Journal of the Grodno State Medical University最新文献

{"title":"PROGNOSTIC ASSESSMENT OF ARTICULAR SURFACE COLLAPSE IN SUBCHONDRAL BONE INSUFFICIENCY FRACTURE OF THE KNEE (SIFK)","authors":"G. A. Koshman","doi":"10.25298/2221-8785-2024-22-3-224-228","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-224-228","url":null,"abstract":"Background. Subchondral insufficiency fracture of the knee (SIFK) is a frequent cause of knee joint pain in patients over 55 years of age. Diagnosis of this pathology at an early stage has certain difficulties, as it requires magnetic resonance imaging (MRI). Aim of the study. To determine the relationship between the size of the lesion in subchondral insufficiency fracture of the knee joint, the patient's body mass index and the risk of articular surface collapse. Material and Methods. In 35 female patients with subchondral insufficiency fracture the size of the lesion in frontal and sagittal planes, as well as its volume according to MRI were determined. The obtained results made it possible to assess the risk of articular surface collapse. Results. The study revealed a relationship between the size of the lesion and the risk of articular surface collapse in subchondral insufficiency fracture of the knee. An anteroposterior size of the lesion of more than 14.1 mm, a transverse size of more than 10.2 mm, and a craniocaudal size of more than 1.22 mm are risk factors for subsequent articular surface collapse and progression of osteoarthritis of the knee joint. The analysis of the correlation between body mass index (BMI) and the development of articular surface collapse found no specific BMI value associated with articular surface collapse. Conclusions. A risk factor for articular surface collapse in patients with subchondral bone insufficiency fracture of the knee joint was determined, which allows predicting the outcomes of the disease treatment. Body mass index and the development of articular surface collapse do not correlate with each other.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"1996 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF THE LEVEL AND STRUCTURE OF PATHOLOGIES AMONG ADOLESCENTS IN THE REPUBLIC OF BELARUS","authors":"O. A. Ezepchyk","doi":"10.25298/2221-8785-2024-22-3-217-223","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-217-223","url":null,"abstract":"Background. Assessment of the health indicators of adolescents, among which morbidity indicators occupy a leading place, makes it possible to determine the need of this age group for preventive measures, as well as to evaluate their effectiveness. Objective. To study the level and etiological structure of pathologies among adolescents residing in the Republic of Belarus. Material and methods. A sample of 1118 people aged 10-18 years was studied. The data was obtained by extracting information from primary medical documentation. Results. It was established that the prevalence of pathologies in the general group of adolescents is 1568.87 [1488.45; 1649.30] cases per 1000 people. The main factors aggravating the health status of adolescents are such classes of diseases and pathological conditions as eye diseases (in the vast majority, myopia), diseases of the musculoskeletal system and connective tissue (primarily postural disorders and flat feet), congenital malformations, deformations and chromosomal abnormalities (in 88.59% cases – congenital anomalies of the circulatory system), diseases of the digestive system (in a quarter of cases – gastritis, duodenitis). The main contributors to these pathologies are schoolrelated ones. It was revealed that less than 20% of 10-18-year-olds are absolutely healthy, almost 2/3 of the surveyed have risk factors for the development of diseases and almost one out of six has a chronic pathology in the compensation stage. Conclusions. The results obtained indicate the need to improve preventive measures aimed to minimize pathologies caused by learning, the need to introduce targeted prevention programs, as well as to improve medical and psychological-pedagogical support for students.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"54 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE MECHANISMS OF ACTION AND THE SCOPE OF APPLICATION OF HYALURONIC ACID","authors":"O. A. Kvyatkovskaya, A. V. Ludchik, N. S. Serdyuchenko, V. Anosov, A.Yu. Kovalenko","doi":"10.25298/2221-8785-2024-22-3-203-210","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-203-210","url":null,"abstract":"Given the fact that today the use of hyaluronic acid is limited only to intra-articular injections or cosmetic products, the purpose of this article was to analyze modern literature concerning the mechanism of action of hyaluronic acid on the body at various levels (molecular, cellular and tissue) in order to increase awareness and demonstrate the possibilities of using hyaluronic acid in medical research and practical medicine.