美托咪定-地西泮-氯胺酮与美托咪定-氯胺酮联合麻醉对犬血液学和血清生化的影响

A. Zaifada
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引用次数: 0

摘要

本研究旨在评价美托咪定-地西泮氯胺酮和美托咪定-氯胺酮联合麻醉对犬血液学和血清化学的影响。选取来自迈杜古里及其周边地区的10只表面健康的当地犬,雌性5只,雄性5只,平均±SD体重为20.4±2.93 kg,随机分为A组(n=5)、B组(n=5)进行实验。所有犬均采用全静脉麻醉(TIVA)。A组先静脉注射0.005 mg/kg美托咪定,3 ~ 5min后静脉注射0.25 mg/kg地西泮+ 4 mg/kg氯胺酮。B组给予美托咪定(0.005 mg/kg)和氯胺酮(5 mg/kg)联合静脉注射。采集血样进行血液学分析,采集血清按标准实验室方案测定总蛋白(TP)、丙氨酸转氨酶(ALT)、血尿素氮(BUN)和肌酐(Cr)。在整个研究过程中,A组和B组血液学指标、ALT、BUN、Cr、TP的测定差异均无统计学意义(p>0.05)。然而,两组患者在给药后30分钟ALT、BUN、Cr和TP均无显著下降,但在麻醉后60分钟恢复到接近基线值。本研究结果表明,静脉给药美托咪定-安定-氯胺酮和美托咪定-氯胺酮联合给药对犬血液学指标和血清化学特征无显著影响。因此,这些麻醉组合可以用于狗的临床使用和程序。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Combinations of Medetomidine-Diazepam-Ketamine and Medetomidine-Ketamine Anesthesia on Haematology and Serum Biochemistry in Dogs
This study was aimed at evaluating the effects of combinations of medetomidine-diazepamketamine and medetomidine-ketamine anesthesia haematology and serum chemistry in dogs. Ten (10) apparently healthy local dogs comprising of five (5) females and five (5) males with Mean ± SD body weight of 20.4 ± 2.93 kg sought from Maiduguri and environs and randomly allocated into two groups A (n=5), B (n=5) were used to conduct the experiment for this study. Total Intravenous anesthesia (TIVA) was induced in all the dogs. Dogs in group A were premedicated with an intravenous injection of 0.005 mg/kg Medetomidine, followed by an intravenous injection of 0.25 mg/kg Diazepam and 4 mg/kg Ketamine combination 3 – 5 minutes later. Meanwhile group B dogs were given an intravenous injection of Medetomidine (0.005 mg/kg) and Ketamine (5 mg/kg) combination. Blood sample was collected for haematological analysis while serum was collected to assay Total protein (TP), Alanine Aminotransferase (ALT), Blood urea nitrogen (BUN) and Creatinine (Cr) using standard laboratory protocols. There was no significant difference (p>0.05) in the measured haematological indices, ALT, BUN, Cr and TP in both groups A and B throughout the study. However, there was non-significant decrease in ALT, BUN, Cr and TP in both groups up to 30 minutes post administration of the drug combinations but return to almost baseline values at 60 minutes post anaesthesia. The results of this study showed that intravenous administration of Medetomidine-Diazepam-Ketamine and Medetomidine-Ketamine combinations have no significant effects on haematological indices and serum chemistry profile of dogs. Therefore, these anaesthetic combinations can be prescribed for clinical use and procedures in dogs.
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