Liver International最新文献

{"title":"MiR-126-3p and MiR-195-5p as Novel Therapeutic Attenuators of Liver Fibrosis by Targeting the IRS1/PI3K Signalling Pathway","authors":"Xia Yuan,&nbsp;Kun Zhang,&nbsp;Dan Wang,&nbsp;Jie Li,&nbsp;Peng Lyu,&nbsp;Xuemei Zhao,&nbsp;Kang Zhang,&nbsp;Hongting Li,&nbsp;Bo Liu,&nbsp;Liping Ma","doi":"10.1111/liv.70302","DOIUrl":"https://doi.org/10.1111/liv.70302","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background &amp; Aims</h3>\u0000 \u0000 <p>Hepatic fibrosis is a progressive response to chronic liver injury. A key event in the development of hepatic fibrosis is the activation of hepatic stellate cells (HSCs); emerging research indicates that microRNAs play crucial roles in regulating HSCs activation. However, the specific roles of miR-126-3p (miR-126) and miR-195-5p (miR-195) in liver fibrosis remain inadequately understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We examined the expression of miR-126 and miR-195 in activated HSCs, fibrotic liver tissues from animal models, and blood samples from patients with liver disease. The effects on cell proliferation and migration were investigated by MTT, colony formation assay, cell wound healing assay, and Transwell assay. Finally, we evaluated the effect of miR-126 and miR-195 on the progression of liver fibrosis in mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We revealed that miR-126 and miR-195 were markedly downregulated in activated HSCs, fibrotic liver tissues from animal models, and blood samples from patients with liver diseases. Functional experiments demonstrated that the overexpression of miR-126 and miR-195 significantly inhibited the proliferation, migration, and fibrotic markers expression in HSCs. Conversely, silencing miR-126 and miR-195 produced the opposite effects. Further mechanistic studies showed that miR-126 and miR-195 downregulate insulin receptor substrate 1 (IRS1) or phosphoinositide 3-kinase regulatory subunit 2 (PIK3-R2), respectively, thereby inhibiting the pro-fibrotic signalling pathway (IRS1/PI3K) and regulating the functions of HSCs. Importantly, in vivo experiments demonstrated that miR-126 and miR-195 markedly alleviated CCL₄-induced hepatic fibrosis in mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results unravel that miR-126 and miR-195 inhibit liver fibrosis by suppressing the IRS/PI3K pathway.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Grade Hepatotoxicity From Dual Checkpoint Inhibitors Is More Common in Hepatocellular Carcinoma Than Other Cancers.","authors":"Elsie Ennin, Niharika Mallepally, Myra Ali, Layla Shojaie, Sean Dewberry, Melissa Trieu, Evanthia T Roussos Torres, Kali Zhou, Jeffrey Kahn, Jennifer L Dodge, Lily Dara","doi":"10.1111/liv.70255","DOIUrl":"10.1111/liv.70255","url":null,"abstract":"<p><strong>Background & aims: </strong>Immune checkpoint inhibitors (ICIs) are therapy for many malignancies including hepatocellular carcinoma (HCC), yet the impact of HCC on immune-mediated liver injury from checkpoint inhibitors (ILICI) remains poorly understood and no direct comparison exists for hepatotoxicity rates between ICI and sorafenib in HCC.</p><p><strong>Methods: </strong>In this retrospective cohort study, we extracted data on adult patients treated with five ICI regimens for HCC or non-HCC cancers, and HCC patients who received sorafenib between 2010 and 2020. The primary outcome was grade ≥ 3 ILICI or sorafenib (DILI). Logistic regression estimated adjusted odds ratios (OR) for liver injury.</p><p><strong>Results: </strong>We identified 530 patients, 129 (24%) HCC-ICI, 256 (48%) non-HCC ICI, and 145 (27%) HCC-sorafenib. Compared to non-HCC ICI, HCC-ICI and HCC-sorafenib were more often male (57%, 82%, 77%), Hispanic (14%, 35%, 34%), and cirrhotic (1%, 85%, 88%). Twenty-three patients developed grade ≥ 3 ILICI. ILICI incidence was higher for HCC-ICI (11%, CI 6-18) versus non-HCC ICI (4%, CI 2-6, p = 0.006) and DILI in HCC-sorafenib (3%, CI 1-8, p = 0.02) with incidence highest for ipilimumab-nivolumab (HCC-ICI 42%, CI 15-72 versus non-HCC 10%, CI 3-24; p = 0.02). On multivariable regression, ILICI was associated with HCC (OR 4.5, CI 1.8-11.4, p = 0.002) and treatment with ipilimumab-nivolumab (OR 6.9, CI 2.6-18.3, p < 0.001). Incidence of liver injury in HCC remained elevated for ICI versus sorafenib (OR 3.5, CI 1.2-10.4, p = 0.02).</p><p><strong>Conclusions: </strong>We identified an elevated risk of liver injury in HCC patients receiving ICIs compared to ICI-treated non-HCC cancers and sorafenib-treated HCC, with dual ipilimumab-nivolumab therapy carrying the highest risk.