Journal of the Brazilian Chemical Society最新文献_第2页

Design, Synthesis and Biological Activities of Novel meta-Diamide Compounds Containing 1,2,4-Oxadiazole Group 含1,2,4-恶二唑基团的新型间位二胺化合物的设计、合成及生物活性研究

4区化学

Journal of the Brazilian Chemical Society Pub Date : 2024-07-15 DOI: 10.21577/0103-5053.20240125

Peng‐Mian Huang, Yang Ting, Jiyong Liu, Juncheng Xiang, Minghui Wu

{"title":"Design, Synthesis and Biological Activities of Novel meta-Diamide Compounds Containing 1,2,4-Oxadiazole Group","authors":"Peng‐Mian Huang, Yang Ting, Jiyong Liu, Juncheng Xiang, Minghui Wu","doi":"10.21577/0103-5053.20240125","DOIUrl":"https://doi.org/10.21577/0103-5053.20240125","url":null,"abstract":"To discover new bisamide compounds with insecticidal and fungicidal activities, 19 novel cyproflanilide derivatives containing 1,2,4-oxadiazole group were designed and synthesized according to the principle of biologically active factor splicing. Preliminary biological assay data indicated that the majority of target compounds demonstrated significant insecticidal activity against Lepidopteran pests. Meanwhile, compounds 5p and 5q showed 97.22 and 100% lethality against Tetranychus cinnabarinus at 400 mg L-1, which were better than cyproflanilide (41.11% at 400 mg L-1). In addition, it is exciting that we have achieved our initial goals as some of the target compounds exhibited both insecticidal and fungicidal activities. For instance, compounds 5b and 5c showed 59.26 and 74.07% fungicidal activities against Cucumber downy mildew at 400 mg L-1, as well as 100% insecticidal activity against Plutella xylostella and armyworm at 100 mg L-1. Compound 5h showed 100% insecticidal activity against armyworm at 10 mg L-1, and also displayed 66.67% fungicidal activity against Cucumber downy mildew at 400 mg L-1. The inhibition rate of compounds 5l and 5s against Cucumber downy mildew reached 88.89 and 96.30% at 400 mg L-1. This work showed the effectively fungicidal application of 1,2,4-oxadiazole group in bisamide compounds and provides insights for optimal structural design.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction Model of Nicotine and Glycerol in Reconstituted Tobacco Leaves Based on Support Vector Machine Algorithm 基于支持向量机算法的烟叶烟碱和甘油含量预测模型

4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-11-01 DOI: 10.21577/0103-5053.20230174

Yang Qifu, Kun Ma, Ying Liang, Jiaquan Wu, Zhang Xinyu, Shuangyan Yang

引用次数: 2

Capillary Electromigration Techniques Applied to Clinical Chemistry Investigations and Alternative Diagnostic Assays: Possibilities and Perspectives 毛细管电迁移技术应用于临床化学调查和替代诊断分析:可能性和前景

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-23 DOI: 10.21577/0103-5053.20230096

Olívia Moreira, Bruna Berlande, Jéssica Cordeiro Queiroz de Souza, J. Candido, Lauren H. Jaeger, L. H. Adriano, Marco Antônio e Brito, Maria Patrícia do Nascimento, Patrícia Geraldo, P. Chellini, M. D. de Oliveira

