Jurnal Kedokteran Brawijaya最新文献_第4页

46 XX Congenital Adrenal Hyperplasia (CAH) after Clitoroplasty, Labioplasty, and Vaginoplasty 先天性肾上腺增生(CAH)在阴蒂成形术，阴唇成形术和阴道成形术后

Jurnal Kedokteran Brawijaya Pub Date : 2022-11-09 DOI: 10.21776/ub.jkb.2022.032.02.9

R. Husein, B. Daryanto, P. Satyagraha, Pradana Nurhadi

{"title":"46 XX Congenital Adrenal Hyperplasia (CAH) after Clitoroplasty, Labioplasty, and Vaginoplasty","authors":"R. Husein, B. Daryanto, P. Satyagraha, Pradana Nurhadi","doi":"10.21776/ub.jkb.2022.032.02.9","DOIUrl":"https://doi.org/10.21776/ub.jkb.2022.032.02.9","url":null,"abstract":"Congenital adrenal hyperplasia (CAH) is the most common cause (60%) of Disorder of Sex Development (DSD), which causes three problems: symptoms and conditions arising due to adrenal endocrine disorders, long-term treatment, and quality of life due to genital ambiguity. An 18-year-old female patient was diagnosed with simple virilizing CAH and had genital ambiguity from birth. The patient was raised as a male. Overall, the examination results indicated a female. Physical examination before surgery showed virilization, such as external genital pigmentation, precocious pubic hair, and bilateral impalpable testis. The karyotype genetic examination confirmed female: 46, XX. Eventually, the patient decided as a female and underwent surgical management consisting of clitoroplasty, labioplasty, and vaginoplasty, followed by long-term corticosteroid therapy. Observations were made for three years after surgery to see the progress of the patient's condition. After undergoing glucocorticoid therapy and surgery, the patient had not experienced menstruation. Her breasts did not enlarge, and mustache and beard were still growing on her face. The patient was concerned about her condition, especially about the risk of infertility and inappropriate physical changes. The management of virilization in CAH with genital ambiguity should be seen from psychological and surgical perspectives. Understanding the disease, the goals of surgery, long-term treatment, and social adaptation help improve quality of life and reduce negative stigma.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80161977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictor Factor for Severity Degree of Pediatric Hydronephrosis in Tertiary Hospital 三级医院儿童肾积水严重程度的预测因素

Jurnal Kedokteran Brawijaya Pub Date : 2022-11-09 DOI: 10.21776/ub.jkb.2022.032.02.6

H. Naim, B. Daryanto, Pradana Nurhadi

{"title":"Predictor Factor for Severity Degree of Pediatric Hydronephrosis in Tertiary Hospital","authors":"H. Naim, B. Daryanto, Pradana Nurhadi","doi":"10.21776/ub.jkb.2022.032.02.6","DOIUrl":"https://doi.org/10.21776/ub.jkb.2022.032.02.6","url":null,"abstract":"Pediatric hydronephrosis is often hideous, and its severity highly correlates with a significantly increased incidence of pathological condition and outcome. The management of this disease is based on the severity level by identifying the clinical manifestation, so performing an early detection is crucial to prevent the disease progression. This research aimed to determine the predictor factors for the severity degree of pediatric hydronephrosis to give better treatments for patients. This study retrospectively reported 51 data of hydronephrosis cases that were collected from January 2012 to August 2019. Severity degree was evaluated using SFU (Society of Fetal Urology) scoring system and divided into two groups, mild-moderate (first and second degree) and moderate-severe (third and fourth degree). Data including age, gender, number of kidneys affected, etiology, and antenatal care were collected and statistically analyzed using Pearson's Chi-square and Fischer Exact test. The research result from 51 pediatric patients, 72.55% were categorized as moderate-severe hydronephrosis while the remaining 27.45% were categorized ad mild-moderate hydronephrosis. Ureteropelvic junction (UPJ) stenosis (37.25%) is the most common cause of pediatric hydronephrosis. Significant correlations are noted among severity degree and gender, the number of kidneys affected, etiology, and chosen antenatal care between obstetrician-gynecologist and midwife (p<0.05). In short, gender, number of kidneys affected, etiology, patient's choice on antenatal care can be the predictor factors for pediatric hydronephrosis. Thus, these findings are essential for urologists in pediatric hydronephrosis management.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85651044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calculus Formation in Bladder from Migrated Intrauterine Devices 宫内节育器迁移导致膀胱结石形成

