Journal of Tropical Pharmacy and Chemistry最新文献_第9页

Antihipercolesterolemia Effects and Acute Toxicity Test of Pheophytin on Green Tea 叶绿素对绿茶的抗胆固醇作用及急性毒性试验

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-20 DOI: 10.25026/jtpc.v5i1.222

L. Kusmita, Ika Puspitaningrum

{"title":"Antihipercolesterolemia Effects and Acute Toxicity Test of Pheophytin on Green Tea","authors":"L. Kusmita, Ika Puspitaningrum","doi":"10.25026/jtpc.v5i1.222","DOIUrl":"https://doi.org/10.25026/jtpc.v5i1.222","url":null,"abstract":"Hypercholesterolemia is a condition characterized by increased levels of total cholesterol in the blood. Pheophytin is the result of degradation of chlorophyll which is the dominant pigment in green tea, and has been shown to have the same antioxidant properties as - carotene. This study aims to determine the antihypercholesterolemia effect and effective dose of pheophytin isolates and acute toxicity tests to determine the safety level of pheophytin isolates. \u0000Antihipocolesterolemia test uses induction of high-fat feed that is a mixture of standard food, pork oil and quail egg yolk (16: 3: 1). While the acute toxicity test is carried out based on OECD 423, Clinical symptoms that arise for 3 hours are observed intensively. Histopathological examination data of liver and kidney organs were performed on day 14. Data obtained in the form of LD 50 and clinical symptoms that arise as well as histopathological results were analyzed qualitatively. \u0000Statistical test results of percent reduction in total cholesterol levels showed a significant difference between the negative control group and the pheophytin isolates of the three doses. This proves that pheophytin isolates can have antihypercholesterolemic effect with an effective dose of 10 mg/kgBW. Histopathological examination results of aorta and liver of rats showed that the higher the dose of pheophytin isolates, the lighter the degree of fatty acid. While the toxicity test results showed that the LD50 value of pheophytin isolates was more than 2000 mg / kgBW (non-toxic category). However, pheophytin isolate with LD50 is more than 2000 mg/kgBW which has shown the presence of pancreatic degeneration and hydropic degeneration, but necrosis has not occurred yet.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":"5 1","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43340869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial activity of different fractional extracts of cerastium glomeratum 不同部位提取物的抑菌活性研究

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-20 DOI: 10.25026/jtpc.v5i1.223

Himayat Ullah, Muhammad Hubaib, Muhammad Israr, Muhammad Mushtaq, Muhammad Zeeshan, Muhammad Mustafa

{"title":"Antibacterial activity of different fractional extracts of cerastium glomeratum","authors":"Himayat Ullah, Muhammad Hubaib, Muhammad Israr, Muhammad Mushtaq, Muhammad Zeeshan, Muhammad Mustafa","doi":"10.25026/jtpc.v5i1.223","DOIUrl":"https://doi.org/10.25026/jtpc.v5i1.223","url":null,"abstract":"Every plant available in the universe is not produced to be the part of biodiversity, but is also produced to obtain medicinal purposes. The medicinal value of the plant is due to the availability of various chemical compounds [1]. Since prehistoric time, the crude extract of plant is used to cure various diseases, although the biologically active components of the plant were unidentified [2]. \u0000In the present study the antibacterial activity is performed for various extracts of cerastium glomeratum. The plant cerastium glomeratum was collected from near kalpani river Mardan, Pakistan and was identified by lecturer Israr department of botany GPGC Mardan, Pakistan. The plant was dried under shade and grinded into powder form. The extraction process was done by using soxhlet apparatus, reflux condenser and maceration process using ethanol as a solvent. The extract was divided into different fractions of n-hexane, DCM, ethyl acetate and water. These four extracts were tested against gram positive (staphylococcus aureus) and gram negative (E.coli) bacteria using well diffusion technique. The water extract show a wide range inhibition zone against both gram positive and gram negative bacteria while n-hexane, DCM and ethyl acetate fractions show no zone of inhibition against bacteria. In effort to find new antibacterial compounds cerastium glomeratum seems to be a good plant for additional phytochemical studies. \u0000","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46094997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antibacterial activity of different fractional extracts of cerastium glomeratum 球花不同部位提取物的抗菌活性

