Journal of thoracic disease最新文献

{"title":"Prognostic value and potential biological function of <i>PMSD11</i> in lung adenocarcinoma.","authors":"Yong Xi, Jing Zeng, Yundong Zhou, Weiyu Shen, Hirokazu Taniguchi, Retnagowri Rajandram, Sivakumar Krishnasamy","doi":"10.21037/jtd-24-1622","DOIUrl":"10.21037/jtd-24-1622","url":null,"abstract":"<p><strong>Background: </strong>The 26S non-ATPase regulatory subunit 11 (<i>PSMD11</i>) is a multiprotein complex that participates in the ATP-dependent degradation of ubiquitinated proteins and is essential to the regulation of embryonic stem cell proteasome activity. <i>PSMD11</i> has been demonstrated to be a factor contributing to the emergence and progression of cancer cells. However, the prognostic value and potential biological function of <i>PMSD11</i> in lung adenocarcinoma (LUAD) remains unclear. The aim of this study was to comprehensively investigate the prognostic and biological value of <i>PSMD11</i> in LUAD.</p><p><strong>Methods: </strong>We primarily endeavored to comprehensively investigate the prognostic and predictive value of <i>PSMD11</i> in patients with LUAD. Additionally, we aimed to further clarify the underlying mechanisms of <i>PSMD11</i> in LUAD tumorigenesis and progression via rigorous bioinformatics analyses, including expression analysis, survival analysis, clinicopathological analysis, immune microenvironment analysis, somatic mutation analysis, drug analysis, and cuproptosis analysis. Subsequently, we examined effect of <i>PSMD11</i> expression on immune escape in a non-small cell lung cancer (NSCLC) cell-T cell coculture model.</p><p><strong>Results: </strong>We found that <i>PSMD11</i> had a significantly higher expression in LUAD tissues than in normal lung tissues. Three clinical characteristics (age, stage, and overall survival event) exhibited significant differences between the <i>PSMD11</i> high- and low-expression groups. In biological function, <i>PSMD11</i> appears to exert its tumorigenic effects predominantly in pathways related to DNA replication and membrane-gated channel functions. Notably, we observed that <i>PSMD11</i> exhibited the strongest positive correlation with T helper 2 cells, gamma-delta T cells, and T regulatory cells and the highest negative correlation with B cells, mast cells, and CD8⁺ T cells. Furthermore, we found that the expression of cuproptosis genes (<i>DLAT, DLD</i>, and <i>PDHA1</i>) was positively correlated with the expression of <i>PSMD11</i> (P<0.001).</p><p><strong>Conclusions: </strong>These results indicate that <i>PSMD11</i> has the potential to be a novel therapeutic target and sensitive biomarker for patients with LUAD.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"7819-7835"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing the ultrasonic shear for internal mammary artery harvesting in minimally invasive coronary artery bypass grafting surgery is worth considering.","authors":"Yi Hong, Yunpeng Zhu, Yunpeng Ling","doi":"10.21037/jtd-24-1226","DOIUrl":"10.21037/jtd-24-1226","url":null,"abstract":"","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"7225-7229"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study of the effects of pirfenidone and nintedanib on joint inflammation and pulmonary fibrosis in a rheumatoid arthritis-associated interstitial lung disease mouse model.","authors":"Jia Liu, Lulu Xu, Xiaoling Guan, Jie Zhang","doi":"10.21037/jtd-24-882","DOIUrl":"https://doi.org/10.21037/jtd-24-882","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a serious pulmonary complication in rheumatoid arthritis (RA) patients, is one of the leading causes of death in RA patients. This study was designed to determine whether pirfenidone and nintedanib can alleviate joint inflammation and pulmonary fibrosis in a mouse model of RA-ILD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Male DBA/1 mice were injected with bovine type II collagen (bCII) to establish the RA-ILD model. Pirfenidone (20 mg/kg) and nintedanib (60 mg/kg) were administered, and body weight, joint swelling, pathology of the lungs and knees, macrophage polarization in bronchoalveolar lavage fluid (BALF), and the fluorescence intensity of phosphorylated janus kinase 2/phosphorylated signal transducer and activator of transcription 3 (p-Jak2/p-Stat3) in the lungs and knees were determined. