Jundishapur Journal of Medical Sciences最新文献_第2页

Effectiveness of the Camperdown Program in Reducing Stuttering Severity of Kurdish-speaking Adolescents With Stuttering in Iran 坎珀唐计划在降低伊朗库尔德语青少年口吃严重程度方面的效果

Jundishapur Journal of Medical Sciences Pub Date : 2023-07-01 DOI: 10.32598/jsmj.21.6.2818

B. Shafiei, Zahra Dindoust, Hamid Karimi

{"title":"Effectiveness of the Camperdown Program in Reducing Stuttering Severity of Kurdish-speaking Adolescents With Stuttering in Iran","authors":"B. Shafiei, Zahra Dindoust, Hamid Karimi","doi":"10.32598/jsmj.21.6.2818","DOIUrl":"https://doi.org/10.32598/jsmj.21.6.2818","url":null,"abstract":"Background and Objectives Stuttering, due to different reactions of stutterers in different ages, needs age-specific treatment. Considering the lack of study on the effect of the Camperdown program on treatment of stuttering in adolescents in Iran, the present study aims to investigate the effect of the Camperdown program on the stuttering severity of Kurdish-speaking adolescents with stuttering in Iran. Subjects and Methods This is a single-subject study with an A-B-A design which was conducted on 4 Kurdish-speaking adolescents with stuttering. The pre-test assessments were first done. Then, they received 40 sessions of intervention using the Camperdown program. The measures were was the percentage of stuttered syllables, the 9-point severity rating scale, and the speech naturalness scale (NAT). The data were analyzed based on visual analysis and descriptive statistics. Results The intervention was effective in reducing the stuttering severity of all four subjects (percentage of non-overlapping data=100%) and the scores of NAT scale in subjects after intervention was significantly different from their pre-intervention scores. Conclusion The Camperdown program is effective in reducing the stuttering severity of Kurdish-speaking adolescents with stuttering.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139365954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of operations and causes of corneal transplantation in patients referred to the ophthalmology ward of Imam Khomeini Hospital in Ahvaz 2003 to 2019 2003 年至 2019 年阿瓦士伊玛目霍梅尼医院眼科病房转诊患者角膜移植手术和原因评估

Jundishapur Journal of Medical Sciences Pub Date : 2023-07-01 DOI: 10.32598/jsmj.21.6.2787

F. Ostadian, Mahmoud Reza Panahi Bazzaz, Vahid Shahsavari, M. S. Mirdehghan

{"title":"Evaluation of operations and causes of corneal transplantation in patients referred to the ophthalmology ward of Imam Khomeini Hospital in Ahvaz 2003 to 2019","authors":"F. Ostadian, Mahmoud Reza Panahi Bazzaz, Vahid Shahsavari, M. S. Mirdehghan","doi":"10.32598/jsmj.21.6.2787","DOIUrl":"https://doi.org/10.32598/jsmj.21.6.2787","url":null,"abstract":"Introduction: Corneal transplantation is one of the most common eye surgeries and the most common and successful tissue transplant in the world. The aim of this study was to determine the frequency of causes and types of corneal transplantation in patients referred to the ophthalmology ward of Imam Khomeini Hospital in Ahvaz from 2003 to 2018. Methods: This descriptive study was performed on the records of the patients who underwent corneal transplantation. The information included age, sex, cause of transplantation, sex and age of the donor, need for re-transplantation, reason for re-transplantation, laterality of cornea and the type of operation. Results: The mean age of patients receiving cornea was 50.93 years and included 491 (49.3%) male and 505 (50.7%) female. 51.7% of corneal transplant operations were related to the right eye and 47.9% of the operations were related to the left eye respectively. PBK was the most cause of corneal transplantation. Most patients underwent corneal transplantation by PK and then DSAEK. Conclusion: Frequency of PBK was increased in this study as compare to other previous studies which may be due to significant increase in the rate of phacoemulsification surgeries. DSEAK and DMEAK have become more accepted and favorable surgeries in the case of corneal endothelial disease. Based on new surgical techniques and advances in post of management we suggest, new meta-analysis study to evaluate associated diseases , comparison of the regraft rate in different surgical techniques and post op management of them.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139366195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Preterm Delivery From the Endocervical Length at 11 to 14 Weeks 从11 ~ 14周宫颈长度预测早产

