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Research of Gastric Management and Hepatology最新文献

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Subtotal Stepwise Cerebral Ischemia - Methodological Approaches to Modeling and Manifestations of Neurological Deficit 次计逐步脑缺血-神经功能缺损的建模和表现的方法学方法
Research of Gastric Management and Hepatology Pub Date : 2023-02-25 DOI: 10.58489/2836-6204/005
Lizaveta I. Bon
{"title":"Subtotal Stepwise Cerebral Ischemia - Methodological Approaches to Modeling and Manifestations of Neurological Deficit","authors":"Lizaveta I. Bon","doi":"10.58489/2836-6204/005","DOIUrl":"https://doi.org/10.58489/2836-6204/005","url":null,"abstract":"The invention relates to experimental medicine and biology and is devoted to the development of a new method for modeling ischemic brain damage, which is a common and severe pathology that causes not only high disability, but mortality. The proposed method of modeling subtotal ischemia by stepwise (non-momentary) ligation of both common carotid arteries has an advantage over the prototype since it does not lead to the death of experimental animals, which allows to study the consequences of severe cerebral ischemia and the pathogenesis of ischemic injuries on the brain in dynamics, to develop corrective measures.","PeriodicalId":173184,"journal":{"name":"Research of Gastric Management and Hepatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133529419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptic Ulcer Disease and Its Implications 消化性溃疡疾病及其影响
Research of Gastric Management and Hepatology Pub Date : 2023-02-25 DOI: 10.58489/2836-6204/004
Isaac John Umaru
{"title":"Peptic Ulcer Disease and Its Implications","authors":"Isaac John Umaru","doi":"10.58489/2836-6204/004","DOIUrl":"https://doi.org/10.58489/2836-6204/004","url":null,"abstract":"Peptic ulcer disease (PUD) is one of the commonest diseases seen throughout the world. Peptic ulcers are open sores that develop on the inside lining of your stomach and the upper portion of your small intestine. The most common symptom of a peptic ulcer is stomach pain. There are various risk factors for the development of peptic ulcer disease, but the most important ones are Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs). Patients generally present with dyspepsia or peptic ulcer bleeding. Acid suppressant therapy, H. pylori eradication, and avoidance of nonsteroidal anti-inflammatory drugs are the cornerstones of treatment of peptic ulcer disease. Peptic ulcer bleeding could be life-threatening. It is managed by appropriate supportive care, intravenous proton pump inhibitor therapy, and endoscopic homeostasis. Trans arterial embolization (TAE), Herbal treated and surgery are rarely required if endoscopic therapy fails.","PeriodicalId":173184,"journal":{"name":"Research of Gastric Management and Hepatology","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123508617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Micronutrients Why and How 微量营养素的原因和方式
Research of Gastric Management and Hepatology Pub Date : 2023-02-25 DOI: 10.58489/2836-6204/001
A. Koleilat
{"title":"Micronutrients Why and How","authors":"A. Koleilat","doi":"10.58489/2836-6204/001","DOIUrl":"https://doi.org/10.58489/2836-6204/001","url":null,"abstract":"Nutrition is one of the important factors that affect the immune system. The key nutrients for a healthy immune system are proteins, antioxidants, micronutrients, prebiotics, and probiotics. The only food that has all the nutrients needed by the body is breastmilk. Breastmilk is not sterile since it has its own microbial composition. It helps in the development of a breastfed infant’s gut microbiome.","PeriodicalId":173184,"journal":{"name":"Research of Gastric Management and Hepatology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114715237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Antifungal Potential and Gastroprotective Effect of Ethanol Seed Extract of Spathodea Campanulata of Indomethacin Induced Gastric Ulcer, A Possible Application for Veterinary Animal 吲哚美辛诱导的胃溃疡的抗真菌活性及保胃作用评价及应用前景
Research of Gastric Management and Hepatology Pub Date : 2023-02-25 DOI: 10.58489/2836-6204/002
Isaac John Umaru
{"title":"Evaluation of Antifungal Potential and Gastroprotective Effect of Ethanol Seed Extract of Spathodea Campanulata of Indomethacin Induced Gastric Ulcer, A Possible Application for Veterinary Animal","authors":"Isaac John Umaru","doi":"10.58489/2836-6204/002","DOIUrl":"https://doi.org/10.58489/2836-6204/002","url":null,"abstract":"The present study evaluates the effects of the plant seed extract of Spathodea Campanulata administration on microbial (Aspergillus niger, Aspergillus flavin, Candida tropicalis and Fusarium oxysporium.) and ulcer inhibition on common Veterinary Albino rats.Spathodea campanulata is an African plant which is used in tropical and subtropical areas for ornamental purposes as well as for the treatment of a range of diseases such as wounds, skin rashes, and haemorrhoids. Materials and Methods: