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Journal of the Nippon Hospital Pharmacists Association最新文献

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Effect of Position of Nonflat Punch on-Dividing Properties of Scored Tablet in One Side Compaction Method 非平冲头位置对单侧压实法压痕片分型性能的影响
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1991-01-01 DOI: 10.5649/jjphcs1975.17.306
A. Ito, M. Sugihara
{"title":"Effect of Position of Nonflat Punch on-Dividing Properties of Scored Tablet in One Side Compaction Method","authors":"A. Ito, M. Sugihara","doi":"10.5649/jjphcs1975.17.306","DOIUrl":"https://doi.org/10.5649/jjphcs1975.17.306","url":null,"abstract":"The significance of the position of nonflat punch on dividing prcperties of scored tablets was investigated in several tablets prepared from excipients or granules by one side compaction method.For the excipients, lactose, perfiller®and microcrystalline cellulose were used.For the granules, sieved granules in 12-16, 16-32 and 32-48 mesh incorporating either hydroxy propyl cellulose or potato starch as binder was used.Different influence of the position of nonflat punch on dividing strength of scored tablets was observed between the case of excipients and granules.Dividing strength of scored tablets made from excipients was not affected by the position of nonflat punch.But tablets made from granules had a tendency to show high dividing strength when tablets were compressed by nonflat upper punch.Then weight variation of divided tablets showed a tendency to become less when compressed by nonflat upper punch in both tablets made from excipients and granules.It was suggested that the effect of the position of nonflat punch on dividing properties of scored tablets was caused by different pressure lines during tablet compression.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"7 1","pages":"306-311"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90460923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
バルプロ酸,サリチル酸のin vitro血清蛋白結合に及ぼす高濃度フェニトインの影響 高浓度苯妥英钠对丙戊酸和水杨酸的体外血清蛋白结合的影响
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1990-12-20 DOI: 10.5649/JJPHCS1975.16.393
Hirofumi Agemura, K. Obara, T. Motoya, Kazuo Nakamura, Tatsuya Yamaguchi, Takuro Shimozono, Y. Shimodozono, Maruo Ishibashi
{"title":"バルプロ酸,サリチル酸のin vitro血清蛋白結合に及ぼす高濃度フェニトインの影響","authors":"Hirofumi Agemura, K. Obara, T. Motoya, Kazuo Nakamura, Tatsuya Yamaguchi, Takuro Shimozono, Y. Shimodozono, Maruo Ishibashi","doi":"10.5649/JJPHCS1975.16.393","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.16.393","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"61 1","pages":"393-396"},"PeriodicalIF":0.0,"publicationDate":"1990-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86913934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
蛍光偏光免疫測定法 (FPIA) による全血中シクロスポリンの濃度測定と臨床評価 荧光偏振免疫测定法(FPIA)对全血环孢素浓度的测定和临床评估
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1990-10-20 DOI: 10.5649/JJPHCS1975.16.288
雅彦 大林, 芳子 堀江, 明宏 原, 安生 紗枝子, 近藤 由利子, 武博 小原
{"title":"蛍光偏光免疫測定法 (FPIA) による全血中シクロスポリンの濃度測定と臨床評価","authors":"雅彦 大林, 芳子 堀江, 明宏 原, 安生 紗枝子, 近藤 由利子, 武博 小原","doi":"10.5649/JJPHCS1975.16.288","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.16.288","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"15 1","pages":"288-293"},"PeriodicalIF":0.0,"publicationDate":"1990-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82068649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trials of Improvements on the Taste of an Oral Amino Acid Preparation for Hepatic Failure 改善肝衰竭口服氨基酸制剂口感的试验
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1990-02-20 DOI: 10.5649/JJPHCS1975.16.30
Tomoko Watanabe, Chiemi Minamisawa, S. Hasegawa, K. Matsuba, M. Watanabe, T. Tsubakihara, K. Ohta, Y. Ohta, K. Tsukada
{"title":"Trials of Improvements on the Taste of an Oral Amino Acid Preparation for Hepatic Failure","authors":"Tomoko Watanabe, Chiemi Minamisawa, S. Hasegawa, K. Matsuba, M. Watanabe, T. Tsubakihara, K. Ohta, Y. Ohta, K. Tsukada","doi":"10.5649/JJPHCS1975.16.30","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.16.30","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"5 1","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"1990-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81659429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Study on the Storage of Fibronectin Eyedrops 纤维连接蛋白滴眼液贮存的研究