Jundishapur Journal of Medical Sciences Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2741

Mohammad Nilchian, A. Adibi, M. Mansourian

{"title":"Prediction of Preterm Delivery From the Endocervical Length at 11 to 14 Weeks","authors":"Mohammad Nilchian, A. Adibi, M. Mansourian","doi":"10.32598/jsmj.21.3.2741","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2741","url":null,"abstract":"Background and Objectives Premature delivery is called delivery before 37 weeks. It is estimated that every year, about 15 million babies are born with preterm delivery worldwide, which is approximately equal to 11% of the total number of deliveries. In this study, a number of pregnant women with 11-14 weeks of pregnancy were evaluated in order to evaluate the value of cervical length at the end of the first trimester of pregnancy in predicting preterm delivery. Subjects and Methods In this cohort study, 156 asymptomatic pregnant women with a gestational age of 11-14 weeks were randomly selected and evaluated. Cervical length was measured by transvaginal ultrasound using a standard method. Cervical length and gestational age at delivery were recorded in a computer database along with demographic information, clinical history, and pregnancy information. Results The mean length of the cervix in women with preterm delivery was 31.32±6.71 mm and in women with term delivery was 38.96±5.80 mm. Data analysis showed that shorter cervical length was significantly associated with preterm delivery. With a threshold of 34.5 mm, the length of the cervix from 3rd month to 6th month could predict preterm delivery with a sensitivity of 76% and a specificity of 81%. Conclusion Measuring cervical length with transvaginal ultrasound in the second trimester can predict preterm delivery.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74841509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of the Effectiveness of Exercise Protocols on Proprioception and Pain in People With Nonspecific Chronic Low Back Pain 运动方案对非特异性慢性腰痛患者本体感觉和疼痛的影响综述

Jundishapur Journal of Medical Sciences Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2784

M. Amini, M. Alizadeh, M. Sahebozamani, M. Akochakian

{"title":"A Review of the Effectiveness of Exercise Protocols on Proprioception and Pain in People With Nonspecific Chronic Low Back Pain","authors":"M. Amini, M. Alizadeh, M. Sahebozamani, M. Akochakian","doi":"10.32598/jsmj.21.3.2784","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2784","url":null,"abstract":"Background and Objectives Chronic low back pain is one of the most common and costly musculoskeletal disorders in societies and is an important clinical and socio-economic epidemic, mostly in industry and non-industry. The aim of this study was to a systematic review of the effectiveness of exercise protocols on lumbar proprioception in patients with chronic nonspecific low back pain. Subjects and Methods From internal and external search engines, including Scopus, Semantic Scholar, Google Scholar, Pubmed, ISC, SID, Magiran, Irandoc, and Doaj with time limit 2010 to 2021 and the keywords exercises, proprioception, non-specific, and chronic low back pain, the present study was done using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyzes). Results Nine articles were selected based on inclusion criteria. These studies mainly focused on systematic review effectiveness of exercise protocols on sensation and low back pain in people with non-specific chronic low back pain. Conclusion According to the research reviewed in the present study, it seems that exercise rehabilitation protocols activate, strengthen, maintain, and increase the central region of the body, especially deep muscles, particularly the multifidus and transverse abdomen, by retraining the pelvic lumbar region. The diaphragm and diagonal of the abdomen and pelvic floor, which play a role in the important segmental stability of the lumbar spine, improve the sense of depth and pain in patients with chronic nonspecific low back pain.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82781912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Candida Albicans Fungal Colonies From the Infant’s Mouth and Mother’s Nipple 婴儿口腔和母亲乳头白色念珠菌菌落的关系

