Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)最新文献

{"title":"Pro-inflammatory cytokine (IL-6) and total count lymphocyte profiles in COVID-19 patients with different severity levels","authors":"S. Sari, Wening Tri Mawanti, Dewi Martalena, E. Listiyaningsih, Rizkyana Avissa, Rini Latifah, W. Sukarya","doi":"10.19106/jmedsci005303202101","DOIUrl":"https://doi.org/10.19106/jmedsci005303202101","url":null,"abstract":"COVID-19 is caused by the SARS-CoV-2 infection that attacked the human respiratory system. In severe conditions it causes pneumonia, kidney failure, acute respiratory distress syndrome (ARDS) and even death. The SARS-CoV-2 infection triggers the immune cells to secrete an excess of pro-inflammatory cytokines that lead to cytokine storm. It is believed to become one of the mechanisms that cause the ARDS condition. The level of pro-inflammatory cytokines will differ with each case severity. This study aimed to evaluate the profile of pro-inflammatory cytokines in COVID-19 patients with different severity. Therefore, it could be used as a therapeutic approach for cytokine storm conditions. It was a cross sectional study using plasma samples of COVID-19 patients from Jakarta Islamic Hospital Pondok Kopi and Dr. M. Goenawan Partowidigdo Hospital Cisarua Indonesia. The COVID-19 patients with severe (n=20) and mild to moderate (n=25) severity were involved in this study. As a negative control plasma sample from healthy subjects (n=13) was used. Plasma IL-6 levels were measured using the ELISA technique and plasma lymphocyte levels were measured using a hematology analyzer. The results showed that no significant difference between severity and gender was observed (p=0.256). Meanwhile there is a significant difference in IL-6 level between negative control mild-moderate and severe categories (p=0.015). The average IL-6 level in severe categories was higher than mild-moderate and negative control categories with values 105.375 59.75 and 64.577 pg/mL respectively. This result becomes supporting evidence that there is a cytokine storm condition in severe COVID-19 patients. Furthermore, the lymphocyte level in the severe group is significantly lower than the mild to moderate group. This result may indicate lymphocytopenia in the severe group.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84960541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative approach of nanoformula moisturizer applications in atopic dermatitis: a review","authors":"Nyoman Suryawati, Made Wardhana","doi":"10.19106/jmedsci005302202112","DOIUrl":"https://doi.org/10.19106/jmedsci005302202112","url":null,"abstract":"The skin barrier defect is the first step in the development of atopic dermatitis (AD). Various therapeutic guidelines recommend using moisturizers to maintain the skin barrier and the prevention of AD. The use of a moisturizer in the form of barrier cream is considered to improve the skin barrier. However, this dosage form is occlusion and has an oily texture, resulting in patient noncompliance with therapy. Various techniques were developed to improve patient compliance in applying topical preparations, one of which is by developing nanotechnology. Recent studies aim to develop nanoformula preparations because they can help deliver drug molecules to specific targets with minimize side effects. The application of nanoformula moisturizer is promising in the management of AD because of its ability to reduce water loss and prevent irritation and produce formulations with a thinner texture to increase therapeutic compliance in AD patients.