Journal of Tissue Science and Engineering最新文献

{"title":"WFIRM and Oracle Health Sciences Collaborate to Combine Body-on-a-Chip with Information Examination","authors":"Sowmya Uttam","doi":"10.37421/JTSE.2020.11.234","DOIUrl":"https://doi.org/10.37421/JTSE.2020.11.234","url":null,"abstract":"The Wake Forest Institute for Regenerative Medicine (WFIRM) and Oracle Health Sciences have joined as a component of the Innovation Quarter's iQ Healthtech Labs™ to build up a consortium of industry, government, and scholastic individuals that will contemplate novel ways to deal with setting up the wellbeing of new medications that are approaching clinical examination in people and FDA endorsement. The cooperation unites Oracle's unrivaled foundation for information investigation with WFIRM's Body-on-a-Chip program to give cutting edge advancements to tranquilize improvement, medicate applicant screening, and customized medication. Body-on-a-Chip is an arrangement of scaled down organs, likewise called \"organoids,\" that can be utilized to identify hurtful and antagonistic impacts of medications before they are tried in people","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"44 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78216216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specialists Create 3D Tissue Models of Cerebrum Tumors in a Mind Mirroring Microenvironment","authors":"Sowmya Uttam","doi":"10.37421/JTSE.2020.11.235","DOIUrl":"https://doi.org/10.37421/JTSE.2020.11.235","url":null,"abstract":"dimensional (3D) human tissue culture models of pediatric and grown-up mind malignant growths in a cerebrum copying microenvironment, a critical headway for the investigation of mind tumor science and pharmacological reaction. The examination was distributed today in Nature Communications. The scientists made models that incorporate cerebrum inferred extracellular grid (ECM) - the perplexing system of proteins and amino acids with bound sugars normally found in the mind. The ECM offers help for encompassing neural tissue, yet additionally assists with controlling cell development and improvement. Changes in ECM piece have been related with mind tumor movement, which thusly adjusts examples of hereditary and protein articulation in the tumor cells","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"20 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78432765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic Regenerative Medicine and Stem Cells","authors":"D. Gerber, Xianwen Yi","doi":"10.37421/JTSE.2020.11.233","DOIUrl":"https://doi.org/10.37421/JTSE.2020.11.233","url":null,"abstract":"Organogenesis of the liver, biliary tree and pancreas is well described in fetal development. Stem/progenitor cells proliferate and subsequently differentiate during early stages of development of the definitive ventral endoderm and these cells contribute to the formation of the foregut. The ongoing debate persists regarding the reactivation of these processes during the postnatal period. Findings regarding this phenomenon have been demonstrated for the liver and biliary tree, and recent studies have demonstrated that this process is also occurring within the pancreas. Despite these observations the mechanisms associated with the processes involved with postnatal organogenesis are not well understood.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"47 3 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89308526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RADA16-I Hydrogel-Released CXCL12 Stably Promotes Stem Cell Migration","authors":"A. Cheng, Janie Xu, Chengcheng Sun, Yanfei Li, Jian Fan, Jinghong Zhu, D. Liu, J. Zhao, Dongsheng Xu","doi":"10.4172/2157-7552.1000221","DOIUrl":"https://doi.org/10.4172/2157-7552.1000221","url":null,"abstract":"Introduction: CXCL12 (Stromal cell-derived factor 1α, SDF - 1α) plays an important role in the nervous system development and neural repair, and is gradiently expressed in the central nervous system, mediating proper neural progenitor cell (NPCs) migration and survival. Due to a relatively short half-life and restriction of the blood-brain barrier (BBB) in systemic bioactive factor delivery, the delivery of CXCL12 and other bioactive factors has become a great challenge in research and clinical application. \u0000Aims: In order to observe the change of concentration grade and release time of CXCL12we studied the dynamic CXCL12 prolonged release pattern with the injectable, nontoxic, modifiable and degradable RADA16-I peptide hydrogel. The hydrogel resulted in a relatively stable CXCL12 concentration and provided more suitable microenvironment for stem cell survival and migration in vitro. The following major experiments were conducted: 1. Anti-adhesion and neural protection with RADA16-I were performed in rabbit skull trauma model; 2. Fluorescent