Jundishapur Journal of Medical Sciences Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2527

Samaneh Aghighi Hatamipour, K. Kheirollahi, Mahin Ghafur Zadeh

{"title":"Relationship Between Candida Albicans Fungal Colonies From the Infant’s Mouth and Mother’s Nipple","authors":"Samaneh Aghighi Hatamipour, K. Kheirollahi, Mahin Ghafur Zadeh","doi":"10.32598/jsmj.21.3.2527","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2527","url":null,"abstract":"Background and Objectives Early diagnosis and appropriate treatment of candidiasis in the infant’s mouth and nipple of breastfeeding mothers can have positive effects on the infant’s nutrition from the mother’s milk. Therefore, the aim of this study was to investigate the prevalence of Candida albicans fungal colonies in the infant’s oral cavities and nipples of breastfeeding mothers. Subjects and Methods This cross-sectional study was performed on 98 breastfeeding mothers and their healthy infants. Samples were taken from the posterior area of the infant’s tongue and the nipple of the breastfeeding mothers. Samples were transferred to a dextrose agar medium containing 0.05% chloramphenicol in the laboratory and were kept at 30 ° C for 48 hours and then the number of Candida colonies was counted and recorded. The data were analyzed by SPSS 17 statistical software and t-test and Pearson correlation coefficient. Results The mean number of cultured colonies from infants’ mouths and nipples of breastfeeding mothers was 64.44±42.99 and 102.62±63.56, respectively. In neonates born by cesarean section and nipple of their mothers, there were significantly more Candida colonies (P<0.05). There was a positive and significant correlation between the number of cultured colonies from the nipple of breastfeeding mothers and the infant’s mouth (P=0.000, r=0.796). Conclusion Candida culture was positive in more than half of the samples both in the mouth of the infant and in their mothers’ nipples.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91424149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Aerobic Activity on Changes in Cystatin C and Homocysteine Levels as Cardiovascular Risk Factors 有氧运动对半胱氨酸C和同型半胱氨酸水平变化的影响

Jundishapur Journal of Medical Sciences Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2521

M. Porsesh, A. Habibi, S. Barati

{"title":"The Effect of Aerobic Activity on Changes in Cystatin C and Homocysteine Levels as Cardiovascular Risk Factors","authors":"M. Porsesh, A. Habibi, S. Barati","doi":"10.32598/jsmj.21.3.2521","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2521","url":null,"abstract":"Background and Objectives Chronic inflammation is associated with the development of various diseases, including atherosclerosis and diabetes. The aim of this study was to investigate the effect of longterm selected aerobic exercises on changes in cystatin C and homocysteine in inactive and overweight middle-aged women. Subjects and Methods Thirty non-athlete middle-aged women (mean age: 46.06±6.97 years, weight: 71.82±9.11 kg, height: 156.9±5.24 cm, and body mass index: 29.2±4.11kg/m2) voluntarily participated in this project and were randomly divided into the experimental and control groups The experimental group performed selected aerobic exercises (65-75% of maximum heart rate) for eight weeks. Blood samples were taken before and 24 hours after the completion of the research protocol to measure the levels of cystatin C and homocysteine. Analysis of covariance was used for intergroup comparisons and paired t-test was used for intergroup comparisons. Results The results showed that there was no significant difference between the experimental and control groups in cystatin C (P=0.09) and homocysteine (P=0.07) after eight weeks of selected aerobic exercises. A significant decrease was observed in weight (P=0.001) and body mass index (P=0.002) in the experimental group compared to the control group. Conclusion Overall, the results of the present study showed that although the eight-week activity program improved the body composition of overweight middle-aged women, longer periods of aerobic exercise are required to examine clearer biochemical results.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88742274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Different Recovery Methods on Oxidative Stress and Hematological Indicators in Female Runners 不同恢复方式对女性跑步者氧化应激及血液学指标的影响

Jundishapur Journal of Medical Sciences Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2826