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"460 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78820606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictor factor of final visual acuity (VA) of acute retrobulbar neuritis patients receiving optic neuritis treatment trial (ONTT) regiment","authors":"Tatang Talka Gani, Melvina Nidya Sandra, I. Mahayana, Datu Respatika, H. Hartono","doi":"10.19106/jmedsci005302202104","DOIUrl":"https://doi.org/10.19106/jmedsci005302202104","url":null,"abstract":"The study aimed to investigate the efficacy of intravenous optic neuritis treatment trial (ONTT) regiment on the treatment ofpatients with acute retrobulbar neuritis.This was a cross sectional studyusing medical records data of patients diagnosed with unilateral or bilateral retrobulbar neuritis by normal funduscopic findings and typical optic neuritis perimetry results within 14 days of onset fromtheNeuro-ophthalmology Clinic, Department of Ophthalmology, Dr. Sardjito General Hospital, Yogyakarta from January to December 2015. Medical records data of patients who received 1000 mg methylprednisolone IV per day for 3 days followed by 11 days 1 mg/kg body weight oral prednisolone were reviewed. Visual acuity (VA) at onset, final VA at time of follow up, delta VA improvement and time of follow up were included in the analyses.Twenty data of patients aged 33.95±8.07 years with VA at onset of 1.96±0.81 (~ 1 mCF) were analyzed in this study. Significantly improvement in final VAafter treatment to be 1.39±1.12 (~5mCF) was reported (p=0.001). The VA at onsetwas a predictive factor for final VA (p 0.05). In conclusion, there is VA improvement after the treatment of ONTT regiment. The VA at onset is a predictive factorof final VA on patients with acute retrobulbar neuritis. ABSTRAK Penelitian ini bertujuan mengkaji efektivitas regimen optic neuritis treatment trial (ONTT) intravena pada pengobatan pasien dengan neuritis retrobulbar faseakut. Penelitian potong lintang ini menggunakan rekam medis pasien yang didiagnosis neuritis retrobulbar unilateral atau bilateral dengan temuan funduskopi normal dan hasil perimetri neuritis optik yang khas dalam waktu 14 haris etelah onset dari Klinik Neuro-optamalmologi, Departemen Oftalmologi, Rumah Sakit Umum Pusat Dr. Sardjito, Yogyakarta dari Januari-Desember 2015. Data rekam medis pasien yang menerima1000 mg metilprednisolon IV per haris elama 3 hari diikuti oleh prednisolon oral selama 11 hari dengan dosis 1 mg/kg berat badan dianalisis. Ketajaman visual (VA) saat onset, VA akhir saat tindaklanjut, peningkatan VA, dan waktu tindak lanjut dianalisis. Sebanyak 20 data pasien berumur 33,95 ±8,07 tahun dengan VA saat onset 1,96 ±0,81 (~ 1 mCF) dianalisis dalam penelitian ini. Perbaikan VA akhir menjadi 1,39±1,12 (~5mCF) dilaporkan (p=0,001). Ketajaman visual saat onset merupakan factor predictor VA akhir (p 0,05). Dapat disimpulkan, terdapat peningkatan VA pasien setelah pengobatan regimen ONTT. Ketajaman visual saat onset merupakan factor prediktor VA akhir pada pasien dengan neuritis retrobulbar akut.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87753614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of intestinal protozoan infection among child students with disabilities in Bantul District, Yogyakarta Special Region, Indonesia","authors":"Fahriana Azmi, E. H. Murhandarwati, M. A. Wijayanti","doi":"10.19106/jmedsci005302202109","DOIUrl":"https://doi.org/10.19106/jmedsci005302202109","url":null,"abstract":"Children with disabilities are excluded from many aspects of life. Unfortunately, they have an increased risk of infection from many kinds of pathogens including intestinal protozoan. This study aimed to determine the prevalence of intestinal protozoan infections and to evaluate the associated factors among children with disabilities in Bantul District, Yogyakarta Special Region, Indonesia. A cross-sectional study was conducted at school with special needs between June-December, 2019. A total of 150 participants were recruited through simple random sampling. Stool samples were examined microscopically by formalin-ether concentration and Ziehl-Neelsen staining technique. Age was analyzed using the Mann-Whitney tests, while the other variables used chi-square tests. Multivariable logistic regression was conducted to identify factors associated with intestinal protozoan infections. The adjusted prevalence ratio with a 95% confidence interval at a 5% level of significance was used to measure the strength of association. Overall, there were 15 children infected by intestinal protozoan among 130 subjects with mean age of participants of 9.83 ± 3.1 years. The intestinal protozoan species were Entamoeba histolytica 7 (5.38%), Giardia lamblia 4 (3.08%), Blastocystis hominis 7 (5.38%) and Iodamoeba butschlii 1 (0.77%). Prevalence