semi-quantitative CLSM was used for analysis of CXCL12 released from CXCL12 hydrogel mixture, and ELISA for detecting CXCL12 release kinetic curve was utilized; 3. Effective concentration was estimated through the peak concentration of CXCL12 load and was determined with trans-well migration assay. \u0000Results: 1. RADA16-I alone potentially played a role in anti-adhesion and neural repair. Furthermore, RADA16-I hydrogel slow-release system smoothly released chemokine CXCL12 in vitro. \u00002. Stable CXCL12 released system was more effective to be used for tissue repair compared to quickly declined CXCL12 without hydrogel system. \u00003. The peak concentration (50 ng/ml) of CXCL12 load released from hydrogel was the functional concentration for the induction of directional migration in mouse neuronal progenitor cells (mNPCs). \u0000Conclusions: Slow-released hydrogel system and mixture, RADA16-I and CXCL12, offered effective grade level for cell migration. This system is potentially beneficial for neural tissue protection and neural repair in clinic.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"132 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2019-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86603311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of Displacement Estimation of Breast Tissue in Ultrasound Elastography","authors":"Taher Slimi, Romaissa Tamali, H. Mahjoubi","doi":"10.4172/2157-7552.1000223","DOIUrl":"https://doi.org/10.4172/2157-7552.1000223","url":null,"abstract":"Breast tissue displacements estimation in static ultrasound elastography, is a medical imaging technique which provides information on the local rigidity of tissues. Despite the fact that this technique has a major interest in clinical diagnosis, it suffers from increased deterioration due to the presence of speckle noise, artifacts and poor detail accuracy which appeared during the B-mode image acquisition process. Therefore, the application of Block Matching (BM) technique will greatly amplify the speckle noise and deteriorate the image quality. In this perspective, the implementation of an optimal technique is crucial for optimizing the quality of mammary displacements tissue. In this paper, we propose a new method based on the BM model that is to improve the old BM (OBM) technique. In this respect, an improvement of pre-processing step is satisfactory, in order to establish accurate tissue displacement estimation. The research was validated on a database of 20 patients with breast malignant tumor. Biophysical parameters has been adapted and used to eliminate artifacts and speckle noise, once the images are filtered; the BM model is implemented after to estimate tissue displacements. Based on the clinical results, quantitative analysis verifies that the tissue displacements estimated by our proposed strategy are more efficient than the OBM and Bilinear Deformable Block Matching (BDBM) techniques, our proposed approach gives better values in term of standard deviation (SD), higher contrast to noise ratio (CNR), greater peak signal-to-noise ratio (PSNR) and excellent structural similarity (SSIM) than OBM and BDBM techniques. The results of the proposed model are encouraging, allowing excellent estimates. The proposed model provides a new and appropriate solution for improving estimation of mammary tissue displacements. The proposed new strategy could be a powerful diagnostic tool to be used in clinical evaluation dedicated to breast ultrasound elastography.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90724513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Device for restricting blood flow: Intracorporeal Pringles maneuver for laparoscopic liver resection","authors":"pKungchen Hop","doi":"10.4172/2157-7552-c3-052","DOIUrl":"https://doi.org/10.4172/2157-7552-c3-052","url":null,"abstract":"","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76791654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific design, realization and clinical use in regenerative medicine of a human derived dermal matrix (HDM)","authors":"E. Bondioli, V. Purpura, D. Melandri","doi":"10.4172/2157-7552-C1-046","DOIUrl":"https://doi.org/10.4172/2157-7552-C1-046","url":null,"abstract":"","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74208755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Nanosilver, Nanogold and their Combination on the Healing Potential of Critical Radial Bone Defects in Rats","authors":"A. Oryan, H. Gholipour, A. Meimandi-Parizi","doi":"10.4172/2157-7552.1000215","DOIUrl":"https://doi.org/10.4172/2157-7552.1000215","url":null,"abstract":"A new composition of platelet-fibrin glue (FPG), gelatin (Gel), nanohydroxyapatite (nHA), silver nanoparticles (SNPs) and gold nanoparticles (GNPs) was synthesized and employed in preparation of hybrid scaffolds and was applied in