Marya Rahmani Ghobadi, S. Hoseini, Ghobad Hasanpour

{"title":"Effect of Different Recovery Methods on Oxidative Stress and Hematological Indicators in Female Runners","authors":"Marya Rahmani Ghobadi, S. Hoseini, Ghobad Hasanpour","doi":"10.32598/jsmj.21.3.2826","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2826","url":null,"abstract":"Background and Objectives Exercise can increase oxidative and metabolic stress. The aim of this research was to investigate the effect of different recovery methods after an acute training session on aspartate aminotransferase activity, oxidative stress, and some hematological indices of female runners. Subjects and Methods In the present quasi-experimental study, 30 semi-professional female runners were selected as the research sample and randomly divided into three groups (n=10): active running recovery, passive recovery, and sports massage. After two weeks, the same training protocol was performed for athletes and also after a week of rest, fasting blood sampling was performed. Blood sampling was performed in three stages: 1- fasting, 2- after 1500 meters competition, and 3- immediately after different stages of recovery. The one-way analysis of variance was used for statistical analysis. Results The results showed that in the massage group, the change in hematocrit, white blood cells, and hemoglobin was more than in the active and inactive recovery group (P<0.05), while in the active recovery group, the level of malondialdehyde decreased more than the massage and inactive recovery groups (P<0.05). There was no significant difference between the three recovery methods on changes in iron, red blood cells, aspartate aminotransferase, and total antioxidant capacity (P<0.05). Conclusion According to the results, it can be said that active recovery can prevent damage caused by oxidative stress by increasing blood flow.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83719802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Job Stress and Its Related Factors in Operating Room Staff in the COVID-19 Pandemic in Hospitals of Guilan Province in 2021 桂兰省医院2021年新冠肺炎疫情手术室工作人员工作压力及相关因素评价

Jundishapur Journal of Medical Sciences Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2763

Reza Salehinia, Ebrahim Nasiri Formi, H. B. Derakhshan, Reza Pourmohammad

{"title":"Evaluation of Job Stress and Its Related Factors in Operating Room Staff in the COVID-19 Pandemic in Hospitals of Guilan Province in 2021","authors":"Reza Salehinia, Ebrahim Nasiri Formi, H. B. Derakhshan, Reza Pourmohammad","doi":"10.32598/jsmj.21.3.2763","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2763","url":null,"abstract":"Background and Objectives Health workers are at the forefront in the diagnosis, treatment, and care of patients with COVID-19, which can increase the psychological burden, stress, and anxiety of staff. The purpose of this study was to determine job stress and related factors of the operating room staff during the COVID-19 pandemic. Subjects and Methods This descriptive study was performed on the operating room staff of hospitals in Guilan province in 2021. The variables evaluated in this study included the relationship between age, gender, marital status, level of education, the field of study, employment status, and anxiety. In order to collect data in this study, the standard SPIO job stress questionnaire was used and the data were analyzed using an independent t-test. Results In this study, 120 people in the age range of 47-23 with a mean age of 31.47±8.79 years participated. Men had less stress than women and married people showed more stress. In terms of job status, officially employed people had the least stress and people who served in the military had the most stress. In terms of field of study, anesthesiologists showed the highest stress level, and the operating room had the lowest score. In terms of education level, those with a master’s degree had the highest score, and those with an associate degree showed the lowest score. Conclusion The results of this study showed that with age, job stress also increases and in terms of gender, women had more stress. In terms of marriage, married people showed more stress, which could be due to having a family and the stress of the family being infected with the virus. In terms of job status, officially employed people showed less stress, in terms of field of study, people with a degree in anesthesia had more stress, and in terms of education, people with a higher degree showed more stress.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80381865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Status of Intraparenchymal Plasma Cells in Terms of IgG4 Expression in Patients Diagnosed With Idiopathic Granulomatous Mastitis 特发性肉芽肿性乳腺炎患者肝实质内浆细胞IgG4表达状况的评价

Jundishapur Journal of Medical Sciences Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.1.2590