of intestinal protozoan infection among children with disabilities in Bantul District, Yogyakarta, Special Region was 11.54%. There were no significant correlations between the risk factors and intestinal protozoan infection among children with disabilities (p>0.05).","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82215329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidermophyton floccosum as apossible aethiological agent of tinea capitis: a case report","authors":"R. Chandra, N. Z. Lubis","doi":"10.19106/jmedsci005302202110","DOIUrl":"https://doi.org/10.19106/jmedsci005302202110","url":null,"abstract":"Tinea capitis is a superficial fungal infection of scalp that affects particularly school-aged children. It is usually caused by dermatophytes, although Epidermophyton floccosum can cause the tinea capitis. Tinea capitis caused by the E. floccosum is quite interesting because it can confirm the sporadic occurrence of hair parasitism by this dermatophyte. In this article, it was reported tinea capitis caused by E. floccosum. A 15-year-old girl, presented with itchy scaly alopecia on scalp since 1 week ago. The patient denied any contact with cat or dog, and there was not any family history. On physical examinations, lymphadenopathies were found at both lateral neck and alopecia with scales and crusts, lenticular to nummular sizes, at scalp. Hair-pull test was positive. The trichoscopy examination found comma hairs, broken hairs, and black dots. The fungal culture examination discovered the growth of E. floccosum. The patient was diagnosed with tinea capitis and treated with 500 mg of griseofulvin orally, 10 mg of cetirizine orally, and 2% of ketoconazole shampoo. Epidermophyton floccosum is an anthropophilic dermatophyte that frequently causes tinea cruris, tinea pedis, tinea corporis and onychomycosis, but not tinea capitis. Several reports have showed the capability of E. floccosum in perforating hairs and causing tinea capitis. In conclusion, E. floccosum is a possible aethiological agent of tinea capitis through its ability to perforate hairs.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80468738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of diagnostic accuracy between clinical examination and magnetic resonance imaging (MRI) in diagnosing anterior cruciate ligament (ACL) rupture on Indonesian population","authors":"Luthfi Hidayat, A. F. R. Triangga, Muhamad Afrizal Farkhan, B. F. P. Rahayu, R. Magetsari","doi":"10.19106/jmedsci005302202107","DOIUrl":"https://doi.org/10.19106/jmedsci005302202107","url":null,"abstract":"Anterior cruciate ligament (ACL) injury is the most common knee ligament injured. Anterior drawer and Lachman tests are the most common physical examinations for helping diagnose ACL injuries, while magnetic resonance imaging (MRI) is the first choice of supporting examination for evaluating any internal abnormality of the knee. However, studies concerning the accuracy of those examinations in the Indonesian population are limited. This study aimed to compare the accuracy between the anterior drawer test, Lachman test, and MRI in diagnosing ACL injury in Javanese patients. This retrospective study used medical records data of patients who underwent knee arthroscopy in the Department of Orthopaedics and Traumatology, Dr. Sardjito General Hospital, Yogyakarta in 2018. The MRI and the clinical examination results were compared to the arthroscopy results as the gold standard. The study showed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for the anterior drawer test were 86.67% (95%CI: 69.28-96.24%), 80% (CI: 44.39-97.48%), 92.86% (CI: 78.88-97.84), 66.67% (CI: 43.28-83.98%), and 85% (CI: 70.16-94.29%), respectively. Lachman test had 96.67% (CI: 82.78-99.92%) sensitivity, 90% (CI: 55.50-99.75%) specificity, 96.67% (CI: 81.86-99.47%) PPV, 90% (CI: 56.44-98.43%) NPV, and 95% (CI: 83.08-99.39%) accuracy. The diagnostic parameters of MRI were 83.33% (CI: 65.28-94.36%) for sensitivity, 60% (CI: 26.24-87.84%) for specificity, 86.21% (CI: 74.21-93.14%) for PPV, 54.55% (CI: 31.77-75.57%) for NPV, and 77.50% (CI: 61.55-89.16%) for accuracy. In conclusion, the Lachman test has better accuracy than the anterior drawer test. Both the anterior drawer and Lachman tests had higher accuracy compared to the MRI.