Magnetic Resonance in Medicine最新文献

{"title":"Time-resolved mapping of myocardial stiffness using 2D multifrequency spiral MR elastography with and without external vibration","authors":"","doi":"10.1002/mrm.70107","DOIUrl":"https://doi.org/10.1002/mrm.70107","url":null,"abstract":"","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":"94 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mrm.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic determination of glymphatic flow with the DTI-ALPS-index along the principal axis system in native imaging space corrects for head and fiber orientation.","authors":"Ali Ajouz, Olav Jansen, Lynn Johann Frohwein, Svea Seehafer, Naomi Larsen, Jan-Bernd Hövener","doi":"10.1002/mrm.70082","DOIUrl":"https://doi.org/10.1002/mrm.70082","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this work is to make the DTI along the perivascular space (DTI-ALPS-index) more robust with respect to region selection and the orientation of the head and fibers. We propose to address this matter by using the principal diffusion directions and an automated, atlas-based region of interest (ROI) placement.</p><p><strong>Methods: </strong>Simulations were used to determine the dependence of the DTI-ALPS-index on the orientations of the head and nerve fibers. Human MRI was performed on 12 healthy volunteers at 3T using a 64 channel head coil (Cima.X Siemens), and the DTI-ALPS-index was calculated along the principal diffusion directions (ALPS-PAS) and along the field of view or laboratory frame (ALPS-LAB). To calculate the DTI-ALPS-index with reduced bias in native space, we developed a novel algorithm for an automatic ROI placement technique. Its calculated index results  were compared to those obtained from a manual ROIplacement in native space and from an existing atlas-based ROI placement. Test-retest scans with varying head rotation were conducted for validation.</p><p><strong>Results: </strong>Simulations showed that ALPS-PAS was more robust toward head and fiber rotations than ALPS-LAB. In vivo, ALPS-PAS yielded a 10% higher index than ALPS-LAB. The automated ROI placement led to a smaller difference in the DTI-ALPS-index between test and retest measurement compared to the manual ROI placement. Stability was enhanced with ALPS-PAS for all ROI placements and varying head rotation.</p><p><strong>Conclusion: </strong>Using the principal components of the diffusion and automated ROI selection increased the measured DTI-ALPS-index, improved the robustness toward head and fiber orientations and eliminated the need for manual region selection.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making RF coils MR-invisible by additive manufacturing using magnetically filled polymer.","authors":"Markus Weiger, Johan Overweg, Amelie Viol, Lauro Singenberger, Thomas Schmid, Emily Louise Baadsvik, Klaas Paul Pruessmann","doi":"10.1002/mrm.70115","DOIUrl":"https://doi.org/10.1002/mrm.70115","url":null,"abstract":"<p><strong>Purpose: </strong>Short-T₂ MRI is sensitive not only to targeted tissues but also to signals from materials in RF coils, which can lead to image background artifacts. Current solutions to this problem either compromise imaging performance or impose restrictions on coil design. The goal of the present work is to make RF coils MR-invisible without such drawbacks.</p><p><strong>Methods: </strong>Effective spoiling of unwanted signals from the housing of RF coils is achieved by filling the material used to construct the housing with magnetic particles. This concept is demonstrated by creating coil formers through additive manufacturing with custom filaments made from magnetite-filled polymer.</p><p><strong>Results: </strong>Unwanted signals from the RF coil are effectively eliminated by using coil formers made from magnetically filled polymer. In this fashion, background-free short-T₂ imaging is enabled.</p><p><strong>Conclusion: </strong>Making RF coils MR-invisible by using magnetically filled materials simplifies coil design and manufacturing and renders the alteration of MR sequences unnecessary, thereby improving the performance of MRI of tissues with short T₂s.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recipe for Hydrogels With Tunable Relaxation and Diffusion Properties for Use as MRI Test Materials.","authors":"V Fritz, F Schick","doi":"10.1002/mrm.70120","DOIUrl":"https://doi.org/10.1002/mrm.70120","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and evaluate a preparation protocol (recipe) for hydrogels with specific relaxation times and ADC values to be used as tissue-like test materials for MRI experiments at 3 Tesla.