Korean Journal of Pharmacognosy最新文献_第3页

Effect of Coptidis Rhizoma and Evodiae Fructus Mixture on Esophageal Mucosa in Chronic Reflux Esophagitis 黄连茱萸合剂对慢性反流性食管炎食管黏膜的影响

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.4.349

A. LeeJin, Shin Mi-Rae, Lee Ji Hye, Roh Seong-Soo

引用次数: 3

Ameliorative Effects of Cirsium jaonicum, Artemisia annua and Curcuma longa on Non-alcoholic Fatty Liver Disease 黄卷草、黄花蒿和姜黄对非酒精性脂肪肝的改善作用

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.3.178

J. Shin, H. Kang, B. Cho, Ji Hyeon Park, Denis Nchang Che, Suping Hao, Feng Wang, Jaeuk Sim, D. Sim, S. Jang

引用次数: 1

Inhibitory Effects of Euchrestaflavone B on Thrombus Formation via Regulation of Cyclic Nucleotides in Collagen-induced Platelets 紫竹黄酮B通过调节胶原诱导的血小板环核苷酸抑制血栓形成的作用

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.4.231

Kwon Hyuk-Woo

引用次数: 0

Atractylenoide II Isolated from Atractylodes macrocephala Inhibited Inflammatory Responses in Lipopolysaccharide-induced RAW264.7 Macrophages and BV2 Microglial Cells 白术中白术内酯抑制脂多糖诱导的RAW264.7巨噬细胞和BV2小胶质细胞的炎症反应

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.4.244

Jin Hong-guang, Kim Kwan-Woo, Li Jing, Im Hyeri, Lee Dae Young, Yoon Dahye, Jeong Jin Tae, Kim Geum-Soog, Oh Hyuncheol, An RenBo, Kim Youn-Chul

引用次数: 2

Simultaneous Analysis of Mycotoxins and Risk Assessment in Seeds using LC-MS/MS LC-MS/MS同时分析种子真菌毒素及风险评估

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.4.270

Eun-Jung Choi, Young Ae Park, S. Choi, Sam-Ju Jung, Youngmin Park, in-Sook Hwang, In-Sil Yu, Gi-young Shin

引用次数: 0

The Comparison Between Various Solvents Extracts of Mahaenggamsuk-tang on The Anti-oxidative, Anti-inflammatory and Neuro-protective Effects 不同溶剂提取物抗氧化、抗炎和神经保护作用的比较

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.3.163

Hwan Lee, Yunhe Han, Wonmin Ko, Nayeong Kim, Jung-Young Kim, Dong-Sung Lee, E. Woo

{"title":"The Comparison Between Various Solvents Extracts of Mahaenggamsuk-tang on The Anti-oxidative, Anti-inflammatory and Neuro-protective Effects","authors":"Hwan Lee, Yunhe Han, Wonmin Ko, Nayeong Kim, Jung-Young Kim, Dong-Sung Lee, E. Woo","doi":"10.22889/KJP.2020.51.3.163","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.3.163","url":null,"abstract":" Mahaenggamsuk-tang (MHGS) has been widely used in Korea and China for the treatment of various diseases. MHGS was constituted the Ephedrea Herba, Armenicae Semen, Glycyrrhizae Radix and Gypsum Fibrosum. In this study, we have made three different solvents extract as MHGS water extract (MHGS-W), MHGS 50% EtOH extract (MHGS-50E), and MHGS 100% EtOH extract (MHGS-100E). The MHGS-W, MHGS-50E and MHGS-100E showed the discernible difference patterns on HPLC analysis. Furthermore, MHGS-50E and MHGS-100E significantly increased the DPPH and ABTS radical scavenging effects than MHGS-W. In addition, the MHGS-50E and MHGS-100E also inhibited significantly nitric oxide (NO) and prostaglandin E2 (PGE 2 ) production, and inducible nitric oxide synthase (iNOS) cyclooxygenase-2 (COX-2) protein expression in RAW264.7. On the other hand, MHGS-50E and MHGS-W showed remarkable protection on the HT22 cell via heme oxygenase (HO)-1, but MHGS-100E did not show. The results of this study proved that MHGS-50E has greater potential therapeutic uses by exerting antioxidant, anti-inflammatory and neuroprotective effects compared to MHGS-100E, MHGS-W. Our study suggests that the different solvent might be affected the biological activities when make the traditional herbal medicines including MHGS.","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"7 1","pages":"163-170"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79477031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Inhibitory Actions of Steppogenin on Platelet Activity Through Regulation of Glycoprotein IIb/IIIa and Ca 2+ Mobilization Steppogenin通过调节糖蛋白IIb/IIIa和ca2 +动员对血小板活性的抑制作用