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76945077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and clinical characteristic of malaria patients in Weoe Public Health Center, Malaka District, East Nusa Tenggara in 2019","authors":"Maria Seraphine Agusta, N. Ariani, C. Setiawan","doi":"10.19106/jmedsci005302202108","DOIUrl":"https://doi.org/10.19106/jmedsci005302202108","url":null,"abstract":"Malaria remains a health problem in Indonesia including in East Nusa Tenggara (ENT) Province where its incidence is high. Weoe Public Health Center located in Malaka District, ENT Province has an important role as the front-line in the malaria control. The high number of malaria cases in this area may induce an economic burden due to unproductiveness at workplaces even death. This study aimed to overview the distribution and clinical characteristics of malaria patients in Weoe Public Public Health Center, Malaka District. This was a descriptive cross sectional study with saturated sampling method using secondary data of patient’s medical record from January-December 2019. Malaria patients treated at the Weoe Public Health Center from eight villages were selected in this study. The data of the time of ill, patient’s residence, gender, age, complaints, temperature, type of malaria, therapy, treatment results, and follow up blood smear tests result were collected. Among 815 patients suspected malaria, 198 (24.3%) were confirmed malaria positive caused by Plasmodium falciparum (41.4%) and P. vivax (58.6%). The highest cases occurred in February which reached 36.4% of the total cases. The highest incidence of malaria was found in Weoe Village (2.33%), dominated by male patients (57.6%), and mostly occurred at age 6-12 years (29.3%). Patients presented with fever (100%) followed by non-classical malaria complaints such as nausea and vomiting (46%), headache (33%), chills (30.8%), and flu symptoms (14.1%). All malaria patients were treated with combination of dihydroartemisinin-piperaquine (DHP) and primaquine (PQ) with a 100% cure rate and follow up blood smear test are negative from malaria parasite.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91331409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of valsartan compared with telmisartan in reducing insulin resistance on type 2 diabetes mellitus (T2DM) patients with hypertension","authors":"Hemi Sinorita, L. B. Purnomo, R. B. Pramono","doi":"10.19106/jmedsci005302202102","DOIUrl":"https://doi.org/10.19106/jmedsci005302202102","url":null,"abstract":"Insulin resistance is a major risk factor for patients with type 2 diabetes mellitus (T2DM). Telmisartan and valsartan are angiotensin II type I receptor blockers (ARBs) that are often used in patients with metabolic syndrome and T2DM. This study aimed to compare the effect of valsartan and telmisartan in reducing insulin resistance on T2DM with hypertension. Patients of T2DM were open-label screened at the Endocrinology Policlinic, Department of Internal Medicine, Dr. Sardjito General Hospital, Yogyakarta, and then randomized into two groups. The first group received valsartan 80 mg per day up to 160 mg per day, the second group received telmisartan 40 mg per day up to 80 mg per day in addition with life-style modifying and diabetes therapy. Homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride and HDL cholesterol levels of patients were measured before and after receiving telmisartan and valsartan for 12 weeks. A total of forty-nine outpatients were involved in this study comprised of 25 female patients (51%) and 24 male patients (49%) with 27 patients (55.1%) received telmisartan and 22 patients (44.9%) received valsartan as the hypertension therapy. No significantl difference were observed between telmisartan group compared with valsartan group in HOMA-IR (14.01 ± 16.39 vs. 5.31 ± 3.51; p=0.053), triglyceride levels (165.71 ± 94.70 vs 144.41 ± 48.33 mg/dL; p=0.620), HDL-C level (48.57 ± 9.78 vs 49.24 vs 49.24 ± 12.56 mg/dL; p=0.999). In conclusion, telmisartan demonstrated no difference compared to valsartan in reducing insulin resistance on T2DM patients with hypertension.