Journal of the Egyptian Women's Dermatologic Society最新文献_第9页

Effect of melanocyte keratinocyte transplantation procedure, using ablative CO2 laser and followed by NB-UVB phototherapy, on the expression of E-Cadherin and matrix metalloproteinase-2 in acral vitiligo: an immunohistochemical study 黑素细胞角化细胞移植手术，使用烧蚀CO2激光和随后的NB-UVB光疗，对肢端白癜风E-Cadherin和基质金属蛋白酶2表达的影响:一项免疫组织化学研究

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-09-01 DOI: 10.4103/jewd.jewd_15_21

S. Esmat, M. Assaf, D. Kadry, M. E. El Hawary, D. Halim, Marwa Saleh, D. Bassiouny, Heba Saad, Ghada M. El-Hanafy

{"title":"Effect of melanocyte keratinocyte transplantation procedure, using ablative CO2 laser and followed by NB-UVB phototherapy, on the expression of E-Cadherin and matrix metalloproteinase-2 in acral vitiligo: an immunohistochemical study","authors":"S. Esmat, M. Assaf, D. Kadry, M. E. El Hawary, D. Halim, Marwa Saleh, D. Bassiouny, Heba Saad, Ghada M. El-Hanafy","doi":"10.4103/jewd.jewd_15_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_15_21","url":null,"abstract":"Background Melanocyte keratinocyte transplantation procedure (MKTP) is a multi-procedural intervention that could hypothetically alter the environment surrounding grafted epidermal cells, helping melanocytes’ migration and adherence to keratinocytes in their basal position. Objective To evaluate the effect of MKTP in acral vitiligo skin prepared by total ablative CO2 laser resurfacing and followed by narrow-band ultraviolet B (NB-UVB) phototherapy on matrix metalloproteinase-2 (MMP2) and E-Cadherin expression and the reflection of these changes on repigmentation. Patients and methods Acral lesions in 20 stable nonsegmental vitiligo patients were prepared by full CO2 ablation down to the papillary dermis followed by MKTP and NB-UVB sessions. Two 4 mm punch biopsies were taken: the first at baseline and the second after the onset of repigmentation or after 6 months of phototherapy if no repigmentation occurred. Immunohistochemical staining for evaluation of E-Cadherin and MMP2 expression was performed. Results Eight patients (40%) achieved repigmentation ranging from 10 to 90% with a median of 62.5%. E-Cadherin intensity was significantly increased after treatment (P<00.1). There was also a significant total increase in epidermal (P<0.001) and dermal (P<0.001) MMP2 with diffuse nuclear pattern of staining. In lesions showing repigmentations, the percentage change in dermal MMP2 was significantly higher (P=0.012), while no such difference was present in epidermal MMP2 and E-Cadherin expression. Conclusion MKTP with recipient site prepared by full CO2 laser ablation followed by NB-UVB phototherapy increased the expression of E-Cadherin and MMP2 in acral vitiliginous skin. The increase of dermal MMP2 could play a favorable role in repigmentation.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"179 - 185"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44645230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Circulating ghrelin and apelin levels in nonobese psoriasis vulgaris patients 非肥胖寻常型银屑病患者的循环胃饥饿素和apelin水平

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-09-01 DOI: 10.4103/jewd.jewd_35_21

Azza G A Farag, H. Abdallah, R. Ibrahem, M. Elshaib, W. Shehata

{"title":"Circulating ghrelin and apelin levels in nonobese psoriasis vulgaris patients","authors":"Azza G A Farag, H. Abdallah, R. Ibrahem, M. Elshaib, W. Shehata","doi":"10.4103/jewd.jewd_35_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_35_21","url":null,"abstract":"Background The metabolism and immune system are linked via a network of many mediators known as adipokines. Ghrelin and apelin-36 are unique adipokines; however, their role in psoriasis, an immune-mediated disease, remains unclear. Objective To detect the serum levels of ghrelin and apelin-36 in psoriasis vulgaris patients in comparison with controls and to correlate their levels with severity of psoriasis, BMI, lipid profile, and glycated hemoglobin (HbA1c). Patients and methods The present case–control study included 70 nonobese psoriasis vulgaris patients and 70 controls. The severity of psoriasis was assessed using the psoriasis area and severity index score. The ghrelin and apelin-36 serum levels, cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and HbA1c were measured. Results Psoriatic patients had significantly higher ghrelin (P<0.001), HbA1c (P<0.001), cholesterol (P<0.001), triglycerides (P<0.001), and low-density lipoprotein (P=0.001) levels and a lower apelin-36 (P<0.001) serum level than controls. Serum ghrelin was negatively correlated with psoriasis area and severity index score (r=−0.75; P<0.001), whereas serum apelin-36 was negatively correlated with HbA1c mean values (r=−0.44; P=0.004) and was found to be a good predictor of prediabetes in psoriatic patients (P=0.012). Nonsignificant correlation between ghrelin and apelin-36 serum levels was observed in psoriatic patients. Conclusion Ghrelin and apelin-36 are dynamic adipokines that might play a role in psoriasis vulgaris pathogenesis. The role of ghrelin and apelin-36 in psoriasis might be mediated through dyslipidemia and impaired glucose metabolism in psoriatic patients, respectively. Targeting both ghrelin and apelin-36 may be of value in management of metabolic syndrome associated with psoriasis. Serum apelin-36 assessment can predict prediabetic state in psoriatic patients.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"198 - 204"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45114495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porokeratosis and mycosis fungoides: cause/result or an association or neither? A case report 毛孔扩张症和蕈样真菌病：原因/结果还是关联？案例报告

