Mansoura Veterinary Medical Journal最新文献_第2页

Timolol as a migraine acute attack therapy: randomized, OTCs control study 替马洛尔作为偏头痛急性发作治疗:随机、otc对照研究

Mansoura Veterinary Medical Journal Pub Date : 2023-03-01 DOI: 10.58775/2735-3990.1370

Shimaa Elgamal, H. Egila, I. Kabbash, Hussien El-Ansarey, Mohamed Elshafie, O. ELShafei

{"title":"Timolol as a migraine acute attack therapy: randomized, OTCs control study","authors":"Shimaa Elgamal, H. Egila, I. Kabbash, Hussien El-Ansarey, Mohamed Elshafie, O. ELShafei","doi":"10.58775/2735-3990.1370","DOIUrl":"https://doi.org/10.58775/2735-3990.1370","url":null,"abstract":"Background: Migraine is manifested by recurrent headache attacks, with variable characteristics and associated symptoms. Oral beta-blockers are widely used to prevent and reduce the frequency of these attacks. However, the use of topical beta-blockers for acute treatment is still controversial. Aims: In this randomized double-armed study, we aim to compare the efficacy of timolol 0.5% eye drops compared with other over-the-counter (OTC) medications used for the acute treatment of migraine. Patients and methods: Fifty-seven patients were randomly allocated to group A (treatment group: timolol 0.5% eye drops) and group B (control group: OTC drugs including NSAIDs, caffeine, aspirin, and acetaminophen). The primary outcome was pain reduction. Secondary outcome measures included reducing nausea, vomiting, photophobia, and phonophobia. Results: Median pain reduction for the OTC group was higher than for timolol (6, 4 prospectively) with a significant U test (P < 0.001). We found a significant correlation between pain severity and degree of pain reduction (r 1⁄4 0.480, P < 0.001). Twenty-six (89.6%) patients in the control group compared with eight (28.6%) patients in the timolol group reported pain reduction by 5 or more. Both timolol and OTC were effective on headache associations: nausea, photophobia, and phonophobia. Conclusion: Both timolol and OTC are equally effective in acute migraine attacks. But OTC drugs are still preferred due to their superior abortion effect.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81282572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Serum Levels of CXCL10 in Patients with Non-Segmental Vitiligo 非节段性白癜风患者血清CXCL10水平的评估

Mansoura Veterinary Medical Journal Pub Date : 2023-03-01 DOI: 10.58775/2735-3990.1369

Sara M. Khashaba, Mohammed M Elmogy, H. F. Mohamed, Mohammad El-Nablaway, A. Ismael, MSc Dermatology, St, Abbas ElAkkad

{"title":"Assessment of Serum Levels of CXCL10 in Patients with Non-Segmental Vitiligo","authors":"Sara M. Khashaba, Mohammed M Elmogy, H. F. Mohamed, Mohammad El-Nablaway, A. Ismael, MSc Dermatology, St, Abbas ElAkkad","doi":"10.58775/2735-3990.1369","DOIUrl":"https://doi.org/10.58775/2735-3990.1369","url":null,"abstract":"Background : Vitiligo is the most common skin depigmentation disorder. Destruction of melanocytes results in depigmented skin lesions. Pathogenesis is not fully understood and mostly is multifactorial. However, the autoimmune theory is the most widely accepted one. Interaction between genetic, environmental, biochemical, and immunologic factors contribute to the disease. Cytokines have an important role in the development of the disease and its progression. Aim : The aim of the study is to measure the blood levels of C-X-C motif chemokine ligand 10 (CXCL10) in vitiligo and to correlate it with disease activity and severity. Patients and methods : This is a case e control study that enrolled 60 vitiligo patients (30 had active vitiligo and 30 had stable vitiligo) and 30 healthy age-matched and sex-matched controls. Vitiligo extent score (VES) was calculated. CXCL10 was measured in venous blood samples using enzyme-linked immunosorbent assay. Results : CXCL10 levels were signi ﬁ cantly higher among vitiligo patients compared with controls ( P < 0.001). Also, CXCL10 levels in vitiligo patients were signi ﬁ cantly higher in the active group compared with the stable group ( P < 0.001). There was statistically signi ﬁ cant positive correlation between CXCL10 levels and VES score ( P ¼ 0.003). Median CXCL10 (pg/ml) in controls was 2.38 versus 8.13 in patients. Furthermore, in vitiligo patients, the median CXCL10 (pg/ml) was 9.5 in the active group versus 7.6 in the stable group. Conclusions : Serum levels of CXCL10 were signi ﬁ cantly higher in vitiligo patients compared with healthy controls. Furthermore, patients with active vitiligo had higher levels of CXCL10 compared with the stable group. Moreover, patients with higher VES had higher CXCL10 serum levels.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"347 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80224001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, virulence genes, and antibiogram profile of Aeromonas hydrophila isolated from diseased Oreochromis niloticus and Clarias gariepinus in Dakahlia province, Egypt 埃及达喀利亚省尼罗鱼和加里平克拉虫病株嗜水气单胞菌的流行、毒力基因和抗生素谱分析