</p><p><strong>Methods: </strong>Gd-DTPA, agarose, and soy lecithin were used as modulators for T1, T2, and ADC. First, systematic measurements were performed to determine the relaxation- and diffusion-modifying properties of the single substances and combinations of them. An algorithm was developed to determine the necessary concentrations of the ingredients to achieve predetermined sets of target values (T1, T2, and ADC). To validate this approach, hydrogels mimicking the relaxation and diffusion properties of different tissues (pancreas, white matter, fibroglandular tissue, liver, prostate) were prepared and evaluated. All measurements (relaxometry, diffusion-weighted imaging) were performed on a 3 Tesla clinical scanner at 20°C.</p><p><strong>Results: </strong>The proposed method allowed the preparation of hydrogels with specific diffusion and relaxation properties by adjusting the concentrations of Gd-DTPA, agarose, and soy lecithin. Test phantoms containing hydrogels for simulation of various tissue types showed good agreement between targeted and measured properties, with deviations of less than 8% for T1, 7.5% for T2, and 11.5% for ADC. With the present approach, the properties (T1, T2, and ADC) of most known tissue classes could be well approximated; only the gray matter of the brain was slightly outside the selectable range. Temporal stability over 3 months was acceptable.</p><p><strong>Conclusion: </strong>This work provides a relatively simple, inexpensive, and reproducible method for the preparation of hydrogels with independently adjustable T1, T2, and ADC values at 3 T.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartesian MaxGIRF: Model-based EPI reconstruction incorporating gradient nonlinearity and concomitant field effects.","authors":"Nam G Lee, Sophia X Cui, Krishna S Nayak","doi":"10.1002/mrm.70113","DOIUrl":"https://doi.org/10.1002/mrm.70113","url":null,"abstract":"<p><strong>Purpose: </strong>Lower field strength scanners with large bore size or complex geometries, and scanners with stronger gradient systems experience increased gradient nonlinearity and concomitant fields, each of which causes distortions in EPI. Current correction approaches based on image-domain interpolation introduce undesirable spatial blurring. To avoid spatial blurring, we introduce a model-based EPI reconstruction framework, denoted Cartesian MaxGIRF (\"Max\"well field correction using \"GIRF\"-predicted gradients), that simultaneously compensates the effects of concomitant fields, gradient nonlinearity, and off-resonance during image reconstruction.</p><p><strong>Theory and methods: </strong>Performance of the proposed framework was compared against standard correction methods using phantom datasets at 0.55T: (1) 2D spin-echo EPI (SE-EPI) with reversed phase-encoding directions and (2) accelerated 2D SE-EPI with partial Fourier. Two unique EPI image artifacts induced by concomitant fields (\"parabolic shift\" and \"slice-dependent Nyquist ghost\") were demonstrated and mitigated by the proposed framework using long-ETL 3D GRE-EPI and high-resolution 3D GRE-EPI, respectively. Resolution improvements and artifact mitigations by the proposed framework were demonstrated using in-vivo human brain datasets: (1) accelerated 2D diffusion-weighted SE-EPI and (2) high-resolution 3D GRE-EPI at 0.55T.</p><p><strong>Results: </strong>The amount of the parabolic shift for each imaging case was theoretically analyzed. The proposed framework demonstrated the mitigation of both parabolic shifts and slice-dependent Nyquist ghosts and retained better image details than standard correction methods when mitigating geometric distortions for all scenarios.</p><p><strong>Conclusion: </strong>The Cartesian MaxGIRF framework simultaneously mitigates the effects of concomitant fields, gradient nonlinearity, and static off-resonance. This approach is particularly useful to mitigate artifacts induced by second-order concomitant fields present in both symmetric and asymmetric gradient systems.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective compensation of second-order concomitant fields in a high-performance gradient system using a second-order harmonic shim coil.","authors":"Afis Ajala, Thomas K F Foo, Seung-Kyun Lee","doi":"10.1002/mrm.70094","DOIUrl":"https://doi.org/10.1002/mrm.70094","url":null,"abstract":"<p><strong>Purpose: </strong>The use of high-performance gradient coils results in stronger spatially dependent second-order concomitant magnetic fields, which can lead to signal dropout, blurring artifacts and phase errors that become more significant at locations farther from the gradient isocenter. A correction coil-based method for prospectively compensating second-order concomitant fields in higher-performance gradient systems is described.</p><p><strong>Methods: </strong>An insertable, axially symmetric second-order field coil to prospectively correct for second-order concomitant field-induced phase errors on a high-performance head-only gradient system at 3.0T was developed. The efficacy of the second-order concomitant-field correction was demonstrated in phantom and healthy volunteer scans using 2D phase contrast (PC) and spiral gradient echo (GRE) imaging.