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HYPERCALCEMIA IN THE PRACTICE OF AN INTERNIST","authors":"S. V. Tishkovskiy, L. Nikonova, J. M. Lukjanchuk","doi":"10.25298/2221-8785-2024-22-3-271-281","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-271-281","url":null,"abstract":"The relevance of the study of hypercalcemia is determined by its prevalence among the population in different age groups which varies from 0.17 to 3.9 cases per 100 people. Most often, hypercalcemia is asymptomatic, but at the same time, this process of calcification of the walls of blood vessels and internal organs as well as bone resorption lead to the development of arterial hypertension, atherosclerosis, osteoporosis, which increase the risk of poor prognosis, especially in the group of elderly patients. Considering that hypercalcemia is believed to be a life-threating condition, medical specialists are challenged to timely diagnose this condition in order to prescribe adequate treatment for the underlying disease and avoid clinical manifestations of both chronic and acute hypercalcemia.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"288 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN BLOOD BIOCHEMICAL PARAMETERS IN WISTAR RATS AFTER IMPLANTATION OF VASCULAR GRAFTS","authors":"H. A. Popel, I. A. Maiseyenka, A. A. Kopats, I. Zhavaranak","doi":"10.25298/2221-8785-2024-22-3-211-216","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-211-216","url":null,"abstract":"Background. This article deals with the use of biological vascular grafts made from bovine xenopericardium as a plastic material for reconstructive operations on the great vessels, which is one of the most important topics in modern vascular surgery. Aim. To compare changes in blood biochemical parameters in Wistar rats after implantation of fragments of biological and synthetic vascular grafts. Material and methods. The experimental study was performed on male laboratory Wistar rats (n = 50). The animals were divided into two groups: group 1 included 25 animals with implantation of a Dacron vascular graft; group 2 was composed of 25 animals with implantation of a vascular graft made from bovine xenopericardium. Blood samples from the laboratory rats were collected on days 3, 7, 14, 21 and 30 after the operation. Plasma urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase levels were measured. Results. No clinically significant changes in concentrations of low molecular weight metabolites of nitrogen metabolism or liver enzymes activity, alkaline phosphatase and lactate dehydrogenase activity were observed after implantation of a biological vascular graft from bovine xenopericardium compared to the animals with implanted synthetic vascular graft. Conclusion. The use of a biological vascular graft made from bovine xenopericardium does not cause clinically significant changes in blood biochemical parameters in laboratory rats.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"193 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"H2S/HOMOCYSTEINE RATIO AS A POTENTIAL BIOMARKER FOR PREDICTING THE PROGRESSION OF ARTERIAL HYPERTENSION IN CHILDREN","authors":"A. V. Luksha, A. V. Naumov, E. M. Doroshenko, I. E. Gulyai","doi":"10.25298/2221-8785-2024-22-3-239-244","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-239-244","url":null,"abstract":"Background. The H2S/homocysteine ratio is a potential biomarker for predicting the progression of cardiovascular diseases. The purpose. To establish the features of changes in the H2S/homocysteine ratio in children with arterial hypertension. Material and methods. A total of 111 children aged 14 to 18 years were examined. Based on the results of 24-hour blood pressure monitoring (n=81), two groups were formed: group 1 (n=51) – children with arterial hypertension (AH), group 2 (n=30) – children with high-normal blood pressure (HNBP). Group 3 included 30 healthy children. Plasma homocysteine level was determined by high-pressure liquid chromatography [Naumov A.V. et al., 2010]. The level of endogenous hydrogen sulfide was assessed by spectrophotometric method based on the reaction between sulfide anion and an acidic solution of the reagent N, N-dimethyl-p-phenylenediamine hydrochloride [Norris Eric J., 2011]. Results. A significant increase in