Kinetoplastid Biology and Disease最新文献_第4页

Concepts of species in trypanosomatids. 锥虫的种概念。

Kinetoplastid Biology and Disease Pub Date : 2003-10-28 DOI: 10.1186/1475-9292-2-13

Hooman Momen

引用次数: 3

Apoptosis-like death in trypanosomatids: search for putative pathways and genes involved. 锥虫的凋亡样死亡:寻找可能的途径和涉及的基因。

Kinetoplastid Biology and Disease Pub Date : 2003-06-25 DOI: 10.1186/1475-9292-2-5

Ali Ouaissi

{"title":"Apoptosis-like death in trypanosomatids: search for putative pathways and genes involved.","authors":"Ali Ouaissi","doi":"10.1186/1475-9292-2-5","DOIUrl":"https://doi.org/10.1186/1475-9292-2-5","url":null,"abstract":"Members of the Trypanosomatidae family comprises species that are causative of important human diseases such as Chagas'disease, Leishmaniasis and sleeping sickness. A wealth of evidence has accumulated that illustrates the ability of these unicellular organisms to undergo, with or without induction (stress conditions), a cell death with some features resembling apoptosis-like phenomenon. However, despite the apparent phenotypic similarities between the apoptosis-like death of kinetoplastids and mammalian nucleated cell programmed cell death (PCD), the pathways seem to differ significantly. This review analyses some of the current data related to the cell death in trypanosomatids. Special attention is given to members of conserved protein families demonstrating remarkable diversity and plasticity of function [i.e. elongation factor-1 subunits alpha and gamma; and the Silent Information Regulator (SIR2)-related gene, showed to be associated with resistance to apoptosis-like death in Leishmania]. The elucidation of the molecular events which tightly regulated the processes of growth arrest, differentiation and death of Trypanosoma cruzi, Leishmania spp and African trypanosomes, might allow not only to define a more comprehensive view of the cell death machinery in term of evolutionary origin but may also be useful to identify new target molecules for chemotherapeutic drug development and therapeutic intervention.","PeriodicalId":17853,"journal":{"name":"Kinetoplastid Biology and Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1475-9292-2-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22491211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Programmed cell death in trypanosomatids: is it an altruistic mechanism for survival of the fittest? 锥虫的程序性细胞死亡:是一种适者生存的利他机制吗?

Kinetoplastid Biology and Disease Pub Date : 2003-06-25 DOI: 10.1186/1475-9292-2-7

Alain Debrabant, Hira Nakhasi

引用次数: 46

The role of apoptotic mimicry in host-parasite interplay: is death the only alternative for altruistic behavior? 凋亡模仿在宿主-寄生虫相互作用中的作用:死亡是利他行为的唯一选择吗?

Kinetoplastid Biology and Disease Pub Date : 2003-06-25 DOI: 10.1186/1475-9292-2-6

Marcello A Barcinski, Maria Elisabete Costa Moreira, José Mario De Freitas Balanco, João Luiz M Wanderley, Adriana C Bonomo

引用次数: 16

Life after death: are trypanosomatids programmed to die for the survival of their partners? 死后的生命:锥虫是否会为了伴侣的生存而死亡?

Kinetoplastid Biology and Disease Pub Date : 2003-06-25 DOI: 10.1186/1475-9292-2-4

Nicolas Fasel, Masina Slavica Masina

引用次数: 1

Role of the long slender to short stumpy transition in the life cycle of the african trypanosomes. 在非洲锥虫的生命周期中由长而细到短而粗的转变所起的作用。

Kinetoplastid Biology and Disease Pub Date : 2003-06-25 DOI: 10.1186/1475-9292-2-3

John Richard Seed, Mary Anne Wenck

{"title":"Role of the long slender to short stumpy transition in the life cycle of the african trypanosomes.","authors":"John Richard Seed, Mary Anne Wenck","doi":"10.1186/1475-9292-2-3","DOIUrl":"https://doi.org/10.1186/1475-9292-2-3","url":null,"abstract":"It is shown using mouse models that the African trypanosomes exert a significant drain upon their host's carbohydrate (energy) resources; and that the higher the parasitemia, the greater the energy demand. It is, therefore, hypothesized that the long slender (LS) to short stumpy (SS) transition evolved, in part, to help control the parasitemia and to increase host survival time. It is also suggested that the SS population is heterogeneous. One part of the population is tsetse infective, while a second older SS population is undergoing apoptotic-like events, which leads to their cell death and their stimulation of the host's immune response. This immune stimulation by the old dying SS forms would eliminate the major LS and SS variant antigen population, and produce the chronic relapsing infection. It is concluded that the SS stages during the apoptosis-like process are acting altruistically. They give their lives to insure the long-term survival of the host, and to insure renewed growth of the minor LS variants and new infective SS forms. This process is predicted to increase the probability for the successful transmission of the trypanosomes to a new host.","PeriodicalId":17853,"journal":{"name":"Kinetoplastid Biology and Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1475-9292-2-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22469551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

Maintainence of parasitaemia - is it to die for? 维持寄生虫病——要为它而死吗?

