Journal of Vaccines and Vaccination最新文献_第7页

Peptide-mRNA Vaccine for SARS-Cov-2 SARS-Cov-2肽mrna疫苗

Journal of Vaccines and Vaccination Pub Date : 2020-01-01 DOI: 10.35248/2157-7560.20.S4.002

E. Farshi

{"title":"Peptide-mRNA Vaccine for SARS-Cov-2","authors":"E. Farshi","doi":"10.35248/2157-7560.20.S4.002","DOIUrl":"https://doi.org/10.35248/2157-7560.20.S4.002","url":null,"abstract":"A vaccine is described which elicits a protective immune response against SARS-Cov-2. Designed engineered peptides that could strongly bind to the spike protein of coronavirus inside cells, and to use these peptides to trigger the cells to break down the viral proteins. In this vaccine the mRNA (encoding Ribonucleic Acid) encodes a stable perfused form (the form before being fused to the cell membrane of the host cell) of Spike protein (S). In this vaccine the main problem of short time remaining of antibodies of SARS-Cov-2 virus in body could be compensated by activation of T cells that causes long term immunity because memory T cells remain in body at least 11 years. A peptide based vaccine with encoding mRNA of virus along the activation of T cells through MHC class-II which elicits protection against SARS-Cov-2 through immune cells from the lymph nodes process the mRNA and synthesize specific viral protein antigens so that other immune cells recognize them. In this vaccine that comprising peptide encoding mRNA along activation of T cells by MHC class-II which immunize body against SARS-Cov-2 are also described. Methods of protecting a host against coronavirus infection will be discussed. Our invented vaccine is type of mRNA vaccine (but combined with other components) against SARS-COV-2 is based on a relatively new genetic method that does not require growing the virus in the laboratory. The technique transforms the human body into a 'living laboratory'. Monkeys given our coronavirus vaccine and then deliberately infected were able to fight off the virus, quickly clearing it from their lungs.","PeriodicalId":17656,"journal":{"name":"Journal of Vaccines and Vaccination","volume":"59 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88713215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effective SARS-CoV-2 Vaccines on the Horizon 有效的SARS-CoV-2疫苗即将问世

Journal of Vaccines and Vaccination Pub Date : 2020-01-01 DOI: 10.35248/2157-7560.20.11.428

Soma Ghosh, P. Ghosh

引用次数: 0

Seroprevalence of Antibodies to Tetanus Toxoid and Diphtheria Toxoid in Perinatally Human Immunodeficiency Virus (HIV) - Infected Children and Adolescents 围产期人类免疫缺陷病毒(HIV)感染儿童和青少年破伤风类毒素和白喉类毒素抗体的血清阳性率

Journal of Vaccines and Vaccination Pub Date : 2020-01-01 DOI: 10.35248/2157-7560.20.11.417

S. Choudhury, FazleMatin

{"title":"Seroprevalence of Antibodies to Tetanus Toxoid and Diphtheria Toxoid in Perinatally Human Immunodeficiency Virus (HIV) - Infected Children and Adolescents","authors":"S. Choudhury, FazleMatin","doi":"10.35248/2157-7560.20.11.417","DOIUrl":"https://doi.org/10.35248/2157-7560.20.11.417","url":null,"abstract":"Introduction: Although data presented in this study is a few years old, the author believes it is important to review in this era of the COVID-19 pandemic in order to underscore the importance of timely immunization of all children, particularly those who are HIV-infected. Even in the era of Highly Active Antiretroviral Therapy (HAART), HIVinfected individuals are at a higher risk of complications from vaccine-preventable diseases than the uninfected. Methods: Anti-diphtheria and anti-tetanus antibodies (correlate of protection: antibody level>0.1 IU/ml) were assessed by ELISA in 29 HIV-infected and 20 uninfected children. Results: HIV- infected children were significantly more likely to have lower levels of antibody to diphtheria toxic when compared to their uninfected counterparts, in both the four dose (p=0.004) and the five dose (p=0.007) recipients. HIV-infected children were significantly (p=0.02) more likely to have non-protective immunity (antibody level<0.1 IU/ml) for diphtheria and tetanus toxoids than their uninfected counterparts, in the five dose recipients only. This difference in immunity between the groups, in the four-dose recipients was observed for diphtheria toxoid (p=0.05) only. Conclusion: Our study has determined that immunity to tetanus and diphtheria toxoids in HIV-infected children and adolescents is suboptimal when compared to their uninfected counterparts. We therefore, strongly recommend developing strategies within the scope of all pediatric practices, to keep up with timely vaccinations of all children and adolescents, particularly the high risk groups, in this era of COVID-19 pandemic.","PeriodicalId":17656,"journal":{"name":"Journal of Vaccines and Vaccination","volume":"78 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75216872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Efficacy of Using Cloth, Surgical, KN95, N95 and Full-face Masks among Indonesian's Travellers in COVID-19 Era 新冠肺炎时期印尼旅客使用布口罩、外科口罩、KN95口罩、N95口罩和全脸口罩的效果