{"title":"Capillary Electromigration Techniques Applied to Clinical Chemistry Investigations and Alternative Diagnostic Assays: Possibilities and Perspectives","authors":"Olívia Moreira, Bruna Berlande, Jéssica Cordeiro Queiroz de Souza, J. Candido, Lauren H. Jaeger, L. H. Adriano, Marco Antônio e Brito, Maria Patrícia do Nascimento, Patrícia Geraldo, P. Chellini, M. D. de Oliveira","doi":"10.21577/0103-5053.20230096","DOIUrl":"https://doi.org/10.21577/0103-5053.20230096","url":null,"abstract":"Capillary electromigration techniques can be understood as the ones used to separate neutral compounds, solvated ions and ionized species, considering the differentiated migration among them when an electrical field is applied within a capillary column filled with a background electrolyte. Several existing capillary electrophoresis setups provides the possibility of developing reliable quantitative assays of inorganic ions, organic acids, fatty acids, amino acids, carbohydrates, nucleic acids, proteins, hormones, vitamins, macromolecules, and more. Therefore, given the chemical complexity of bodily fluid matrices, capillary electrophoresis (CE) and its variations present themselves as an advantageous strategy for enhancing traditional clinical diagnostic methods and for the development of new ones. The recent advances in the study of the human metabolome associated with technological improvements towards medical applications make CE a very useful and versatile technique for clinical laboratory assays. Within this context, this review has the purpose of presenting some traditional methods used for exams of blood, urine, saliva, feces, and sweat, and how CE can be implemented as a real alternative to enable faster, automated, and cost-effective analysis with a comprehensive perspective that shall result in better diagnostic possibilities for patients, being a powerful tool for helping the physicians on the precision medicine achievements.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Residues of Pesticides in Tomato Processed Foods 番茄加工食品中农药残留分析

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-23 DOI: 10.21577/0103-5053.20230140

F. Costa, P. Maia, F. D. da Silva, C. Nobre, Renata Silva, M. Milhome

{"title":"Analysis of Residues of Pesticides in Tomato Processed Foods","authors":"F. Costa, P. Maia, F. D. da Silva, C. Nobre, Renata Silva, M. Milhome","doi":"10.21577/0103-5053.20230140","DOIUrl":"https://doi.org/10.21577/0103-5053.20230140","url":null,"abstract":"The tomato (Solanum lycopersicon L.) crop has great economic relevance, being one of the most processed agricultural products worldwide. Some pesticides are chemically stable and can remain in food even after processing. In this context, the objective of this work was to analyze food products derived from tomatoes (extract, sauce and ketchup), regarding the levels of pesticide residues. Fifteen samples were acquired from Vale do Jaguaribe, Ceará, Brazil. Six pesticides (bifenthrin, chlorothalonil, chlorpyrifos, cyfluthrin, pyriproxyfen, trifluralin) authorized by Agência Nacional de Vigilância Sanitária (Anvisa) for tomato cultivation were selected for the study. QuEChERS (quick, easy, cheap, effective, rugged, safe) extraction and gas chromatography coupled to mass spectrometry (GC-MS) were used in method validation, according to the recommendations of SANTE 11312/2021 guidelines. Statistical analyzes of linearity show that the six pesticides studied were classified as heterocesdastic. Limits of detection (LOD) and quantification (LOQ) values (0.01-0.03 and 0.03-0.10 mg kg-1, respectively) were below the established maximum residue limits (MRLs) for tomatoes. Accuracy and precision (78-121 and 2.3-16.7%, respectively) were satisfactory. The results indicated that among the 15 analyzed samples, one active ingredient was detected (0.05 mg kg-1) in a tomato sauce sample, lower than MRLs (Anvisa 0.15 mg kg-1 and FAO 0.3 mg kg-1). The results show the relevance of monitoring pesticide residues in tomato-derived products and the validation of new methodologies for food control.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"135 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68340748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pesticide Determination in Fresh Coconut Water (Cocos nucifera Linn.) by GC-MS Using Microwave-Assisted Liquid-Liquid Extraction 微波辅助液-液萃取-气相色谱-质谱法测定新鲜椰子汁中的农药

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-23 DOI: 10.21577/0103-5053.20230125

