Mansoura Veterinary Medical Journal最新文献_第4页

Impact of COVID - 19 Pandemic on The Clinical Course of Inflammatory Bowel Disease in Egyptian Tertiary Centers COVID - 19大流行对埃及三级中心炎症性肠病临床病程的影响

Mansoura Veterinary Medical Journal Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1371

Alaa Alsawak, O. Abdallah, A. Madian, H. Atalla, Ramadan Eldamarawy, Ahmed Eliwa, A. Khamiss, A. Sharkawy, Sadek Mostafa, A. Alaboudy, M. Maher, Ashraf Elbahrawy

{"title":"Impact of COVID - 19 Pandemic on The Clinical Course of Inflammatory Bowel Disease in Egyptian Tertiary Centers","authors":"Alaa Alsawak, O. Abdallah, A. Madian, H. Atalla, Ramadan Eldamarawy, Ahmed Eliwa, A. Khamiss, A. Sharkawy, Sadek Mostafa, A. Alaboudy, M. Maher, Ashraf Elbahrawy","doi":"10.58775/2735-3990.1371","DOIUrl":"https://doi.org/10.58775/2735-3990.1371","url":null,"abstract":"Background/aim: The coronavirus disease 2019 (COVID-19) pandemic has a major impact on the clinical course of chronic diseases including inflammatory bowel disease (IBD). In the current study, we aimed to evaluate the clinical relapse and worsening of IBD activity during the COVID-19 pandemic. Patients and methods: In this study 125 patients were included and were followed up for 1 year. Of them, 98 and 27 patients had inactive and active IBD before the study, respectively. The clinical activity of IBD was assessed by Crohn's disease activity index and simplified colitis clinical activity index. Severe acute respiratory distress syndrome coronavirus 2 infection was detected by real-time PCR. Results: The mean age of included patients was 34.3 ± 11.2 years, of them 54 (43.2%) were males. Forty three (34.4%) and 82(65.6%) patients had Crohn's disease and ulcerative colitis, respectively. Forty-six (47%) patients developed a clinical relapse within 1 year. Of them, 22 (48%) patients were not adherent to treatment during the pandemic (P ≤ 0.05); 33.3% of patients with active IBD before the study had worsened activity during the pandemic. The incidence of severe acute respiratory distress syndrome coronavirus 2 infection among the included patients was 8% (n 1⁄4 10). Conclusion: The majority of relapsed IBD patients were not adherent to treatment due to the fear of COVID-19 infection.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88669498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wheezy and Cough Asthma Phenotypes in a cohort of Egyptian Children: Clinical features and CCR3 T51C Gene Polymorphism 埃及儿童队列中的喘息和咳嗽哮喘表型:临床特征和CCR3 T51C基因多态性

Mansoura Veterinary Medical Journal Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1379

M. Zedan, Mai Magdy Kera, E. Khashaba, Mona El wassefy, A. Osman

{"title":"Wheezy and Cough Asthma Phenotypes in a cohort of Egyptian Children: Clinical features and CCR3 T51C Gene Polymorphism","authors":"M. Zedan, Mai Magdy Kera, E. Khashaba, Mona El wassefy, A. Osman","doi":"10.58775/2735-3990.1379","DOIUrl":"https://doi.org/10.58775/2735-3990.1379","url":null,"abstract":"Background: Asthma is a heterogenous disease with variable characteristic phenotypes. Correlating clinical asthma phenotypes with the underlying genotypes could pave the way for the development of tailored asthma medications. Objective: The purpose of this study was to describe the clinical features of wheezy and cough asthma phenotypes and to assess the frequency of CCR3 T51C gene polymorphism among Egyptian asthmatic children. Methods: A group of 60 Egyptian asthmatic children (40 wheezy phenotypes and 20 cough phenotypes) together with 100 controls were enrolled and analyzed for the genotypes of CCR3 T51C polymorphisms using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Serum IgE levels were determined by the ELISA technique. Results: Regarding clinical characteristics, associated allergic rhinitis and atopic dermatitis were found to be significantly higher among the wheezy phenotype compared with the cough phenotype. Also, most of the patients with the wheezy phenotype had moderate to severe asthma, while most of the patients with the cough phenotype had mild asthma. Regarding the frequency of CCR3 T51C genotypes, the TT homozygote genotype was the most frequent genotype among cases and controls. However, no statistically significant differences were found between the two clinical phenotypes. Conclusion: In our studied population, the wheezy asthma phenotype was characterized by a higher frequency of associated allergic march and increased asthma severity. Yet, our results deny the value of CCR3 T51C genetic polymorphism as a genetic marker for differentiating between wheezy and cough asthma phenotypes.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85234867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prognostic value of androgen receptor and cyclin D1 in infiltrating duct carcinoma of the breast 雄激素受体和细胞周期蛋白D1在乳腺浸润导管癌中的预后价值

Mansoura Veterinary Medical Journal Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1387