plasma homocysteine concentration was revealed in patients with AH and HNBP compared with healthy children. The plasma levels of hydrogen sulfide in children with AH were significantly lower than in the comparison group. Hypertensive children in comparison to healthy children showed significantly lower plasma H2S/homocysteine ratio. Correlations have been established between the H2S/homocysteine ratio and plasma levels of homocysteine and hydrogen sulfide. Conclusions. Hypertensive children have a lower H2S/homocysteine ratio, which is due to the presence of hyperhomocysteinemia and reduced H2S levels. The H2S/homocysteine ratio can be used as a potential marker for predicting the progression of AH.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EXPERIENCE OF THE PILOT PROJECT “GRODNO UNIVERSITY CLINIC” IMPLEMENTATION REGARDING THE EFFICIENCY OF SCIENTIFIC ACTIVITY","authors":"I. G. Zhuk, S. N. Lazarevich, E. V. Mahiliavets, E. A. Moiseenok","doi":"10.25298/2221-8785-2024-22-3-258-265","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-258-265","url":null,"abstract":"The development and prompt implementation of advanced medical methods of diagnosis, treatment and prevention, based on the latest achievements of science and technology is a healthcare focus area for any state. The purpose of this publication is to summarize the experience of the pilot project “Grodno University Clinic” implementation regarding the efficiency of scientific activities. 12 indices of the University clinic innovative development were included in the model for final results activities of the clinic’s departments. Significant growth in innovation has been achieved, 25 employees of the clinic participate in the educational process of the medical university, 15 theses are being carried out by the clinic staff and teaching staff, and 6 patents have been jointly received. 11 initiative research projects are planned and carried out at the clinic. In addition, funded projects are being implemented, the implementation of which made it possible to attract 209,850 BYN in 2022. Scientific and practical conference “Innovative achievements in the work of Grodno University Clinic” is held annually as a part of the “Perspective plan for the development of the health care institution “Grodno University Clinic” implementation regarding the increase of the efficiency of scientific activities and personnel of the highest scientific qualifications. The clinic conducts clinical trials of medicines and medical products; income for 2022 amounted to 523.88K BYN. The experience of this project implementation makes it possible to draw the following conclusions. The presented interim results of pilot project “Grodno University Clinic” implementation regarding the efficiency of scientific activities allow us to assess positively this initiative transformation of the model for organizing the functioning of a multidisciplinary medical healthcare institution. The marked tendencies in the dynamics of the main indices reflect the efficiency of scientific research in the applied healthcare areas of high priority. The positive influence on innovation impacted by this favorable environment under a new integration project of science and practice for national healthcare is shown. Further research on the role and place of university clinics in the Republic of Belarus under their contribution and influence on the training of highly qualified scientific staff for healthcare, the development and implementation of import-substituting and export-oriented innovative methods of diagnosis, treatment and prevention in practical medicine are considered to be relevant.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"29 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL AND ECONOMIC EFFECTIVENESS OF PHOTODYNAMIC THERAPY IN THE TREATMENT OF PATIENTS WITH PHLEGMON OF THE MAXILLOFACIAL AREA AND NECK","authors":"L. A. Cherniak, M. Surmach","doi":"10.25298/2221-8785-2024-22-3-245-249","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-245-249","url":null,"abstract":"Background. Treatment of patients with phlegmon of the maxillofacial area is an urgent problem in modern maxillofacial surgery. Objective. To conduct a clinical and economic evaluation of the local photodynamic therapy (PDT) effectiveness during the postoperative period in comparison with traditional treatment in patients with phlegmon of the maxillofacial area and neck. Material and methods. Clinical and economic features of treatment of patients with a confirmed diagnosis of “Phlegmon of the maxillofacial area and neck” (ICD-10: L03.2) with local use of