T. Nakamura, Enoc Lima do Rego, J. D. de Souza, Paulo Diniz, J. D. Da Silva

{"title":"Pesticide Determination in Fresh Coconut Water (Cocos nucifera Linn.) by GC-MS Using Microwave-Assisted Liquid-Liquid Extraction","authors":"T. Nakamura, Enoc Lima do Rego, J. D. de Souza, Paulo Diniz, J. D. Da Silva","doi":"10.21577/0103-5053.20230125","DOIUrl":"https://doi.org/10.21577/0103-5053.20230125","url":null,"abstract":"Fresh coconut (Cocos nucifera) water, a popular beverage in tropical countries, is often exposed to pesticide contamination due to agricultural practices. Thus, this work proposed the simultaneous determination of 36 pesticides in fresh coconut water samples using liquid-liquid extraction, drying assisted by a household microwave oven, and gas gas chromatography-mass spectrometry (GC-MS) analysis. Limits of detection varied from 5.4 (disulfoton) to 9.6 ng L-1 (parathion-methyl). Nine pesticides residues were detected (dimethoate, γ-HCH, β-HCH, 4,4’-dichlorodiphenyldichloroethylene, endosulfan II, 4,4’-dichlorodiphenyldichloroethane, 4,4’-dichlorodiphenyltrichloroethane, endrin ketone, and methoxychlor) with concentrations from < limit of quantification to 5,768.34 ± 1.64 ng L-1. Dimethoate was quantified in all samples, indicating its recent use. The proposed methodology offers several advantages, including the use of small sample volumes and solvent extraction, which eliminates the need for costly cartridges and reduces waste production. Additionally, the obtained results can be valuable for regulatory agencies, aiding in the mitigation of environmental damage and the protection of human health.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68340493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative GC-MS Analysis of Sawdust Bio-Oil 木屑生物油的GC-MS定量分析

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-23 DOI: 10.21577/0103-5053.20230060

A. D. dos Santos, Ana Nadja L. Lucas, Iuri D. P. da Mota, Jaderson Schneider, A. Polidoro, A. Pinho, F. Mendes, E. Caramão

{"title":"Quantitative GC-MS Analysis of Sawdust Bio-Oil","authors":"A. D. dos Santos, Ana Nadja L. Lucas, Iuri D. P. da Mota, Jaderson Schneider, A. Polidoro, A. Pinho, F. Mendes, E. Caramão","doi":"10.21577/0103-5053.20230060","DOIUrl":"https://doi.org/10.21577/0103-5053.20230060","url":null,"abstract":"Bio-oils from biomass pyrolysis have a highly promising potential as biofuels or sources of chemicals. The quantitative analysis of bio-oils is quite difficult and requires many standards. In this study, we developed a methodology using only 16 standards for determining the concentration of 49 compounds, representatives of the main chemical classes commons in bio-oils, using relative response factors (RRF) and analytical curves. Five Pinus sawdust bio-oils were analyzed using a GC-MS-DB-5 capillary column (60 m). SCAN mode (from 45 to 450 Daltons) and retention indices (LPTRI) were used for qualitative analysis. For quantitative analysis, SIM mode was preferred, and analytical curves were constructed from an initial solution at 400 mg g-1 of each of the 16 standards, with concentrations ranging from 1 to 150 mg g-1 added to the internal standard (methyl hexanoate) at 70 mg g-1. After the positive identification and quantification of 9 compounds (among the 16 standards used), the other compounds were quantified using the RRF obtained from a standard solution at 30 mg g-1, considering the similarities with those identified standards. 196 compounds were identified, while 49 compounds were quantified, highlighting the monoaromatic hydrocarbons, naphthalenes, benzofurans, alkyl phenols, and catechols.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68338432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Molecularly Imprinted Polymer for In-Tube SPME/UHPLC-MS/MS of Anandamide in Plasma Samples 一种新型分子印迹聚合物用于血浆样品中阿南达胺的管内SPME/UHPLC-MS/MS分析

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-23 DOI: 10.21577/0103-5053.20230074

