Hepatology最新文献

{"title":"The pressure is on: Elucidating hemodynamic profiles associated with esophageal varices in the Fontan circulation","authors":"Moira B. Hilscher","doi":"10.1097/hep.0000000000001510","DOIUrl":"https://doi.org/10.1097/hep.0000000000001510","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"15 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Biliary tract cancer subtype heterogeneity: An overlooked key analytic dimension","authors":"DengYong Zhang, Yan Yang, Zheng Lu","doi":"10.1097/hep.0000000000001490","DOIUrl":"https://doi.org/10.1097/hep.0000000000001490","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"50 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Honey, I shrunk the tumor: Downstaging HCC before liver transplantation","authors":"John Grady, Juan Pablo Arab","doi":"10.1097/hep.0000000000001457","DOIUrl":"https://doi.org/10.1097/hep.0000000000001457","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"107 1","pages":"541-542"},"PeriodicalIF":13.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surging sludge: Intrahepatic cholangiocarcinoma mortality on the rise worldwide","authors":"Robert M. Wilechansky","doi":"10.1097/hep.0000000000001454","DOIUrl":"https://doi.org/10.1097/hep.0000000000001454","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"23 1","pages":"543-544"},"PeriodicalIF":13.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144901861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic stellate cells and macrophages: Key players in HCC immune suppression","authors":"Hanna Erickson","doi":"10.1097/hep.0000000000001456","DOIUrl":"https://doi.org/10.1097/hep.0000000000001456","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"37 1","pages":"545-546"},"PeriodicalIF":13.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking immunity’s memory: Epigenetic keys to HBV control","authors":"Brett M. McGettigan","doi":"10.1097/hep.0000000000001455","DOIUrl":"https://doi.org/10.1097/hep.0000000000001455","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"1 1","pages":"547-548"},"PeriodicalIF":13.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMART Steps to HBV Cure.","authors":"Veronica Miller, Norah Terrault","doi":"10.1097/HEP.0000000000001499","DOIUrl":"10.1097/HEP.0000000000001499","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel mechanism involving USP53-regulated BSEP trafficking underlies low-GGT intrahepatic cholestasis.","authors":"Jian Ding, Hui-Yu She, Ye Cheng, Hong-Yuan Sun, Jia-Yan Feng, Teng Liu, Yi-Ling Qiu, Bing-Xuan Wei, Jin Zhang, Yu Su, Yun-Qian Li, Jun-Jie Zhang, Si-Yuan Chen, Ting Wang, Yue Yu, Sven C D van IJzendoorn, Jian-She Wang, Qing-He Xing","doi":"10.1097/HEP.0000000000001501","DOIUrl":"10.1097/HEP.0000000000001501","url":null,"abstract":"<p><strong>Background and aims: </strong>USP53 variants cause low-GGT progressive familial intrahepatic cholestasis (PFIC). The mechanism is not well understood. USP53, which encodes a ubiquitin-specific protease, has been proposed to be involved in blood-bile barrier impairment. However, Usp53 knockout mice did not show blood-bile barrier impairment. The aim of this study was to investigate the molecular mechanism underlying USP53 -PFIC.</p><p><strong>Approach and results: </strong>Immunohistochemistry of patient tissue, confocal immunofluorescence microscopy and surface protein biotinylation were performed to investigate the localization of proteins of interest. Small-interference RNA and CRISPR-Cas9 technology were used to downregulate or knock out genes, respectively. Site-directed mutagenesis was performed to generate gene variants for expression in cells. Co-immunoprecipitation experiments were performed to investigate (variant) protein-protein interactions. Live cell imaging and fluorescence recovery after photobleaching were performed to investigate protein dynamics. The mislocalization of the bile salt export pump (BSEP) was demonstrated in hepatocytes of a USP53-associated PFIC patient and USP53 -KO cells. Loss of USP53 caused BSEP accumulation in MYO5B-positive and RAB11A-positive recycling endosomes and impaired BSEP trafficking to the plasma membrane. USP53 colocalized with MYO5B and interacted with its IQ domain. The recurrent MYO5B-PFIC-associated p.(Arg824Cys) variant, located in the IQ domain, failed to interact with USP53. Loss of USP53 expression resulted in increased ubiquitination of MYO5B and interfered with the endosomal recruitment of MYO5B.</p><p><strong>Conclusions: </strong>Loss of USP53 interaction with MYO5B and its p.(Arg824Cys) variant impaired BSEP trafficking in USP53 -associated and MYO5B -associated low-GGT intrahepatic cholestasis. These results provide a novel mechanism that underlies USP53 -PFIC and implicates USP53 in the pathogenesis of MYO5B -PFIC.</p>","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: A positive feedback loop between cancer stem-like cells and tumor-associated neutrophils controls hepatocellular carcinoma progression.","authors":"Shao-Lai Zhou, Dan Yin, Zhi-Qiang Hu, Chu-Bin Luo, Zheng-Jun Zhou, Hao-Yang Xin, Xin-Rong Yang, Ying-Hong Shi, Zheng Wang, Xiao-Wu Huang, Ya Cao, Jia Fan, Jian Zhou","doi":"10.1097/HEP.0000000000001476","DOIUrl":"https://doi.org/10.1097/HEP.0000000000001476","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of liver stiffness measurement for hepatocellular carcinoma risk stratification in metabolic dysfunction associated steatotic liver disease.","authors":"Binu V John,Dustin R Bastaich,Yangyang Deng,Amit G Singal,Bassam Dahman, ","doi":"10.1097/hep.0000000000001498","DOIUrl":"https://doi.org/10.1097/hep.0000000000001498","url":null,"abstract":"BACKGROUND AND AIMSMetabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is the fastest-rising cause of hepatocellular carcinoma (HCC). A third of MASLD-HCC occur in the absence of cirrhosis, but tools to predict MASLD-HCC are lacking. Our study aimed to examine whether liver stiffness measurement (LSM) is associated with HCC risk in MASLD and to identify if LSM thresholds can predict HCC risk and identify patients for cost-effective HCC surveillance.METHODSWe conducted a retrospective study of the Veterans Analysis of Liver Disease (VALID) cohort and included patients with MASLD who underwent transient elastography between 5/27/2014 and 1/5/2023. HCC incidence rates were calculated and we fit multivariable Cox proportional models to study the association of LSM with HCC risk.RESULTSAmong 30,414 participants with MASLD followed over 69,974 person-years, HCC risk increased by 18% with every 5 kPa increase in LSM (sHR 1.18, 95% CI 1.14-1.21).The annual incidence of HCC per 100 person-years was 0.34 (0.24-0.49) with LSM 10-14.9, 0.45 (0.27-0.76) with LSM 15-19.9, 0.78 (0.50-1.20) for LSM 20-24.9, and 0.94 (0.68-1.29) per 100 PY with LSM ≥25 kPa. In patients with MASLD without cirrhosis or clinically significant portal hypertension, diabetes and an LSM of ≥10 kPa, annual HCC rates were 0.46 per 100 PY (0.29-0.78), which is above the previously described threshold for cost-effectiveness for HCC surveillance.CONCLUSIONSLSM is associated with HCC risk in MASLD. HCC surveillance should be considered in non-cirrhotic MASLD with diabetes and LSM of ≥10 kPa.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"16 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}