PDT were studied and analyzed. Economic efficiency was evaluated based on the cost-effectiveness analysis. The economic effect of preventing direct damage (for inpatient treatment, payment of temporary disability benefits) as well as indirect damage (loss of gross domestic product) because of reduced hospital length of stay has been determined. Results. The advantage of a local application of PDT both from a clinical point of view (reducing the time for cleansing a wound from purulent-necrotic masses, relieving edema, resolving infiltrate, the appearance of granulations, reduced length of inpatient treatment) and from an economic point of view (the overall economic effect for the period of inpatient treatment of 1 patient with PDT was 3092.67 BYN) has been shown. Conclusion. The results demonstrate the clinical and economic feasibility of wider local use of PDT in the complex treatment of patients with phlegmon of the maxillofacial area and neck.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"59 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL SIGNIFICANCE OF AMBULATORY BLOOD PRESSURE MONITORING AND CIRCADIAN SYNTHESIS OF MELATONIN IN PREDICTING OBSTRUCTIVE SLEEP APNEA SYNDROME IN PATIENTS WITH GRADE 1-2 ARTERIAL HYPERTENSION","authors":"V. Shyshko, I. A. Zubel, G. V. Malevich, V. V. Klysheiko, A. A. Targonskaya","doi":"10.25298/2221-8785-2024-22-3-250-257","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-250-257","url":null,"abstract":"Objective. To study the role of 24-hour ambulatory blood pressure monitoring (ABPM) and circadian melatonin (MT) synthesis in predicting obstructive sleep apnea syndrome (OSAS) in patients with grade 1-2 arterial hypertension (AH) and to reveal the relationship between the study findings. Material and methods. 67 patients aged 50.0 (41.0; 56.0) having grade 1-2 AH were examined and divided into 2 groups in regard to the complex of clinical and instrumental research methods: Group 1 – 25 patients having AH and Group – 45 patients having AH associated with OSAS. 24-hour ABPM, anthropometric measurements, and respiratory monitoring were performed. MT levels were evaluated by the content of its metabolite 6-sulfatoxymelatonin (6-COMT) in the urine. Results It has been found that according to ABPM diastolic blood pressure variability during the day was ≥12 mm Hg and had high sensitivity (74.1%) and specificity (91.7%) for predicting the OSAS in patients with hypertension receiving standard antihypertensive therapy. The characteristic feature of the daily MT production in patients with AH in combination with OSAS is an increase in the level of 6-SOMT in daily urine (p=0.031) and its daily portion (p=0.037), correlating with the severity of OSAS (r=0.43; p=0.00065 and r=0.40; p=0.00079, respectively) and independent of the grade of AH (p>0.05). Conclusion. The obtained results allow us to recommend the use of ABPM as a screening, low-cost study to predict OSAS in patients with grade 1-2 AH. The identified changes in the daily rhythm of MT synthesis weakly correlate with the severity of OSAS and the degree of hypertension.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE CRYPTOGENIC ORGANIZING PNEUMONIA (CLINICAL CASE)","authors":"N. V. Glutkina, E. Y. Kulaga, E. T. Volkova, Vl. V. Zinchuk","doi":"10.25298/2221-8785-2024-22-3-266-270","DOIUrl":"https://doi.org/10.25298/2221-8785-2024-22-3-266-270","url":null,"abstract":"Recently, there has been the rise in interest in the problem of rare and interstitial lung diseases. This is due, among other things, to the wide spread of non-invasive diagnostic tools and the expansion of therapeutic possibilities thanks to modern pharmacotherapy. The objective of this study is to analyze a clinical case (diagnosis and management) of the cryptogenic organized pneumonia. An example of the diagnostic challenges in cryptogenic organizing pneumonia is given. A female patient was admitted to the Department of Pulmonology with the diagnosis of bilateral polysegmental pneumonia, prolonged course (was receiving antibiotic therapy for 1.5 month, however the condition hasn’t improved despite the received treatment). After further examination, the diagnosis of cryptogenic organizing pneumonia was made and the therapy was administered. Conclusion. The described case demonstrates diagnostic challenges in cryptogenic organizing pneumonia (the need for interdisciplinary approach) and a good response to therapy with glucocorticosteroids.","PeriodicalId":177418,"journal":{"name":"Journal of the Grodno State Medical University","volume":"23 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}