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D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS最新文献

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PLN-74809, a Dual-Selective Inhibitor of Integrins αvβ6 and αvβ1, Shows Dose-Dependent Target Engagement in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF) 整合素αvβ6和αvβ1的双选择性抑制剂PLN-74809在特发性肺纤维化(IPF)患者的肺中显示剂量依赖性靶标作用
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5254
J. Mooney, K. Morris, S. Jacobs, E. Lefebvre, G. Cosgrove, S. Wong, J. Bellini, M. Jurek, S. Turner, M. Decaris, R. Jiron, B. Williams, H. Duan, R. Gunn, G. Rizzo, M. Wardak, H.H. Guo
{"title":"PLN-74809, a Dual-Selective Inhibitor of Integrins αvβ6 and αvβ1, Shows Dose-Dependent Target Engagement in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF)","authors":"J. Mooney, K. Morris, S. Jacobs, E. Lefebvre, G. Cosgrove, S. Wong, J. Bellini, M. Jurek, S. Turner, M. Decaris, R. Jiron, B. Williams, H. Duan, R. Gunn, G. Rizzo, M. Wardak, H.H. Guo","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5254","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5254","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125756817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of Remodilins - a Novel Class of Small Molecules That Inhibit Myofibroblast Differentiation of Human Lung Fibroblasts and Pulmonary Fibrosis in Mice 一种抑制人肺成纤维细胞分化和小鼠肺纤维化的新型小分子Remodilins的发现
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5250
B. Chen, C.Y. Park, L. Diane, E. B. Reed, J. Wang, R. Krishnan, V. Gurvich, S. Byrn, D. Maloney, M. Rosner, N. Prabhakar, J. Nanduri, G. Mutlu, R. Amy, S. White, B. Laxman, S. Kales, D. Tao, G. Bantukallu, A. Simeonov, M. Muzzio, R. Moellering, J. Huang, L. Hwang, D. Mccormick, J. Fredberg, J. Solway, N. O. Dulin
{"title":"Discovery of Remodilins - a Novel Class of Small Molecules That Inhibit Myofibroblast Differentiation of Human Lung Fibroblasts and Pulmonary Fibrosis in Mice","authors":"B. Chen, C.Y. Park, L. Diane, E. B. Reed, J. Wang, R. Krishnan, V. Gurvich, S. Byrn, D. Maloney, M. Rosner, N. Prabhakar, J. Nanduri, G. Mutlu, R. Amy, S. White, B. Laxman, S. Kales, D. Tao, G. Bantukallu, A. Simeonov, M. Muzzio, R. Moellering, J. Huang, L. Hwang, D. Mccormick, J. Fredberg, J. Solway, N. O. Dulin","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5250","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5250","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"238 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115655970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma Biomarkers of Inflammation and Lung Injury in Obese Surgical Patients Ventilated with Low vs. High Positive End-Expiratory Pressure and Lung Recruitment Maneuvers - A Substudy of the PROBESE Randomized Controlled Trial 低与高呼气末正压通气和肺招募操作的肥胖手术患者炎症和肺损伤的血浆生物标志物- PROBESE随机对照试验的亚研究
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5252
M. Scharffenberg, T. Bluth, J. Wittenstein, R. Huhle, T. Koch, P. Pelosi, M. Schulz, J. Sprung, M. Gama de Abreu
{"title":"Plasma Biomarkers of Inflammation and Lung Injury in Obese Surgical Patients Ventilated with Low vs. High Positive End-Expiratory Pressure and Lung Recruitment Maneuvers - A Substudy of the PROBESE Randomized Controlled Trial","authors":"M. Scharffenberg, T. Bluth, J. Wittenstein, R. Huhle, T. Koch, P. Pelosi, M. Schulz, J. Sprung, M. Gama de Abreu","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5252","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5252","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"206 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121244068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Different Levels of Positive End-Expiratory Pressure on Regional Distribution of Pulmonary Perfusion During One-Lung-Ventilation in Pigs 不同呼气末正压水平对猪单肺通气时肺灌注区域分布的影响
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5256
J. Wittenstein, M. Scharffenberg, J. Fröhlich, C. Rothmann, X. Ran, Y. Zhang, Y. Chai, X. Yang, S. Müller, T. Koch, R. Huhle, M. Gama de Abreu
{"title":"Effects of Different Levels of Positive End-Expiratory Pressure on Regional Distribution of Pulmonary Perfusion During One-Lung-Ventilation in Pigs","authors":"J. Wittenstein, M. Scharffenberg, J. Fröhlich, C. Rothmann, X. Ran, Y. Zhang, Y. Chai, X. Yang, S. Müller, T. Koch, R. Huhle, M. Gama de Abreu","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5256","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5256","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129044180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aged Ferrets Demonstrate Decreased Whole Lung Mucociliary Clearance at Baseline and Worse Fibrotic Remodeling Following Bleomycin Injury Compared to Young Ferrets 与年轻雪貂相比，老年雪貂在博莱霉素损伤后表现出全肺粘膜纤毛清除率降低和纤维化重塑恶化
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5805
