次计逐步脑缺血-神经功能缺损的建模和表现的方法学方法

Lizaveta I. Bon
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引用次数: 0

摘要

本发明涉及实验医学和生物学,致力于开发一种模拟缺血性脑损伤的新方法,缺血性脑损伤是一种常见且严重的病理,不仅导致高致残率,而且导致死亡率。所提出的通过逐步(非瞬间)结扎双颈总动脉来模拟次全缺血的方法与原型相比具有优势,因为它不会导致实验动物死亡,从而可以从动力学角度研究严重脑缺血的后果和缺血性脑损伤的发病机制,从而制定纠正措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Subtotal Stepwise Cerebral Ischemia - Methodological Approaches to Modeling and Manifestations of Neurological Deficit
The invention relates to experimental medicine and biology and is devoted to the development of a new method for modeling ischemic brain damage, which is a common and severe pathology that causes not only high disability, but mortality. The proposed method of modeling subtotal ischemia by stepwise (non-momentary) ligation of both common carotid arteries has an advantage over the prototype since it does not lead to the death of experimental animals, which allows to study the consequences of severe cerebral ischemia and the pathogenesis of ischemic injuries on the brain in dynamics, to develop corrective measures.
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