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-20 DOI: 10.25026/JTPC.V5I2.223

H. Ullah, Muhammad Hubaib, M. Israr, M. Mushtaq, Muhammad Zeeshan, Muhammad Mustafa

{"title":"Antibacterial activity of different fractional extracts of cerastium glomeratum","authors":"H. Ullah, Muhammad Hubaib, M. Israr, M. Mushtaq, Muhammad Zeeshan, Muhammad Mustafa","doi":"10.25026/JTPC.V5I2.223","DOIUrl":"https://doi.org/10.25026/JTPC.V5I2.223","url":null,"abstract":"Every plant available in the universe is not produced to be the part of biodiversity, but is also produced to obtain medicinal purposes. The medicinal value of the plant is due to the availability of various chemical compounds [1]. Since prehistoric time, the crude extract of plant is used to cure various diseases, although the biologically active components of the plant were unidentified [2]. \u0000In the present study the antibacterial activity is performed for various extracts of cerastium glomeratum. The plant cerastium glomeratum was collected from near kalpani river Mardan, Pakistan and was identified by lecturer Israr department of botany GPGC Mardan, Pakistan. The plant was dried under shade and grinded into powder form. The extraction process was done by using soxhlet apparatus, reflux condenser and maceration process using ethanol as a solvent. The extract was divided into different fractions of n-hexane, DCM, ethyl acetate and water. These four extracts were tested against gram positive (staphylococcus aureus) and gram negative (E.coli) bacteria using well diffusion technique. The water extract show a wide range inhibition zone against both gram positive and gram negative bacteria while n-hexane, DCM and ethyl acetate fractions show no zone of inhibition against bacteria. In effort to find new antibacterial compounds cerastium glomeratum seems to be a good plant for additional phytochemical studies. \u0000","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43420055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Activity of Different Extract of Medicinal Plant Antirrihnum Orontium. 药用植物天竺葵不同提取物的抑菌活性研究。

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-20 DOI: 10.25026/jtpc.v5i1.221

H. Ullah, Shehzad Saleem, Wisal Ahmad, M. Hanif, Z. Ali, M. Israr

引用次数: 1

Isolation and Characterization of the Roots of Rumex nervosus 神经酸模根的分离与鉴定

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-05 DOI: 10.21203/rs.2.22592/v1

Gashaw Nigussie

引用次数: 10

The Antioxidant Activity and Phytochemical Analysis of Medicinal Plant Veronica Biloba 药用植物维罗妮卡的抗氧化活性及植物化学分析

Journal of Tropical Pharmacy and Chemistry Pub Date : 2019-12-30 DOI: 10.33263/lianbs84.732738

Amir Hassan, H. Ullah, M. Israr

{"title":"The Antioxidant Activity and Phytochemical Analysis of Medicinal Plant Veronica Biloba","authors":"Amir Hassan, H. Ullah, M. Israr","doi":"10.33263/lianbs84.732738","DOIUrl":"https://doi.org/10.33263/lianbs84.732738","url":null,"abstract":"A medicinal plant veronica genus has 450 well known species and found across both temperate and hemisphere region their 26 species are endemic and known in a total of 79 popular species and are widely utilized throughout the world due to important biological activities. In this study fully powdered uniform size specie veronica biloba plant taken in porous bag were manually subjected to soxhlet hot continuous process for cyclization of extraction using ethanol (300 mL) a concentrated dried extract obtained after solvent evaporation. Furthermore, liquid-liquid extracted fractions as water, dichloromethane, n-hexane, and ethyl acetate yields results founds polar fraction with highest percentage (water 47.51 %). The phytochemical screening of veronica biloba has shown all major compounds entirely present in extracts. One of the primitive phenolic compound flavonoid is present in plant and show potency towards antioxidants. All the extracted fractions of plant showed excellent antioxidant activity using a stable DPPH (1,1-diphenyl-2-picryl-hydrazyl) method at concentration (range from 31.25 to 500µg/mL). Primary our ethyl acetate extract fraction showed highest inhibition potential at IC50 = 1.70±0.05µg/mL which is much closer to a standard positive control Propyl gallate showed IC50 = 1.6±0.05µg/mL percent potential. The purification and isolation of these extract is important which can provide us help in novel antioxidants discovery also natural antioxidants currently in cosmetics products, food and therapeutics health related products significantly demanded because they are very effective, efficient and harmless as compared to synthetic one.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41729255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