D. El-Ghaffar, Amal AF Halim, E. Abdallah, Doaa A Sharaf, S. Yussif

{"title":"The prognostic value of androgen receptor and cyclin D1 in infiltrating duct carcinoma of the breast","authors":"D. El-Ghaffar, Amal AF Halim, E. Abdallah, Doaa A Sharaf, S. Yussif","doi":"10.58775/2735-3990.1387","DOIUrl":"https://doi.org/10.58775/2735-3990.1387","url":null,"abstract":"Objective : Breast cancer (BC) tissue is heterogeneous with a number of cellular pathways involved in cell growth and proliferation. Activation of androgen receptors (AR) signaling pathways plays a role in BC. On the other hand, cyclin is a regulatory subunit of cyclin-dependent kinases that affect cell cycle G1/S transition. This study aimed at investigating the relationship between the expression of AR and cyclin D1 and the clinicopathological details of BC patients registered in the archive of our department within a speci ﬁ ed period and determining the prognostic impact of such expression. Methods : The study included 182 IDC patients aged from 20 to 65 whom were registered in the archive of the Clinical Oncology & Nuclear Medicine Department from January 2013 to December 2015. All clinicopathological data were obtained from patient records. Immunohistochemistry study for AR and cyclin D1 was done for the pathologic specimens. Results : The expression ratio of AR in 182 specimens was 43.4% (79/182). AR positivity was signi ﬁ cantly associated with estrogen receptor (ER) and progesterone receptor (PR) positivity and negative HER2 status, lower tumor grade, smaller tumor size, and negative lymph node involvement ( P values < 0.05). Cyclin D1 positivity was reported in 116/182 (64%). There was positive correlation between cyclin D1 and ER, PR positivity, triple negativity, small tumor size, and negative lymph node involvement ( P value < 0.05). The","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78441639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term stability of electrical stapedial reflex and electrodes impedance in children with MED-EL cochlear implants MED-EL型人工耳蜗儿童镫骨电反射和电极阻抗的长期稳定性

Mansoura Veterinary Medical Journal Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1381

Maram Mohamed Rashad Ghoniem, A. Elsharabasy, Y. Shabana, E. Ismail

{"title":"Long-term stability of electrical stapedial reflex and electrodes impedance in children with MED-EL cochlear implants","authors":"Maram Mohamed Rashad Ghoniem, A. Elsharabasy, Y. Shabana, E. Ismail","doi":"10.58775/2735-3990.1381","DOIUrl":"https://doi.org/10.58775/2735-3990.1381","url":null,"abstract":"Background: The purpose of this study was to investigate changes in electrical evoked stapedial reflex thresholds (ESRTs) and electrodes impedance over time in children with MED-EL cochlear implants. Methods: In this study, 60 kids were included, while 15 kids were excluded because their cases did not fit the requirements. Patients who received MED-EL cochlear implants were monitored postoperatively over 5 years to determine whether or not their electrical evoked stapedial reflex thresholds (ESRT) and electrode impedance remained stable. Results: At the initial fitting, electrodes 4, 5, 6, 8, and 9 showed significantly different impedances, while electrodes 1, 2, 3, 7, 10, 11, and 12 showed no significantly different impedances. Excluding electrode 12, all electrodes showed a statistically significant difference in ESRT at three and 6 months. All electrodes, except electrodes 7 and 8, showed no difference between ESRT and the behaviorally based MAP most comfortable level (MCL). After three months, there was a highly significant difference between ESRT and the behavioral MAP for the audiometric frequencies 500, 1000, 2000, and 4000 Hz. Conclusion: Particularly at 3 and 6 months, there was a considerable decrease in electrode impedance, which stabilized throughout the course of the remaining follow-up period. Nearly all the electrodes showed a significant variation in ESRT between 3 and 6 months, but over the subsequent 5 years, ESRT essentially stabilized. Additionally, there was no difference between behavioral-based MAP and ESRT MCL; nevertheless, after 3 months, there was a highly significant difference between ESRT and the behavioral MAP at the 500, 1000, 2000, and 4000 Hz audiometric frequencies.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73487808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Late Presentation of Kartagener Syndrome: A Case Report 罕见的晚期出现的Kartagener综合征1例报告

Mansoura Veterinary Medical Journal Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1389

A. H. Al-Mazroea

引用次数: 0

Outcome of COVID-19 in patients with rheumatic diseases treated with immunosuppressive drugs 免疫抑制药物治疗风湿性疾病患者COVID-19的疗效

Mansoura Veterinary Medical Journal Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1391

A. Sobh, Noha Elnagdy, Mohamed Elegezy, Mohamed Mofreh, Mohamed Tohlob, Ahmad M. Eita, Ragheed Rizk, Ola Eliwa, M. H. Elnagdy, A. E. Abdulgalil

引用次数: 0

Association of vitamin D receptor Cdx-2 polymorphism with COVID-19: A case-control study 维生素D受体Cdx-2多态性与COVID-19的关系:一项病例对照研究

Mansoura Veterinary Medical Journal Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1382

