Kidney MedicinePub Date : 2025-04-16DOI: 10.1016/j.xkme.2025.101006
Hiroki Ito , Takuo Hirose , Takefumi Mori
{"title":"Unusual Central Venous Catheter Position in Hemodialysis: Anatomical Considerations","authors":"Hiroki Ito , Takuo Hirose , Takefumi Mori","doi":"10.1016/j.xkme.2025.101006","DOIUrl":"10.1016/j.xkme.2025.101006","url":null,"abstract":"","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"7 6","pages":"Article 101006"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kidney MedicinePub Date : 2025-04-16DOI: 10.1016/j.xkme.2025.101008
Jonathan E. Zuckerman , Tom Yang
{"title":"Dual Occurrence of DNAJB-9 Positive Fibrillary Glomerulonephritis and Diffuse Lupus Nephritis: A Unique Overlap Glomerulopathy","authors":"Jonathan E. Zuckerman , Tom Yang","doi":"10.1016/j.xkme.2025.101008","DOIUrl":"10.1016/j.xkme.2025.101008","url":null,"abstract":"<div><div>Cases of lupus nephritis (LN) with substructured deposits detected by electron microscopy are not uncommon in nephropathology practice. Rare cases of LN have been reported to show fibril formation similar to the type found in fibrillary glomerulonephritis (FGN). It is uncertain if fibril formation in such cases represents a unique manifestation of LN or LN with a superimposed FGN. FGN is a rare disease with unknown pathogenesis and a poor prognosis. Diagnosis of FGN has required the demonstration, by electron microscopy, of haphazardly arranged fibrils measuring 10 to 30<!--> <!-->nm in thickness in the mesangium or along the glomerular basement membranes. DnaJ homolog subfamily B member 9 (DNAJB-9) immunohistochemical staining is a recently discovered sensitive and specific marker for FGN and is now considered essentially pathognomonic for FGN. No cases of bone fide LN with concurrent DNJAB-9 positive FGN have been reported. Here, we report on one such overlap glomerulopathy showing well developed features of LN (full house immunofluorescence staining, strong C1q staining, extraglomerular deposits, tubuloreticular inclusions) with concurrent fibrillar deposits with strong DNAJB-9 positivity highly consistent with FGN.</div></div>","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"7 6","pages":"Article 101008"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kidney MedicinePub Date : 2025-04-15DOI: 10.1016/j.xkme.2025.101004
Kamel Omer , Kristin K. Clemens , Yunxu Zhu , Heather LaPier , Louise Moist , Jaclyn Ernst , Sonja M. Reichert , Alla Iansavichene , Michael Chiu , OK TRANSPLANT Investigators
{"title":"Nonpharmacologic and Nonsurgical Weight Management Interventions for Patients With Advanced CKD: A Scoping Review of the Medical Literature","authors":"Kamel Omer , Kristin K. Clemens , Yunxu Zhu , Heather LaPier , Louise Moist , Jaclyn Ernst , Sonja M. Reichert , Alla Iansavichene , Michael Chiu , OK TRANSPLANT Investigators","doi":"10.1016/j.xkme.2025.101004","DOIUrl":"10.1016/j.xkme.2025.101004","url":null,"abstract":"<div><h3>Rationale & Objective</h3><div>Obesity is associated with morbidity and mortality in people with chronic kidney disease (CKD). Identifying safe and effective nonpharmacologic and nonsurgical interventions to achieve a healthier body weight is essential.</div></div><div><h3>Study Design</h3><div>Scoping review of observational studies and randomized control trials.</div></div><div><h3>Setting & Study Populations</h3><div>Adults aged<!--> <!-->≥18 years with a body mass index (BMI) ≥30<!--> <!-->kg/m<sup>2</sup> and advanced CKD (category G3-G5D).</div></div><div><h3>Selection Criteria for Studies</h3><div>Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Reviews (PRISMA-ScR), we systematically searched 2 electronic databases (MEDLINE and Embase) for studies that examined the effect of nonpharmacologic and nonsurgical interventions for weight loss between January 2010-July 2024. Outcomes included weight loss and BMI. We also examined adherence, whether participants were involved in the design of the study, and adverse events.</div></div><div><h3>Data Extraction</h3><div>Two reviewers screened relevant citations and extracted study characteristics and outcomes. Discrepancies were resolved by a third reviewer.</div></div><div><h3>Analytical Approach</h3><div>Study data were summarized descriptively following guidance from the PRISMA-ScR.