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-09-01 DOI: 10.4103/jewd.jewd_13_21

M. Eldarouti, H. Rasheed, A. M. Eltawdy, P. Mostafa

引用次数: 0

Hypertrophic striae gravidarum as an eruptive dermatosis of pregnancy 肥厚性妊娠纹是妊娠期的一种爆发性皮肤病

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-09-01 DOI: 10.4103/jewd.jewd_27_21

A. Valle, Daniel López, A. Velázquez, Carmen Donoso

引用次数: 0

Il17A (rs2275913 G>A) and IL17F (rs2397084 T>C) gene polymorphisms: relation to psoriasis risk and response to methotrexate Il17A（rs2275913 G>A）和IL17F（rs2397084 T>C）基因多态性与银屑病风险和甲氨蝶呤反应的关系

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-09-01 DOI: 10.4103/jewd.jewd_6_21

Ashraf M. Hamza, R. A. Abo Elwafa, N. Ramadan, S. Omar

{"title":"Il17A (rs2275913 G>A) and IL17F (rs2397084 T>C) gene polymorphisms: relation to psoriasis risk and response to methotrexate","authors":"Ashraf M. Hamza, R. A. Abo Elwafa, N. Ramadan, S. Omar","doi":"10.4103/jewd.jewd_6_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_6_21","url":null,"abstract":"Background IL17F rs763780 polymorphism results in substitution of histidine to arginine at amino acid 161, leading to upregulation of IL17F and increased propensity to autoimmune diseases. The single nucleotide polymorphism rs2275913 (G197A) involves a substitution of the guanine by an adenine nucleotide base in IL17A gene promotor which plays a key role in regulation of cytokine transcription. The relation of IL17 polymorphisms however to psoriasis risk and response to methotrexate has not been previously studied in Egyptians. Objective To study the relation of IL17A (rs2275913 G>A) and IL17F (rs2397084 T>C) polymorphisms to psoriasis risk and assess their predictive role regarding response to methotrexate. Patients and methods The study was conducted in two phases. First, a case–control study including 100 patients with chronic plaque psoriasis and 100 healthy control patients was conducted for IL17A (rs2275913) and IL17F (rs2397084) polymorphisms by real-time PCR. Second, a cohort study was adopted where the patients with psoriasis were treated with methotrexate weekly intramuscularly (0.6 mg/kg) for 12 weeks and followed for clinical response. Results IL17F TT genotype was more frequent in patients (87%) than controls (68%), whereas TC genotype was more frequent in controls (32%) than patients (13%). TT genotype was associated with increased risk of psoriasis, whereas the TC allele was associated with a decreased risk. There was no significant difference regarding IL17A GG, GA, and AA genotype frequencies between patients and controls. Psoriasis area and severity index greater than or equal to 75% was achieved in 22 patients (73.3%) with the TT genotype and eight patients (26.7%) with TC genotype (P=0.019). Conclusion IL17F (rs2397084 T>C) TT genotype could be considered a susceptibility marker in Egyptian patients. Psoriatic patients with TT genotype and T allele of IL17F (rs2397084 T>C) are likely to show a better response to methotrexate.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"167 - 173"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45453776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Novel subcision technique combined with either microneedling or trichloroacetic acid 35% peeling for acne scars: a comparative study 微针或三氯乙酸35%剥离治疗痤疮疤痕的新型亚细胞切除技术的比较研究

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-05-01 DOI: 10.4103/jewd.jewd_58_20

