Journal of the Egyptian Women's Dermatologic Society最新文献

{"title":"Efficacy of intralesional measles, mumps and rubella vaccine immunotherapy in Molluscum contagiosum: a prospective study","authors":"Fariz Sarshar, Mohammad Adil, Prateek Pathak, Triveni Harode, Mitali Sethi","doi":"10.4103/jewd.jewd_17_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_17_23","url":null,"abstract":"Introduction Molluscum contagiosum(MC) is a viral infection of the skin and mucous membrane characterized by single or multiple, pearly white to flesh-colored umbilicated papules. There are certain therapies that increase the cellular immune response either through a topical or systemic approach as cell-mediated immunity plays an important role in the regression of MC. Immunomodulatory medications are relatively newer modalities of treatment that have been more successful for patients with widespread and potentially disfiguring eruptions. Objective To study the effect and safety of Measles, Mumps, and Rubella (MMR) immunotherapy in patients with multiple Mollusca. Patients and methods The study included 200 patients with multiple MC. They were injected with the MMR vaccine intralesionally into 2-3 lesions including the largest mollusca up to a maximum of 0.3 ml in one sitting every 2 weeks for a maximum of 5 treatments at a 2-week interval (week: 0, 2, 4, 6, 8) or till the complete resolution of MC whichever was earlier. The action of the MMR vaccine was assessed by the reduction of the number of lesions and the day of resolution of lesions. The response of all patients at subsequent visits (at second, fourth, sixth, eighth, and 10th week from the initiation of therapy which was taken as week 0) was analyzed. All the patients were subjected to photographic documentation before the initiation of therapy, during therapy, and at 1 month (week 14) and 3 months (week-22) of the follow-up period. Results Out of 200 patients, 184 completed the study. There were 116 males and 84 females. The mean age of study participants was 17.17±12.64 years. At the end of the study complete resolution of MC was seen in 149 (81%) patients, 21 (11.4%) patients had relative response while a poor response was seen in 14 (7.6%) of patients. Mild tolerable pain was seen in 25 (12.5%) patients during injection followed by pigmentary changes in 17 (8.5%) patients and scarring in 12 (6%) patients. Conclusion Intralesional immunotherapy with the MMR vaccine is an effective and safe modality for the treatment of MC.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"196 - 200"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70792372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molluscum contagiosum in an HIV-negative adult with idiopathic CD4 lymphocytopenia easily missed by dermatologists: a case report","authors":"Pakinam Mostafa","doi":"10.4103/jewd.jewd_60_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_60_22","url":null,"abstract":"Molluscum contagiosum is a viral skin infected that is seen in children, sexually active adults, as well as immunocompromised adults in different situations of T-cell dysfunction. We report a rare case of molluscum contagiosum in an HIV-negative adult with idiopathic CD4 lymphocytopenia, a rare, underreported T-cell dysfunction.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"206 - 209"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70792931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin reactions to COVID-19 vaccination among Egyptians in three governorates","authors":"Osama Alkady, Sara Abdelhameed, Shymaa Rezk","doi":"10.4103/jewd.jewd_26_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_26_23","url":null,"abstract":"Background In the first 6 months of the pandemic, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused more than a million deaths. Vaccines from several manufacturers, such as Pfizer-BioNTeck, AstraZeneca’s Vaxzevria, and Sinopharm, have been used in an effort to contain the pandemic. Objective To evaluate the skin reactions that occurred after receiving multiple types of coronavirus disease-19 (COVID-19) vaccinations among Egyptians in three governorates. Patients and methods This clinical cohort study was conducted on 1000 individuals receiving COVID vaccines. The registry’s vaccination module gathered data on vaccine dosage dates, cutaneous reaction(s), reaction timing, and duration. There were four categories of adverse responses to vaccines: systemic, local acute site reactions, delayed local skin reactions, and generalized cutaneous side effects. Results Of all individuals, 53.1% had previously contracted Covid-19. 76.3% of the study patients experienced systemic side effects. 91.4% of patients had an ‘injection site’ acute local cutaneous side effect. The Johnson and Johnson vaccination was associated with the highest systemic and local cutaneous side effects incidence, whereas the Sinopharm vaccine was linked to the lowest incidence. 10.2% of individuals experienced delayed cutaneous reactions, with the AstraZeneca vaccine having the greatest incidence and the Pfizer vaccine having the lowest. Conclusion Acute cutaneous side effect differs from one vaccine to another. Johnson and Johnson was associated more with bruising and redness, AstraZeneca was more associated with itching, and Pfizer was linked to increased discomfort and tenderness at the injection site. The AstraZeneca vaccination showed the highest prevalence of delayed cutaneous side effects.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"187 - 195"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70792596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New-onset unilateral cutaneous annular atrophic lichen planus after COVID-19 infection and reactivation after re-infections","authors":"Enas Attia","doi":"10.4103/jewd.jewd_21_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_21_23","url":null,"abstract":"A huge number of related dermatological manifestations have been stated, since the outbreak of coronavirus (COVID-19) in December 2019. Here inside, a case of recent-onset unilateral cutaneous annular atrophic lichen planus (AALP) after COVID-19 infection, with reactivation after re-infection, is documented.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"204 - 205"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70792398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acral interdigital melanoma mimicking tinea pedis","authors":"Omar El Ghanam, G. El Enany, H. Nada, MonaR.E Abd El Halim, Suzan Shalaby, Riham MohyeEldeen Mohamed","doi":"10.4103/jewd.jewd_23_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_23_23","url":null,"abstract":"We report a case of interdigital acral nodular melanoma on the right fourth toe cleft of a 56‐year‐old Caucasian man that was initially misdiagnosed and mistreated as tinea pedis for over one year. Despite undergoing complete tumor resection and therapeutic lymphadenectomy, as well as adjuvant immunotherapy, the patient died of metastatic disease 18 months after his first visit. This case emphasizes that refractory interdigital dermatophytoses should raise suspicion for the possibility of concomitant malignant neoplasms. Histopathological assessment is indispensable for definite diagnosis of acral interdigital lesions not responding to treatment.