</div></div><div><h3>Results</h3><div>Of the 2,453 citations, 17 met inclusion criteria (9 randomized controlled trials, 2 nonrandomized trials, 5 prospective cohort studies, and 1 retrospective cohort study) and included a total of 960 participants. Interventions included exercise programs, dietary therapy, and/or cognitive behavioral therapy with follow-up ranging from 3-12 months. It appeared that dietary intervention that promoted significant caloric restriction over the short term led to the most weight loss (average, 7<!--> <!-->kg). Interventions with monitored coaching appeared helpful. No adverse events were reported. None of the studies involved participants as partners.</div></div><div><h3>Limitations</h3><div>Not all studies included participants’ estimated glomerular filtration rate or BMI category, and we may have included some without severe CKD or BMI<!--> <!-->≥30<!--> <!-->kg/m<sup>2</sup>.</div></div><div><h3>Conclusions</h3><div>Programs encouraging very low-energy diets along with monitored coaching, may result in modest short-term weight loss. Patient views on these programs and their longer term success remain unclear.</div></div>","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"7 6","pages":"Article 101004"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Acute Kidney Injury During Eltrombopag Use Successfully Treated With Plasma Exchange in Addition to Antithrombotic Therapy","authors":"Noriko Ueno , Yasuo Kusunoki , Toru Kida , Shun Oda , Akane Yamano , Fumi Nakayama , Shungo Fukuda , Natsuko Ikeda , Tomoko Namba-Hamano , Masato Homma , Masanobu Takeji","doi":"10.1016/j.xkme.2025.101007","DOIUrl":"10.1016/j.xkme.2025.101007","url":null,"abstract":"<div><div>Eltrombopag (EPAG), a thrombopoietin receptor agonist, has emerged as a valuable option for the treatment of immune thrombocytopenic purpura. However, its use has raised concerns regarding thrombotic complications. Herein, we present a case involving a 60-year-old woman with immune thrombocytopenic purpura and underlying antiphospholipid antibody syndrome who developed abdominal pain and acute kidney injury shortly after initiating EPAG therapy. Kidney histopathology revealed thrombi in the afferent glomerular arterioles, suggesting a link between EPAG and thrombotic events. Despite EPAG discontinuation, the patient’s kidney function deteriorated, necessitating hemodialysis. As an additional treatment, plasma exchange (PE) was performed to remove EPAG. High-performance liquid chromatography analysis showed a reduction in the EPAG concentration after PE, indicating partial removal. The patient’s kidney function gradually improved, and hemodialysis was successfully discontinued. The findings from this case suggest that thrombotic complications should be considered when administering EPAG to patients with antiphospholipid antibody syndrome. PE may be a useful treatment option if thrombosis is induced by EPAG.</div></div>","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"7 6","pages":"Article 101007"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kidney MedicinePub Date : 2025-04-15DOI: 10.1016/j.xkme.2025.101005
Liangyu Yin, Furong Li, Tangli Xiao, Jun Zhang, Yan Li, Jicong Luo, Jinghong Zhao, Jiachuan Xiong
{"title":"Functional Performance Decline Outperforms Sarcopenia and Its Components in Predicting New-Onset Chronic Kidney Disease: A Nationwide Multicenter Study","authors":"Liangyu Yin, Furong Li, Tangli Xiao, Jun Zhang, Yan Li, Jicong Luo, Jinghong Zhao, Jiachuan Xiong","doi":"10.1016/j.xkme.2025.101005","DOIUrl":"10.1016/j.xkme.2025.101005","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the associations of functional performance, sarcopenia, and components of sarcopenia with the onset of chronic kidney disease (CKD), while also determining the optimal predictive factor.</div></div><div><h3>Methods</h3><div>This observational multicenter study included 8,647 community-dwelling adults. Activities of daily living (ADL) scale, physical performance, and sarcopenia were assessed at baseline, and participants were followed to track CKD incidents. The discriminatory performance and cutoffs of ADL and other indices for predicting CKD onset were evaluated. Multivariable-adjusted logistic regression models were employed to analyze the association of ADL with CKD occurrence.</div></div><div><h3>Results</h3><div>There were 4,681 women and 3,966 men (median age<!--> <!-->=<!--> <!-->57.0 years). Over a 7-year follow-up, 940 CKD incidents occurred. Optimal thresholds for left handgrip strength, right handgrip strength, the 5-time chair stand test, appendicular skeletal muscle index, and ADL to predict CKD onset were established at 35.2<!--> <!-->kg, 30.9<!--> <!-->kg, 10.4 seconds, 7.3<!--> <!