ANALYSIS ANALYSIS OF CAFFEINE IN TABLET DOSAGE FORM WITH SPECTROPHOTOMETRIC AND IODOMETRIC BACK TITRATION METHODS 用分光光度法和碘量反滴定法分析片剂中咖啡因的含量

Journal of Tropical Pharmacy and Chemistry Pub Date : 2019-09-09 DOI: 10.25026/jtpc.v4i6.214

E. Yazid

{"title":"ANALYSIS ANALYSIS OF CAFFEINE IN TABLET DOSAGE FORM WITH SPECTROPHOTOMETRIC AND IODOMETRIC BACK TITRATION METHODS","authors":"E. Yazid","doi":"10.25026/jtpc.v4i6.214","DOIUrl":"https://doi.org/10.25026/jtpc.v4i6.214","url":null,"abstract":"Caffeine (1, 3, 5-trimethylxanthine) is an active ingredient that is often added to analgesics drugs to teat headaches or reduce pain. This study aims to quantitatively analyze caffeine levels in tablet dosage forms by spectrophotometric methods and iodometric back titration. In the spectrophotometric method the measurement of caffeine levels was carried out using a maximum wavelength of 272 nm.The results of caffeine levels were found for bodrex drugs (50.87 ± 0.195 mg/tab), extra panadol (64.92 ± 0.579 mg/tab), saridon (51.38 ± 0.273 mg/tab) and paramex (46.78 ± 0.072 mg/tab). The purity percentage of caffeine was found in the range between 93.57-102.76%. While the iodometric back titration method was obtained for bodrex (48.04 ± 0.889 mg/tab), extra panadol (64.45 ± 0.697 mg/tab), saridon (43.38 ± 0.756 mg/tab) and paramex (42.36 ± 0.889 mg/tab) with a purity range of 84.73-99.15%. The average caffeine content of the two method extant suitability close to the true value as stated on the label. The results of the spectrophotometric method are more accurate, while the titrimetry method is still good to use because it is cheaper and only requires simple apparatus and common chemicals.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47157589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metabolite Profiling of 96% Ethanol Extract from Marsilea crenata Presl. Leaves Using UPLC-QToF-MS/MS and Anti-Neuroinflammatory Predicition Activity with Molecular Docking 红毛冬青96%乙醇提取物的代谢产物分析。利用UPLC QToF-MS/MS的叶片及其分子对接的抗炎作用

Journal of Tropical Pharmacy and Chemistry Pub Date : 2019-09-09 DOI: 10.25026/jtpc.v4i6.213

