Hepatology最新文献

{"title":"Letter to the Editor: Refining the role of HAF in hepatocellular carcinoma","authors":"Jiashu Han, Dan Shan","doi":"10.1097/hep.0000000000001171","DOIUrl":"https://doi.org/10.1097/hep.0000000000001171","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"15 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Refining the role of HAF in hepatocellular carcinoma","authors":"Scott A. Summers, Mei Yee Koh","doi":"10.1097/hep.0000000000001173","DOIUrl":"https://doi.org/10.1097/hep.0000000000001173","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"71 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Expression and functional significance of Twist1 in hepatocellular carcinoma: Its role in vasculogenic mimicry","authors":"","doi":"10.1097/hep.0000000000001139","DOIUrl":"https://doi.org/10.1097/hep.0000000000001139","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"38 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulatory effects of CNNM4 on protein- l -isoaspartyl- O -methyltransferase repair function during alcohol-induced hepatic damage.","authors":"Irene González-Recio, Naroa Goikoetxea-Usandizaga, Claudia M Rejano-Gordillo, Carolina Conter, Rubén Rodríguez Agudo, Marina Serrano-Maciá, Leidy Estefanía Zapata-Pavas, Patricia Peña-Sanfélix, Mikel Azkargorta, Félix Elortza, José María Herranz, Álex Guillamon Thiery, Armando Raúl Guerra-Ruiz, Ramiro Jover, Unai Galicia-Garcia, César Martín, Ute Schaeper, Teresa C Delgado, Irene Díaz-Moreno, Antonio Díaz Quintana, Daniela Buccella, Rubén Nogueiras, JosepMaria Argemi, Matías A Ávila, Jordi Gratacós-Ginès, Paula Iruzubieta, Elisa Pose, Ramón Bataller, Javier Crespo, Luis Alfonso Martínez-Cruz, María Luz Martínez-Chantar","doi":"10.1097/HEP.0000000000001156","DOIUrl":"10.1097/HEP.0000000000001156","url":null,"abstract":"<p><strong>Background and aims: </strong>Alcohol-associated liver disease (ALD) is a leading cause of liver-related mortality worldwide, with limited treatment options beyond abstinence and liver transplantation. Chronic alcohol consumption has been linked to magnesium (Mg 2+ ) deficiency, which can influence liver disease progression. The mechanisms underlying Mg 2+ homeostasis dysregulation in ALD remain elusive. This study aimed to investigate the role of the Mg 2+ transporter Cyclin M4 (CNNM4) in ALD by analyzing its expression patterns in patients with ALD and preclinical animal models.</p><p><strong>Approach and results: </strong>In this study, CNNM4 is upregulated in the liver of both patients with ALD and animal models. CNNM4 overexpression triggers Mg 2+ homeostasis dysregulation, linked to ALD progression. We propose a novel therapeutic approach for ALD treatment using N -acetylgalactosamine silencing RNA technology to specifically modulate Cnnm4 expression in the liver, improving mitochondrial function and alleviating endoplasmic reticulum stress. Notably, silencing Cnnm4 restores protein isoaspartyl methyltransferase (PCMT1) activity, essential for repairing ethanol-induced protein damage. Enhancing mitochondrial activity through Cnnm4-dependent mechanisms increases S -adenosylmethionine levels, crucial for PCMT1 function, highlighting the interconnected roles of mitochondrial health and protein homeostasis in ALD treatment.</p><p><strong>Conclusions: </strong>These findings shed light on the dysregulation of Mg 2+ homeostasis in ALD, providing a promising therapeutic approach targeting CNNM4. N -acetylgalactosamine si Cnnm4 therapy boosts the repair processes of ethanol-damaged proteins through the upregulation of PCMT1 activity.</p>","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":""},"PeriodicalIF":12.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fellows’ Corner","authors":"Maya Deeb","doi":"10.1097/hep.0000000000001108","DOIUrl":"https://doi.org/10.1097/hep.0000000000001108","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"20 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Reviewers (Volumes 79 and 80)","authors":"","doi":"10.1097/hep.0000000000001127","DOIUrl":"https://doi.org/10.1097/hep.0000000000001127","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"98 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video introduction: Special issue on alcohol use disorder and liver disease","authors":"Michael R. Lucey","doi":"10.1097/hep.0000000000001119","DOIUrl":"https://doi.org/10.1097/hep.0000000000001119","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"46 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HNF4α-CDKL3 axis restricts MASLD progression by targeting FoxO1 via non-canonical phosphorylation","authors":"Zhongqiu Pang, Hui Zhang, Shaoqin Zheng, Xueling Yang, Chang Liu, Qing Han, Yi Chen, Zexu Li, Xi Zhang, Liu Cao, Qiang Wang, Yanli Cao, Xun Sun, Pu Zhao, Xuexin Li, Qianqian Zheng, Ren Sheng","doi":"10.1097/hep.0000000000001147","DOIUrl":"https://doi.org/10.1097/hep.0000000000001147","url":null,"abstract":"Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide disease with a broad spectrum of symptoms. Though being mild at early stages, further development of MASLD causes steatohepatitis, cirrhosis, liver cancers and accompanied diabetes. Discovery of the critical regulators in MASLD progression hold great values in both basic and translational medicine. Approach and Results: Herein, we identified Cyclin-dependent kinase like 3 (CDKL3) as a primary guardian against MASLD progression. Mice with liver-specific <jats:italic toggle=\"yes\">Cdkl3</jats:italic> ablation developed severe MASLD-related hepatic inflammation, fibrosis and diabetes. Mechanism-wise, CDKL3 directly phosphorylates FoxO1 on an unconventional site for the ubiquitination-dependent degradation of FoxO1, thereby remarkably alleviating glycogen and lipid accumulation and essentially preventing the onset of higher MASLD stages. Moreover, hepatic <jats:italic toggle=\"yes\">CDKL3</jats:italic> is a direct target gene of HNF4α. HNF4α is inhibited during MASLD, which led to diminished <jats:italic toggle=\"yes\">CDKL3</jats:italic> expression. The CDKL3-mediated crosstalk of HNF4α and FoxO1 hence forms a feedback loop in MASLD progression. Conclusions: We unearthed an alternative but critical regulatory path of FoxO1 by HNF4α-CDKL3 axis. CDKL3 serves as a guardian against MASLD and also may function as a prognosis indicator of FoxO1 inhibitor in MASLD treatment.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"20 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial genome diversity drives heterogeneity in hepatocellular carcinoma","authors":"Tatsuhiro Shibata, Yujin Hoshida","doi":"10.1097/hep.0000000000001161","DOIUrl":"https://doi.org/10.1097/hep.0000000000001161","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"72 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Quality indicators and the safety profile of endoscopic intervention in patients with bleeding esophageal varices.","authors":"Yu Jun Wong, Margaret Teng, Alyssa Sim, Juan G Abraldes, Jason Chang","doi":"10.1097/HEP.0000000000001155","DOIUrl":"https://doi.org/10.1097/HEP.0000000000001155","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":""},"PeriodicalIF":12.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}