Mansoura Veterinary Medical Journal Pub Date : 2023-02-28 DOI: 10.21608/mvmj.2023.184330.1126

Marwa Genedy, Mai A. M. El‐Son, R. Adawy, V. Zaki

引用次数: 0

Naringenin attenuates Hematobiochemical and histopathological alterations induced by lead intoxication in rats 柚皮素可减轻大鼠铅中毒引起的血液生化和组织病理学改变

Mansoura Veterinary Medical Journal Pub Date : 2023-02-12 DOI: 10.21608/mvmj.2023.186736.1131

E. Risha

引用次数: 0

Comparative immunological changes in cattle vaccinated with sheep pox virus (RM-65) or sheep and goat pox virus (KSGP-0240) vaccines 接种羊痘病毒(RM-65)或绵羊和山羊痘病毒(KSGP-0240)疫苗的牛的免疫学变化比较

Mansoura Veterinary Medical Journal Pub Date : 2023-02-07 DOI: 10.21608/mvmj.2023.190298.1133

Verginia M. Farag, Yasser F. Elnaker, Mohamed Saad, Hydar Abou-Saleh, S. Atwa

引用次数: 0

Pathological, ultrastructural and hematological studies on single and combined effect of dietary supplementation with lauric and benzoic acids on Nile tilapia 饲料中单独和联合添加月桂酸和苯甲酸对尼罗罗非鱼的病理、超微结构和血液学研究

Mansoura Veterinary Medical Journal Pub Date : 2023-02-06 DOI: 10.21608/mvmj.2023.190788.1134

Abdelaziz Rabea, I. Ibrahim, Hebatallah A. Mahgoub, Ahmed Elshaieb

引用次数: 0

The effect of season and ovarian storage time on oocytes recovery and quality in dromedary camel 季节和卵巢贮存时间对单峰骆驼卵母细胞恢复和质量的影响

Mansoura Veterinary Medical Journal Pub Date : 2023-02-06 DOI: 10.21608/mvmj.2023.118019.1100

Mohamed Salah Masoud, M. Badr, H. El-Sheikh Ali

引用次数: 0

Evaluating the potential use of resveratrol in alleviating biochemical alterations, immune responses, and tissue pathology-associated with subacute malathion toxicity in Nile tilapia. 评估白藜芦醇在缓解尼罗罗非鱼亚急性马拉硫磷毒性相关的生化改变、免疫反应和组织病理方面的潜在用途。

Mansoura Veterinary Medical Journal Pub Date : 2023-01-28 DOI: 10.21608/mvmj.2023.185869.1130

Seham Gomma

引用次数: 0

Phylotypes, antimicrobial susceptibility phenotypes and virulence determinants of Escherichia coli isolates from broiler chickens infected with colibacillosis 大肠杆菌感染肉鸡大肠杆菌分离株的种型、抗菌药物敏感性表型和毒力决定因素

Mansoura Veterinary Medical Journal Pub Date : 2023-01-22 DOI: 10.21608/mvmj.2023.181997.1125

Amal Awad, W. Mohamed, G. Younis

引用次数: 0

Effect of protein reduction with indispensable amino acid supplementation at different levels in practical diets of Nile tilapia (Oreochromis niloticus) fish. 在尼罗罗非鱼实际饲料中添加不同水平必需氨基酸对蛋白质降低的影响。

Mansoura Veterinary Medical Journal Pub Date : 2023-01-22 DOI: 10.21608/mvmj.2023.164547.1122

Sara Youssef, S. Salem, Rania A. Ahmed, Tarek Ibrahim

引用次数: 0