-->kg/m,<sup>2</sup> and 1 for men; and 16.1<!--> <!-->kg, 30.9<!--> <!-->kg, 12.8 seconds, 6.3<!--> <!-->kg/m,<sup>2</sup> and 1 for women, respectively. Among all factors investigated, the ADL score was optimal to predict CKD onset in both men (area under the curve<!--> <!-->=<!--> <!-->0.546; 95% CI, 0.528-0.564) and women (area under the curve<!--> <!-->=<!--> <!-->0.559; 95% CI, 0.538-0.581). Functional performance decline (ADL score<!--> <!-->≥1) demonstrated an independent and dose-dependent association with CKD (OR<!--> <!-->=<!--> <!-->1.841; 95% CI, 1.446-2.329; <em>P</em> for trend<!--> <!--><<!--> <!-->0.001).</div></div><div><h3>Limitations</h3><div>The use of an anthropometric equation to estimate skeletal muscle mass may not be as precise as other methods. Additionally, the observational nature of the study and reliance on self-reported CKD data may lead to potential confounding, misclassification, and reverse causality, requiring further validation through studies with laboratory-confirmed CKD events and larger, more diverse populations.</div></div><div><h3>Conclusions</h3><div>The ADL score indicated that functional performance is superior to sarcopenia and its components in predicting the onset of CKD in middle-aged and older Chinese adults. These findings may facilitate the prevention and management of CKD.</div></div><div><h3>Plain-Language Summary</h3><div>This study looked at how physical function, sarcopenia (loss of muscle mass and strength), and related factors might predict the development of chronic kidney disease (CKD). This study followed over 8,600 adults for 7 years and found that declines in daily functioning—measured by an activities of daily living score—were linked to an increased risk of CKD. Among several factors studied, the activities of daily living sco","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"7 6","pages":"Article 101005"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kidney MedicinePub Date : 2025-04-10DOI: 10.1016/j.xkme.2025.101003
Abhinaya Sridhar , Kurtis Pivert , Dinushika Mohottige , Kirk N. Campbell , Samira S. Farouk
{"title":"Why Not Transplant Nephrology? A Survey of US Nephrology Fellows","authors":"Abhinaya Sridhar , Kurtis Pivert , Dinushika Mohottige , Kirk N. Campbell , Samira S. Farouk","doi":"10.1016/j.xkme.2025.101003","DOIUrl":"10.1016/j.xkme.2025.101003","url":null,"abstract":"<div><h3>Rationale & Objective</h3><div>The current transplant nephrology workforce may be inadequate to care for the growing population of kidney transplant recipients, particularly as the United States aims to increase kidney transplantation rates. Although transplant nephrology fellowship programs experience similar challenges as general nephrology programs in filling positions, few studies have explored nephrology fellows’ perspectives on transplant careers. We aimed to describe nephrology fellows’ interest in transplant nephrology careers, training experiences, and potential factors influencing transplant nephrology career interests.</div></div><div><h3>Study Design</h3><div>A cross-sectional survey-based study was conducted among US nephrology fellows.</div></div><div><h3>Setting & Participants</h3><div>An electronic survey was distributed in 2024 to 962 current adult, pediatric, and adult and pediatric nephrology fellows in training via the American Society of Nephrology.</div></div><div><h3>Exposure</h3><div>Prior transplant experiences.</div></div><div><h3>Outcome</h3><div>Responses to survey items.</div></div><div><h3>Analytical Approach</h3><div>Descriptive statistics and a χ<sup>2</sup> test for independence evaluating relationship between respondents’ transplant rotation experiences and their likelihood of pursuing transplant nephrology.</div></div><div><h3>Results</h3><div>The survey response rate was 45%. 23% (90/393) were somewhat/highly likely to pursue transplant nephrology fellowship. Those less likely to pursue transplant nephrology cited additional training time (66%), inadequate compensation (37%), lifestyle/work-life balance (34%), job availability (23%), and focus on immunology (23%). Free-text responses mentioned challenges with the surgical team as a deterrent. Transplant experiences were similar between those who were likely and those who were not likely to pursue transplant. Of those likely to pursue transplant (n<!--> <!-->=<!--> <!-->90), 19% (17/90) indicated that the introduction of a hypothetical transplant nephrology certification examination would make them not likely to pursue a transplant nephrology career.