Journal of Tropical Pharmacy and Chemistry最新文献_第8页

Monitoring Use of Antibiotic with ATC/DDD and DU 90% on Pediatric Patients at One of the Government Hospitals in East Borneo 监测东婆罗洲一所政府医院儿科患者使用ATC/DDD和DU 90%抗生素的情况

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-06-29 DOI: 10.25026/jtpc.v5i2.252

Risna Agustina, W. Prabowo

引用次数: 0

Formulation and Characterization on Self Nanoemulsifying Drug Delivery System of Eleutherine Palmifolia Extract Employing Short, Medium, and Long Chain Triglyceride 短、中、长链甘油三酯棕榈叶提取物纳米自乳化给药体系的制备及表征

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-06-22 DOI: 10.25026/jtpc.v5i2.232

R. Annisa, Yen yen Ari Indrawijaya, D. Megawati, Ana Fikrotus Zakia

{"title":"Formulation and Characterization on Self Nanoemulsifying Drug Delivery System of Eleutherine Palmifolia Extract Employing Short, Medium, and Long Chain Triglyceride","authors":"R. Annisa, Yen yen Ari Indrawijaya, D. Megawati, Ana Fikrotus Zakia","doi":"10.25026/jtpc.v5i2.232","DOIUrl":"https://doi.org/10.25026/jtpc.v5i2.232","url":null,"abstract":"Eleutherine palmifolia (E. palmifolia) is a common plant used as an anticancer drug in Kalimantan, Indonesia. The active compound present in it is naphthoquinone, which has low water solubility and needs to be formulated into SNEDDS preparations to improve its dissolution and bioavailability in the body. The dispersion method is used in the preparation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) and PEG 400 cosurfactants. Furthermore, this study aims to ascertain the effects of oil on the SNEDDS preparations. The results showed that the effect of the preparations on olive oil, VCO, and oleic acid in the organoleptic test produced dark red, clear, and non functional emulsion. The average particle sizes obtained in the AGF media were 61,10, 774,33, and 211,70 nm; in AIF media it amounted to 211,70, 123,65, and 830,22 nm. The pH value for each formula was 6,8, while the average emulsification time for the AGF media was 24,10, 22,53, and 25,75 seconds, and, lastly, for the AIF media, they were 20,96, 19,62, and 23,74 second.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":"5 1","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2020-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43114579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiopental Elevates Steady-State Levels of Intracellular Ca2+ and Zn2+ in Rat Thymic Lymphocytes 硫喷妥钠提高大鼠胸腺淋巴细胞内Ca2+和Zn2+的稳态水平

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-06-17 DOI: 10.25026/jtpc.v5i2.259

Norio Kamemura, Keisuke Oyama, S. Ueno, Mizuki Mizobuchi, K. Ishidoh, Naoki Kanematsu

{"title":"Thiopental Elevates Steady-State Levels of Intracellular Ca2+ and Zn2+ in Rat Thymic Lymphocytes","authors":"Norio Kamemura, Keisuke Oyama, S. Ueno, Mizuki Mizobuchi, K. Ishidoh, Naoki Kanematsu","doi":"10.25026/jtpc.v5i2.259","DOIUrl":"https://doi.org/10.25026/jtpc.v5i2.259","url":null,"abstract":"Thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of general anesthesia. However, the toxic effect of thiopental is not completely clear.　The effect of thiopental on intracellular Ca2+ ([Ca2+]i) levels was investigated in non-excitable cells. Experiments were carried out using a flow-cytometric technique, rat thymic lymphocytes (as non-excitable cells), and appropriate fluorescent probes. Treatment of cells with 300 µM thiopental increased Fluo-3 fluorescence intensity, indicating elevation of [Ca2+]i. This increase was partially attenuated by a chelator of intracellular Zn2+. Thus, thiopental elevated both [Ca2+]i and intracellular Zn2+ ([Zn2+]i) levels. Under intracellular Zn2+-free conditions, 100–300 µM thiopental was still able to induce a statistically significant increase in [Ca2+]i, whereas removal of extracellular Ca2+ greatly reduced the increase in [Ca2+]i induced by this dose of thiopental. Therefore, the thiopental-induced increase in [Ca2+]i was mainly due to an increased influx of Ca2+. Treatment of cells with 300 µM thiopental increased FluoZin-3 fluorescence intensity, indicating the presence of [Zn2+]i, both in the presence and absence of extracellular Zn2+. The thiopental-induced elevation of [Zn2+]i was due to an increase in both influx of Zn2+ and intracellular Zn2+ release. Concanavalin A (10 µg/mL) augmented Fluo-3 fluorescence in the presence of an intracellular Zn2+ chelator. The combination of concanavalin A and 100–300 µM thiopental synergistically increased [Ca2+]i. Results suggest that thiopental increases [Ca2+]i in both quiescent and activated lymphocytes, possibly resulting in modulation of immune system function. \u0000","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43612049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Optimization of Essential Oil Extraction from Java Cardamom 爪哇豆蔻精油提取工艺的优化