</p><p><strong>Results: </strong>By employing the correction coil, there was a significant reduction in second-order concomitant field-induced blurring in the 2D spiral images, and reduction in phase errors and signal degradation in the GRE PC images. In the single-sided PC, the z- and radially-directed second-order concomitant phase accrued in the coronal and axial PC acquisition was reduced by 100% and 83%, respectively. Signal enhancement up to 968.9% was obtained in the two-sided PC acquisitions. In spiral GRE images, blurring was reduced by ˜40.2% at 60 mm from the gradient isocenter in a phantom. Correspondingly, the reduction in concomitant field-induced blurring in in-vivo spiral GRE images was noted with the correction coil.</p><p><strong>Conclusions: </strong>The described second-order correction coil insert prospectively compensates erroneous phase accruals due to second-order concomitant fields on a high-performance gradient system at the source, complementing or replacing software corrections/compensations during image reconstruction.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust Extrapolated Semi-Solid Magnetization Transfer Reference Fitting for Quantitative Amide Proton Transfer Imaging at 3 T: Application to Patients With Mild Cognitive Impairment and Mild Dementia.","authors":"Jingpu Wu, Zongpai Zhang, Isabel M Rios Pulgar, Shanshan Jiang, Puyang Wang, Keyi Chai, Arvind P Pathak, Kenichi Oishi, Yuguo Li, Jee Bang, Abhay Moghekar, Carrie Wagandt, Gwenn S Smith, Chiadi U Onyike, Gregory M Pontone, Arnold Bakker, Jinyuan Zhou","doi":"10.1002/mrm.70122","DOIUrl":"https://doi.org/10.1002/mrm.70122","url":null,"abstract":"<p><strong>Purpose: </strong>To refine the utility of the extrapolated semi-solid magnetization transfer reference (EMR) method for amide proton transfer (APT) quantification.</p><p><strong>Methods: </strong>Twelve patients (7 mild cognitive impairment and 5 mild dementia; 66.3 ± 8.7 years) and 13 age-matched, cognitively normal volunteers (68.6 ± 8.0 years), as well as a 10% cross-linked bovine-serum-albumin phantom, were scanned at 3 T. A two-step, coarse-to-fine EMR fitting approach was developed, and a bias term was introduced to compensate for the discrepancy between the ideal model and practical data. The fitted model parameters and calculated APT^# and NOE^# (nuclear Overhauser effect) were compared across different EMR fitting methods and between the two groups. The normalized-root-mean-squared-error was used to measure the discrepancy between fitted curves and acquired Z-spectra.</p><p><strong>Results: </strong>Phantom results confirmed that the proposed EMR method had lower fitting errors and closer-to-zero APT^# and NOE^# signals. Human results showed the specific APT^# signals peaked at 3.5 ppm. A noticeable APT^# increase in the hippocampus was seen in the mild cognitive impairment/mild dementia group (mean APT^# = 3.09%, compared to 2.41% in the cognitively normal group; p = 0.002). The APT^# signal in the hippocampus provided higher accuracy in differentiating between cognitively normal individuals and those with mild cognitive impairment/mild dementia than APT-weighted signal (an area-under-the-curve of 0.92 compared to 0.67).</p><p><strong>Conclusion: </strong>The proposed EMR method enabled more accurate quantification of APT signals and could potentially facilitate the use of APT imaging in the diagnosis and staging of Alzheimer's disease and related dementias.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radial TRASE: 2D RF encoding through mechanical rotation and active digital decoupling.","authors":"Christopher J Sedlock, Aaron R Purchase, Boguslaw Tomanek, Jonathan C Sharp","doi":"10.1002/mrm.70104","DOIUrl":"https://doi.org/10.1002/mrm.70104","url":null,"abstract":"<p><strong>Purpose: </strong>Two-dimensional (2D) transmit array spatial encoding (TRASE) previously required four radiofrequency fields; however, interactions between transmit (Tx) array elements caused significant challenges for 2D imaging. Here, we present a low-cost, 2D radial encoding scheme (Radial TRASE) using a simplified two-coil array.</p><p><strong>Theory and methods: </strong>The system consists of two B₁ phase gradient coils capable of encoding any one transverse direction. By incremental mechanical rotation over a 90° range, the encoding axis can be changed, allowing a complete radial k-space acquisition. As a first demonstration, a wrist-sized coil pair was experimentally verified on a 2-MHz Halbach magnet, incorporating a static B₀ slice-selection gradient. Although a high level of isolation is achievable geometrically, for a more robust implementation, we demonstrate the capability of active digital decoupling in eliminating residual coupling through a parallel-transmit system.