J.E. Peabody Lever, S. S. Hussain, H. Kim, E. Onuoha, M.Q. Sonnier, S. Gowda, D. Stanford, J. P. Kennemur, S. Thomas, E. McMillian, S. Samuel, Q. Li, J. Campos-Gómez, S.E. Phillips, S. Rowe
{"title":"Aged Ferrets Demonstrate Decreased Whole Lung Mucociliary Clearance at Baseline and Worse Fibrotic Remodeling Following Bleomycin Injury Compared to Young Ferrets","authors":"J.E. Peabody Lever, S. S. Hussain, H. Kim, E. Onuoha, M.Q. Sonnier, S. Gowda, D. Stanford, J. P. Kennemur, S. Thomas, E. McMillian, S. Samuel, Q. Li, J. Campos-Gómez, S.E. Phillips, S. Rowe","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5805","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5805","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121825765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene-Based Collapsing Genetic Analyses to Identify Rare Protein-Coding Variants Associated with Susceptibility to Idiopathic Pulmonary Fibrosis (IPF): Data from the IPF-PRO Registry 基于基因的崩溃遗传分析鉴定与特发性肺纤维化(IPF)易感性相关的罕见蛋白质编码变异:来自IPF- pro注册的数据
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5258
G. Povysil, J. Todd, A. Allen, D. Dilling, H.J. Kim, M. Neely, I. Noth, Z. Ren, L. Snyder, M. Strek, A. Swaminathan, D. Zhang, C. Hesslinger, T. Leonard, D. Goldstein, S. Palmer, on behalf of the IPF-PRO Registry investigators
{"title":"Gene-Based Collapsing Genetic Analyses to Identify Rare Protein-Coding Variants Associated with Susceptibility to Idiopathic Pulmonary Fibrosis (IPF): Data from the IPF-PRO Registry","authors":"G. Povysil, J. Todd, A. Allen, D. Dilling, H.J. Kim, M. Neely, I. Noth, Z. Ren, L. Snyder, M. Strek, A. Swaminathan, D. Zhang, C. Hesslinger, T. Leonard, D. Goldstein, S. Palmer, on behalf of the IPF-PRO Registry investigators","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5258","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5258","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134644879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterogeneous Changes in Airspace Morphometry During Murine Acute Lung Injury 小鼠急性肺损伤时空气形态的异质性变化
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5247
M. Osovskaya, J. Bilodeaux, A. Wallbank, H. Farooqi, B.J. Smith
{"title":"Heterogeneous Changes in Airspace Morphometry During Murine Acute Lung Injury","authors":"M. Osovskaya, J. Bilodeaux, A. Wallbank, H. Farooqi, B.J. Smith","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5247","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5247","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133329183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Training Dataset Composition on Model Predictive Accuracy in Two-Hit Models of Acute- and Ventilator-Induced Lung Injury 训练数据集组成对急性和呼吸机诱导肺损伤双击模型预测准确性的影响
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5257
B.J. Smith, J. Bilodeaux, A. Wallbank, H. Farooqi, A. Benjamin
{"title":"The Effect of Training Dataset Composition on Model Predictive Accuracy in Two-Hit Models of Acute- and Ventilator-Induced Lung Injury","authors":"B.J. Smith, J. Bilodeaux, A. Wallbank, H. Farooqi, A. Benjamin","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5257","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5257","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"21 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116235672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treprostinil, an EP-2 Agonist, Decreases Lung Fibroblasts Extra-Cellular Matrix Production in a cAMP Dependent Manner Treprostinil，一种EP-2激动剂，以cAMP依赖的方式减少肺成纤维细胞胞外基质的产生
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5248
S. Orfanos, G. Cao, B. Deeney, V. Parikh, R. Panettieri
{"title":"Treprostinil, an EP-2 Agonist, Decreases Lung Fibroblasts Extra-Cellular Matrix Production in a cAMP Dependent Manner","authors":"S. Orfanos, G. Cao, B. Deeney, V. Parikh, R. Panettieri","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5248","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5248","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125056584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Dynamic and Static Mechanical Energy and Neutrophilic Inflammation in Experimental Acute Lung Injury in Pigs 猪实验性急性肺损伤中动态和静态机械能与中性粒细胞炎症的关系
D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5246
R. Huhle, M. Scharffenberg, J. Wittenstein, J. Zhang, X. Ran, A. Braune, T. Koch, J. Kotzerke, M. Gama de Abreu
{"title":"Association of Dynamic and Static Mechanical Energy and Neutrophilic Inflammation in Experimental Acute Lung Injury in Pigs","authors":"R. Huhle, M. Scharffenberg, J. Wittenstein, J. Zhang, X. Ran, A. Braune, T. Koch, J. Kotzerke, M. Gama de Abreu","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5246","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5246","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126902163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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