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-06-16 DOI: 10.25026/jtpc.v5i2.257

R. Raissa, Windi Cahya Amalia, Meri Ayurini, Khabib Khumaini, P. J. Ratri

{"title":"The Optimization of Essential Oil Extraction from Java Cardamom","authors":"R. Raissa, Windi Cahya Amalia, Meri Ayurini, Khabib Khumaini, P. J. Ratri","doi":"10.25026/jtpc.v5i2.257","DOIUrl":"https://doi.org/10.25026/jtpc.v5i2.257","url":null,"abstract":"Indonesia is one of the largest spice-producing regions such as the Java Cardamom (Amomum compactum). The cardamom can be converted into derivative products in the form of cardamom essential oil. In this work, we attempted to extract the essential oil from the cardamom by comparing two methods of extraction which are the steam distillation and the simple distillation. The optimization factors considered on the extraction yield were solvent (ethyl acetate and n-hexane) and extraction time (3-6 h). The extraction yield obtained by both methods in ethyl acetate solvents was almost equal to that obtained in n-hexane. Also, the result obtained revealed that the extraction yield increased with time. The optimum essential oil yield was obtained by the simple distillation method in 6 hours duration time using n-hexane solvent giving the yield of 6.3 %. Gas Chromatography-Mass Spectrometry (GC-MS) was used to identify the chemical composition of the extracted oil. The results showed that the chemical composition of the essential oils is different in each extraction time. The main compounds in all oil samples were eucalyptol and camphene among four other constituents. The concentration of eucalyptol reached an optimum (90.89 - 93.74 %) at 4 – 5 h of distillation times, while the concentration of camphene reached an optimum (52.98 %) at 6 h. The purity of the essential oil was confirmed by Fourier Transform Infra-Red (FTIR). Moreover, this research will help to utilize the cardamom due to its main compounds that act as herbal medicine.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":"238 2","pages":"125-129"},"PeriodicalIF":0.0,"publicationDate":"2020-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41312909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of Media Types on the Growth of Callus Culture in Kumis Kucing Orthosiphon aristatus (Blume) Miq. 不同培养基类型对Kumis kuching Orthosiphon aristatus (Blume) Miq愈伤组织生长的影响。

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-25 DOI: 10.25026/jtpc.v5i1.210

W. Widayat, Muhammad Satyo Pradana, Mirhansyah Ardana

引用次数: 0

Antibacterial Activity of Scopoletin from Stem Bark of Aleurites moluccana Against Salmonella typhi 黑木耳茎皮东莨菪碱对伤寒沙门氏菌的抑菌活性研究

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-25 DOI: 10.25026/jtpc.v5i1.218

W. Prabowo, Risna Agustina

{"title":"Antibacterial Activity of Scopoletin from Stem Bark of Aleurites moluccana Against Salmonella typhi","authors":"W. Prabowo, Risna Agustina","doi":"10.25026/jtpc.v5i1.218","DOIUrl":"https://doi.org/10.25026/jtpc.v5i1.218","url":null,"abstract":"Background: Based on a previous survey of ethnopharmaceutical studies (local culture), it was known that the use of decoction of candlenut stem bark (Aleurites Moluccana) was used as typhoid medicine in the treatment tradition of the people of East Kalimantan. In antibacterial screening by diffusion test, methanol extract of stem bark A.moluccana showed excellent growth inhibition of Salmonella thypimurium. Working method: Simplicia of A.moluccana stem bark was extracted by maceration using methanol. Maserate was extracted liquid-liquid using n-hexane and ethyl acetate solvents. The hexane and ethyl acetate fraction was monitored for active spots with TLC bioautography. The active compound is separated using vacuum liquid chromatography and radial chromatography. Results: The fraction J of KCV and J2 subfraction results from radial chromatography provides antibacterial activity of S. thpimurium. From the J2 subfraction obtained pure isolates in the form of yellowish needle crystals. The isolate was tested for antibacterial S.thypimurium using the microdilution method with a value of MIC is 250 µg/ml. Based on spectroscopic data and comparing the published spectra of the compound, the elucidation of the isolate is Scopoletin (7-hydroxy-6-methoxycoumarin).","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":"5 1","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49177294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Test of the Potential of Ethanol Extracts, Simplician Medium and Forest Umbi Juice (Eleutherine bulbosa (Factory) Urb.) against Blood Glucose Levels of Rats, and Histopatology Ratkreas Rat (Rattus norvegicus) Hypercolesterolemia Model Diabetic 乙醇提取物、简易培养基和森林Umbi汁（球茎Eleutherine bulbosa（Factory）Urb.）的潜力测试抗大鼠血糖水平和组织病理学Ratkreas大鼠（褐家鼠）高胆固醇血症糖尿病模型

