Journal of Veterinary and Biomedical Sciences最新文献_第3页

Effects of Combinations of Medetomidine-Diazepam-Ketamine and Medetomidine-Ketamine Anesthesia on Haematology and Serum Biochemistry in Dogs 美托咪定-地西泮-氯胺酮与美托咪定-氯胺酮联合麻醉对犬血液学和血清生化的影响

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0111

A. Zaifada

{"title":"Effects of Combinations of Medetomidine-Diazepam-Ketamine and Medetomidine-Ketamine Anesthesia on Haematology and Serum Biochemistry in Dogs","authors":"A. Zaifada","doi":"10.36108/jvbs/2202.40.0111","DOIUrl":"https://doi.org/10.36108/jvbs/2202.40.0111","url":null,"abstract":"This study was aimed at evaluating the effects of combinations of medetomidine-diazepamketamine and medetomidine-ketamine anesthesia haematology and serum chemistry in dogs. Ten (10) apparently healthy local dogs comprising of five (5) females and five (5) males with Mean ± SD body weight of 20.4 ± 2.93 kg sought from Maiduguri and environs and randomly allocated into two groups A (n=5), B (n=5) were used to conduct the experiment for this study. Total Intravenous anesthesia (TIVA) was induced in all the dogs. Dogs in group A were premedicated with an intravenous injection of 0.005 mg/kg Medetomidine, followed by an intravenous injection of 0.25 mg/kg Diazepam and 4 mg/kg Ketamine combination 3 – 5 minutes later. Meanwhile group B dogs were given an intravenous injection of Medetomidine (0.005 mg/kg) and Ketamine (5 mg/kg) combination. Blood sample was collected for haematological analysis while serum was collected to assay Total protein (TP), Alanine Aminotransferase (ALT), Blood urea nitrogen (BUN) and Creatinine (Cr) using standard laboratory protocols. There was no significant difference (p>0.05) in the measured haematological indices, ALT, BUN, Cr and TP in both groups A and B throughout the study. However, there was non-significant decrease in ALT, BUN, Cr and TP in both groups up to 30 minutes post administration of the drug combinations but return to almost baseline values at 60 minutes post anaesthesia. The results of this study showed that intravenous administration of Medetomidine-Diazepam-Ketamine and Medetomidine-Ketamine combinations have no significant effects on haematological indices and serum chemistry profile of dogs. Therefore, these anaesthetic combinations can be prescribed for clinical use and procedures in dogs.","PeriodicalId":17442,"journal":{"name":"Journal of Veterinary and Biomedical Sciences","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85104114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluid Therapy in Small Ruminants – A Review 小反刍动物体液疗法综述

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0190

A. A. Anaedum,, R. Okafor, J. Onah

引用次数: 0

Prevalence of Tick Infestation and Endo Parasites Infection of Dogs in Abuja, Nigeria 尼日利亚阿布贾市犬类蜱虫感染和内多寄生虫感染流行情况

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0120

C. Simon

引用次数: 0

Left Atrioventricular (AV) Thrombosis and a Compacted Fracture of Lumber Six and Seven Vertebrae in a Ten Year Old Alsatian Bitch 一只10岁的阿尔萨斯母狗的左房室血栓形成和第六和第七椎骨的压缩性骨折

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0160

K. Ezema

引用次数: 0

Preliminary Report on the Effects of Varied Diminazene Diaceturate Dosages and Treatment Regimens on Trypanosoma brucei Clearance and Relapse in Experimentally Infected Wistar Rats 不同剂量和治疗方案对实验性感染Wistar大鼠布鲁氏锥虫清除和复发影响的初步报告