Jurnal Kedokteran Brawijaya Pub Date : 2022-11-04 DOI: 10.21776/ub.jkb.2022.032.02.11

Mangkubumi Putra Wijaya, Kurnia Penta Seputra, B. Daryanto, Taufiq Nur Budaya

{"title":"Calculus Formation in Bladder from Migrated Intrauterine Devices","authors":"Mangkubumi Putra Wijaya, Kurnia Penta Seputra, B. Daryanto, Taufiq Nur Budaya","doi":"10.21776/ub.jkb.2022.032.02.11","DOIUrl":"https://doi.org/10.21776/ub.jkb.2022.032.02.11","url":null,"abstract":"Migration of the intrauterine device (IUD) into the bladder has been a rare case. There were reported 31 cases of IUD migration into the bladder until 2006. Although IUD migration is asymptomatic, it should be removed to prevent complications such as pelvic abscess, bladder or intestinal rupture, and adhesion. A 52-year-old woman came to the urology clinic with pyuria since the previous 3 months. She had a history of IUD insertion in 1982; and two months later, she got pregnant. Since 2015, she has suffered from dysuria but has never been treated and has worsened in the past 3 months. On physical examination, tenderness was found in the suprapubic region. The results of urinalysis showed pyuria and hematuria. The ultrasonography findings, there were large bladder stones. An abdominal x-ray revealed the presence of a bladder stone with the IUD tail. Vesicolithotomy was performed and the IUD was found attached to an 11x7 cm bladder stone. The patient had a good postoperative condition without any special complications. The IUD in the bladder is a medium for forming secondary bladder stones. Most cases of IUD migration are caused by a lack of evaluation after the installation procedure. This case suggested that the physician should be more careful in carrying out the installation procedure. It is necessary to evaluate the location of the IUD after installation to prevent further patient complications.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88095225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Properties of TeNan Herbal Tea Formulation “Telang (Clitoria ternatea) and Pineapple (Ananas comosus)” 田南凉茶配方“泰朗菠萝”的抗氧化性能

Jurnal Kedokteran Brawijaya Pub Date : 2022-11-04 DOI: 10.21776/ub.jkb.2022.032.02.3

W. Widowati, T. Wargasetia, Meganita Marthania, Tazkia Salma Hanifa, Teddy Marcus Zakaria, Michael Sebastian Gunadi, Natanael Halim, Sheryl Santiadi

{"title":"Antioxidant Properties of TeNan Herbal Tea Formulation “Telang (Clitoria ternatea) and Pineapple (Ananas comosus)”","authors":"W. Widowati, T. Wargasetia, Meganita Marthania, Tazkia Salma Hanifa, Teddy Marcus Zakaria, Michael Sebastian Gunadi, Natanael Halim, Sheryl Santiadi","doi":"10.21776/ub.jkb.2022.032.02.3","DOIUrl":"https://doi.org/10.21776/ub.jkb.2022.032.02.3","url":null,"abstract":"Herbal teas was are widely consumed by people around the world have high antioxidant activities. The flavor and color combination of specific teas enriches the aroma and appearance of the tea, producing a tea with fresh color and tastier flavor. This study determines the antioxidant activity of telang flower tea (Clitoria ternatea), pineapple tea (Ananas comosus), and the formula of the combination of telang flower tea and pineapple tea called TeNan. The antioxidant activities of herbal teas were measured by 2,2 Diphenyl-1-picrylhydrazyl (DPPH), Hydrogen Peroxide (H2O2), 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), Ferric Reducing Antioxidant Power (FRAP) assay. The total phenol measurement used Gallic Acid Equivalent (GAE), while the flavonoid content measurement used Quercetin Equivalent (QE). The DPPH scavenging activities of telang flower tea, pineapple tea, and TeNan tea (IC50: 17.07%, 11.81%, and 22.22%), H2O2 scavenging activities (IC50: 26.62%, 41.81%, and 96.22%), ABTS-reducing activities (IC50: 2.51%, 3.39%, and 1.02%), and FRAP activities (IC50: 5.56%, 18.67%, and 7.48%). The total phenolic and flavonoid contents of TeNan tea were lower (9.44 μg GAE/100%; 3.46 μg QAE/100% sample concentration) than those of telang flower tea (16.20 μg GAE/100%; 4.88 μg QAE/100% sample concentration) but higher than those of pineapple tea (0.82 μg GAE/100%; 0.17 μg QAE/100% sample concentration). TeNan tea has the higher in ABTS and FRAP activities but lower in H2O2 and DPPH scavenging activities compared to telang flower tea and pineapple tea. In summary, telang tea has stronger antioxidant activity compared to pineapple and TeNan tea in FRAP and H2O2 assays.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84717754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Demographic, Clinical, and Laboratory Characteristics of HIV Patients with Cerebral Toxoplasmosis at Haji Adam Malik General Hospital Medan 棉兰哈吉亚当马利克综合医院HIV脑弓形虫病患者的人口学、临床和实验室特征