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure mRNA, and western blotting was conducted to detect the protein. Macrophage line RAW264.7 were divided into the following groups: the RAW264.7, RAW264.7 + IL-4/IL-13 (IL-4/IL-13, 60 ng/mL), RAW264.7 + IL-4/IL-13 + pirfenidone (0.5 and 1.0 mmol/L), RAW264.7 + IL-4/IL-13 + nintedanib (0.1 and 0.5 µmol/L). Mouse primary fibroblast-like synovial (FLS) cells were divided into the following groups: the FLS, FLS + transforming growth factor-β1 (TGF-β1; 10 µg/L), FLS + TGF-β1 + pirfenidone (0.5 and 1.0 mmol/L), FLS + TGF-β1 + nintedanib (0.1 and 0.5 µmol/L) groups. Proteins in each group were detected.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The body weights of the mice in the pirfenidone and nintedanib groups were greater than those in the RA-ILD group (P&lt;0.05), the arthritis scores were also significantly lower (P&lt;0.05). The proportion of M2-type macrophages in the BALF of the nintedanib group significantly decreased (P&lt;0.05). Inflammatory cell infiltration in the lung was reduced in the pirfenidone and nintedanib groups; additionally, decreased levels of synovium, collagen, angiogenesis, and bone destruction of the knee joint and a lower synovitis score were observed (P&lt;0.05). Masson staining revealed that collagen deposition in the lungs in the pirfenidone and nintedanib groups was reduced (P&lt;0.05). P-Jak2/p-Stat3 expression in the lungs and knee joints in the pirfenidone and nintedanib groups was low (P&lt;0.001 in the lung and P&lt;0.005 in the knee joint). The mRNA expression of collagen-IV, Stat3, and Jak2 in the lungs was lower in the pirfenidone and nintedanib (P&lt;0.05); the protein expression levels of p-Jak2/Jak2, p-Stat3/Stat3, p-Smad3/Smad3, and TGF-β receptor 2 (TGF-βR2) in the lungs in the pirfenidone and nintedanib groups decreased (P&lt;0.05). P-Jak2/Jak2, p-Stat3/Stat3, TGF-βR2, cluster of differentiation 206 (CD206), and arginase-1 (ARG-1) were lower in the pirfenidone and nintedanib groups of RAW264.7 cells (at all different concentrations, P&lt;0.05). P-JAK2/JAK2, p-Stat3/Stat3, and TGF-βR2 were","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"7458-7476"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcomes and learning curve of complex versus simple segmentectomy for uniportal video-assisted thoracoscopic surgery: an initial experience of 100 cases of a single experienced surgeon.","authors":"Takahiro Homma, Hisashi Saji, Yoshifumi Shimada, Keitaro Tanabe, Koji Kojima, Hideki Marushima, Tomoyuki Miyazawa, Hiroyuki Kimura, Hiroki Sakai, Kanji Otsubo, Takayuki Hatakeyama, Toshihiro Ojima, Tomoshi Tsuchiya, Hitoshi Igai","doi":"10.21037/jtd-24-1028","DOIUrl":"https://doi.org/10.21037/jtd-24-1028","url":null,"abstract":"<p><strong>Background: </strong>Complex segmentectomy for uniportal video-assisted thoracoscopic surgery (VATS) remains controversial due to procedural complexity and the risk of increased complications, unlike multiportal VATS. Demonstrating the perioperative results and proficiency of individual surgeon is believed to influence future dissemination for uniportal VATS. In this study, we aimed to compare the perioperative outcomes and learning curves of complex versus simple segmentectomy for uniportal VATS.</p><p><strong>Methods: </strong>This retrospective cohort study included all patients who had an elective uniportal VATS segmentectomy between July 2018 and June 2023. We documented our initial experience with 100 consecutive segmentectomy cases. A single board-certified experienced surgeon performed all procedures. The perioperative outcomes of the complex (n=45) and simple (n=55) segmentectomy groups were compared using propensity score matching and the cumulative sum technique.</p><p><strong>Results: </strong>Using propensity score matching, 29 patients were chosen from each group. There was no statistically significant difference between the two groups in perioperative outcomes. The initial learning curve for simple segmentectomy was completed after 20 cases, while that for complex segmentectomy was completed after 11 cases.</p><p><strong>Conclusions: </strong>Uniportal VATS complex segmentectomy was safe and comparable to simple segmentectomy in terms of perioperative outcomes and learning curves in an experienced surgeon. Uniportal VATS complex segmentectomy should be considered a viable surgical option.