M. M. ALseoudy, Maha O. Hammad, Mohmed Elgamal, D. Abdelghany, A. Borg, Ahmed El-Mesery, Dina Elzeiny

{"title":"Association of vitamin D receptor Cdx-2 polymorphism with COVID-19: A case-control study","authors":"M. M. ALseoudy, Maha O. Hammad, Mohmed Elgamal, D. Abdelghany, A. Borg, Ahmed El-Mesery, Dina Elzeiny","doi":"10.58775/2735-3990.1382","DOIUrl":"https://doi.org/10.58775/2735-3990.1382","url":null,"abstract":"Background : Host genetic variability has been suggested as an important explanation for inter-individual differences in COVID-19 susceptibility and severity. Most vitamin D actions in the regulation of immunity are mediated by vitamin D receptors (VDRs). Polymorphisms in the VDR gene have been associated with several health outcomes; however, their effects on COVID-19 still need more clari ﬁ cation. This study aims to investigate the association of the VDR SNP (rs11568820, Cdx-2) with susceptibility and interindividual variability of the severity of COVID-19. Methods : A total of 100 con ﬁ rmed COVID-19 patients and 100 age and sex-matched controls were enrolled in this study between July and September 2021. COVID-19 patients were further subdivided into severe ( n ¼ 50) and nonsevere ( n ¼ 50) cases. All participants were subjected to genotyping of Cdx-2 SNP using the allelic discrimination of the Real-time PCR technique and assay of serum 25(OH)D levels by ELISA. Results : The results showed that the homozygous “ GG ” genotype was signi ﬁ cantly higher in patients vs. controls, whereas the heterozygous “ AG ” genotype was signi ﬁ cantly lower in COVID-19 patients. Thus, the heterozygous “ AG ” genotype is considered the protective genotype. This protection was more signi ﬁ cant among males vs. females ( P ¼ 0.02). However, there were no statistically signi ﬁ cant differences in the genotype distributions of VDR Cdx-2 SNP between severe and nonsevere patients. Moreover, COVID-19 patients with the “ AG ” genotype presented higher 25(OH)D levels than the “ GG ” genotype ( P ¼ 0.02). Conclusions : VDR SNP (rs11568820, Cdx-2) might be a potential risk factor for COVID-19, particularly among male patients.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89652659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening for obstructive sleep apnea in a sample of Egyptian idiopathic intracranial hypertension female patients using the Berlin questionnaire 使用柏林问卷对埃及特发性颅内高压女性患者进行阻塞性睡眠呼吸暂停筛查

Mansoura Veterinary Medical Journal Pub Date : 2022-12-14 DOI: 10.21608/mjmu.2022.151954.1131

N. Elsaid, Ahmed A H Mosa, A. Saied

{"title":"Screening for obstructive sleep apnea in a sample of Egyptian idiopathic intracranial hypertension female patients using the Berlin questionnaire","authors":"N. Elsaid, Ahmed A H Mosa, A. Saied","doi":"10.21608/mjmu.2022.151954.1131","DOIUrl":"https://doi.org/10.21608/mjmu.2022.151954.1131","url":null,"abstract":"Background : Obstructive sleep apnea (OSA) is one of the risk factors for idiopathic intracranial hypertension (IIH). The Berlin questionnaire (BQ) is a validated reliable method for the identi ﬁ cation of an increased likelihood of OSA. We aimed to screen a sample of female IIH patients for OSA using the BQ. Patients and methods : This study included 40 females; 20 newly diagnosed IIH patients and 20 healthy controls. The BQ was obtained from all of the study participants, and it was divided into high or low risk for OSA. Results : The patient and control cohorts were age-matched. The BMI was signi ﬁ cantly higher in the IIH group (median 36, range 24 e 42) than in the control group (median 28, range 20 e 41) ( P ¼ 0.005). Of the IIH patient group, 45% had a high-risk BQ score, while only 15% of the healthy control group had a high-risk score ( P ¼ 0.038). Conclusion : Stratifying the risk of OSA in IIH may be feasible using the BQ. A high likelihood for OSA in BQ is more common in patients of IIH. Polysomnography may be warranted in IIH patients with high-risk BQ scores to reduce the morbidities associated with OSA, especially in obese patients.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74098664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Epidural and Intramuscular Bupivacaine Injection for Patients Undergoing Lumbar Spine Discectomy on Post-operative Pain Assessment by Visual Analogue Score (VAS) 硬膜外肌注布比卡因对腰椎间盘切除术患者术后疼痛视觉模拟评分(VAS)的影响

Mansoura Veterinary Medical Journal Pub Date : 2022-12-13 DOI: 10.21608/mjmu.2022.178838.1151

A. Mowafy

引用次数: 0

Clinical and biochemical parameters in obese women with polycystic ovary syndrome 肥胖女性多囊卵巢综合征的临床及生化指标

Mansoura Veterinary Medical Journal Pub Date : 2022-12-13 DOI: 10.21608/mjmu.2022.176871.1150

Asmaa Ibrahim

引用次数: 0