Journal of Thrombosis and Haemostasis最新文献

{"title":"Assessing loss of platelet sialic acid using lectin flow cytometry","authors":"Marie A. Hollenhorst","doi":"10.1016/j.jtha.2025.07.003","DOIUrl":"10.1016/j.jtha.2025.07.003","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 10","pages":"Pages 3079-3081"},"PeriodicalIF":5.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Anticoagulation Peripartum.","authors":"Arielle L Langer, Brandon Togioka, Nicole A Smith, Bethany T Samuelson Bannow","doi":"10.1016/j.jtha.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.jtha.2025.09.003","url":null,"abstract":"<p><p>Due to the elevated thrombosis risk during pregnancy, anticoagulants are amongst the most common medications prescribed during gestation. For patients on anticoagulation antepartum, planning for delivery in advance is central to a safe and patient-centered delivery. Peripartum anticoagulation management must balance the benefits of continued therapy against the risks of postpartum hemorrhage and potential limitations in offering neuraxial anesthesia. Key considerations for delivery planning for patients on anticoagulation include 1) prophylactic versus therapeutic dosing; 2) mode of delivery (vaginal vs cesarean); 3) scheduled vs spontaneous delivery; 4) specific indications for neuraxial anesthesia (e.g. twin gestation, difficult airway); 5) the patient's valuation of neuraxial anesthesia; 6) time since diagnosis of venous thromboembolism (VTE) where applicable. Optimal patient management requires prenatal collaboration between thrombosis experts, obstetrics, and anesthesia to develop a personalized plan for delivery that balances risk of thrombosis, the potential for hemorrhagic complications, and patient preferences. This includes evaluating whether a patient on low molecular weight heparin should switch prior to delivery to subcutaneous unfractionated heparin (UFH) for prophylaxis or UFH continuous infusion, for those at high risk from a break in therapeutic anticoagulation. We also review postpartum anticoagulation options, emphasizing the importance of adherence during this high-risk period. Our discussion is limited to anticoagulation indicated for VTE.</p>","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Novel p.C252G and p.C280X mutations in EGF-1 domain of thrombomodulin lead to a thrombosis–bleeding syndrome”","authors":"Takayuki Iwaki","doi":"10.1016/j.jtha.2025.07.009","DOIUrl":"10.1016/j.jtha.2025.07.009","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 10","pages":"Pages 3082-3083"},"PeriodicalIF":5.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory testing of factor XI inhibitors: methodological challenges remain","authors":"Michael Hardy ,&nbsp;Henri Thonon ,&nbsp;Thomas Lecompte ,&nbsp;François Mullier","doi":"10.1016/j.jtha.2025.07.027","DOIUrl":"10.1016/j.jtha.2025.07.027","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 10","pages":"Pages 3070-3072"},"PeriodicalIF":5.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A central role of factor XI in a baboon model of Staphylococcus aureus sepsis","authors":"Nigel Mackman,&nbsp;Ana T.A. Sachetto,&nbsp;Steven P. Grover","doi":"10.1016/j.jtha.2025.07.015","DOIUrl":"10.1016/j.jtha.2025.07.015","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 10","pages":"Pages 3075-3078"},"PeriodicalIF":5.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-1α alters megakaryocyte maturation, promotes emperipolesis, and induces a distinct proteomic profile.","authors":"Robert Kolman, Hannah Voß, Ivana Bertović, Josip Peradinović, Ivana Munitić, Daniel Robert Engel, Olga Shevchuk, Antonija Jurak Begonja","doi":"10.1016/j.jtha.2025.08.037","DOIUrl":"10.1016/j.jtha.2025.08.037","url":null,"abstract":"<p><strong>Background: </strong>Megakaryocytes (MKs) are large, polyploid cells and precursors of blood platelets. Interleukin (IL)-1α is a proinflammatory cytokine and a known mediator of emergency thrombopoiesis. However, its effect on MK maturation in vitro has not been studied in detail.</p><p><strong>Objectives: </strong>We aimed to investigate the phenotypical and molecular consequences of IL-1α-based MK maturation.</p><p><strong>Methods: </strong>Murine bone marrows were cultured in the presence of IL-1α, in addition to thrombopoietin (TPO), in vitro and analyzed for MK maturation at days 3 and 5 of culture. Furthermore, proteome analysis of MKs cultured with IL-1α and/or TPO was performed.</p><p><strong>Results: </strong>IL-1α induced differentiation of a greater number of larger MKs with higher ploidy and increased the release of platelet-like particles, but had decreased expression of maturation markers. Interestingly, we found a significantly higher rate of emperipolesis, characterized by transiently present Ly6G+ neutrophils within the MK cytoplasm in early cultures, which was dependent on IL-1α. At later stages, IL-1α-cultured MKs were morphologically indistinguishable from TPO-cultured MKs, although they kept the ability to produce more platelet-like particles. Proteome analysis further revealed a significantly higher abundance of neutrophil-related proteins, antimicrobial peptides, and inflammation-related proteins in early-stage IL-1α-cultured MKs, a pattern that persisted throughout late maturation.</p><p><strong>Conclusion: </strong>Taken together, these results shed light on the modulatory role of IL-1α on MK maturation, influencing not only platelet biogenesis but also promoting emperipolesis and an immune-driven proteomic MK phenotype.