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"7361-7371"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TNM classification of lung cancer-a historic perspective.","authors":"Ramón Rami-Porta","doi":"10.21037/jtd-24-1212","DOIUrl":"https://doi.org/10.21037/jtd-24-1212","url":null,"abstract":"<p><p>Developed by Pierre F. Denoix in the mid-20th century as a clinical classification of anatomic tumour extent, the tumour, node, and metastasis (TNM) classification was adopted by the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC). The first lung cancer classification was published as a brochure in 1966 by the UICC, and 2 years later, the UICC published the first edition of the <i>TNM Classification of Malignant Tumours</i>, which was followed 9 years later by the first edition of the <i>AJCC Manual for Staging of Cancer</i>. The 2^nd to 6^th editions of the lung cancer classification were based on a North American database managed by Clifton F. Mountain, who also introduced the pathologic classification for tumours undergoing resection. Most descriptors used today originated in the second edition of the classification. To address the limitation of the North American database being restricted to a single geographic region, Peter Goldstraw proposed the creation of a larger, international database within the International Association for the Study of Lung Cancer (IASLC). The IASLC Staging Project, developed by the members of the IASLC Staging and Prognostic Factors Committee (SPFC) and the statisticians of Cancer Research and Biostatistics (CRAB), has already compiled three databases, which informed the analyses for the 7^th, the 8^th, and the 9^th editions of the lung cancer TNM classification. This classification has stood the test of time and will remain valuable as long as the anatomic extent of lung cancer continues to play a role in therapy and research.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"8053-8067"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localization strategies for deep lung nodule using electromagnetic navigation bronchoscopy and indocyanine green fluorescence: a technical note.","authors":"Yuan Xu, Hongsheng Liu, Yingzhi Qin, Chao Guo, Shanqing Li, Naixin Liang","doi":"10.21037/jtd-24-1303","DOIUrl":"10.21037/jtd-24-1303","url":null,"abstract":"<p><p>Accurate localization of pulmonary nodules is crucial for successful video-assisted thoracoscopic surgery (VATS) resection. Electromagnetic navigation bronchoscopy (ENB) combined with indocyanine green (ICG) fluorescence has emerged as a promising technique for precise pulmonary nodule marking. This study aims to evaluate the efficacy and safety of four ENB-guided ICG marking techniques: direct lesion marking, superficial marking, resection boundary marking, and margin sphere marking. We prospectively enrolled 80 patients with deep lung nodules and evaluated the procedural outcomes, accuracy, complications, and postoperative results of each ENB-guided strategy. The overall success rate of ENB-guided ICG marking was 97.5%, with no significant differences among the four techniques. The superficial marking and resection boundary marking methods achieved 100% fluorescence visibility and superior consistency in marking. The visibility of fluorescence varied among the four marking methods. No severe complications occurred during the ENB procedures, while 1 patient had minor bleeding at the dye injection site. Our study demonstrates that ENB-guided localization using ICG dye and fluorescence thoracoscopy is a safe and effective technique for the preoperative marking of deep lung nodules. Among the four localization strategies investigated, we recommend prioritizing the superficial marking and resection boundary marking methods in clinical practice when feasible, as they provide reliable and precise guidance for the resection of deep lung nodules.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"7910-7919"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of applying oxidized regenerated cellulose sheets to the parietal pleura of open chest wounds in thoracic surgery: a prospective randomized controlled trial protocol.","authors":"Takahiro Ochi, Hidemi Suzuki, Yuki Sata, Takahide Toyoda, Terunaga Inage, Kazuhisa Tanaka, Yuichi Sakairi, Yukiko Matsui, Yuki Shiko, Ichiro Yoshino","doi":"10.21037/jtd-24-1296","DOIUrl":"10.21037/jtd-24-1296","url":null,"abstract":"<p><strong>Background: </strong>According to a large-scale clinical trial in Japan, segmentectomy for small peripheral non-small cell lung cancer has an advantage over lobectomy in terms of overall survival, while it could also increase the incidence of local recurrence. In ipsilateral reoperations, intrathoracic adhesions from a previous surgery increase the risk of lung injury and bleeding, which may result in intraoperative and postoperative complications. The ability of oxidized regenerated cellulose (ORC) sheets to prevent postoperative adhesions has been demonstrated in the abdomen, and the same effect is expected in the thoracic region. The purpose of this study is to provide evidence supporting the application of ORC sheets to the parietal pleura of an open chest wounds to prevent postoperative adhesions in the thoracic region.