Korean Journal of Family Medicine最新文献

{"title":"Policy to increase exclusive breastfeeding in Indonesia: a secondary analysis to identify priority promotion groups.","authors":"Agung Dwi Laksono, Ratna Dwi Wulandari, Nikmatur Rohmah, Masruroh Masruroh, Hastin Dyah Kusumawardani, Mohamad Samsudin, Ina Kusrini","doi":"10.4082/kjfm.25.0139","DOIUrl":"10.4082/kjfm.25.0139","url":null,"abstract":"<p><strong>Background: </strong>Exclusive breastfeeding (EBF) is critical during the early stages of life. Babies require only breast milk from birth until 6 months of age. This study analyzed the correct target for increasing EBF in Indonesia.</p><p><strong>Methods: </strong>This cross-sectional study included 12,534 infants and examined EBF practices as outcome variables. Seven maternal characteristics were included as exposure variables (residence, age, marital status, education, employment, prenatal class, and wealth) and four infant characteristics as control variables (age, sex, birth weight, and early initiation of breastfeeding). Finally, binary logistic regression analysis was performed.</p><p><strong>Results: </strong>Result showed that the proportion of EBF in Indonesia is 52.90% (95% confidence interval [CI], 52.37%-53.43%). Mothers in rural areas were 1.134 times more likely to perform EBF than were those in urban areas (95% CI, 1.126-1.141). All maternal age groups were more likely to achieve EBF than the youngest group (<20 years), except for those aged >44 years, for which there was no significant difference compared with those aged <20 years. Married mothers were 1.361 times more likely to achieve EBF than were divorced/widowed mothers (95% CI, 1.311-1.412). Maternal education and employment were associated with EBF achievement. There was no significant relationship between the prenatal class and EBF performance in Indonesia. Furthermore, results indicate that all wealth statuses are less likely to achieve EBF than the poorest in Indonesia.</p><p><strong>Conclusion: </strong>Six maternal characteristics were specifically targeted to increase EBF in Indonesia: living in urban areas, being young, having a divorced/widowed status, having poor education, being employed, and being wealthy.</p>","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":" ","pages":"357-365"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sense of coherence and health-related outcomes among patients with breast cancer: a systematic review.","authors":"Hyu Jung Choe, Da Min Jung, Seo Yeong An, Yun Sung Kim, Justin Y Jeon, Dong Hoon Lee","doi":"10.4082/kjfm.26.0005","DOIUrl":"10.4082/kjfm.26.0005","url":null,"abstract":"<p><p>Patients with breast cancer frequently experience substantial psychological burden and persistent symptoms. Sense of coherence (SOC), a central construct of the salutogenic framework, has emerged as a key psychosocial resource for chronic illnesses. However, its association with diverse health-related outcomes in patients with breast cancer has not yet been systematically investigated. This systematic review examined the association between SOC and health-related outcomes in patients with breast cancer. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, and literature searches were conducted in PubMed, EMBASE, PsycINFO, and CINAHL from inception through October 2025. A total of 28 eligible studies were included. A higher SOC was consistently associated with greater psychological well-being and lower symptom burden, including pain, fatigue, and insomnia. SOC was also positively associated with quality of life (QoL), especially in the emotional, social, cognitive, and role-functioning domains. Some studies have suggested that a higher SOC is associated with more favorable QoL outcomes during the treatment phases. Evidence on the clinical prognosis is limited, with only one study examining survival outcomes reporting a positive association between SOC and survival. In conclusion, higher SOC was consistently associated with various health-related outcomes among patients with breast cancer, including psychological adjustment, symptom burden, and QoL. These findings suggest that higher SOC is associated with more favorable health-related functioning and overall well-being in this population.</p>","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":"47 4","pages":"289-300"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of metabolomic markers on gastric cancer risk: a two-sample Mendelian randomization study.","authors":"Tung Hoang, Van Mai Truong, Tho Thi Anh Tran","doi":"10.4082/kjfm.25.0229","DOIUrl":"10.4082/kjfm.25.0229","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to examine the relationship between genetically predicted metabolite levels and gastric cancer (GC) risk using Mendelian randomization (MR), and to identify the metabolic pathways potentially involved.</p><p><strong>Methods: </strong>We selected genetic instruments for metabolites from 64 genome-wide association studies covering 362,750 participants. A two-sample MR design was applied to evaluate the associations with GC using summary-level data from a combined analysis of the UK Biobank and FinnGen. The primary analysis relied on the inverse-variance weighted method, while the median-weighted and MR-Egger methods were used to account for potential violations of instrumental variable assumptions and provide the estimate even when a subset of instruments was invalid. The MR-Egger intercept test was performed to detect directional pleiotropy. Metabolites showing significant associations with GC were further examined using pathway enrichment analysis to identify relevant metabolic and lipid processes.