</p>","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper extremity post-thrombotic syndrome score: consensus results from an international Delphi study.","authors":"Tjep Hoedemakers, Eline S van Hattum, Bart-Jeroen Petri, Gert J de Borst","doi":"10.1016/j.jtha.2025.08.026","DOIUrl":"10.1016/j.jtha.2025.08.026","url":null,"abstract":"<p><strong>Background: </strong>There is no gold standard to diagnose or classify upper extremity post-thrombotic syndrome (UE-PTS). Recently, 2 Delphi consensus studies were conducted to develop a score for diagnosing and classifying UE-PTS.</p><p><strong>Objectives: </strong>The aim of the present study was to gain expert consensus on the definitions of the individual components of the UE-PTS score to enable the consistent application of this score.</p><p><strong>Methods: </strong>The Delphi approach was chosen as the appropriate method to gain expert consensus, and 53 experts were invited to participate. Definitions were collaboratively developed by a Delphi Steering Committee together with UE-PTS patients. Experts were asked to provide feedback and rated the proposed definitions across 3 Delphi rounds using a 9-point Likert scale, with consensus defined as ≥75% of scores ≥7.</p><p><strong>Results: </strong>Thirty-five of the 53 (66%) experts agreed to participate in this Delphi study. The expert panel included vascular surgeons, internists, hematologists, and physical therapists. In round 1, 45 alternative definitions or comments were collected. In round 2, no consensus was reached for any statement. In round 3, consensus was reached for all statements, with the highest level of consensus being 96% for the symptoms: heavy feeling of the arm, fatigue when using arm, and pain (chronic or during specific exercises).</p><p><strong>Conclusion: </strong>Consensus was reached on the optimal definitions of 5 symptoms and 2 clinical signs of the UE-PTS score. The next step is to validate and finalize the UE-PTS score in a patient cohort before it can be implemented in future research and clinical practice.</p>","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walking capacity and venous claudication after deep vein thrombosis: prospective follow-up, risk factors, and quality of life.","authors":"Daniel Steiner, Stephan Nopp, Timothy Hoberstorfer, Ingrid Pabinger, Eva Dassler, Moritz Staudacher, Markus Müller, Sabine Steiner, Benedikt Weber, Philip Kienzl, Cihan Ay, Oliver Schlager","doi":"10.1016/j.jtha.2025.08.038","DOIUrl":"10.1016/j.jtha.2025.08.038","url":null,"abstract":"<p><strong>Background: </strong>Data on the course of walking capacity after acute deep vein thrombosis (DVT) are scarce.</p><p><strong>Objectives: </strong>The aim of this prospective observational study was to assess the course of walking impairment and venous claudication after DVT and the association with clinical characteristics and quality of life (QoL).</p><p><strong>Methods: </strong>Walking capacity was assessed by standardized treadmill exercise tests (TETs) at DVT diagnosis and after 3 months. Pain-free walking distance (PWD) and maximum walking distance (MWD) were recorded. Venous claudication during TET was evaluated and documented by trained biomedical scientists according to a standardized protocol. QoL was evaluated with the EuroQoL Group 5-Dimension 5-Level and the VEnous INsufficiency Epidemiologic and Economic Study (VEINES-QoL/Sym) questionnaires.</p><p><strong>Results: </strong>Seventy-three patients (30.1% women; median age, 53.8 years; IQR, 42.9-60.0 years) were included. PWD and MWD generally improved over time, with a median change of 305 m (IQR, 33-710 m) and 30 m (IQR, 0-258 m), respectively. However, 16 (28.1%) patients reported persistent venous claudication after 3 months. Patients with venous claudication after 3 months tended to have higher rates of suprainguinal DVT, higher body mass index, and higher rates of arterial hypertension and were admitted to the hospital at DVT diagnosis more often. Generic and disease-specific QoL improved overall, but patients with venous claudication had significantly lower QoL scores than those without.</p><p><strong>Conclusion: </strong>Walking capacity generally improved after DVT, but about one-third of patients had persisting venous claudication after 3 months, which was associated with poorer QoL. Suprainguinal DVT, higher body mass index, arterial hypertension, and hospital admission at diagnosis were more common in patients with venous claudication 3 months after DVT.</p>","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelets as evolution's answer to both hemorrhage and infection.","authors":"Gerard Gurumurthy, Jecko Thachil","doi":"10.1016/j.jtha.2025.09.002","DOIUrl":"10.1016/j.jtha.2025.09.002","url":null,"abstract":"<p><p>Hemorrhage and infections have remained substantial causes of mortality and morbidity throughout history. Platelets are classically known for their role in thrombosis. However, our recent understanding has revealed their role in innate immunity. This historical sketch explores the evolutionary origins of platelets through the concept of immunothrombosis. We trace the emergence of hemocytes in invertebrates, the development of thrombocytes in early vertebrates, and the eventual rise of anucleate platelets in mammals. Mammalian platelet fragments retain immune capabilities alongside their clotting abilities. These include pathogen sensing, antimicrobial peptide release, and coordination with leukocytes. Evolutionary pressures may have shaped blood-based systems that rapidly respond to both vascular injury and microbial invasion. We argue that platelets represent an elegant solution to the evolution's threats of hemorrhage and infection.</p>","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obituary: Gualtiero Palareti (1943-2025).","authors":"Giancarlo Castaman, Valerio De Stefano","doi":"10.1016/j.jtha.2025.08.035","DOIUrl":"https://doi.org/10.1016/j.jtha.2025.08.035","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}