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0180

P. Umeakuana

{"title":"Preliminary Report on the Effects of Varied Diminazene Diaceturate Dosages and Treatment Regimens on Trypanosoma brucei Clearance and Relapse in Experimentally Infected Wistar Rats","authors":"P. Umeakuana","doi":"10.36108/jvbs/2202.40.0180","DOIUrl":"https://doi.org/10.36108/jvbs/2202.40.0180","url":null,"abstract":"Comparison of the diminazene diaceturate (DD) varied treatment regimen in male Wistar rats experimentally infected with Trypanosoma brucei was done. Forty-nine rats were randomly assigned to seven groups of seven rats each (A – G). Group A was the uninfected untreated control while groups B – G were infected with 1.4 × 106. Groups C and D were treated with 3.5 mg/kg DD once and for five consecutive days while group B was left untreated. Groups E and F were treated with 7 mg/kg DD once and for five consecutive days while group G was treated with 7 mg/kg DD and repeated after 14 days. The effect of varied doses and treatment regimen was evaluated using parasites clearance and relapse of infection. Parasitaemia was established 4 – 9 days post infection in all groups except for one rat in Group G. Trypanosomes were cleared 3 – 5 days post treatment (PT) in all the treated groups. Trypanosomes relapsed in groups C, D, E, F, and group G on days 14, 42, 25, 56, and 39 post treatment, respectively. Relapse also occurred in about 67% of the rats in Group D and 14% of the rats in Group F within 80 days post treatment (PT). Increasing the dosage and or extending the duration of treatment with DD, marginally delayed the clearance of parasite in the infected rats but delayed the onset of relapse and reduced its occurrence in the infected rats. The curative efficacy of DD in this study appeared to be dose dependent as increasing the dosage and duration of treatment elicited a better therapeutic outcome. However, further experimental trials are imperative in rats and other animal species..","PeriodicalId":17442,"journal":{"name":"Journal of Veterinary and Biomedical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75286926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Cyclosporine on the Body Weight of Mice Inoculated with Prostate Cancer Tissues 环孢素对前列腺癌组织接种小鼠体重的影响

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0121

S. Ngulde

{"title":"Effect of Cyclosporine on the Body Weight of Mice Inoculated with Prostate Cancer Tissues","authors":"S. Ngulde","doi":"10.36108/jvbs/2202.40.0121","DOIUrl":"https://doi.org/10.36108/jvbs/2202.40.0121","url":null,"abstract":"Cancer is a disease characterized by uncontrolled cell proliferation in the body, leading to impaired functions and high mortality. Different models are used to study cancer in vivo and in vitro. Facilities for many of the studies are not available in developing countries. Genetically modified mice for in vivo model may not be available. Cyclosporine is an immunosuppresant drug that may be used to alter mice immunity necessary for development of implanted xenograft cancer tissues. Mice were randomly separated into four groups of five and subcutaneously administered cyclosporine at different doses (5, 20 and 40 mg/kg including negative control) daily for twentyone days. At seven days of drug administration, cancer tissues from prostate cancer human patients were administered to all mice. Body weights of mice were measured at weekly interval. Tumor-like nodules were observed at the site of cancer inoculation and when present were measured. Gross pathology and histopathology were performed. The results showed significant (p< 0.05) increase in body weight gain in only control group where cyclosporine was not administered. The number of tumor-like growth (first observed at day 14) per group and the magnitude of swelling vary directly (p < 0.05) with cyclosporine dose. Mortality varies inversely with the dose. No lesions were observed from the gross pathology. Histopathology revealed presence of neutrophil, plasma cells and oedema with no cancer cells detected. It was concluded that cyclosporine at the dose of 20 mg/kg in mice followed by administration of prostate cancer tissue caused decrease in body weight gain and allow growth of nodule bulging at the site of cancer tissue administration..","PeriodicalId":17442,"journal":{"name":"Journal of Veterinary and Biomedical Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83892595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic and Molecular Characterization of Escherichia coli Isolated from Donkeys Slaughtered in Abattoirs in Kaduna State, Nigeria 尼日利亚卡杜纳州屠宰场屠宰的驴分离的大肠杆菌表型和分子特征

