Global Medical and Health Communication (GMHC)最新文献

{"title":"Activity of Javanese Ginger, Turmeric, Garlic, and Pomegranate Flower on LDL-C and Total-C on Dyslipidemia Model Rats","authors":"Larissa Larissa, Penny Setyawati Martioso, D. Jasaputra","doi":"10.29313/gmhc.v9i2.7767","DOIUrl":"https://doi.org/10.29313/gmhc.v9i2.7767","url":null,"abstract":"High levels of LDL cholesterol are risk factors for coronary heart disease. Different types of medicinal plants have hypolipidemic effects. The study aimed to compare the potential of Javanese ginger ethanol extract, turmeric, garlic, and pomegranate flowers with rosuvastatin on levels of LDL cholesterol (LDL-C) and total cholesterol (total-C) male Wistar rats dyslipidemia models. This experimental laboratory research was conducted in Maranatha Animal Research Laboratory Bandung and was carried out in January–December 2020. The experimental animals were divided into six groups (n=5): the control group, the Javanese ginger group, the turmeric group, the garlic group, the pomegranate flower group, and the comparison control group. The induction given to experimental animals was administering vitamin D3, a high-fat diet, and propylthiouracil for 14 days. The results showed that the administration of 175 mg/kg BW of garlic ethanol extract (−44.85%), pomegranate flowers (−58.74%), and rosuvastatin (−40.00%) reduced LDL-C compared to control (p<0.05). The administration of 175 mg/kg BW of Javanese ginger ethanol extract (−15.16%), turmeric (−14.02%), garlic (−22.80%), pomegranate flower (−65.24%), and rosuvastatin (−18.70%) reduced total-C compared to controls (p<0.05). The conclusion is that garlic and pomegranate flowers lowered LDL-C, while Javanese ginger, turmeric, garlic, and pomegranate flowers reduced total-C. AKTIVITAS TEMULAWAK, KUNYIT, BAWANG PUTIH, DAN BUNGA DELIMA TERHADAP K-LDL DAN K-TOTAL PADA TIKUS MODEL DISLIPIDEMIAKadar kolesterol LDL yang tinggi adalah faktor risiko penyakit jantung koroner. Berbagai jenis tanaman obat memiliki efek hipolipidemik. Penelitian ini bertujuan membandingkan potensi ekstrak etanol temulawak, kunyit, bawang putih, dan bunga delima dengan rosuvastatin pada kadar kolesterol LDL (K-LDL) dan kolesterol total (K-total) tikus Wistar jantan model dislipidemia. Penelitian laboratorium eksperimental ini dilakukan di Laboratorium Penelitian Hewan Maranatha Bandung dan dilakukan pada Januari–Desember 2020. Hewan coba dibagi menjadi enam kelompok (n=5), yaitu kelompok kontrol, kelompok temulawak, kelompok kunyit, kelompok bawang putih, kelompok bunga delima, dan kelompok  pembanding. Induksi yang diberikan kepada hewan coba adalah pemberian vitamin D3, pakan lemak tinggi, dan propyltiouracil selama 14 hari. Hasil penelitian menunjukkan bahwa pemberian 175 mg/kgBB ekstrak etanol bawang putih (−44,85%), bunga delima (−58,74%), dan rosuvastatin (−40,00%) mengurangi K-LDL dibanding dengan kontrol (p<0,05). Pemberian 175 mg/kgBB ekstrak etanol temulawak (−15,16%), kunyit (−14,02%), bawang putih (−22,80%), bunga delima (−65,24%), dan rosuvastatin (−18.70%) mengurangi K-total dibanding dengan kontrol (p<0,05). Kesimpulannya, bunga bawang putih dan delima menurunkan K-LDL, sedangkan temulawak, kunyit, bawang putih, dan bunga delima menurunkan K-total.","PeriodicalId":178376,"journal":{"name":"Global Medical and Health Communication (GMHC)","volume":"502 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134356037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Halal Critical Point Analysis of Bajakah Wood (Spatholobus littoralis Hassk.) Nano Particle as Anticancer Agent","authors":"L. Yuniarti, Y. Kharisma, T. Respati, M. Tejasari","doi":"10.29313/gmhc.v9i2.6997","DOIUrl":"https://doi.org/10.29313/gmhc.v9i2.6997","url":null,"abstract":"Bajakah wood contains phenolic compounds, flavonoids, tannins, and saponins with anticancer activity. The discovery and development of new drugs require several stages. In the process, there are many possibilities of adding other substances to form new active substances or as solvents that allow drug preparations to be doubtful of halalness. Hence, it is necessary to analyze the critical point of halal ingredients. The purpose of this study was to determine the characteristics of the nanoparticles of bajakah wood (Spatholobus littoralis Hassk.) and to test the anticancer activity in several cancer cell cultures, as well as to analyze the critical point of halalness of the material. This research method is a composition test using chromatography and anticancer activity test using MTT. Analysis of the critical point of halal materials using hazard analysis critical control point (HACCP). The research was carried out at the Indonesian Engineering Nanotechnology Laboratory South Tangerang and the UGM Integrated Laboratory Sleman in July–December 2020. The results showed that bajakah wood nanoparticles contained pure water as a solvent, viscosity 0.08878 cP, scattering intensity 1.1059 cps, diameter 176.1+/−43.7 (nm). Cytotoxic test results showed IC50 against cell culture MCF7 1,063.28 (±114.98) g/mL, HepG2 53.34 (±0.35) g/mL, T47D 150.63 (±8.44) g/mL, WiDR 114.38 (±7.82) μg/mL, HTB 97.50 (±3.49) μg/mL, HeLa 182.95 (±36.22) μg/mL, and