植入血管移植物后 Wistar 大鼠血液生化指标的变化

H. A. Popel, I. A. Maiseyenka, A. A. Kopats, I. Zhavaranak
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摘要

背景。本文论述了使用牛心包膜制成的生物血管移植物作为大血管重建手术的整形材料,这是现代血管外科最重要的课题之一。目的:比较血液生化指标的变化比较 Wistar 大鼠在植入生物和合成血管移植物碎片后血液生化指标的变化。材料和方法。实验研究以雄性实验室 Wistar 大鼠(n = 50)为对象。动物被分为两组:第 1 组包括 25 只植入达克龙血管移植物的动物;第 2 组包括 25 只植入牛心包膜血管移植物的动物。手术后第 3、7、14、21 和 30 天采集实验鼠的血液样本。测量血浆尿素、肌酐、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、碱性磷酸酶和乳酸脱氢酶水平。结果显示与植入合成血管移植物的动物相比,植入牛异种心包生物血管移植物后,氮代谢低分子量代谢物的浓度、肝酶活性、碱性磷酸酶和乳酸脱氢酶活性均无明显临床变化。结论使用牛心包膜生物血管移植物不会导致实验鼠血液生化指标发生明显的临床变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CHANGES IN BLOOD BIOCHEMICAL PARAMETERS IN WISTAR RATS AFTER IMPLANTATION OF VASCULAR GRAFTS
Background. This article deals with the use of biological vascular grafts made from bovine xenopericardium as a plastic material for reconstructive operations on the great vessels, which is one of the most important topics in modern vascular surgery. Aim. To compare changes in blood biochemical parameters in Wistar rats after implantation of fragments of biological and synthetic vascular grafts. Material and methods. The experimental study was performed on male laboratory Wistar rats (n = 50). The animals were divided into two groups: group 1 included 25 animals with implantation of a Dacron vascular graft; group 2 was composed of 25 animals with implantation of a vascular graft made from bovine xenopericardium. Blood samples from the laboratory rats were collected on days 3, 7, 14, 21 and 30 after the operation. Plasma urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase levels were measured. Results. No clinically significant changes in concentrations of low molecular weight metabolites of nitrogen metabolism or liver enzymes activity, alkaline phosphatase and lactate dehydrogenase activity were observed after implantation of a biological vascular graft from bovine xenopericardium compared to the animals with implanted synthetic vascular graft. Conclusion. The use of a biological vascular graft made from bovine xenopericardium does not cause clinically significant changes in blood biochemical parameters in laboratory rats.
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