Jurnal Kedokteran Brawijaya Pub Date : 2022-11-04 DOI: 10.21776/ub.jkb.2022.032.02.7

Alfansuri Kadri, Eko Yandra

引用次数: 1

A Two-Year-Old Boy with Diphallia and Multiple Congenital Anomalies 两岁男童双阴茎及多重先天性畸形

Jurnal Kedokteran Brawijaya Pub Date : 2022-11-04 DOI: 10.21776/ub.jkb.2022.032.02.10

Rizal Trianto, Pradana Nurhadi, B. Daryanto

引用次数: 0

Effect of Simvastatin on Eosinophilic Inflammation of Bladder Tissue in Interstitial Cystitis Rat Model 辛伐他汀对间质性膀胱炎大鼠膀胱组织嗜酸性炎症的影响

Jurnal Kedokteran Brawijaya Pub Date : 2022-11-04 DOI: 10.21776/ub.jkb.2022.032.02.1

Muhamad Nur Syukriani Yusuf, Abdi Dzul Ikram Hasanuddin, Zuhriana K. Yusuf, Trinny Tuna, N. Ibrahim, Marshanda Tiara Posumah, Ridho Tianggara

{"title":"Effect of Simvastatin on Eosinophilic Inflammation of Bladder Tissue in Interstitial Cystitis Rat Model","authors":"Muhamad Nur Syukriani Yusuf, Abdi Dzul Ikram Hasanuddin, Zuhriana K. Yusuf, Trinny Tuna, N. Ibrahim, Marshanda Tiara Posumah, Ridho Tianggara","doi":"10.21776/ub.jkb.2022.032.02.1","DOIUrl":"https://doi.org/10.21776/ub.jkb.2022.032.02.1","url":null,"abstract":"In the urogenital system, simvastatin is associated with interstitial cystitis adverse effects, but the exact mechanism is not yet clearly defined. This study aims to determine the effect of simvastatin on eosinophilic inflammation of bladder tissue in vivo. Laboratory experimental research design with the post-test only control group using 24 female Wistar rats aged 8-10 weeks were randomly divided into simvastatin 50mg/kg BW (n=12) or placebo carboxymethylcellulose 0.5% (n=12). All groups received treatment through oral gavage for thirty days. After that, each group was divided equally into three subgroups: control rat, day 0 Interstitial Cystitis (IC) rat (IC0), and day 3 IC rat (IC3). Control or IC0 rats each received intravesical instillation of buffered saline or protamine sulfate (PS), respectively, and were terminated immediately less than 3 hours after instillation. The IC3 rats received intravesical PS instillation and were terminated three days post-instillation. The bladder tissue was made in Hematoxylin-Eosin histology preparations. As in previous studies, the results showed successful desquamation of the urothelium after PS instillation. Tissue eosinophil counts were significantly higher in the simvastatin group than in the placebo group in the IC3 model (15.50±5.92 vs. 4.00±2.83, p=0.013). It can be concluded that the mechanism of the adverse effect of simvastatin on bladder tissue is through increased tissue inflammation mediated by eosinophils along with urothelial layer destruction by the protamine sulfate.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80867065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

How Do Hospital Staff Cope with Covid-19 at Work? A Phenomenological Study 医院工作人员如何应对Covid-19 ?现象学研究

Jurnal Kedokteran Brawijaya Pub Date : 2022-08-05 DOI: 10.21776/ub.jkb.2021.031.02.6s