</p>","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 9","pages":"e70255"},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: “The Role of Platelets in MASLD: From Mechanisms to Clinical Implications”","authors":"Marco Castelli,&nbsp;Mirko Zoncapè,&nbsp;Alessandra Meneguzzi,&nbsp;Anna Mantovani,&nbsp;David Sacerdoti,&nbsp;Pietro Minuz,&nbsp;Andrea Dalbeni","doi":"10.1111/liv.70304","DOIUrl":"https://doi.org/10.1111/liv.70304","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Completely Occlusive Portal Vein Thrombosis as a Predictor of Mortality in Acute Variceal Bleeding","authors":"Xiaoze Wang,&nbsp;Ju Huang,&nbsp;Guofeng Liu,&nbsp;Tong Xiang,&nbsp;Yazhou He,&nbsp;Shang Wan,&nbsp;Ziqi Chen,&nbsp;Li Yang,&nbsp;Xuefeng Luo","doi":"10.1111/liv.70272","DOIUrl":"https://doi.org/10.1111/liv.70272","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Risk stratification plays a critical role in acute variceal bleeding (AVB) management, while portal vein thrombosis (PVT) has uncertain prognostic significance in AVB.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to investigate the impact of PVT on the prognosis of patients with cirrhosis and AVB, with a particular focus on the influence of PVT severity stratification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted on 1389 cirrhotic patients with PVT (<i>n</i> = 292, 21.1%) and without PVT (<i>n</i> = 1096, 78.9%) admitted between 2016 and 2022 due to AVB. Patients were stratified based on PVT presence and severity according to the AASLD criteria. Propensity score matching was applied to balance baseline characteristics. The primary endpoint was 6-week mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall 6-week mortality was 8.6%. Patients with PVT had a similar risk of mortality compared with those without PVT (10.14% vs. 8.10%; HR 1.26, 95% CI 0.81–1.96, <i>p</i> = 0.306). However, complete occlusive PVT was associated with significantly higher 6-week mortality compared to non-PVT patients (35.3% vs. 8.1%; HR 5.61, 95% CI 2.61–11.90, <i>p</i> &lt; 0.001). Transjugular intrahepatic portosystemic shunt (TIPS) could reduce the risk in these patients (0% vs. 44.4%; HR 0.22, 95% CI 0.05–0.97, <i>p</i> = 0.046).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients with completely occlusive PVT had a higher risk of 6-week mortality after AVB. These findings highlight the importance of incorporating PVT severity into AVB risk stratification and support considering TIPS in high-risk patients, although the benefit of preemptive TIPS needs further investigation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding ‘Effects of Remote Ischemic Conditioning on Postoperative Recovery After Hepatectomy’","authors":"Shunsheng Wang","doi":"10.1111/liv.70319","DOIUrl":"https://doi.org/10.1111/liv.70319","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Clinical Implications of High Spleen-To-Liver Stiffness Ratio in MASH—A Prospective, Comparative Study","authors":"Christian Sebesta,&nbsp;Mathias Jachs,&nbsp;Lukas Hartl,&nbsp;Michael Schwarz,&nbsp;Lorenz Balcar,&nbsp;Benedikt S. Hofer,&nbsp;Nina Dominik,&nbsp;Georg Kramer,&nbsp;Bernhard Scheiner,&nbsp;Albert F. Stättermayer,&nbsp;Benedikt Simbrunner,&nbsp;Till Schöchtner,&nbsp;Friedrich Haimberger,&nbsp;Nicolas Balutsch,&nbsp;Michael Trauner,&nbsp;Mattias Mandorfer,&nbsp;Thomas Reiberger,&nbsp;David J. M. Bauer","doi":"10.1111/liv.70261","DOIUrl":"https://doi.org/10.1111/liv.70261","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Liver stiffness measurement (LSM) and spleen stiffness measurement (SSM) represent non-invasive surrogates of portal hypertension (PH) that both correlate with hepatic venous pressure gradient (HVPG). SSM may overcome limitations of HVPG and LSM in detecting presinusoidal PH components. We investigated the SSM/LSM ratio as a PH surrogate and its relationship to HVPG and spleen diameter across different liver disease aetiologies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>399 consecutive patients with compensated liver disease undergoing same-day measurement of HVPG, LSM and SSM were prospectively included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>While patients with alcohol-related liver disease (ALD; <i>n</i> = 200) showed higher LSM (median: 45.5 kPa) and HVPG (15.0 mmHg) than patients with metabolic dysfunction–associated steatohepatitis (MASH; <i>n</i> = 49; LSM: 20.9 kPa; HVPG: 12.0 mmHg), their SSM (median: 58.8 vs. 52.8 kPa; <i>p</i> = 0.868) was not significantly different. Consequently, the SSM/LSM ratio was higher in MASH (1.66) vs. ALD (1.28), but highest in patients with non-cirrhotic PH (3.19). When adjusting for HVPG, SSM and spleen diameter remained significantly higher in MASH than in ALD at any given HVPG.