Kinetoplastid Biology and Disease Pub Date : 2003-06-24 DOI: 10.1186/1475-9292-2-2

Kevin M Tyler

引用次数: 5

The development of Trypanosoma brucei within the tsetse fly midgut observed using green fluorescent trypanosomes. 用绿色荧光锥虫观察采采蝇中肠内布氏锥虫的发育。

Kinetoplastid Biology and Disease Pub Date : 2003-04-10 DOI: 10.1186/1475-9292-2-1

Wendy Gibson, Mick Bailey

{"title":"The development of Trypanosoma brucei within the tsetse fly midgut observed using green fluorescent trypanosomes.","authors":"Wendy Gibson, Mick Bailey","doi":"10.1186/1475-9292-2-1","DOIUrl":"https://doi.org/10.1186/1475-9292-2-1","url":null,"abstract":"BACKGROUND: The protozoan pathogen, Trypanosoma brucei, undergoes complex cycles of differentiation and multiplication in its vector, the tsetse fly, genus Glossina. Flies are refractory to infection and resistance mechanisms operate at a number of levels and timepoints. Here we have used highly conspicuous green fluorescent trypanosomes to study the early events in establishment of infection in the fly midgut. RESULTS: Less than 10% of the bloodstream form trypanosomes in the infected feed differentiated into viable procyclics. Up to day 3, trypanosomes were found in the bloodmeal in every fly examined, and increased in number between days 1 and 3. Flies dissected on days 5 and 6 fell into 2 clearly distinct groups: those with high numbers of trypanosomes and those with undetectable infection. Trypanosomes were found in the ectoperitrophic space and proventriculus from 6 days following the infective feed. CONCLUSION: Trypanosomes that have undergone successful differentiation appear to experience an environment within the midgut suited to their unrestricted growth for the first 3 days. After this time, a process of attrition is evident in some flies, which leads to the complete elimination of infection. By day 5, flies fall into 2 groups according to the level of infection: high or undetectable. This timecourse coincides with lectin secretion, development of the PM and the digestion and movement of the bloodmeal along the gut. Further experiments are needed to discriminate between these factors.","PeriodicalId":17853,"journal":{"name":"Kinetoplastid Biology and Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1475-9292-2-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22405093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Leishmania species and zymodemes isolated from endemic areas of cutaneous leishmaniasis in Jordan. 从约旦皮肤利什曼病流行地区分离的利什曼原虫种类和酶解菌。

Kinetoplastid Biology and Disease Pub Date : 2002-11-20 DOI: 10.1186/1475-9292-1-7

Laila Nimri, Radwan Soubani, Marina Gramiccia

{"title":"Leishmania species and zymodemes isolated from endemic areas of cutaneous leishmaniasis in Jordan.","authors":"Laila Nimri, Radwan Soubani, Marina Gramiccia","doi":"10.1186/1475-9292-1-7","DOIUrl":"https://doi.org/10.1186/1475-9292-1-7","url":null,"abstract":"BACKGROUND: Cutaneous leishmaniasis (CL) is endemic in the Middle Eastern countries. New cases are emerging in areas previously free of the disease. In Jordan, the diagnosis of cases during the 1960s and 1970s was mainly reported in military hospitals in Amman. Endemicity of the disease was ascertained after reporting a total of 524 cases during 1973-1978. RESULTS: Leishmania major and Leishmania tropica were isolated from seventy-six autochthonous and imported cases of CL, during eight-year period. The highest infection rates recorded were in the central part of Jordan (60.5%), in males (72.4%) and in the age group 21-30 years (30.5%). Lesions were on the exposed sites of the body, mainly on the face (40%). Both Leishmania spp. were isolated from all parts of the country, although L. major was the predominant species (75% of cases) in all areas except in the north part of Jordan. Isoenzyme characterization of the isolates identified four previously undescribed zymodemes (Z). Four Leishmania major zymodemes were found, one of which was a new zymodeme (ZMON-103 variant in GLUD220); L. major ZMON-103 was the most common zymodeme. Four Leishmania tropica zymodemes were identified, of which three were previously unreported. Of these, ZMON-54 var PGD96-97 was isolated from autochthonous cases, whereas ZMON-59 var MDH100 and ZMON-75 var FH110 were obtained from both autochthonous and imported cases, or from an imported CL case, respectively. CONCLUSION: The findings of this study indicate the emergence of the CL disease in new areas. New foci are reported, where the sporadic nature of the cases indicates recent spread of the disease to these areas and the urge for the implementation of control measures.","PeriodicalId":17853,"journal":{"name":"Kinetoplastid Biology and Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1475-9292-1-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22146958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Salivaria or Stercoraria? The Trypanosoma rangeli dilemma. 唾液病还是血吸虫病?兰氏锥虫困境。

Kinetoplastid Biology and Disease Pub Date : 2002-07-05 DOI: 10.1186/1475-9292-1-5

Edmundo C Grisard

引用次数: 17