S. Taghipour zahir, K. Rahmani, M. Vakili

{"title":"Evaluation of the Status of Intraparenchymal Plasma Cells in Terms of IgG4 Expression in Patients Diagnosed With Idiopathic Granulomatous Mastitis","authors":"S. Taghipour zahir, K. Rahmani, M. Vakili","doi":"10.32598/jsmj.21.1.2590","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2590","url":null,"abstract":"Background and Objectives Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory lesion that mimics the clinical symptoms of carcinoma. Another type of chronic granulomatous mastitis is immunological mastitis, which is related to the infiltration of IgG4 plasma cells. This study aims to determine the status of IgG4 positive plasma cells in IGM samples. Subjects and Methods This is an analytical-cross-sectional study. 46 women diagnosed with IGM were selected for the study using census method. The percentage of IgG and IgG4 in plasma cells was determined based on immunohistochemical method. Age and type of surgery were also recorded. The data was entered into SPSS software, version 22 and analyzed using statistical tests. P<0.05 were considered statistically significant. Results The mean age of patients was 35.02±6.82 years. The mean percentage of IgG positive plasma cells among tissue inflammatory cells was 6923±23.42 and the mean percentage of IgG4 positive plasma cells was 23.39±22.33. Among infiltrated plasma cells, 1.89% were positive for IgG4 and the ratio of IgG4 to IgG in plasma cells was 0.91. Based on the results of Pearson correlation test, a positive and significant correlation was found between the percentage of IgG4 and IgG in plasma cells (r=0.600, P=0.004). Conclusion A significant percentage of infiltrated plasma cells are IgG4 positive, which can play a role in the development of IGM. Therefore, further investigation and comparison with immunological mastitis is recommended.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76978154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Moderate-intensity Continuous Exercise and Nanocurcumine Supplementation on STAT3 Gene Expression in Rats With Glioblastoma Multiforme Brain Tumor 中等强度持续运动和补充纳米莪术碱对多形性脑肿瘤大鼠STAT3基因表达的影响

Jundishapur Journal of Medical Sciences Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2793

S. Hajinajaf, H. Shirvani, Mehdi Roozbehani, A. Khademi

{"title":"The Effect of Moderate-intensity Continuous Exercise and Nanocurcumine Supplementation on STAT3 Gene Expression in Rats With Glioblastoma Multiforme Brain Tumor","authors":"S. Hajinajaf, H. Shirvani, Mehdi Roozbehani, A. Khademi","doi":"10.32598/jsmj.21.3.2793","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2793","url":null,"abstract":"Background and Objectives Continuous exercise with moderate intensity and the use of nanocurcumin supplementation has the potential to control and reduce tumors of the central nervous system, including glioblastoma. We assessed the simultaneous effect of moderate-intensity continuous exercises and nanocurcumin supplementation on STAT3 gene expression in mice with glioblastoma multiforme brain tumors. Subjects and Methods Thirty-five male Wistar rats were randomly divided into seven groups of five rats: basal control (BC), 4-week control (4wC), basal cancer control (BT), 4-week cancer control (4 wT), cancer+training (TE), cancer+nanocurcumin (TN), cancer+ exercise + nanocurcumin (TEN). After injection of cancer cells in the forehead, the animals were treated with nanocurcumin by gavage at the dose of 80 mg/kg for 28 days, five days a week, and started moderate-intensity continuous training on the treadmill for four weeks, three days/weeks, 25 to 40 minutes per week at a speed of 18 m/min. Finally, and then rats were sacrificed and data were collected. Results Moderate-intensity continuous training with nanocurcumin supplementation significantly reduced tumor volume and STAT3 gene expression in the TEN group (P<0.05). But this decrease was not significant in the TE and TN groups. Conclusion It seems that with decreased STAT3 gene expression and brain tumor size, the combination of moderate-intensity continuous training and nanocurcumin supplementation has a therapeutic role in the treatment process of glioblastoma multiforme brain tumors.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73705134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0