Wahyu Febrianto, Wiwin Indriani, A. Dewanto, H. Holipah

{"title":"How Do Hospital Staff Cope with Covid-19 at Work? A Phenomenological Study","authors":"Wahyu Febrianto, Wiwin Indriani, A. Dewanto, H. Holipah","doi":"10.21776/ub.jkb.2021.031.02.6s","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.02.6s","url":null,"abstract":"The Covid-19 pandemic has brought negative consequences on hospital finances, the mental health of health care workers (HCWs), and even resulted in the deaths of several health workers at Hasta Brata Hospital (HBH). This study aimed to explore the experiences of HBH's staff in dealing with the pandemic in the hospital. This research is qualitative research with a phenomenological approach. Data were collected using in-depth interviews with two of HBH's staff and then followed by the theme analysis. Hospital staff experienced job demands including emotional and physical stress at work, fear of infection, repeated conflicts with patient visitors, different mindsets among staff, increased workload, and feelings of frustration towards people who do not comply with prevention protocols. Fortunately, they had adequate job resources, ranging from the provision of personal protective equipment, nutrition improvement, and regular Covid-19 screening; update knowledge and methods of handling Covid-19; to motivational and spiritual support from HBH leaders. The staff also had strong personal resources so that they could cope with stressful work situations, feel optimistic that they could win against Covid-19, and hoped that the pandemic would end. Spiritual support embodies tawakal, an Islamic concept that gives complete surrender to God after employing maximum effort. The presence of strong job and personal resources has moderated job demands and resulted in work engagement. Tawakal is an added value for personal resources staff who finally realize that Covid-19 cannot be avoided and must be fought before surrendering entirely to God.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"24 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91496134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Caesarean Section Clinical Pathway: A Lesson Learned 剖宫产临床路径的发展:一个教训

Jurnal Kedokteran Brawijaya Pub Date : 2022-07-15 DOI: 10.21776/ub.jkb.2021.031.02.7s

I. Sastrawan, V. Wardhani

{"title":"Development of Caesarean Section Clinical Pathway: A Lesson Learned","authors":"I. Sastrawan, V. Wardhani","doi":"10.21776/ub.jkb.2021.031.02.7s","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.02.7s","url":null,"abstract":"Although clinical pathway (CP) is aimed to ensure quality and cost, the development of CP at hospitals is primarily for administrative purposes as it is required by accreditation standards, thus causing high variations in its implementation. This study aimed to develop a clinical pathway for caesarean section and explore the problem during development and implementation test. The selection of caesarean section was based on high volume, risk, and cost. Using participatory action research, the researcher started the program by performing an implementation evaluation, literature review, and regulatory development. The evaluation identified implementation discrepancies and prolonged length of stay. Based on the evaluation and literature review results, the Professional Care Provider (PCP) in the hospital conducted discussions and made suggestions by considering available resources, current practices, and behavior. The main differences of the new clinical pathway are: 1) it is developed based on literature and current practice, and 2) it should be added with notification, explanation, inclusion and exclusion criteria, and references. Before the implementation test, the hospital provide resources, develops a standard operational procedure followed by monitoring and evaluation. Differences in the type of medication and documentation method were found, which then further discussed with all involved PCP to define the agreed solutions. Professional engagement and openness culture that embraces along the process are the main key lesson learned in addition to the understanding that CP development and implementation is a continuous learning process.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72938446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Key Strategies to Reduce Waiting Time in Outpatient Pharmacy 减少门诊药房等候时间的关键策略

Jurnal Kedokteran Brawijaya Pub Date : 2022-07-15 DOI: 10.21776/ub.jkb.2021.031.02.10s

Menis Rahmawati, V. Wardhani

{"title":"Key Strategies to Reduce Waiting Time in Outpatient Pharmacy","authors":"Menis Rahmawati, V. Wardhani","doi":"10.21776/ub.jkb.2021.031.02.10s","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.02.10s","url":null,"abstract":"Waiting time in the outpatient pharmacy is still a problem in hospitals. This study aimed to identify the root causes and implement solutions to reduce the waiting time at a type C hospital. This study applied a descriptive approach. The potential causes were identified using HFMEA (Healthcare Failure Mode Effect and Analysis) confirmed through an online survey on 15 staff involved in pharmacy services. Scoring and Focus Group Discussion were used to identify the priority problems and solutions. The study results revealed six causing factors of the lengthy waiting time at the outpatient pharmacy, which were doctor's schedule, absence of specific time target for each drug preparation stage, changes of the drug storage, drug stock different from the planning, incomplete standard operating procedures, and one counter for prescription collection and drug dispensing. Three solutions were implemented in six days: checking drug stock in every shift, developing an SOP, and separating the counters for prescription collection and drug dispensing. The implementation results showed a significant increase in the waiting time percentage of compounded drugs, which met the standard (≤60 minutes) from 26% to 43%. This increase was even higher for non-compounded drug waiting time (<20), from 27% to 48%. Drug stock checking, procedure standardization, and separation of service counters are the keys to reducing outpatient pharmacy waiting time.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75020685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1