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0130

M. Esonu

{"title":"Phenotypic and Molecular Characterization of Escherichia coli Isolated from Donkeys Slaughtered in Abattoirs in Kaduna State, Nigeria","authors":"M. Esonu","doi":"10.36108/jvbs/2202.40.0130","DOIUrl":"https://doi.org/10.36108/jvbs/2202.40.0130","url":null,"abstract":"Escherichia coli is a natural inhabitant of the gastrointestinal tract of both humans and animals. There are several strains of which some are harmless while some are pathogenic causing various fatal conditions in both humans and animals. A cross sectional study was conducted to determine the occurrence of E. coli and detection of virulent genes of E. coli isolated from liver, spleen and small intestine of donkeys slaughtered in Maraban Idah, Kaduna State, Nigeria. A total of 384 samples were collected from 128 donkeys from April to August 2018 based on owners’ consent. The samples were analyzed using standard methods of cultural enrichment, growth on selective media, biochemical test for identification and isolation of E. coli. Multiplex PCR was then used to detect presence of virulence genes in the E. coli isolates. The isolation rate was 5.2 % with organ distribution of 4.7 %. 4.7 % and 6.3 % for the intestine, liver and spleen respectively. Nineteen (19) of the 20 positive isolates profiled haboured different combinations of virulent genes viz: stx1-rfbO157-hlyA (n=2), stx1-rfbO157-eaeA-hlyA (n=6), stx1-eaeA (n=4), stx1-rfbO157 (n=1), stx1-rfbO157-eaeA (n=3), eaeA-hlyA (n=1), stx1-eaeA-hlyA (n=1) stx1-hlyA (n=1) hlyA (n=1) gene. This study showed that 60% of the isolates had the rfbO157 gene (E. coli O157 serotype), which is of great public health importance. Therefore, proper sanitation and hygienic practices should be ensured during and after slaughtering donkeys.","PeriodicalId":17442,"journal":{"name":"Journal of Veterinary and Biomedical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84329299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serological Survey of Brucella Infection in Small Ruminants in Yobe North, Yobe State, Nigeria 尼日利亚约贝州北约贝地区小反刍动物布鲁氏菌感染血清学调查

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0170

S. Adamu

{"title":"Serological Survey of Brucella Infection in Small Ruminants in Yobe North, Yobe State, Nigeria","authors":"S. Adamu","doi":"10.36108/jvbs/2202.40.0170","DOIUrl":"https://doi.org/10.36108/jvbs/2202.40.0170","url":null,"abstract":"Brucella infection is a zoonotic bacterial disease which affects variety of animals and humans. A cross-sectional survey was conducted in Jakusko Yobe North to determine the seroprevalence and risk factors associated with brucellosis. A total of 250 sera samples were collected aseptically from the jugular vein of sheep of both sex and different age groups, sera were screened against Brucella spp. using Rose Bengal Plate test (RBPT). The seroprevalence of 10.4% was recorded out of 250 sheep sampled, with the prevalence rates of 12.1% and 8.3% for female and male sheep respectively. There was no significant difference between sex and Brucella infection (OR = 0.6565, 95% CI = 0.2806 – 1.536, p = 0.443). Seroprevalence obtained was higher in sheep above two years (14.6%) but the seroprevalence was lower in sheep below two years (5.8 %), there was significant statistical difference between the age of sheep and Brucella infection (OR = 0.3619, 95% CI = 1463 – 0.8951, p = 0.0364). Though, brucellosis was reported in all the locations of sheep sampled, but there was no significant difference between the location of sheep. The study indicated the presence of Brucella infection in Jakusko and this is the first report of brucellosis in the study area, which is of public health significant because of the close contact between people and their animals. The information obtained will be useful in setting control, prevention, and eradication program among herdsmen/farmers.","PeriodicalId":17442,"journal":{"name":"Journal of Veterinary and Biomedical Sciences","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73626446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal Variations of Haematological and Biochemical Parameters Associated with Potential Laminitis in Apparently Healthy Horses 在表面健康的马中与潜在板膜炎相关的血液学和生化参数的季节变化