Indomethacin for gastric-ulcer induction, Omeprazole and Tetracycline as standard drug, Disc diffusion method for antifungal and Histopathology for ulcer index. Results: The effects of ethanol seeds extract were studied for antifungal and antiulcer. Where a significant activity observed in various concentration on different fungi indicating a positive agent for the selected pathogens. Also, with 40 albino rats over a period of 7 days, the rats were divided into five groups, those in group one served as the control, group two as the negative control (Indomethacin), group three as the positive control (Omeprazole) and group four and five are dosed ranged groups from 200-400mg/kg extract. Tissue injury and its infiltration were examined and scored; the length and breadth of the lesion were measured for ulcer index. Inflammatory and fibrosis alteration were present in ulcer treated rats, at days 7 colonic wall thickening and fibrotic remodelling were evident as well as blood vessels remodelling. The percentage rate of healing was 10.03% at 200 ppm and 25.51% at 500ppm. The present findings provide an integrated view of ulcer healing processes occurring in the ulcer induced colonic compartment of rats induced by indomethacin. Conclusion: These ulcerogenic alterations may represent a suitable basis for understanding the effects of Spathodea campanulata ethanol seeds extract to ulcer treatment as well as an antifungal.","PeriodicalId":173184,"journal":{"name":"Research of Gastric Management and Hepatology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123375291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical Method Development and Validation of Hptlc Method for Simultaneous Estimation of Telmisartan and Azelnidipine in Tablet Dosage Form 高效液相色谱法同时测定片剂剂型中替米沙坦和阿泽尼地平含量的方法建立与验证
Research of Gastric Management and Hepatology Pub Date : 2023-02-25 DOI: 10.58489/2836-6204/006
Ashwini Dhruv
{"title":"Analytical Method Development and Validation of Hptlc Method for Simultaneous Estimation of Telmisartan and Azelnidipine in Tablet Dosage Form","authors":"Ashwini Dhruv","doi":"10.58489/2836-6204/006","DOIUrl":"https://doi.org/10.58489/2836-6204/006","url":null,"abstract":"Background: A specific, accurate, precise, robust and cost effective HPTLC method was developed and validated for quantitative analysis of Telmisartan and Azelnidipine in fixed dose combination. The separation was carried out on pre-coated TLC plates with Silica gel 60 F254 as stationary phase using Chloroform: Ethyl acetate: Methanol (7.5:2:0.5 v/v/v) as developing system followed by densitometry measurement of bands at 280nm. Result: The separation of Telmisartan and Azelnidipine was found to be at the following RF values 0.3 and 0.63 respectively. Calibration curves were found to be linear over the concentration ranges 400-4000ng/band, 80-800ng/band for Telmisartan and Azelnidipine with correlation coefficient 0.9957 and 0.9966 respectively. Accuracy was found between 98.03% - 102% and 98.72% - 102 % for Telmisartan and Azelnidipine respectively. LOD was found to be 1.04% and 1.6% and LOQ was found to be 3.49% and 5.57% for Telmisartan and Azelnidipine respectively Conclusion: The results showed that the proposed HPTLC method is reliable for routine analysis for simultaneous determination of Telmisartan and Azelnidipine without any interference.","PeriodicalId":173184,"journal":{"name":"Research of Gastric Management and Hepatology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125401830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomathematical analysis on impedance measurement during COVID-19 pandemic 新冠肺炎大流行期间阻抗测量的生物数学分析
Research of Gastric Management and Hepatology Pub Date : 2022-11-22 DOI: 10.58489/2836-6204/003
Bin Zhao
{"title":"Biomathematical analysis on impedance measurement during COVID-19 pandemic","authors":"Bin Zhao","doi":"10.58489/2836-6204/003","DOIUrl":"https://doi.org/10.58489/2836-6204/003","url":null,"abstract":"The coating impedance size can reflect the aging degree of the coating to a certain extent; therefore, the measurement of the coating impedance size can monitor the aging degree of the coating in real time. Since the coating is traditionally considered as an insulating medium, its impedance value before aging is as high as 10^8 Ω or more, it is difficult to achieve accurate impedance measurement, and the current generated by loading by voltammetry at low voltage is very weak and easily affected by external electromagnetic interference noise, and the measurement accuracy is low. In this paper, by pluralizing the high impedance, establishing the mathematical model of differential amplification circuit, and then using sinusoidal fitting in which processing, so that the obtained signal is more accurate during COVID-19 pandemic.","PeriodicalId":173184,"journal":{"name":"Research of Gastric Management and Hepatology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122218963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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