</p><p><strong>Results: </strong>MR analyses identified 25 and 17 metabolites that were positively and inversely associated with GC risk, respectively. Notably, hexanoylcarnitine and cis-4-decenoylcarnitine were strongly associated with increased risk, whereas pregnanediol disulfate, acetylcarnitine, prolyl-hydroxyproline, and X-18914 were associated with reduced risk, with no evidence of heterogeneity or directional pleiotropy. Enrichment analyses highlighted key metabolic pathways, including cysteine and methionine catabolism, beta-oxidation of pristanoyl-CoA (coenzyme A), oxidation of branched-chain fatty acids, and peroxisomal lipid metabolism.</p><p><strong>Conclusion: </strong>This study identified a set of genetically predicted metabolites associated with GC risk, highlighting the potential utility of metabolite panels and lipid-based biomarkers for risk stratification and early detection. However, further standardization and extensive validation are necessary prior to clinical application.</p>","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":" ","pages":"325-335"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle and family factors associated with childhood overweight: evidence from a case-control study in Indonesian schoolchildren.","authors":"Iche Andriyani Liberty, Laily Hanifah, Nur Alam Fajar, Pariyana, Fildzah Hashifah Taufiq, Resy Asmalia, Salsadilla Dwiffa Putri, Muhammad Irfian, Hamzah Hasyim","doi":"10.4082/kjfm.25.0164","DOIUrl":"10.4082/kjfm.25.0164","url":null,"abstract":"<p><strong>Background: </strong>Childhood obesity is a growing health concern that increases the risk of cardiometabolic disorders. This study investigated family and lifestyle factors that contribute to overweight in schoolchildren.</p><p><strong>Methods: </strong>This case-control study of 1,016 children (6-12 years) in Palembang was conducted using questionnaires and anthropometry. Multivariable logistic regression analysis was used to assess the association between selected variables and overweight, reported using adjusted odds ratios (AORs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Frequent consumption of carbohydrate-rich foods, such as noodles or pasta, was associated with a higher risk of overweight (AOR, 1.76; 95% CI, 1.11-2.78; P=0.014). Limited protein 1 time per a day (AOR, 3.30; 95% CI, 2.00-5.43; P<0.001), flavored cow's milk (AOR, 1.76; 95% CI, 1.06-2.95; P=0.029), and snacking (≥5 times per week) (AOR, 1.57; 95% CI, 1.04-2.39; P=0.031) also increased the risk. Conversely, daily fruit consumption reduced the risk (AOR, 0.66; 95% CI, 0.45-0.95; P=0.027). Family-related factors such as formal maternal employment (AOR, 1.57; 95% CI, 1.06-2.33; P=0.023), eating together less than 5 times per a week (AOR, 1.78; 95% CI, 1.04-3.04; P=0.032), and not bringing lunch to school (AOR, 1.96; 95% CI, 1.15-3.31; P=0.012) significantly increased the risk.</p><p><strong>Conclusion: </strong>Several factors are associated with overweight among schoolchildren, including high intake of noodles or pasta, limited protein consumption, flavored milk, frequent snacking, low fruit intake, maternal employment, infrequent family meals, and not bringing food to school.</p>","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":" ","pages":"316-324"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifelong lifestyle management: the foundation of primary care.","authors":"Su Hwan Cho","doi":"10.4082/kjfm.47.4E","DOIUrl":"10.4082/kjfm.47.4E","url":null,"abstract":"","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":"47 4","pages":"287-288"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The generalist's context advantage: why family physicians may be uniquely positioned for artificial intelligence-augmented clinical practice.","authors":"Sang Hyun Ahn","doi":"10.4082/kjfm.26.0061","DOIUrl":"10.4082/kjfm.26.0061","url":null,"abstract":"","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":" ","pages":"383-385"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco use among older Korean men: a classification and regression tree analysis.","authors":"Sung Seek Moon, Hyeouk Chris Hahm, Jinwon Lee","doi":"10.4082/kjfm.25.0179","DOIUrl":"10.4082/kjfm.25.0179","url":null,"abstract":"<p><strong>Background: </strong>Tobacco use among older adults remains a pressing public health concern in South Korea, particularly among men. Despite the decline in tobacco use rates with age, a range of sociodemographic, psychological, and behavioral factors persist to influence tobacco use behaviors. However, prior studies have primarily relied on linear modeling approaches, which may overlook indirect associations. This study addressed this gap using classification and regression tree (CART) analysis to identify hierarchical and interactive patterns among factors associated with tobacco use.</p><p><strong>Methods: </strong>We analyzed data from the 2023 Korea Community Health Survey, which included 34,924 Korean men aged ≥65 years. Using CART analysis, we identified distinct subgroups and patterns across multiple predictors of tobacco use behavior, including demographic factors, lifestyle characteristics, and chronic health conditions.