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0140

M. Ememe

{"title":"Seasonal Variations of Haematological and Biochemical Parameters Associated with Potential Laminitis in Apparently Healthy Horses","authors":"M. Ememe","doi":"10.36108/jvbs/2202.40.0140","DOIUrl":"https://doi.org/10.36108/jvbs/2202.40.0140","url":null,"abstract":"Early detection of laminitis in horses is valuable as it provides information that can be used as a basis for advice to trainers of race and performance horses. The study was aimed to determine the seasonal variations in haematological and biochemical parameters of horses developing laminitis at Polo Club Port Harcourt, River State, Nigeria. A total of 18 horses were sampled during the dry season (February) and rainy season (July). The horses sampled were aged between 3 and 8 years. The hoof temperature, weight, packed cell volume (PCV), red blood cell (RBC) count, hemoglobin (Hb) concentration, total and differential leucocyte counts, glucose level and fibrinogen concentration were determined using standard methods. The mean hoof temperature of the horses was 36.1± 0.11oC and 35.6 ± 0.2 oC during the dry and rainy season respectively. The mean body weight of the horses was 323 ± 8.90 kg in dry season while that of rainy season was 330 ± 11.0 kg. Glucose concentration during the dry season (71.6 ± 1.5 dl/mg) was significantly lower (P ˂ 0.05) than that obtained during the rainy season (91.7 ± 1.9 dl/mg). Furthermore, the PCV, RBC count and Hb concentration were significantly higher (P ˂ 0.05) in the rainy season than the corresponding parameters in the dry season. Similarly, the total leucocyte, neutrophil and lymphocyte counts were significantly higher (P ˂ 0.05) during the rainy season than the dry season. It was concluded that variations on the parameters determined may aid to identify early warning signs of laminitis.","PeriodicalId":17442,"journal":{"name":"Journal of Veterinary and Biomedical Sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73235257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Aqueous-Methanol Bulb Extract of Allium sativum on Gastric Ulcer and Gastrointestinal Motility 大蒜水-甲醇球茎提取物对胃溃疡及胃肠蠕动的影响

Journal of Veterinary and Biomedical Sciences Pub Date : 2022-06-28 DOI: 10.36108/jvbs/2202.40.0150

H. Anthony, F. Nwinyi, A. Mohammed

{"title":"Effects of Aqueous-Methanol Bulb Extract of Allium sativum on Gastric Ulcer and Gastrointestinal Motility","authors":"H. Anthony, F. Nwinyi, A. Mohammed","doi":"10.36108/jvbs/2202.40.0150","DOIUrl":"https://doi.org/10.36108/jvbs/2202.40.0150","url":null,"abstract":"This research work evaluated the ulcer protective effects of aqueous-methanol bulb extract of Allium sativum in rats using acetylsalicylic acid and cold-stress induced ulceration model. Adult Wistar rats were grouped into 5 (consisting of 5 rats each). Rats in group A were administered normal saline (30 ml/kg P.O) to serve as negative control. Rats in groups. B, C and D were pretreated with graded doses of the extract (50, 100, and 200 mg/kg P.O). Rats in group E were treated with Cimetidine (50 mg/kg P.O) to serve as the positive control. Ulceration was induced in all groups afterwards and gross examination of the excised stomach revealed a dose-dependent decrease in ulcer indices in groups treated with the extract. The highest reduction in ulceration was observed in the group treated with 200 mg/kg of the extract, although statistically insignificant but comparable to the cimetidine treated group. This suggests that Allium sativum extract possesses antiulcer properties. Another aspect of this research work evaluated the effect of the same extract (50, 100 and 200 mg/kg P.O) on gastrointestinal motility in mice using activated charcoal meal model. Normal saline (20 ml/kg P.O) was used as the negative control. The results obtained from the study revealed a dose-dependent increase in intestinal motility which is suggestive of stimulant laxative mechanism of action. This validates its traditional use as a treatment for constipation and aid in digestion.","PeriodicalId":17442,"journal":{"name":"Journal of Veterinary and Biomedical Sciences","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86658718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0