Burhan Ma’arif, Denis, Arief Suryadinata, Artabah, H. Laswati, M. Agil

{"title":"Metabolite Profiling of 96% Ethanol Extract from Marsilea crenata Presl. Leaves Using UPLC-QToF-MS/MS and Anti-Neuroinflammatory Predicition Activity with Molecular Docking","authors":"Burhan Ma’arif, Denis, Arief Suryadinata, Artabah, H. Laswati, M. Agil","doi":"10.25026/jtpc.v4i6.213","DOIUrl":"https://doi.org/10.25026/jtpc.v4i6.213","url":null,"abstract":"Phytoestrogen is a group of compounds that can replace the estrogen function in the body. One of its roles was as anti-neuroinflammatory by inhibiting the microglia M1 polarity activation. Marsilea crenata Presl. is a plant that suspected to contain phytoestrogens. The aim of this research was to determine the metabolite profile of 96% ethanol extract of M. crenata using UPLC-QToF-MS/MS, and prediction the anti-neuroinflammatory activity of compounds with molecular docking. The 100 ppm of 96% ethanol extract in DCM and methanol were injected 5 µl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The result of metabolite profiling shows a total 59 compounds in both DCM and methanol. Molecular docking was done with Autodock 4.2.6. After being analyzed, there are 3 compounds that are predicted to have activities similar to 17β-estradiol, they are prochlorperazine, 12-Aminododecanoic acid, and 1-methyl-2-[(4-methylpiperazin-1-yl)methyl]benzimidaol-5-amine hydrochloride. The results showed that the three compounds were predicted to be phytoestrogen compounds from M. crenata leaves, which have potential as anti-neuroinflammatory.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47763614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

REVIEW: STUDY THE ROLE OF CHINA ACUPUNCTURE AND "GI" ACUPUNCTURE AS AN ALTERNATIVE AND COMPLEMENTARY THERAPY IN THE TREATMENT 综述：中国针灸与吉针作为替代和补充疗法在治疗中的作用

Journal of Tropical Pharmacy and Chemistry Pub Date : 2019-09-09 DOI: 10.25026/jtpc.v4i6.209

Risna Agustina, A. Soemardji, Felesia Fanty, L. Amalia

引用次数: 0

Molluscicidal activities of Tetrapleura tetraptera fruit extract, Aridanin and their particulate formulations on adult and newly hatched Biomphalaria glabrata snails 毒蕈果实提取物、Aridanin及其颗粒制剂对成年和新孵化的光斑螺的杀螺活性

Journal of Tropical Pharmacy and Chemistry Pub Date : 2019-09-09 DOI: 10.25026/jtpc.v4i6.217

G. Akinniyi, F. Fisusi, B. J. Taiwo

{"title":"Molluscicidal activities of Tetrapleura tetraptera fruit extract, Aridanin and their particulate formulations on adult and newly hatched Biomphalaria glabrata snails","authors":"G. Akinniyi, F. Fisusi, B. J. Taiwo","doi":"10.25026/jtpc.v4i6.217","DOIUrl":"https://doi.org/10.25026/jtpc.v4i6.217","url":null,"abstract":"The study investigated the molluscicidal activities of chloroform/methanol (1:1) extract of Tetrapleura tetraptera and isolated Aridanin. It also developed useable particulate formulation of chloroform methanol extract and Aridanin and evaluated their molluscicidal activities. This is with a view to providing information on development of useable particulate formulations for the control of snail intermediate hosts of schistosomiasis. The plant material was extracted successively in n-hexane (100%), chloroform (100%), chloroform/methanol (1:1) and methanol (100%) respectively by maceration. Bioactivity-guided fractionation of chloroform methanol extract was performed using column chromatography to isolate the active compound, Aridanin. Particulate formulations of chloroform methanol extract and Aridanin were prepared by emulsion solvent evaporation method. Molluscicidal screening on adult and newly hatched Biomphalaria glabrata snails was evaluated according to WHO protocols. The blank polymer formulation, dechlorinated water and Niclosamide served as controls. The result showed that Aridanin demonstrated the highest molluscicidal activity on adult B. glabrata snails with 24 h- LC50 of 1.61 ppm. The chloroform methanol extract had an LC50 value of 23.00 ppm, while particulate formulation of Aridanin and chloroform methanol extract had LC50 of 13.40 and 170.60 ppm respectively. This study showed that newly hatched B. glabrata snails are less susceptible to molluscicides compared to adult snails (P","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49447701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0