</p><p><strong>Results: </strong>CART analysis identified age as the strongest predictor of tobacco use. Men aged ≤72.5 years had higher tobacco use rates, especially those with low social engagement (24.8%). Younger men with higher social activity and aged ≤67.5 years had the lowest rate (12.9%). Among men ≥72.5 years, alcohol use was the key predictor. Non-drinkers had the lowest tobacco use rate (9.3%), whereas drinkers aged ≤78.5 years showed elevated rates (22.0%), suggesting persistent risk even in later life.</p><p><strong>Conclusion: </strong>These findings underscore the importance of promoting social engagement and reducing alcohol use to decrease tobacco use among older men, particularly those under 73 years of age.</p>","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":" ","pages":"336-346"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of hyaluronic acid injection compared to corticosteroids injection in hand osteoarthritis: a systematic review and meta-analysis of randomized control trials.","authors":"Saran Malisorn, Non Sowanna, Kansak Boonpattharatthiti, Teerapon Dhippayom","doi":"10.4082/kjfm.25.0125","DOIUrl":"10.4082/kjfm.25.0125","url":null,"abstract":"<p><strong>Background: </strong>Treatment of hand osteoarthritis (OA) often includes corticosteroid and hyaluronic acid (HA) injections. Some studies have reported better pain relief and improved function, whereas others have reported minimal long-term benefits. This study aimed to evaluate the effects of corticosteroids and HA injections on the management of hand OA.</p><p><strong>Methods: </strong>PubMed, Embase, CENTRAL, and EBSCO Open Disk were searched from their inception to May 2024. Randomized controlled trials (RCTs) comparing intra-articular corticosteroid and HA injections in adults with hand OA were included. Data on demographics, interventions, and outcomes were extracted and the risk of bias was assessed using the Cochrane Risk of Bias 2. We performed a pairwise meta-analysis using a random-effects model to estimate the pooled effects of the included trials, that is, standardized mean differences (SMDs) with their corresponding 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Of 189 articles, three RCTs involving 180 participants (mean age, 62-62.9 years) were included. One RCT was identified through a database search, and two RCTs were identified through other searching techniques. The risk of bias was considered low in two trials and high in one trial. No significant difference in pain relief was found between the corticosteroid and HA treatments (SMD, 0.06; 95% CI, -0.23 to 0.35; I2=0.0%).</p><p><strong>Conclusion: </strong>Corticosteroid and HA injections offered similar pain relief in patients with hand OA. Further long-term studies are necessary to evaluate the functional outcomes and potential side effects. However, this conclusion should be interpreted with caution due to the small sample size of the studies (PROSPERO registration number: CRD42024511411).</p>","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":" ","pages":"310-315"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of \"Preventing depression in older adults with chronic illnesses through the SMART Elderly Program: a quasi-experimental study in Central Thailand\".","authors":"Muhammad Wasi Hassan, Tehseen Sajjad, Noor Un Nisa","doi":"10.4082/kjfm.26.0068","DOIUrl":"10.4082/kjfm.26.0068","url":null,"abstract":"","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":"47 4","pages":"386-387"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paroxysmal nocturnal hemoglobinuria presenting with acute kidney injury in an 18-year-old male: a case report.","authors":"Anum Rizwan, Sajid Islam Bhatti, Huda Raja, Tajammul Waqar, Sidra German","doi":"10.4082/kjfm.25.0273","DOIUrl":"10.4082/kjfm.25.0273","url":null,"abstract":"<p><p>Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon acquired hematological disease resulting from somatic PIGA gene mutations. These mutations cause a deficiency in glycosylphosphatidylinositol-anchored-anchored proteins such as CD55 and CD59 on blood cell surfaces, leading to uncontrolled complement-mediated hemolysis. Although this condition is typically identified in individuals in their third or fourth decades of life, diagnosis during late adolescence is rare. Renal complications are a known feature of PNH; however, they present more frequently as a gradual decline in function rather than as a severe acute insult. This report describes the unusual case of an 18-year-old male who presented with a 6-month history of intermittent dark urine followed by an acute illness. Laboratory evaluation revealed severe Coombsnegative hemolytic anemia, significantly elevated lactate dehydrogenase levels, and acute kidney injury requiring immediate hemodialysis. Renal biopsy-confirmed pigment nephropathy, and high-sensitivity flow cytometry detected a large PNH clone, establishing the diagnosis of classical PNH. The patient's renal function improved with supportive care, but hemolysis persisted. This case highlights the fact that PNH can manifest in young adults with acute kidney injury as the primary presenting symptom. Including PNH in the differential diagnosis of patients with unexplained hemolytic anemia and renal impairment is crucial, even in atypical age groups. Prompt diagnosis is vital for initiating appropriate management, including supportive measures and the consideration of complementary inhibitor therapy, to improve outcomes.</p>","PeriodicalId":17893,"journal":{"name":"Korean Journal of Family Medicine","volume":" ","pages":"377-382"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}