Journal of Vaccines and Vaccination Pub Date : 2020-01-01 DOI: 10.35248/2157-7560.11.7.437

A. T. Utami, A. B. Prasetya

引用次数: 1

A Low Gluten Diet Suppresses Disease Activity of Rheumatoid Arthritis 低麸质饮食抑制类风湿关节炎的疾病活动

Journal of Vaccines and Vaccination Pub Date : 2020-01-01 DOI: 10.35248/2157-7560.20.S7:001

Kenji Tani, Hinako Takagishi, Yoshihiro Okura, Shingo Kawaminami, Keisuke Kawahito, Keisuke Inaba, KaoriInaba, Akiko Miyatake, Keisuke Kondo, Yoshinori Nakanishi, R. Tabata, Teruki Shimizu, Harutaka Yamaguchi

{"title":"A Low Gluten Diet Suppresses Disease Activity of Rheumatoid Arthritis","authors":"Kenji Tani, Hinako Takagishi, Yoshihiro Okura, Shingo Kawaminami, Keisuke Kawahito, Keisuke Inaba, KaoriInaba, Akiko Miyatake, Keisuke Kondo, Yoshinori Nakanishi, R. Tabata, Teruki Shimizu, Harutaka Yamaguchi","doi":"10.35248/2157-7560.20.S7:001","DOIUrl":"https://doi.org/10.35248/2157-7560.20.S7:001","url":null,"abstract":"Background: This study aimed to evaluate the efficacy of a low gluten diet in the disease activity of Rheumatoid Arthritis (RA). Methods: Among 109 patients with RA enrolled in this study, 98 patients who completed 16 weeks on a low gluten diet regimen were included in the study. At baseline, we gave the patients the information about gluten-free and gluten-contained foods, and asked them to refrain from the daily gluten consumption during the experimental period. Results: The low gluten diet significantly improved DAS28-CRP and CDAI scores after 16 weeks. The percentages of patients achieving DAS28-CRP and CDAI-defined remission or LDA were significantly increased after 16 weeks. There was a significant increase in the percentage of the responders in EULAR treatment response after 16 weeks. Rheumatoid Factor (RF) but not C-reactive protein was significantly decreased after 16 weeks. When the self-reported level about adherence to the low gluten diet was divided into three categories, a significant decrease in DAS28-CRP, CDAI and RF was detected in the patients with the strict adherence to the low gluten diet. Conclusion: This study demonstrates that the strict adherence to a low gluten diet results in the decreased disease activity of RA.","PeriodicalId":17656,"journal":{"name":"Journal of Vaccines and Vaccination","volume":"1 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89172524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twenty Years of Coronaviruses 二十年的冠状病毒

Journal of Vaccines and Vaccination Pub Date : 2020-01-01 DOI: 10.35248/2157-7560.20.S4.004

T. Divya, On

引用次数: 0

Efficacy of Porcine Circovirus Type 2a and 2d Based Vaccines Following PCV2 Challenge 猪圆环病毒2a型和2d型疫苗在PCV2攻击后的效力

Journal of Vaccines and Vaccination Pub Date : 2019-01-01 DOI: 10.24105/2157-7560.10.402

Rachel Friedrich, A. Patterson, Wesley Johnson, B. Fergen, Luis Hern, Ez, B. G. Liesner, J. Hermann

引用次数: 1

Psychological Barrier to Tetanus-Toxoid Vaccination among Nigerian Women 尼日利亚妇女接种破伤风类毒素疫苗的心理障碍

Journal of Vaccines and Vaccination Pub Date : 2019-01-01 DOI: 10.4172/2157-7560.1000397