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85721729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between vascular endothelial growth factor (VEGF) expression with histopathological findings in osteosarcoma","authors":"Fikar Arsyad Hakim, Y. Putro, Y. M. Sakti, R. Magetsari, I. Widodo, E. Dwianingsih","doi":"10.19106/jmedsci005302202101","DOIUrl":"https://doi.org/10.19106/jmedsci005302202101","url":null,"abstract":"Vascular endothelial growth factor (VEGF) expression is associated with malignancy progression, metastasis, and poor prognosis in many malignancies, including osteosarcoma. However, studies concerning correlations between VEGF expression and histopathological prognostic factors ofosteosarcoma are limited. This study aimed to evaluate the correlations between VEGF expression and histopathological findings in osteosarcoma’spatients.This was a cross-sectional study using formalin-fixed paraffin embedded (FFPE) samples of 32 osteosarcoma’s patients from Dr. Sardjito General Hospital, Yogyakarta. Histopathological findings of specimens were re-evaluated by two independent observers, recorded for the subtypes, invasiveness, grading, mitotic counts, and tumor infiltrating lymphocytes (TIL). Expression of VEGF was determined based on immunostaining and evaluated using immunoreactivity score (IRS).Chi-square and Spearman correlation test were used to analyze the association between variables. Range of VEGF expression score was 0 to 11, with mean 5.09. Significant negative correlation between the VEGF expression and TIL was observed (p=0.046). However, there was no significant correlations between the VEGF expression and osteosarcomas subtypes, invasion, grading or mitotic counts (p> 0.05). In conclusion, the VEGF expression is associated with TIL. Further study is needed to evaluate the roles of VEGF and lymphocytes in osteosarcoma development dan progression in order to better understand of the role of VEGF in immunotherapy of osteosarcoma.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78835308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hirschsprung’s disease: epidemiology, diagnosis, and treatment in a retrospective hospital-based study","authors":"Andi Sinapati Palissei, Ahmadwirawan Ahmadwirawan, M. Faruk","doi":"10.19106/jmedsci005302202103","DOIUrl":"https://doi.org/10.19106/jmedsci005302202103","url":null,"abstract":"Hirschsprung’s disease (HD), or congenital megacolon, is a disease characterized by the absence of ganglion cells in the myenteric (Auerbach’s) and submucosal (Meissner’s) plexuses of the intestine, causing maximum obstruction in neonates. The purpose of this study was to investigate patient characteristics, clinical presentation, investigations, surgical treatment, and outcome. This study is a retrospective study of HD cases. Data obtained from medical records at the institution. Of the 109 with a positive rectal biopsy diagnosis, 91 were patients with this disease. There were more cases in boys than girls with a ratio of 1.37: 1. The patients were grouped into 4 age groups: neonates 29 cases (26.61%); infants/toddlers/young children 55 cases (50.46%); children over 5 years16 cases (14.69%); and teenagers 9 cases (8.24%). The neonates generally presented with abdominal distension, green vomiting, and a history of delayed meconium release, while the toddler, child, and adolescent groups experienced constipation and abdominal distension. Furthermore, from 37 patients (33.94%) that got barium enema examination, the most common transition zone was observed in the rectosigmoid (17 patients, or 45.9%). In addition, The Duhamel procedure was the most frequent pull-through procedure found in our cohort which was performed in 40 patients (36.70%). In conclusion, HD is mostly found in male infants/toddlers/young children with abdominal distention and chronic constipation as common symptoms. The barium enema shows the rectosigmoid as the most common transition zone, while the Duhamel pull-through procedure is the primary definitive operative action performed.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76299950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}