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-25 DOI: 10.25026/jtpc.v5i1.229

Joni Tandi, T. W. Handayani, N. Purwasih

{"title":"Test of the Potential of Ethanol Extracts, Simplician Medium and Forest Umbi Juice (Eleutherine bulbosa (Factory) Urb.) against Blood Glucose Levels of Rats, and Histopatology Ratkreas Rat (Rattus norvegicus) Hypercolesterolemia Model Diabetic","authors":"Joni Tandi, T. W. Handayani, N. Purwasih","doi":"10.25026/jtpc.v5i1.229","DOIUrl":"https://doi.org/10.25026/jtpc.v5i1.229","url":null,"abstract":"This study aims to examine the presence or absence of secondary metabolite compounds in ethanol extract, simplicia steeping and forest onion tuber juice, in male glucose parameters and pancreatic histopathology. Using test animals as many as 30 male white rats divided into 6 groups and each group consisted of 5 rats with group I details as normal controls, group II as negative controls given 0.5% Na-CMC suspension, group III as positive control who were given Metformin 45 mg / kg BB and IV, V, VI as the test group were given ethanol extract, simplicia extract and forest onion tuber juice with each dose of 20 g / kg BW. The results showed that there were secondary metabolites in the ethanol extract of forest onion tubers, namely flavonoids, saponins, alkaloids, steroids and tannins, giving ethanol extract of forest onion bulbs had the effect of reducing blood glucose levels in white mice with a dose of 20g / kgBW with an average of 132 and ethanol extract of forest onion bulbs at a dose of 20g / kg BB with an average of 0.5 can regenerate pancreatic tissue.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":"5 1","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47464033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation of Caffeine from Carbonated Beverages 碳酸饮料中咖啡因的分离

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-25 DOI: 10.25026/jtpc.v5i1.234

Amir Hassan, Muhammad Ashfaq, Ali Khan, M. S. Khan

引用次数: 2

The Effectiveness of the Antiinfamation Combination Gel of Okra Fruit (Abelmoschus esculentus) Extracts and Shallots Extract (Allium cepa L.) 秋葵（Abelmoschus esculentus）提取物和葱（Allium cepa L.）提取物联合凝胶的抗炎效果

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-20 DOI: 10.25026/jtpc.v5i1.228

Sara Nurmala, Moerfia Moerfia, S. Novianti

{"title":"The Effectiveness of the Antiinfamation Combination Gel of Okra Fruit (Abelmoschus esculentus) Extracts and Shallots Extract (Allium cepa L.)","authors":"Sara Nurmala, Moerfia Moerfia, S. Novianti","doi":"10.25026/jtpc.v5i1.228","DOIUrl":"https://doi.org/10.25026/jtpc.v5i1.228","url":null,"abstract":"Wound is a condition that is the destruction of the unity or network components, which are specifically found the substance of tissue damaged or lost, either damage the continuity of the skin, mucous membranes and bones or other organs. Wound healing is a very complex process involving many cells. The process of wound healing is portrayed as occurs in biological surgical wound occurred. Several phases of wound healing are: the process of inflammation (inflammatory), the process of cell multiplication (proliferation) and cell maturation process (maturase). Okra is a plant that allegedly came from Southeast Asia. Okra has grown in many countries in almost all over the world. In the UK okra known as the Lady's Finger, in India it is called by the name of Bhindi while the United States called Gumbo. In Indonesia, this plant also has a local name that is Rabamea (Bima), Coffee Java (Java), Arabian Coffee (Sulawesi), Hoinu (Southeast Sulawesi), but better known by the name of okra. This study aims to determine the effective concentration and determine the length of time of wound healing using a combination gel okra fruit extract (Abelmoschus esculentus) And shallots (Allium cepa L.) as an anti-inflammatory against cuts in male white rats (Sprague -Dawley) with a length of observation for 9 days. This study uses Betadine® ointment as a positive control. The results showed the combination of fruit extract gel okra 6% and shallots 2% contained in the formula 3 most effective as an anti-inflammatory against cuts in male rats by administration for 6 days.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":"5 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44471765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method 离子凝胶法制备槟榔叶提取物纳米颗粒及表征

Journal of Tropical Pharmacy and Chemistry Pub Date : 2020-02-20 DOI: 10.25026/jtpc.v5i1.224

Dwi Saryanti, Dian Nugraheni, Nisa Sindi Astuti

引用次数: 2