Ryoko Sato

{"title":"Psychological Barrier to Tetanus-Toxoid Vaccination among Nigerian Women","authors":"Ryoko Sato","doi":"10.4172/2157-7560.1000397","DOIUrl":"https://doi.org/10.4172/2157-7560.1000397","url":null,"abstract":"Objectives: We evaluate psychological barrier to and demand for tetanus-toxoid vaccination among women at childbearing age in rural northern Nigeria. Methods: In this individual-level randomized controlled trial, we randomize the condition under which women can receive cash incentives among 1,700 women; Clinic condition (N=822) and Vaccine condition (N=878). Women under Clinic condition could receive cash incentives if they visit assigned clinic, while women under Vaccine condition could receive cash incentives if they visit assigned clinic and get vaccinated at the clinic. Results: 1,268 (74.6%) women visited the clinic (611 [74.3%] of 822 in Clinic condition and 657 [74.8%] of 878 in Vaccine condition), and 1,242 (73.1%) women received the vaccination (585 [71.2%] of 822 in Clinic condition and 657 [74.8%] of 878 in Vaccine condition). There was no statistical difference in clinic attendance between two conditions. Under Clinic condition, 95.7% of women received the vaccination once they visited the clinic, although it was not a requirement for them to receive cash incentives. Conclusion: Psychological barrier is not a major barrier to vaccination among women in northern Nigeria because there is no need of additional incentive for women to receive vaccination once they visit the clinic.","PeriodicalId":17656,"journal":{"name":"Journal of Vaccines and Vaccination","volume":"44 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74272483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPV Vaccination Concepts in the Reality of Today HPV疫苗接种的概念在今天的现实

Journal of Vaccines and Vaccination Pub Date : 2019-01-01 DOI: 10.24105/2157-7560.10.399

A. Paderno, A. Garolla, S. Pecorelli, Alberto Lombardi, C. Pinto, G. Icardi, F. Bonetti, F. Mennini, M. Conversano, A. Isidori, L. Mariani, G. Rezza, A. Peracino

{"title":"HPV Vaccination Concepts in the Reality of Today","authors":"A. Paderno, A. Garolla, S. Pecorelli, Alberto Lombardi, C. Pinto, G. Icardi, F. Bonetti, F. Mennini, M. Conversano, A. Isidori, L. Mariani, G. Rezza, A. Peracino","doi":"10.24105/2157-7560.10.399","DOIUrl":"https://doi.org/10.24105/2157-7560.10.399","url":null,"abstract":"The aim of this review is to evaluate the complex interaction between HPV and human body, in order to contextualize its role in the development of infective-related disease and neoplastic transformation. While the clinical value of vaccination on the field of gynecology has been widely investigated, the growing introduction of universal coverage (both males and females) leads to the need to extend investigations to adjunctive areas of interest. This is the rationale to extend and combine in a single review the main emerging areas where the HPV vaccination could induce an effective immunological response: HPV-related upper aerodigestive tract (UADT) pathologies, and HPV-related alterations of reproductive processes in males and females. There is no doubt that universal vaccination against HPV (9vHPV) is demonstrating its effectiveness in the prevention of most HPV-related conditions and worldwide prevalence data allow us to consider HPV vaccination from adolescence to late adulthood. We can conclude that: i) HPV infection is still very prevalent in sexually active population and may be associated to cervical, oropharyngeal, penile and anal cancers; ii) due to HPV vaccination and screening for cervical cancer, the incidence of cervical carcinoma is strongly decreased; iii) the rate of oropharyngeal cancer is growing worldwide and since 2010 it represents in males the most frequent HPV related cancer among U.S. population; iv) HPV semen infection, has been related to impaired sperm parameters, higher miscarriage rate and, in general, to couple infertility both by natural and assisted conception; v) recent efforts toward a universal vaccination against HPV have demonstrated its effectiveness in the prevention of most HPV-related conditions; vi) growing evidences suggest positive effects of adjuvant vaccination in patients with HPV related cancer and in HPV infected infertile couples.","PeriodicalId":17656,"journal":{"name":"Journal of Vaccines and Vaccination","volume":"5 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84841788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactive Pericarditis Post Meningococcal Vaccine 脑膜炎球菌疫苗后反应性心包炎

Journal of Vaccines and Vaccination Pub Date : 2019-01-01 DOI: 10.4172/2157-7560.1000403

E. Al-Ebrahim, A. Algazzar, Mohammed A. Qutub

引用次数: 0