Journal of the Nippon Hospital Pharmacists Association最新文献_第6页

Construction of an In-house Database by Modifying Formulary's Data 通过修改Formulary的数据构建内部数据库

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1994-06-20 DOI: 10.5649/JJPHCS1975.20.253

Takako Kaneda, Tougen Masauji, Noriko Satoh, M. Nakata

引用次数: 0

Preparation of Liposomal-encapsulated SOD and Serum Pharmacokinetics after Intravenous Administration 脂质体囊化SOD的制备及静脉给药后血清药代动力学

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1994-02-20 DOI: 10.5649/JJPHCS1975.20.1

I. Hirata, S. Tanaka, M. Ashihara, S. Tsukamoto, N. Sugioka, H. Kishimoto, T. Yoshikawa, T. Tanigawa, Y. Naito, M. Kondo, Kazuto Nosaka

{"title":"Preparation of Liposomal-encapsulated SOD and Serum Pharmacokinetics after Intravenous Administration","authors":"I. Hirata, S. Tanaka, M. Ashihara, S. Tsukamoto, N. Sugioka, H. Kishimoto, T. Yoshikawa, T. Tanigawa, Y. Naito, M. Kondo, Kazuto Nosaka","doi":"10.5649/JJPHCS1975.20.1","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.20.1","url":null,"abstract":"Liposomal-encapsulated superoxide dismutase (L-SOD) was prepared with a view to prolonging the half-life and pharmacodynamic action time. Presome® was adopted as a phospholipid in the preparation of L-SOD.L-SOD was sterilized through polycarbonate membrane filters having pore diameters of 0.2 μm and 0.4μm. The liposomal particle size, as measured by the dynamic light scattering method, was 198±40 nm. Effective SOD encapsulation efficiency was approximately 25.8%.Immediately after the i.v. injection of L-SOD into rats, blood levels of SOD decreased in a bi-exponential manner; the half-lives of the α-and β-phases were 16.6 minutes and 7.8 hours, respectively.AUC and MRT increased as compared with the i. v. injection of r-hSOD (free SOD), The SOD-activity in plasma was on a low level.These results suggested that still more L-SOD was trapped in the reticulo-endothelial system (RES), involving such organs as in the liver and spleen.In an effect to increase the SOD activity in plasma and prolong the circulation time of liposomes in blood, we prepared L-SOD modified with polyethyleneglycol derivatives (L-SOD/PEG. DOPE; L-SOD/PEG·DMG).After the i. v. injection of L-SOD/PEG·DOPE and L-SOD/PEG·DMG into rats, the SOD activity in plasma became higher and also the circulation time of liposomes in blood became longer as compared with the L-SOD i. v. injection.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"12 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"1994-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74584966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Determinations of Phenobarbital and Carbamazepine in Serum by Nephelometric Immunoassay 浊度免疫分析法定量测定血清中苯巴比妥和卡马西平

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1993-10-20 DOI: 10.5649/JJPHCS1975.19.464

H. Muro, T. Tatsuhara, K. Otsubo

引用次数: 0

Correlation between Accuracy of Dividing Weight and Physical Properties of the Drugs on Automatic Pre-packing Machine 自动预包装机分装精度与药品物性的关系

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1993-03-20 DOI: 10.5649/JJPHCS1975.19.129

Eriko Matsubara, Yuichiro Kosugi, Kimiko Kano, Yusuke Matsumoto, H. Shimodaira, Y. Uchida, H. Yuasa, Y. Kanaya

引用次数: 0

Prediction and Evaluation of Penetration of Drugs into Cerebrospinal Fluid in Human 药物对人脑脊液渗透的预测与评价

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1992-08-20 DOI: 10.5649/JJPHCS1975.18.349

J. Hamada, Y. Sawada, Kouichi Nakamura, Yasuhiko Yamada, T. Iga

引用次数: 1

Sensitivity of Clinical Isolates of Bacterial Strains to Antibiotics and the Amount of Antibiotics Used for Inpatients 临床分离菌株对抗生素的敏感性及住院患者抗生素用量

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1992-03-20 DOI: 10.5649/JJPHCS1975.18.153

H. Hashimoto, Osamu Kitamura, Reiko Muramatsu, Yumi Sano, Y. Akaike, T. Goto

{"title":"Sensitivity of Clinical Isolates of Bacterial Strains to Antibiotics and the Amount of Antibiotics Used for Inpatients","authors":"H. Hashimoto, Osamu Kitamura, Reiko Muramatsu, Yumi Sano, Y. Akaike, T. Goto","doi":"10.5649/JJPHCS1975.18.153","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.18.153","url":null,"abstract":"We investigated the sensitivity of clinical isolates of bacterial strains to antibiotics and the amount of antibiotics dispensed for inpatients in each ward of our hospital.In the surgery ward, Bacteroides sp., E.coli, P.aeruginosa and S.aureus were frequently isolated, and cephem antibiotics and piperacillin sodium (PIPC) were mainly used, while many isolates were resistant to PIPC.In the neurosurgery ward, frequent isolates were S.aureus, P.aeruginosa, S.epidermidis. In the internal and cardiovascular medicine ward, P.aeruginosa, S.aureus, K.pneumoniae and S.epidermidis were frequent isolates.In these wards, imipenem/cilastatin sodium (IPM/CS) and cephem antibiotics were mainly used, although most isolates of S.aureus were resistant to these drugs.In the urology ward, Enterococcus sp.and P.aeruginosa were fre quently isolated, whereas cephem antibiotics which were ineffective to these isolates were mainly used.The frequent isolates which were resistant to cephem drugs or IPM/CS probably resulted from the frequent use of these drugs.Considering the present results, choice of antibiotics should be more discussed.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"25 10 1","pages":"153-163"},"PeriodicalIF":0.0,"publicationDate":"1992-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82690028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diagnosis of Drug Allergy by Lymphocyte Stimulation Test with Ethidium Bromide Fluorescence Assay. 溴化乙锭荧光法淋巴细胞刺激试验诊断药物过敏。