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.2.100

Jung-Hae Shin, J. Ha, Hyuk-Woo Kwon

{"title":"Inhibitory Actions of Steppogenin on Platelet Activity Through Regulation of Glycoprotein IIb/IIIa and Ca 2+ Mobilization","authors":"Jung-Hae Shin, J. Ha, Hyuk-Woo Kwon","doi":"10.22889/KJP.2020.51.2.100","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.2.100","url":null,"abstract":" The extract of Cudrania tricuspidata is used in ethnomedicine throughout Eastern Asia in China, Korea and Japan. In Korean traditional medicine, Cudrania tricuspidata has been used to treat eczema, mumps, tuberculosis, contusions, insom-nia and acute arthritis. In addition, it has been reported that root extract of Cudrania tricuspidata has anti-platelet effects. There-fore, we investigated which compound in Cudrania tricuspidata has inhibitory effect on platelet aggregation. In this study, we tried to explain the inhibitory mechanism of steppogenin from Cudrania tricuspidata on human platelet aggregation. Collagen-induced human platelet aggregation and [Ca 2+ ] i mobilization were dose-dependently inhibited by steppogenin and we deter-mined the inhibition by steppogenin is due to the down regulation of extracellular-signal-regulated kinase(ERK) and inositol-1,4,5-triphosphate receptor type I(IP 3 RI) phosphorylation. In addition, steppogenin inhibited collagen-induced fibronectin adhesion to  IIb/  3 and thromboxane A 2 generation. Thus, in the present study, steppogenin showed an inhibitory effect on human platelet aggregation, suggesting its potential use for preventing","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"28 1","pages":"100-106"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81776428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Anti-platelet Effects of Isoscopoletin through Regulation of PI3K/Akt and MAPK on Collagen-induced Human Platelets 异东莨菪素通过调节PI3K/Akt和MAPK对胶原诱导的人血小板的抗血小板作用

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.3.151

Dong-Ha Lee

{"title":"Anti-platelet Effects of Isoscopoletin through Regulation of PI3K/Akt and MAPK on Collagen-induced Human Platelets","authors":"Dong-Ha Lee","doi":"10.22889/KJP.2020.51.3.151","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.3.151","url":null,"abstract":" When blood vessels are damaged, a rapid hemostatic reaction occurs to minimize blood loss and maintain normal circulation. Platelet activation and aggregation is essential in this process. However, excessive platelet aggregation or abnormal platelet aggregation may be the cause of cardiovascular disease, such as thrombosis, stroke and atherosclerosis. Therefore, it is important to prevent and treat cardiovascular disease by finding substances that can regulate platelet activation and suppress aggregation reactions. Isoscopoletin, which is mainly found in the roots of plants Artemisia or Scopolia, has been reported to have potential pharmacological effects on anticancer and Alzheimer’s disease, but its role and mechanisms for platelet aggregation and thrombus formation are unknown. This study confirmed the effect of isoscopoletin on major regulation of collageninduced human platelet aggregation, TXA 2 production and intracellular granular secretion (ATP and serotonin release). In addition, the effects of isoscopoletin on phosphorylation of phosphorylated proteins PI3K/Akt and MAPK involved in signal transduction in platelet aggregation was studied. As a result, isoscopoletin significantly inhibited the phosphorylation of PI3K/Akt and MAPK, significantly inhibiting platelet aggregation through TXA 2 production and intracellular granular secretion (ATP and serotonin release). Therefore, we suggest that isoscopoletin is an anti-platelet substance that regulates phosphorylation of phosphorus proteins such as PI3K/Akt and MAPK and is valuable as a preventive and therapeutic agent for platelet-derived cardiovascular disease.","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"14 1","pages":"151-157"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74246781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPLC/UV Quantification of (+)-Catechin in Filipendula glaberrima from Different Regions and Flowering Stages HPLC/UV定量测定不同地区、不同花期光黄莲中(+)-儿茶素含量

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.4.291

Lee Hak-Dong, Lee Yunji, K. Hoon, Kim Hangeun, Park Chun-Gun, Lee Sang-hyun

引用次数: 2

Validation of an HPLC/UV Analysis Method for Cirsimaritin in Cirsium japonicum var. maackii 鸢尾草中鸢尾素HPLC/UV分析方法的验证

Korean Journal of Pharmacognosy Pub Date : 2020-01-01 DOI: 10.22889/KJP.2020.51.3.217

Ju Sung Lee, L. Paje, Joyce P. Rodriguez, K. Kang, D. Hahm, J. Shim, Y. Choi, Sanghyun Lee

引用次数: 2