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrates that SSM/LSM ratios vary across different liver disease aetiologies. Since MASH patients—after adjusting for liver disease severity—show higher SSM/LSM ratios and larger spleen diameters than ALD, our results support the concept of a presinusoidal component of PH in MASH patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/liv.70261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appraisal of AI-Based Fibrosis Quantification in MASH","authors":"Jiamin Wang,&nbsp;Jingyi Li","doi":"10.1111/liv.70320","DOIUrl":"https://doi.org/10.1111/liv.70320","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Cytoprotective Effects of Taurocholic Acid Feeding on the Biliary Tree after Adrenergic Denervation of the Liver","authors":"","doi":"10.1111/liv.70267","DOIUrl":"https://doi.org/10.1111/liv.70267","url":null,"abstract":"<p>\u0000 <b>RETRACTION:</b> <span>Marzioni, M.</span> <span>Ueno, Y.</span> <span>Glaser, S.</span> <span>Francis, H.</span> <span>Benedetti, A.</span> <span>Alvaro, D.</span> <span>Venter, J.</span> <span>Fava, G.</span> <span>Alpini, G.</span> <span>Cytoprotective Effects of Taurocholic Acid Feeding on the Biliary Tree after Adrenergic Denervation of the Liver</span> <i>Liver International</i> <span>27</span> no. <span>4</span> <span>2007</span> <span>558</span> <span>568</span> https://doi.org/10.1111/j.1478-3231.2007.01443.x\u0000 </p><p>The above article, published online on 16 February 2007 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Luca Valenti; and John Wiley &amp; Sons Ltd. An institutional representative notified the publisher that a joint institutional investigation had found evidence of image manipulation in Figure 3, as part of their investigation into claims of research misconduct by author Gianfranco Alpini. An investigation by the publisher confirmed that elements in the figure had been duplicated and resized in Figures 1C, 2C, and 3. Additionally, the institutional investigation found that that the same immunoblot band was used to represent different experimental conditions in two previously published articles (Marzioni et al., 2005 [https://doi.org/10.1053/j.gastro.2004.10.002]; Marzioni et al., 2003 [https://doi.org/10.1152/ajpgi.00398.2002]). This retraction has been agreed due to the evidence of image manipulation and reuse which fundamentally compromises the conclusions presented in the article. No evidence of misconduct was found for the other authors.</p>","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/liv.70267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MEF2D Aggravates Hepatic Ischaemia–Reperfusion Injury by Transcriptionally Regulating CXCL1 Through Interacting With NAT10","authors":"Zhigao Deng,&nbsp;Zhongshan Lu,&nbsp;Quanwei Cheng,&nbsp;Liyang Pan,&nbsp;Lihua Zhou,&nbsp;Wei Zhou,&nbsp;Chengbiao Xue,&nbsp;Zhongzhong Liu,&nbsp;Qifa Ye,&nbsp;Rui Zhou,&nbsp;Yan Xiong,&nbsp;Shaojun Ye","doi":"10.1111/liv.70315","DOIUrl":"https://doi.org/10.1111/liv.70315","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Hepatic ischaemia–reperfusion injury (IRI), a common complication after hepatectomy and liver transplantation (LT), is a local sterile inflammatory response driven by innate immunity. Myocyte enhancer factor-2D (MEF2D) plays an important role in immune inflammatory response by transcriptionally activating or inhibiting gene expression, which is tightly associated with the pathogenic progression of hepatic disorders. However, the role of MEF2D in hepatic IRI is still unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, we measured MEF2D expression in liver tissue from LT patients, mice subjected to hepatic I/R surgery, and hepatocytes challenged by hypoxia/reoxygenation (H/R) treatment. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, tissue pathology, inflammatory cell infiltration, inflammatory factor expression and apoptosis were used to evaluate liver injury and function in these models. We further explored the regulatory mechanisms of MEF2D in the murine liver IRI model by using hepatocyte-specific MEF2D knockout mice in the liver IRI model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We observed that MEF2D expression was significantly up-regulated after liver I/R in both humans and mice. Notably, high MEF2D levels in human I/R liver specimens were strongly associated with poor prognosis after LT. Additionally, hepatocyte-specific MEF2D deficiency significantly alleviated I/R-induced liver injury and inhibited the hepatic inflammatory response and apoptosis. Mechanistically, MEF2D interacted with NAT10, which increased the transcriptional activity of MEF2D by acetylating its K279 lysine site, thereby promoting the transcription of <i>CXCL1</i>. Moreover, inhibition of NAT10 effectively ameliorated hepatic IRI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>NAT10-induced MEF2D acetylation aggravates hepatic IRI by positively regulating transcription of <i>CXCL1</i> in hepatocytes, which provides a promising therapeutic target for hepatic IRI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Models for BCS: Ideals Meet Reality","authors":"Dongdong Xia,&nbsp;Guohong Han","doi":"10.1111/liv.70317","DOIUrl":"https://doi.org/10.1111/liv.70317","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}