</p><p><strong>Methods: </strong>This phase II prospective open-label, randomized, parallel-group study will validate adhesion prevention by applying ORC sheets to the parietal pleura of open chest wounds at the time of surgical closure. In the control group, the chest is closed by the usual procedure without ORC sheets. The primary endpoint is the presence rate of pleural adhesion findings on chest echography performed 4-20 weeks postoperatively. Data analysis will be performed in 2025-2026.</p><p><strong>Discussion: </strong>This study will provide evidence to the adhesion prevention effect of ORC sheet in the thoracic region, with the aim of establishing a strategy to prevent postoperative intrapleural adhesions.</p><p><strong>Trial registration: </strong>This trial has been registered on the Japan Registry of Clinical Trials 1032230271 (https://jrct.niph.go.jp/latest-detail/jRCT1032230271).</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"8149-8155"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative day of surgery ambulation improves outcomes following lung resection: a multicenter prospective cohort study.","authors":"Christina M Stuart, Adam R Dyas, Nicole M Mott, Kyle E Bata, Michael R Bronsert, Alyson D Kelleher, Katherine O McCabe, Crystal Erickson, Simran K Randhawa, Elizabeth A David, John D Mitchell, Robert A Meguid","doi":"10.21037/jtd-24-1183","DOIUrl":"10.21037/jtd-24-1183","url":null,"abstract":"<p><strong>Background: </strong>The impact of post-surgical same day ambulation in lung resection patients is relatively unstudied. We sought to determine the relationship between day of surgery ambulation and postoperative outcomes after lung resection.</p><p><strong>Methods: </strong>This was a prospective cohort study at one healthcare system with six hospitals (1/2019-3/2023). Patients undergoing segmentectomy and lobectomy were targeted for inclusion. Patients who had missing ambulation data were excluded. Patients were divided into two cohorts based on whether or not they ambulated postoperatively on the day of surgery. Postoperative outcomes were compared using chi-square, Fisher's exact, or Mann-Whitney-<i>U</i> tests. Multivariable logistic regression controlling for pertinent perioperative confounders was performed to identify the independent effect of ambulation on complication rates.</p><p><strong>Results: </strong>Of 1,056 patients included in the analytic cohort, 443 patients (42.0%) ambulated postoperatively on the day of surgery. Patients who ambulated day of surgery had significantly lower rates of morbidity, including respiratory complications, surgical site infection, bleeding, cardiac complications, cardiac arrhythmias, infectious complications, and opioid use, and had shorter length of stay, shorter chest tube duration, and lower total hospital cost. After risk-adjustment, patients who ambulated day of surgery had lower odds of overall morbidity, less opioid consumption, shorter length of stay, and shorter chest tube duration.</p><p><strong>Conclusions: </strong>Patients who ambulated postoperatively on the day of surgery had better surgical recovery and outcomes after lung resection than those who did not. Day of surgery ambulation is an excellent quality metric and associated with avoidance of postoperative complications.