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1990-02-20 DOI: 10.5649/JJPHCS1975.16.20
T. Mizutani, Hiroo Nomura, M. Kako, Y. Kitou
{"title":"The Study on the Storage of Fibronectin Eyedrops","authors":"T. Mizutani, Hiroo Nomura, M. Kako, Y. Kitou","doi":"10.5649/JJPHCS1975.16.20","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.16.20","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"60 1","pages":"20-24"},"PeriodicalIF":0.0,"publicationDate":"1990-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74844927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of High Dose Methotrexate : 1 : In Acute Renal Failure 大剂量甲氨蝶呤的药代动力学:1:急性肾衰竭
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1990-01-01 DOI: 10.5649/jjphcs1975.16.94
T. Toyoguchi, H. Nagaoka, Shu Isikawa, Y. Nakagawa, Y. Izumi, Michihiko Katuura, Y. Okuyama, M. Okada, Tadashi Hayashi
{"title":"Pharmacokinetics of High Dose Methotrexate : 1 : In Acute Renal Failure","authors":"T. Toyoguchi, H. Nagaoka, Shu Isikawa, Y. Nakagawa, Y. Izumi, Michihiko Katuura, Y. Okuyama, M. Okada, Tadashi Hayashi","doi":"10.5649/jjphcs1975.16.94","DOIUrl":"https://doi.org/10.5649/jjphcs1975.16.94","url":null,"abstract":"Acute renal failure developed in a 5 year-old girl during the fifth course of high dose methotrexate (MTX) treatment for osteosarcoma. She showed oliguria, and the serum MTX concentration, BUN and Scr were 461 μmoles/1, 50 mg/dl and 2.6 mg/dl, respectively, at 27 hr after infusion.Massive leucovorin calcium rescure, direct hemoperfusion, hemodialysis and plasma exchange therapies were successfully treated and she recovered gradually.Neither toxic bone marrow suppression nor side effect of massive leucovorin calcium appeared.The pharmacokinetic analysis of MTX during the renal failure and the dialysis treatment was investigated.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"23 1","pages":"94-100"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86017186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of the fluorescence polarization immunoassay method for determination of serum mexiletine concentrations. 荧光偏振免疫分析法测定血清美西汀浓度的评价。
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1989-10-20 DOI: 10.5649/JJPHCS1975.15.368
M. Hamashima, S. Fukushima, N. Inotsume, H. Ogawa, K. Okumura, H. Yasue, M. Nakano
{"title":"Evaluation of the fluorescence polarization immunoassay method for determination of serum mexiletine concentrations.","authors":"M. Hamashima, S. Fukushima, N. Inotsume, H. Ogawa, K. Okumura, H. Yasue, M. Nakano","doi":"10.5649/JJPHCS1975.15.368","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.15.368","url":null,"abstract":"脈薬で あ り,静 脈 内投与 と経 ロ投与 が可能 であ る.メ キ シ レチ ンを経 ロ投 与後の吸収 は良好 であ り,bioavailabilityは83%以 上4),最 高血中薬物濃度 は2~4時 間で 得 られ4),ま た半減期 は10時 間 と比較 的長い4,5).こ のた め1日2~3回 の投 与で有効血中濃度 を維持 で きるとさ れ る6).し か し治療域 は0.5~2.0μ9/ml7)と 狭 く,2.0 μg/ml以 上で副作用の発現頻度 が増加 す る8).ま た排泄 速度 には個人差 が大 きい ことが知 られ てい る6).こ のた め メキシ レチ ソに よる治療 では血中濃度 モニタ リングが 必要 である. 血中 メキシ レチ ン濃度測 定は,従 来高速液体 クロマ ト グラフ法(HPLC法)で 行 われて きた9)が,簡 便性,迅 速性の点 で臨床的 な有用性 は十分で はなか った.今 回著 者 らは,螢 光偏光免疫測定 法(FPIA法)に よる,新 し く開発 された簡便 な血中 メキ シレチ ソ測定 キ ヅ トを試用 す る機 会を得た.そ こで本 キ ッ トの同時測定 内再現性, 測 定間再 現性,血 中共存物質の影響 な ど,そ の信頼性 を 評価 し,ま たHPLC法 との相関性 につ いて検 討 したので 報告す る.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"6 1","pages":"368-372"},"PeriodicalIF":0.0,"publicationDate":"1989-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84076981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
ニトログリセリン・β-シクロデキストリン複合体舌下錠の安定性及び生物学的同等性 硝酸甘油- β-环糊精复合物舌下片的稳定性和生物等效性
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1989-02-20 DOI: 10.5649/JJPHCS1975.15.36
源市 井津, 隆信 寺田, 宏之 二宮, 康彦 古田, 功一 吉田, 敏信 青山, 正義 堀岡