</div></div><div><h3>Limitations</h3><div>Nonresponse bias.</div></div><div><h3>Conclusions</h3><div>This first survey to assess nephrology fellows’ interest in transplant nephrology careers identified several potential barriers to the lack of interest in transplant nephrology that may serve as areas for intervention in the future.</div></div>","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"7 6","pages":"Article 101003"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemoadsorption as a Supportive Strategy for Severe Toxicity Associated With Chimeric Antigen Receptor T-Cell Therapy: A Case Series","authors":"Pasquale Esposito , Massimiliano Gambella , Elisa Russo , Anna Maria Raiola , Elena Beltrametti , Novella Conti , Elisa Porcile , Stefania Bianzina , Monica Centanaro , Francesca Viazzi , Emanuele Angelucci","doi":"10.1016/j.xkme.2025.101001","DOIUrl":"10.1016/j.xkme.2025.101001","url":null,"abstract":"<div><h3>Rationale & Objective</h3><div>To describe the use and effects of extracorporeal blood purification with hemoadsorption in managing severe complications after treatment with chimeric antigen receptor T-cells (CAR-T).</div></div><div><h3>Study Design</h3><div>Retrospective analysis of a case series.</div></div><div><h3>Setting & Participants</h3><div>Hematological department and intensive care unit from a single institution. Patients with hematological cancer who underwent CAR-T therapy between 2021 and 2023, developed severe toxicity, and were treated with hemoadsorption based on clinical indications.</div></div><div><h3>Results</h3><div>Of 48 patients, extracorporeal blood purification was prescribed to 4 (8.3%): 3 with diffuse large B-cell lymphoma and 1 with mantle cell lymphoma. These patients experienced rapid increases in serum interleukin-6 and ferritin levels after CAR-T infusion, which progressed to severe cytokine release syndrome with hemodynamic instability and multiple-organ toxicity. Despite corticosteroid and anakinra rescue therapy after tocilizumab failure, extracorporeal blood purification with hemoadsorption was initiated at a mean of 5.2<!--> <!-->±<!--> <!-->1.7 days following CAR-T infusion due to rapid clinical deterioration. The treatment was performed using continuous venovenous hemodiafiltration with an AN69ST hemofilter and a CytoSorb cartridge. One patient died 1<!--> <!-->day after the initiation of blood purification because of concomitant cardiomyopathy progressing to multiple-organ failure. In the 3 surviving patients, interleukin-6 levels significantly decreased (from<!--> <!-->−18% to<!--> <!-->−95%), cytokine release syndrome resolved, and vasoactive support was reduced. Treatment-related complications were not observed.</div></div><div><h3>Limitations</h3><div>Small sample size, retrospective design, and lack of a predefined hemoadsorption therapy protocol.</div></div><div><h3>Conclusions</h3><div>A strategy based on hemoadsorption was safe and effective in mitigating inflammation and improving hemodynamics in patients with hematological cancer treated with CAR-T therapy who developed early severe toxicity.</div></div><div><h3>Plain Language Summary</h3><div>Chimeric antigen receptor T-cell (CAR-T) therapy may improve remission rates and survival in hematological cancers but can lead to severe side effects, including cytokine release syndrome (CRS). CRS is characterized by systemic inflammation and multiorgan toxicity and is often associated with poor outcomes. Although pharmacological treatments are available, some cases remain refractory. In this study, we share our experience with hemoadsorption as a supportive therapy for severe CRS in CAR-T recipients. Of the 4 patients treated, 3 experienced CRS resolution with reduced inflammation and improved hemodynamic stability, without treatment-related complications. These findings highlight hemoadsorption as a promising adjunctive therapy to pharm","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"7 6","pages":"Article 101001"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kidney MedicinePub Date : 2025-03-22DOI: 10.1016/j.xkme.2025.101000
{"title":"Erratum Regarding “Protein Biomarkers and Major Cardiovascular Events in Older People With Advanced CKD: The European Quality (EQUAL) Study” (Kid Med. 2023;6(1):100745)","authors":"","doi":"10.1016/j.xkme.2025.101000","DOIUrl":"10.1016/j.xkme.2025.101000","url":null,"abstract":"","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"7 5","pages":"Article 101000"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}