Vero 710.10 (±106.46) μg/mL. This study concludes that bajakah wood nanoparticles are not critical in terms of halal ingredients. At the same time, their anticancer activity is weak against breast cancer and uterine cervical cancer, medium categories against liver cancer and lung cancer, and is not toxic to normal cells. ANALISIS TITIK KRITIS KEHALALAN NANOPARTIKEL KAYU BAJAKAH (SPATHOLOBUS LITTORALIS HASSK.) SEBAGAI AGEN ANTIKANKERKayu bajakah mengandung senyawa fenolik, flavonoid, tanin, dan saponin yang memiliki aktivitas antikanker. Penemuan dan pengembangan obat baru memerlukan beberapa tahapan. Dalam prosesnya terdapat banyak kemungkinan penambahan zat lain untuk membentuk zat aktif baru atau sebagai pelarut yang memungkinkan sediaan obat diragukan kehalalannya. Oleh sebab itu, perlu dilakukan analisis titik kritis kehalalan bahan. Tujuan penelitian ini mengetahui karakteristik sediaan nanopartikel kayu bajakah (Spatholobus littoralis Hassk.) dan menguji aktivitas antikanker pada beberapa kultur sel kanker, serta menganalisis titik kritis kehalalan bahan. Metode penelitian ini adalah uji komposisi menggunakan kromatografi dan uji aktivitas antikanker menggunakan MTT. Analisis titik kritis kehalalan bahan menggunakan hazard analysis critical control point (HACCP). Penelitian dilakukan di Laboratorium Nanovasi Rekayasa Indonesia Tangerang Selatan dan Laboratorium Terpadu UGM Sleman pada Juli–Desember 2020. Hasil penelitian menunjukkan sediaan nanopartikel kayu bajakah mengandung pelarut air murni, viskositas 0,08878","PeriodicalId":178376,"journal":{"name":"Global Medical and Health Communication (GMHC)","volume":"438 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115920110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Health Counseling about IUD to Knowledge and Attitude on Married Couple in Serang Regency","authors":"Suraya Mansur, Dewi Hartaningrum, Titi Legiati","doi":"10.29313/gmhc.v9i2.5986","DOIUrl":"https://doi.org/10.29313/gmhc.v9i2.5986","url":null,"abstract":"Health counseling about contraception is essential to provide more knowledge about how to use contraception and improve the attitude and behavior of the family toward the Family Planning Program. This study aimed to determine the effect of counseling on the intrauterine device (IUD) knowledge and attitudes. This research was conducted in Bojong Menteng village, Tunjung Teja district, Serang regency, in February–July 2019. This study used the true experimental design method to look for the treatment effect on others in controlled conditions using pretest-posttest control group design and a quantitative research approach. In this study, the experimental and the control group are given a pretest to find out the initial conditions to see whether there are differences between the experimental group and the control group. Samples used random sampling techniques where 40 people were divided into two groups who have not used the IUD and have two children and more. The study employed paired t test and unpaired t test to analyze the data. The results showed that the average knowledge of the experiment group increased to 72, and the average knowledge of the control group increased to 70.2. In addition, the average attitude of the experiment group increased to 82.35. The difference between the two groups was only seen in wearing, where the experimental group showed positive behavior towards using the IUD. The conclusion is that counseling through leaflets, information education counseling kit, and direct explanation have positive responses.EFEK PENYULUHAN KESEHATAN MENGENAI IUD TERHADAP PENGETAHUAN DAN SIKAP PADA PASANGAN DI KABUPATEN SERANGPenyuluhan kesehatan tentang kontrasepsi penting dilakukan untuk memberikan lebih banyak pengetahuan tentang cara penggunaan kontrasepsi serta meningkatkan sikap dan perilaku keluarga terhadap Program Keluarga Berencana. Penelitian ini bertujuan mengetahui pengaruh penyuluhan tentang alat kontrasepsi dalam rahim (AKDR) terhadap pengetahuan dan sikap. Penelitian ini dilaksanakan di Desa Bojong Menteng, Kecamatan Tunjung Teja, Kabupaten Serang pada Februari–Juli 2019. Metode yang digunakan true experimental design dengan menggunakan pretest-posttest control group design dan pendekatan kuantitatif untuk mencari pengaruh perlakuan terhadap yang lain dalam kondisi yang terkendalikan. Dalam penelitian ini kelompok eksperimen dan kelompok kontrol diberi pretest untuk mengetahui keadaan awal adakah perbedaan antara kelompok eksperimen dan kelompok kontrol. Sampel menggunakan teknik random sampling berjumlah 40 orang dibagi dalam dua kelompok yang belum menggunakan AKDR dan mempunyai dua anak dan lebih. Data dianalisis dengan uji t berpasangan dan uji t tidak berpasangan. Hasil penelitian menunjukkan bahwa rerata pengetahuan kelompok eksperimen meningkat menjadi 72, sedangkan rerata pengetahuan kelompok kontrol meningkat menjadi 70,2. Selain itu, rerata sikap kelompok eksperimen meningkat menjadi 82,35. Perbedaan kedua kelompok te","PeriodicalId":178376,"journal":{"name":"Global Medical and Health Communication (GMHC)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134086613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}