{"title":"ニトログリセリン・β-シクロデキストリン複合体舌下錠の安定性及び生物学的同等性","authors":"源市 井津, 隆信 寺田, 宏之 二宮, 康彦 古田, 功一 吉田, 敏信 青山, 正義 堀岡","doi":"10.5649/JJPHCS1975.15.36","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.15.36","url":null,"abstract":"Vaporization of nitroglycerin (TNG), thermoanalysis (DTA/TG) and X-ray diffractometry (X-RD) for the complex with TNG and β-cyclodextrin (TNG·β-CD) prepared by saturated solution method and kneading method, and TNG dispersed β-CD and lactose powder were evaluated. The stabilities of strip packaged sublingual tablet of TNG·β-CD (β-CD Tab, TNG content 0.3mg) and conventional sublingual tablet (JP Tab, TNG content 0.3mg, vehicle: lactose) were compared under the each storage condition of room temperature, 37°and 50°C. Pulse pressure in anesthetized dogs, and systolic blood pressure and plasma TNG concentration in 10 healthy male volunteers were measured after sublingual administration of β-CD Tab and JP Tab.The results showed that vaporization of TNG from TNG·β-CD was extremely smaller than that from TNG dispersed β-CD and lactose powder. DTA/TG and X-RD curves for TNG·β-CD showed specific patterns differed from dispersed powder. The decrease of TNG content in β-CD Tab was extremely lower than that of JP Tab under strip packaging. It is also ascertained that β-CD Tab has the same bioequivalency as JP Tab.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"29 1","pages":"36-42"},"PeriodicalIF":0.0,"publicationDate":"1989-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89975425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Quinone Derivatives on Ethanol and Acetaldehyde Metabolism in Rats 醌类衍生物对大鼠乙醇和乙醛代谢的影响
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1989-01-01 DOI: 10.5649/jjphcs1975.15.33
N. Hobara, A. Watanabe, Y. Gomita, Y. Araki
{"title":"Effect of Quinone Derivatives on Ethanol and Acetaldehyde Metabolism in Rats","authors":"N. Hobara, A. Watanabe, Y. Gomita, Y. Araki","doi":"10.5649/jjphcs1975.15.33","DOIUrl":"https://doi.org/10.5649/jjphcs1975.15.33","url":null,"abstract":"Quinone derivatives, such as 2, 3-dimethoxy-5-methy1-6-decapreny1-1, 4-benzoquinone (ubidecarenone, coenzyme Q10, CoQ10), 4, 5-dihydro-4, 5-dioxo-1H-pyrrolo [2, 3-f] quinoline-2, 7, 9-tricarboxylic acid (pyrroloquinoline quinone, PQQ) and 6-(10-hydroxydecy1)-2, 3-dimethoxy-5-methy1-1, 4-benzoquinone (idebenone), significantly inhibited rise of acetaldehyde concentration in blood and liver of rats following ethanol ingestion.Acetaldehyde concentrations decreased in vitro with incubation with 1, 4-benzoquinone or PQQ solution at 40°C. Low acetaldehyde concentrations following ethanol ingestion might be due to PQQ-accelerated oxidation of acetaldehyde.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"7 1","pages":"33-35"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87654842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of Ethanolamine Oleate Injection Mixed with Iopamidol 油酸乙醇胺注射液与Iopamidol混合的制备
Journal of the Nippon Hospital Pharmacists Association Pub Date : 1988-08-20 DOI: 10.5649/JJPHCS1975.14.291
Y. Katagiri, Miki Akiyama, Yoshimasa Nozu, Shun Yamamoto, Toshio Kawai, T. Itakura, K. Mabuchi, K. Iwamoto
{"title":"Preparation of Ethanolamine Oleate Injection Mixed with Iopamidol","authors":"Y. Katagiri, Miki Akiyama, Yoshimasa Nozu, Shun Yamamoto, Toshio Kawai, T. Itakura, K. Mabuchi, K. Iwamoto","doi":"10.5649/JJPHCS1975.14.291","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.14.291","url":null,"abstract":"(Received February 17,1988) Ethanolamine oleate injection containing 30% iopamiron 300 (30% IP 300-E0) has been previously prepared for endoscopic sclerotherapy of esophageal varices on X-ray TV monitor. However,the ability of fluoroscopic visualization of this sclerosing agent was slightly insufficient in clinical use.We prepared ethanolamine oleate injection containing 30% iopamiron 370 (30% IP 370-E0),and measured the physical characteristics such as viscosity and osmotic pressure of this agent.The ability of visualization was observed in patients with esophageal varix by X-ray. The viscosity,which was inversely related to the injectability into varices,of 30% IP 370-E0 was relatively low and its osmotic nressure was almost the same as that of normal saline.30 % IP 370-E0 was easily injected into varices.Better fluoroscopic visualization was obtained by intravariceal injection with 30% IP 370-E0 than with 30% IP 300-E0.These results suggest that 30% 1P370-E0 is more useful agent for endoscopic sclerotherapy of esophageal varices.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"66 1","pages":"291-295"},"PeriodicalIF":0.0,"publicationDate":"1988-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73394551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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