Subtotal Stepwise Cerebral Ischemia - Methodological Approaches to Modeling and Manifestations of Neurological Deficit

Abstract

The invention relates to experimental medicine and biology and is devoted to the development of a new method for modeling ischemic brain damage, which is a common and severe pathology that causes not only high disability, but mortality. The proposed method of modeling subtotal ischemia by stepwise (non-momentary) ligation of both common carotid arteries has an advantage over the prototype since it does not lead to the death of experimental animals, which allows to study the consequences of severe cerebral ischemia and the pathogenesis of ischemic injuries on the brain in dynamics, to develop corrective measures.