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"7300-7309"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of lymph node evaluation standard in patients undergoing lung resection for clinical stage IA pulmonary adenocarcinoma and squamous cell carcinoma.","authors":"Raffaele Rocco, Brandon S Hendriksen, Belisario A Ortiz, K Robert Shen, Stephen D Cassivi, Sahar Saddoughi, Janani S Reisenauer, Dennis A Wigle, Luis F Tapias","doi":"10.21037/jtd-24-971","DOIUrl":"10.21037/jtd-24-971","url":null,"abstract":"<p><strong>Background: </strong>The American College of Surgeons Commission on Cancer (CoC) revised operative quality standards recommending resection of lymph nodes from at least one hilar station and three different mediastinal stations in all curative-intent pulmonary resections. This study evaluated the prognostic value and factors associated with adherence to this new CoC standard in patients with resected clinical stage IA non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>Retrospective review of 654 patients who underwent pulmonary resection for clinical IA NSCLC. The study population was divided into patients that met and did not meet the CoC standard.</p><p><strong>Results: </strong>The CoC standard was met in only 254 (38.8%) patients. Factors associated with meeting the CoC standard included left-sided resections, open technique, and type of pulmonary resection. CoC standard was met in 51.6% of lobectomies, 29.9% of segmentectomies, and 17.1% of wedge resections (P<0.001). Nodal upstaging was more frequent in patients meeting the CoC standard (21.3% <i>vs.</i> 12.5% when standard not met; P=0.004). Time to recurrence [adjusted hazard ratio (aHR): 0.86, 95% confidence interval (CI): 0.63-1.17, P=0.33] and overall survival (aHR: 0.78, 95% CI: 0.58-1.05, P=0.10) were not different between CoC standard groups. However, patients not meeting the CoC standard and classified as pN0 exhibited an overall survival that resembled that of patients with pN1 disease.</p><p><strong>Conclusions: </strong>Left-sided resections, open technique and lobectomy were associated with meeting the CoC standard. However, this standard did not have a significant impact on long-term outcomes. Larger studies with longer follow-up are needed to clarify the role of the CoC standard in patients with resected stage IA NSCLC.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"7663-7674"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and survival analysis of non-hypertensive aortic dissection patients post-thoracic endovascular aortic repair: a 10-year retrospective study.","authors":"Shuangshuang Li, Xianfei Liu, Jin Yang, Zilin Lu, Jian Dong, Jia He, Jian Zhou","doi":"10.21037/jtd-24-318","DOIUrl":"10.21037/jtd-24-318","url":null,"abstract":"<p><strong>Background: </strong>The clinical characteristics and predictors for aortic adverse events (AAEs) after thoracic endovascular aortic repair (TEVAR) of non-hypertensive aortic dissection (AD) patients remain unclear. This study sought to clarify the clinical features of non-hypertensive AD and its incidence of AAEs after TEVAR.</p><p><strong>Methods: </strong>Clinical data were collected from the electronic medical records, imaging databases and follow-up. Baseline characteristics were balanced by propensity score matching (PSM). Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to asses postoperative AAEs and risk factors.</p><p><strong>Results: </strong>Eight hundred and eighty-eight eligible AD patients who had received TEVAR were included. The proportion of males (72.2% <i>vs.</i> 80.6%, P=0.006) and the mean age of onset (55.17±14.95 <i>vs.</i> 59.08±13.34 years, P=0.001) were lower in the non-hypertension group. Type A dissection still accounted for a higher proportion in the non-hypertensive group than the hypertensive group (38.2% <i>vs.</i> 28.3%, P=0.02) after matching. Non-hypertensive AD showed a lower mean survive time (36.65±2.08 <i>vs.</i> 42.74±1.41 months, P=0.01) with a higher 5-year adverse event ratio (37.4% <i>vs.</i> 29.0%, P=0.05). Hazard ratio (HR) of type A dissection, international normalized ratio (INR), prothrombin time (PT), aortic root diameter (AoRoot) and left ventricular volume associated with AAEs after TEVAR were 3.348 [95% confidence interval (CI): 2.313-4.846], 269.197 (95% CI: 3.46-20,946.462), 0.595 (95% CI: 0.369-0.959), 2.446 (95% CI: 1.542-3.880), 1.008 (95% CI: 1.004-1.012), respectively.</p><p><strong>Conclusions: </strong>Non-hypertensive patients presented a higher proportion of female and type A classification, and a younger mean age of TEVAR treatment. Preoperative indicators including Stanford classification, PT, activated partial thromboplastin time (APTT), AoRoot and left ventricular volume were major risk factors for adverse events after TEVAR, which deserve to be further explored and evaluated for its predictive value for better management of AD.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"16 11","pages":"7397-7407"},"PeriodicalIF":2.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}