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1991-12-01 DOI: 10.5649/JJPHCS1975.17.399

T. Yoshimura, H. Yamada, M. Hayata, H. Nagai

{"title":"Diagnosis of Drug Allergy by Lymphocyte Stimulation Test with Ethidium Bromide Fluorescence Assay.","authors":"T. Yoshimura, H. Yamada, M. Hayata, H. Nagai","doi":"10.5649/JJPHCS1975.17.399","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.17.399","url":null,"abstract":"Lymphocyte stimulation test (LST) is one of the useful laboratory tests for identification of allergy to a specific drug.The present study was conducted to examine utility of LST using ethidium bromide (EB) fluorescence assay as a method for diagnosis of drug allergy.In a preliminary experiment, phytohemagglutinin (PHA) was used instead of suspected drugs.PHA at concentrations between 0.001-1.2% caused an activation of lymphocytes with elevation on stimulation index (SI).Interleukin 2 at concentrations between 1-100 ng/ml enhanced PHA-induced activation of lymphocytes. From these results, LST using EB fluorescence assay would be available for diagnosis of drug allergy.At first we carried out LST on 22 cases of suspicious drug-induced hepatitis.As a result, 9 cases were positive and 13 cases were negative.In order to analyze the relationship between background of the patients and LST, we studied transaminase (GOT and GPT) activities in the sera which were obtained from the patients in different states (remission and acute disease states). As a result, when LST was carried out in remission state, relatively high positive incidence (50%) was obtained.When LST was carried out in acute disease state, positive incidence of LST was low (25%).These results indicate that this method is useful for clinical diagnosis of drug allergy, And in the case of the diagnosis of drug-induced hepatitis, LST would be recommended to be carried out in remission state.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"98 1","pages":"399-407"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76120355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescription Ordering System in Hokkaido University Hospital (2) : Improvements of On-lined Automatic Tablet Packaging System 北海道大学医院处方订购系统(2):在线自动片剂包装系统的改进

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1991-08-20 DOI: 10.5649/JJPHCS1975.17.270

S. Kawai, T. Oh-E, T. Takashima, O. Ogino, Katsumi Miyazaki, G. Irie, T. Kudo

引用次数: 1

TOXI-LABシステム(急性薬物中毒分析法)の評価 TOXI-LAB系统(急性药物中毒分析法)的评估

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1991-06-20 DOI: 10.5649/jjphcs1975.17.123

大輔手嶋, 祐滋上田, 紀子田中, 二神幸次郎, 健司大坪, 駿樋口, 敏信青山

{"title":"TOXI-LABシステム(急性薬物中毒分析法)の評価","authors":"大輔手嶋, 祐滋上田, 紀子田中, 二神幸次郎, 健司大坪, 駿樋口, 敏信青山","doi":"10.5649/jjphcs1975.17.123","DOIUrl":"https://doi.org/10.5649/jjphcs1975.17.123","url":null,"abstract":"Recently, the acute drug poisonings have been increasing in Japan.Therefore, the accurate and rapid screening method of unknown drug caused poisoing has occupied the more important position in acute medicine.Though many kinds of chromatographies and spectrophotometries have been used to screen the unknown drug caused the poisoning, there is no proper method in Japan from the standpoint of utility and rapidity.Therefore, the practical use of the TOXILAB system (Marion) developed in USA was examined this time.Twenty-five drugs caused frequently acute poisoning were selected and added to the serum, urine and artificial gastric fluid.We investigated both the separation and the lower limit of detection of the drugs by TOXI-LAB system.The separative spots obtained on the TOXIGRAMs were compared to the authentic samples by HPLC.Furthermore, we applied the TOXILAB system to the patient sample in the acute poisoning and examined the utility of this system. Seven kinds of drug, i. e. agricultural medicines, theophylline, diphenhydramine and bromvalerylurea, could not be detected.It was confirmed that prednisolone, acetaminophen, phenacetin, hydroxyzine, chlorpromazine, carbamazepine, amobarbital and amitriptyline were detected even at half or a quarter of the lower limit of detection recorded in a TOXI-LAB compendium.Each spot on the TOXI-GRAM was in agreement with the authentic sample in HPLC.TOXI-LAB system is considered to be a very useful screening method if the drug caused acute poisoning could be predicted to some extent.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"1 1","pages":"123-132"},"PeriodicalIF":0.0,"publicationDate":"1991-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89353572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Levels of Carbamazepine and Valproic Acid in Pediatric Patients. Influence of Age and Drug Combination Therapy of L/D Ratios. 小儿患者卡马西平和丙戊酸的血清水平。年龄及药物联合治疗对L/D比值的影响。

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1991-02-20 DOI: 10.5649/JJPHCS1975.17.26

Suzuki Akito, 彰人鈴木, 栄二湯川, Yukawa Eiji, 健司大坪, Ohtsubo Kenji, 一郎家入, Ieiri Ichiro, 大輔手嶋, Teshima Daisuke, 駿樋口, Higuchi Shun, 敏信青山, Aoyama Toshinobu

引用次数: 1