bone tissue engineering in the surgically critical-sized bone defect in a rat model. Sixty bilateral radial bone defects were randomly divided into six groups including untreated defects, autograft and those treated with Gel/FPG/nHA containing scaffolds including nHA alone, nHA/SNPs, nHA/GNPs and nHA/SNPs/GNPs (n=10 in each group). The defects were assessed by radiography, histopathology, scanning electron microscopy and biomechanical testing. In comparison with the untreated defects, all the treated defects demonstrated significantly superior new bone formation, remodeling and bone tissue volume. Moreover, the defects treated with GNPs showed significantly higher ultimate strength, yield strength and stiffness. The nHA and nHA/SNPs moderately improved bone regeneration that were not close to the autograft in some parameters, whereas nHA/GNPs and nHA/SNPs/ GNPs significantly improved bone healing closely comparable with those of the autograft group in most parameters. In conclusion, although all the scaffolds had some beneficial effectiveness on bone regeneration, the scaffolds containing GNPs were more effective in improving the structural and functional properties of the newly formed bone and were more osteoinductive than other scaffolds and were comparable to the autograft. Therefore, the scaffolds including GNPs can be regarded as a promising option to be used in bone tissue engineering.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"21 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2018-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73864851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Question for Scientists in Tissue Physiology","authors":"S. Foote","doi":"10.4172/2157-7552.1000217","DOIUrl":"https://doi.org/10.4172/2157-7552.1000217","url":null,"abstract":"","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"174 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76316872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Technique for Processing Tissue Displacements Estimation in Breast Ultrasound Elastography","authors":"Taher Slimi, I. Moussa, T. Kraiem, H. Mahjoubi","doi":"10.4172/2157-7552.1000214","DOIUrl":"https://doi.org/10.4172/2157-7552.1000214","url":null,"abstract":"Breast ultrasound elastography allows acquiring a displacements estimation images that reflects the tissue elasticity of the area under ultrasound examination. The displacements analysis of the mammary tissues helps to provide an accurate diagnosis related to tissue stiffness evaluation. However; despite the fact that this imaging modality is promising and effective, it encounters a major problem, B-mode images are altered by speckle noise which comes from the difference in echogenicity of the imaged tissues, which deteriorates the diagnostic information, therefore, an application of displacements estimation methods on contaminated B-mode images, amplifies indirectly the speckle noise, causing a reduction of clinical evaluation capacity and prevention of rigorous clinical assessment. In this perspective, the development of tools for treating this problem is crucial and indispensable for controlling the appearance of speckle noise. In this paper, we propose a new strategy based on the bilinear deformable block matching (BDBM) technique, in order to improve the old bilinear deformable block matching (OBDBM) technique by improving the B-mode images pre-processing step, at this stage, the B-mode images processing before estimating displacements is sufficient to have a good estimate. The proposed approach does not only filter the image against noise, it also improves the estimation of tissue deformations, the developed approach is based on the coupling between the reconstruction by filtered back projection (FBP) technique with shrinkage wavelets. The proposed model was validated using in vivo database containing 20 B-mode images acquired before and after compression. The FBP approach was used to reconstruct the tissue texture, consequently improves the resolution and the contours erased by the noise, after that the shrinkage wavelets have been introduced to completely filter the image against speckle noise. By comparing our proposed method with OBDBM and monogenic techniques (displacement estimation method based monogenic technique), we show that it is the most efficient in term of standard deviation calculation between the pixels (SD), it is better also for calculating the contrast to noise ratio (CNR) and it provides an excellent structural similarity (SSIM). The results of the proposed technique are encouraging and it is ready to be used in mammary tissues displacements enhancement images for ultrasound elastography.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"32 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73683284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}