</p><p><strong>Results: </strong>Radial TRASE-encoded images of water phantoms were acquired, achieving a resolution better than 1.67 mm. Rotation of the Tx array was performed during the recovery period, which caused no imaging delays. All acquired images show minimal distortions, indicating the advantage of the simplified Tx array. The active digital decoupling technique is demonstrated to eliminate residual coupled currents, effectively increasing the isolation of the two-coil array to -50 dB. Sequential axial slice images were demonstrated using a uniform B₀ coil to shift the slice position.</p><p><strong>Conclusion: </strong>Two-coil Radial TRASE can encode a 2D slice without rapidly switched B₀ gradients. Compared with previous three-coil or four-coil Cartesian TRASE, the design and isolation of the Tx array are significantly simplified.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid whole-brain T₂* and susceptibility mapping using 3D multiple overlapping-echo detachment acquisition and missing modality synthesis embedded simulation.","authors":"Qinqin Yang, Longkun Chen, Nuowei Ge, Jie Chen, Jingying Yang, Zejun Wu, Chenyang Dai, Shuhui Cai, Zhong Chen, Lijun Bao, Liuhong Zhu, Jianfeng Bao, Congbo Cai","doi":"10.1002/mrm.70108","DOIUrl":"https://doi.org/10.1002/mrm.70108","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a 3D multiple overlapping-echo detachment (3D-MOLED) imaging technique, along with data generation and reconstruction strategies, for rapid whole-brain T₂* and QSM.</p><p><strong>Methods: </strong>MOLED encoding was extended to a 3D multi-shot acquisition and combined with dual-echo blip-reversed EPI trains to simultaneously acquire T₂* and QSM signals while reducing image distortion. To enable Bloch simulation for training data generation, a deep learning-based missing modality synthesis approach was employed to produce co-registered multi-parametric templates. In addition, a pseudo-3D Bloch simulation was proposed to accelerate synthetic data generation for network training. A cohort of healthy volunteers and clinical participants were recruited to evaluate the motion robustness of the proposed method in comparison with conventional 3D-GRE.</p><p><strong>Results: </strong>Compared to 3D-GRE, 3D-MOLED achieved significant improvements in both scan speed and motion robustness, with over 70% of scans rated as good image quality in both healthy and clinical cohorts. The missing modality synthesis approach generated high-quality 3D multi-parametric maps. Combined with the pseudo-3D Bloch simulation framework, it enabled efficient generation of paired training data with acceptable computational cost, thereby facilitating accurate quantitative mapping.</p><p><strong>Conclusion: </strong>3D-MOLED enables simultaneous whole-brain T₂* and QSM mapping at 1 mm isotropic resolution in 50 s, offering superior motion robustness compared to conventional 3D-GRE.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceleration of slice encoding for metal artifact correction at 0.55 T using hexagonal sampling.","authors":"Bahadır Alp Barlas, Kübra Keskin, Bochao Li, Brian A Hargreaves, Krishna S Nayak","doi":"10.1002/mrm.70077","DOIUrl":"https://doi.org/10.1002/mrm.70077","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate a hexagonal sampling approach for accelerated slice encoding for metal artifact correction (SEMAC) at 0.55 T. Contemporary mid-field systems (0.1 T-1.0 T) show tremendous potential for imaging near metal implants. However, the limited parallel-imaging options necessitate alternative methods for scan time reduction.</p><p><strong>Methods: </strong>We apply retrospective hexagonal undersampling to current state-of-the-art SEMAC with 2-fold generalized autocalibrating partially parallel acquisitions-based parallel imaging at 0.55 T. The hexagonal sampling approach results in an additional 50% scan time reduction. Feasibility is evaluated with phantom experiments involving spinal fixation and total hip arthroplasty hardware, and in vivo experiments involving patients with spinal fusions with varying compositions and 1 volunteer with a total hip arthroplasty.</p><p><strong>Results: </strong>Hexagonal sampling provides an additional 50% scan time reduction with compatible image quality. The two tradeoffs are (i) a small increase in signal void due to the loss of signal from one SEMAC spectral bin during post-acquisition filtering and (ii) position-dependent signal-to-noise-ratio reduction at locations close to the edge of the field of view in the phase-encoding direction.</p><p><strong>Conclusion: </strong>We demonstrate that hexagonal sampling can provide 50% scan time reduction in addition to generalized autocalibrating partially parallel acquisitions/parallel imaging for SEMAC at 0.55 T without introducing substantial artifacts. This may be a valuable mechanism for reducing scan time at 0.55 T and other midfield strengths, where parallel-imaging acceleration is limited.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}