and interpreted according to EUCAST guidelines.</p><p><strong>Results: </strong>A total of 694 specimens were collected during the study period, of which 336 (48%) specimen yielded visible bacterial growth. Of the 336 specimens, a total of 411 phenotypically different isolates were recovered. Of the 411 isolates, 84 isolates (20%) were excluded and the remaining 327 (80%) were further characterised. The characterised isolates were identified as ESKAPE pathogens (n=195/327; 60%), <i>Escherichia coli</i> (n=92/327; 28%), <i>Proteus mirabilis</i> (n=33/327; 10) or <i>Salmonella</i> spp. (n=7/327; 2%) and were included for further analysis. The excluded isolates (n=84) comprised of coagulase-negative staphylococci (n=25), streptococci (n=33), and low-prevalence Gram-negative bacilli (n=26). <i>E. coli</i> (n=92; 28%) and <i>S. aureus</i> (n=86; 26%) were the most dominant species. A multidrug resistant (MDR) extended spectrum β- lactamase (ESBL)-positive phenotype was detected in <i>Klebsiella pneumoniae</i> (n=20/29; 69%) and <i>E. coli</i> (n=49/92; 53%). One third of the <i>Pseudomonas aeruginosa</i> isolates were resistant to meropenem (MEM), but did not appear to be carbapenemase-producers. Methicillin resistant <i>Staphylococcus aureus</i> (MRSA) was molecularly confirmed in 10.5% of <i>S. aureus</i> (n=9/86).</p><p><strong>Conclusion: </strong>The high proportion of the MDR ESBL-phenotype in clinical isolates of <i>Enterobacterales</i>, strongly limits antimicrobial treatment options and has consequences for empirical and targeted antimicrobial treatment as well as clinical microbiology services and hospital infection control. There is need for a continuous surveillance and an antimicrobial stewardship (AMS) program to contain and prevent the spread of AMR.</p>","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":"34 1","pages":"9-16"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/d6/MMJ3401-0009.PMC10230581.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The beneficial effect of Adansonia digitata products success to modulate lipid profiles and inhibit LDL oxidation in-vitro: An associational study. adansononia digitata产品在体外成功调节脂质分布和抑制LDL氧化的有益作用:一项关联研究。
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-03-01 DOI: 10.4314/mmj.v34i1.5
Ahmed M Ahmed, Omar F Khabour, Amjad Yousuf, Saber M Eweda, Walaa Mohammedsaeed, Haytham M Daradka, Salwa F M Hassanein, Amna M Ibrahim
{"title":"The beneficial effect of <i>Adansonia digitata</i> products success to modulate lipid profiles and inhibit LDL oxidation <i>in-vitro</i>: An associational study.","authors":"Ahmed M Ahmed,&nbsp;Omar F Khabour,&nbsp;Amjad Yousuf,&nbsp;Saber M Eweda,&nbsp;Walaa Mohammedsaeed,&nbsp;Haytham M Daradka,&nbsp;Salwa F M Hassanein,&nbsp;Amna M Ibrahim","doi":"10.4314/mmj.v34i1.5","DOIUrl":"https://doi.org/10.4314/mmj.v34i1.5","url":null,"abstract":"<p><strong>Background: </strong>There is a growing interest in medicinal plants in recent years due to their many therapeutic benefits and low side effects. Among the medicinal plants is the African <i>Adansonia digitata</i> (baobab) that has edible fruit. In the current study, the effect of <i>A. digitata</i> juice consumption on the lipid profile was investigated. In addition, inhibition of the oxidation of low-density lipoprotein cholesterol (LDL-C) <i>in-vitro</i> by <i>A. digitata</i> essential oil (EO) was also investigated.</p><p><strong>Methods: </strong>In this cohort study, a total of 70 subjects of <i>A. digitata</i> users (AD group, 42 male and 28 female) and 70 non <i>A. digitata</i> users (Non-AD group, 44 male and 26 female) were recruited to participate in this study. We evaluated lipid profile, HbA1c, liver/kidney functions, and phytosterol contents in fasting blood samples of all participants.</p><p><strong>Results: </strong>The present findings illustrated significantly lower levels of total cholesterol, triglycerides, and LDL in the AD group compared to Non-AD (p < 0.01). In addition, essential oil of <i>A. digitata</i> inhibited LDL oxidation <i>in-vitro</i> as shown by the significant decreases in the formation of malonaldehyde (MDA), protein carbonyl (PC), and lipid hydroperoxide (LHP) (P<0.05). No significant changes in fasting blood glucose, HbA1c, HDL, kidney function, and liver function enzymes between the two groups were detected (P>0.05).</p><p><strong>Conclusion: </strong>The juice of <i>A. digitata</i> has hypolipidemic and antioxidative effects and might be beneficial for the management of lipid levels in the body.</p>","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":"34 1","pages":"25-30"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/4f/MMJ3401-0025.PMC10230582.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacists' Readiness to Receive, Recommend and Administer COVID-19" Vaccines. 药剂师接受、推荐和管理COVID-19疫苗的准备情况。
IF 0.8 4区 医学
Malawi Medical Journal Pub Date : 2022-03-01 DOI: 10.4314/mmj.v34i1.13
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
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