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"201 - 203"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70792522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and aging: an overview of COVID-19 effects on different dermatological topics","authors":"Lucia Brambilla, Umberto Cerino, Stefano Pasi","doi":"10.4103/jewd.jewd_20_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_20_23","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2, known to affect almost any organ and system in the body, triggering a powerful, but often dysregulated immune response that contributes to the creation (or worsening) of a chronic inflammatory state. Consequently, this impacts many biological processes including aging. Therefore, we performed an overview of the current literature on the consequences and manifestations of COVID-19 on nails, hair, and skin, but also on its sequelae on cognitive functions, on its effects on the diagnosis of skin cancers, and on molecular mechanisms of aging focusing primarily on telomeres length. We concluded that COVID-19 had a detrimental effect on the aging process and that these effects varied among different patient populations. COVID-19 seems to accelerate and exacerbate the occurrence of many dermatological disorders that are typical of the elderly. Moreover, it impacted the cognitive functions of patients and patients that reported cognitive dysfunctions months after the resolution of the infection.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"149 - 153"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70792773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of tissue level of interleukin-9 in psoriasis and vitiligo","authors":"Sara Mahmoud, Nesma Salem, O. Shaker, A. Fahim","doi":"10.4103/jewd.jewd_18_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_18_23","url":null,"abstract":"Background Psoriasis is a chronic, inflammatory, T-cell-mediated autoimmune disease. Vitiligo is an acquired depigmentary disease that occurs due to the loss of functional melanocytes from the epidermis. Interleukin (IL)-9 is a T cell-derived cytokine that was initially designated as a T helper2 cytokine. There is a link between the expression and action of IL-9 and pro-inflammatory cytokines tumor necrosis factor, IL-1, IL-17, and interferon-γ, suggesting that IL-9 is associated with the pathogenesis of autoimmune diseases. Objective To evaluate the tissue levels of IL-9 in patients with psoriasis and vitiligo in comparison with controls, to assess the possible role of IL-9 in the pathogenesis of these diseases. Patients and methods This case–control study included 30 patients with psoriasis, 30 patients with vitiligo, and 30 age-matched and sex-matched healthy controls. A skin biopsy was taken from all participants for evaluation of tissue IL-9 levels by enzyme-linked immunosorbent assay. Results Tissue IL-9 was significantly higher in patients with psoriasis (28.65±18.456) and patients with vitiligo (51.056±41.536) than controls (P=0.013 and P<0.001, respectively). In addition, it was significantly higher in patients with vitiligo than in patients with psoriasis (P=0.004). Conclusion This study suggests a possible role for IL-9 in the pathogenesis of psoriasis and vitiligo by documenting significantly higher tissue levels in patients than in controls.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"162 - 167"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70792422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryotherapy alone versus cryotherapy followed by intralesional vitamin D3 in treatment of anogenital warts: a randomized comparative clinical study","authors":"Mohamed Azab, Hesham A. Nada, Ahmed Mohamed Maamoon El Azab, H. Halim","doi":"10.4103/jewd.jewd_34_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_34_23","url":null,"abstract":"Background Anogenital warts (AGW) have an important impact on quality of life since they cause discomfort and shame. AGW cannot be effectively treated with a single technique. Objective To compare effectiveness and safety of intralesional vitamin D3 injection and cryotherapy in the treatment of AGW. Patients and methods A randomized comparative clinical study included patients with AGW attending to dermatology, Venerology and andrology clinics, Suez Canal University hospitals, Ismailia, Egypt. 36 patients were divided randomly into 2 groups, group A, included 18 patients who were treated with cryotherapy alone and group B that included 18 patients who were treated with cryotherapy then 0.25–1 ml of intralesional vitamin D3 injection in the same session. Results Complete response was obtained in 55.6% versus 94.4% of patients and clinical recurrence occurred in 27.9% versus 5.6% of patients in group A and B respectively (P<0.05). There was significant improvement in number and size of warts in group B more than group A (P<0.05). Conclusion The clinical response of combination of intralesional vitamin D3 as an immune therapy and cryotherapy as an ablative therapy for treatment of AGW is significantly higher than cryotherapy alone with lower recurrence rates and tolerable side effects.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"179 - 186"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70793292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crusted scabies in an elderly healthy male: a case report","authors":"Aamir Suhail, Panchatsharam Adithyan","doi":"10.4103/jewd.jewd_11_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_11_23","url":null,"abstract":"A 70-year-old man with no significant medical history presented with pruritic scaly rash all over body since 2 years. On examination, diffuse crusted plaques were seen over groin, hands, feet, genitals, and buttocks. Potassium hydroxide mount of skin scraping revealed plenty of mites. Diagnosis of crusted scabies was made. The patient and his contacts were treated with oral ivermectin, topical permethrin, and antihistamines.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"210 - 212"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70792053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA 155 in lichen planus","authors":"R. Doss, LailaA Rashed, Rehab Naguib","doi":"10.4103/jewd.jewd_15_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_15_23","url":null,"abstract":"","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"127 1","pages":"213 - 214"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70791898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}