A. Zayed, Rasha Abelghafar, Ahmed Hehazy, Sarah Orabi, M. El-Mesidy

{"title":"Novel subcision technique combined with either microneedling or trichloroacetic acid 35% peeling for acne scars: a comparative study","authors":"A. Zayed, Rasha Abelghafar, Ahmed Hehazy, Sarah Orabi, M. El-Mesidy","doi":"10.4103/jewd.jewd_58_20","DOIUrl":"https://doi.org/10.4103/jewd.jewd_58_20","url":null,"abstract":"Background Challenging treatment of acne scars makes it a must to have a plan for each case specifically. Subcision breaks the fibrous strands tethering the scar but is followed by recurrence. Chemical peeling and microneedling are other treatment options. Objectives To evaluate a new subcision technique combined with either microneedling or peeling in the treatment of acne scars. Patients and methods A total of 20 patients with bilateral rolling and boxcar acne scars were enrolled. Subcision using microkeratomes was done followed by either peeling using 35% trichloroacetic acid on one side or microneedling on the other side. Evaluation of response was done by Echelle d’Evaluation clinique des Cicatrices d’acné grading scale and optical coherence tomography imaging. Results Both therapeutic modalities yielded statistically significant improvement of acne scars and statistically significant decrease in acne scar depth. There was neither a statistically significant difference between the two sides regarding Echelle d’Evaluation clinique des Cicatrices d’acné scoring after treatment (P=0.968) nor regarding optical coherence tomography acne scar depth after treatment (P=0.583). Conclusion This novel technique of subcision is a safe and effective method for rolling and boxcar scar treatment, with almost no adverse effects and no downtime. In addition, trichloroacetic acid 35% peel is cheaper, as well as does not need any extensive special training or expensive instruments, as compared with microneedling, but microneedling shows better skin tightness and improvement of skin elastolysis especially in older patients.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"109 - 118"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48199701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The landscape of ‘podoplanin’ in dermatology: a narrative review “足平面蛋白”在皮肤病学中的应用：叙述性综述

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-05-01 DOI: 10.4103/jewd.jewd_18_21

N. Diab, M. Assaf, Nourhan Anis, E. Salah

引用次数: 0

Serum interleukin 15 as a marker of activity in patients with vitiligo 白癜风患者血清白细胞介素15的活性标志

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-05-01 DOI: 10.4103/jewd.jewd_60_20

Ashraf M. Hamza, Mona Aiad, Ahmed Abdel-Bary, Eman Gouda

{"title":"Serum interleukin 15 as a marker of activity in patients with vitiligo","authors":"Ashraf M. Hamza, Mona Aiad, Ahmed Abdel-Bary, Eman Gouda","doi":"10.4103/jewd.jewd_60_20","DOIUrl":"https://doi.org/10.4103/jewd.jewd_60_20","url":null,"abstract":"Background Interleukin 15 (IL15) is a proinflammatory cytokine that is involved in the pathogenesis of several autoimmune and inflammatory diseases. The stability of vitiligo represents the periods of no activity of the disease, and it is crucial in determining the line of treatment of the patient. Objective To assess serum IL15 in patients with vitiligo and to evaluate its predictive capacity as a marker of vitiligo activity. Patients and methods A total of 40 patients with nonsegmental vitiligo were included, in addition to 30 age-matched and sex-matched healthy individuals as a control. The severity of vitiligo was assessed using vitiligo area severity index score, whereas the activity of disease in patients was assessed using vitiligo disease activity score. Serum levels of IL15 were measured using the ELISA technique. Results The mean serum level of IL15 was significantly higher in patients with vitiligo (201.14±115.41 ng/l) than in control (136.13±22.57 ng/l). Moreover, the mean serum level of IL15 was significantly higher in patients with unstable/active vitiligo (243.12±136.64 ng/l) than in patients with stable vitiligo (144.35±28.82 ng/l). Patients with serum level of less than or equal to 150.90 ng/l can be diagnosed as stable vitiligo, with 76.47% sensitivity and 73.91% specificity. Conclusion IL15 is a good and reliable marker for the detection of activity in patients with vitiligo, but further studies are needed to follow the progression of disease and to correlate this with the serum level of IL15. Targeting IL15 could be a novel treatment approach for patients with vitiligo.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"104 - 108"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43778231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can patients with urticaria be contagious to COVID-19? a new disguise: a hypothesis from an Egyptian experience 荨麻疹患者会传染COVID-19吗?一种新的伪装:来自埃及经验的假设

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-05-01 DOI: 10.4103/jewd.jewd_8_21

P. Mostafa

引用次数: 1

Fluoroscopy-induced chronic radiodermatitis: three cases presenting after cardiac catheterization 荧光镜诱发的慢性放射性皮炎：3例心导管插入术后表现

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2021-05-01 DOI: 10.4103/jewd.jewd_67_20

G. El-Enany, Khaled El Hoshy, R. Youssef, N. Nagui, H. Nada, M. Halim, A. Nada, Dina Elantably, Iman Sany

引用次数: 0