M. Pinto, I. D. de Souza, L. F. Miranda, M. E. Queiroz

{"title":"A New Molecularly Imprinted Polymer for In-Tube SPME/UHPLC-MS/MS of Anandamide in Plasma Samples","authors":"M. Pinto, I. D. de Souza, L. F. Miranda, M. E. Queiroz","doi":"10.21577/0103-5053.20230074","DOIUrl":"https://doi.org/10.21577/0103-5053.20230074","url":null,"abstract":"Parkinson’s disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons. There is substantial evidence that the endocannabinoid system modulates the dopaminergic activity in the basal ganglia, a forebrain system that integrates cortical information to coordinate motor activity regulating signals. In this article, a fused-silica capillary with a molecularly imprinted polymer was developed for in-tube solid-phase microextraction of the endocannabinoid anandamide in plasma samples from Parkinson’s disease patients and further analysis by ultra-high-performance liquid chromatography with tandem mass spectrometry. The molecularly imprinted polymer capillary presented recognition sites with complementary shape, size, and functionality to anandamide. Scanning electron micrographs and Fouriertransform infrared spectra illustrated the physical and chemical modification of the printed and non-printed capillary surface. The in-tube solid-phase microextraction ultra-high-performance liquid chromatography with tandem mass spectrometry method presented a linear range from 0.1 to 20 ng mL-1, precision with coefficient of variation values ranging from 1.2 to 13%, and relative standard deviation accuracy ranging from -3.6 to 7.5%. The method developed herein can adequately determine anandamide in plasma samples from Parkinson’s disease patients. By applying the standard addition approach, the anandamide plasmatic concentration in these samples was found to range from 0.2 to 0.4 ng mL-1.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"111 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68338863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversed-Phase Liquid Chromatography Methods Based on C18 Polymer Monoliths for the Determination of Urinary Myoglobin 基于 C18 聚合物单片的反相液相色谱法测定尿肌红蛋白

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-23 DOI: 10.21577/0103-5053.20230084

R. Vitek, Fernando H. do Nascimento, J. Masini

{"title":"Reversed-Phase Liquid Chromatography Methods Based on C18 Polymer Monoliths for the Determination of Urinary Myoglobin","authors":"R. Vitek, Fernando H. do Nascimento, J. Masini","doi":"10.21577/0103-5053.20230084","DOIUrl":"https://doi.org/10.21577/0103-5053.20230084","url":null,"abstract":"This study describes reversed-phase liquid chromatography (RPLC) methods to quantify urinary myoglobin using polymer monolithic columns produced by copolymerization of stearyl methacrylate (SMA) and ethylene glycol dimethacrylate (EDMA). The columns were prepared in the coffins of 1.5 mm internal diameter (i.d.) ethylene tetrafluoroethylene (ETFE) tubing for use in sequential injection chromatography (SIC) and solid phase extraction (SPE), and inside 1.0 mm i.d. Silcosteel ® tube for use in narrow-bore liquid chromatography. The monoliths inside the ETFE were produced via UV, whereas thermal polymerization formed the monoliths inside the Silcosteel ® tube. The separation of carbonic anhydrase, lysozyme, and myoglobin was demonstrated because they may occur simultaneously in urine samples. Quantification was undertaken by external calibration, and the accuracy was evaluated by the spiking/recovery strategy. The methods exhibited linearity from 5.0 to 60 µ g mL -1 (SIC), 2.5 to 50 µ g mL -1 (high-performance liquid chromatography (HPLC)), and 1.0 to 7.5 µ g mL -1 for an SPE-HPLC method. The lowest limits of detection and quantification were 0.13 and 0.43 µg L -1 , respectively, obtained after concentrating myoglobin by SPE. Recoveries ranged from 98 to 105%. The low cost, simplicity, reusability, and analytical features provided by these polymeric stationary phases make them affordable alternatives to routine analyses of urinary myoglobin.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"30 1","pages":"1601 - 1610"},"PeriodicalIF":1.4,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UPLC-QTOF-MSE-Based Metabolic Profile to Screening Candidates of Biomarkers of Dwarf-Cashew Clones Resistant and Susceptible to Anthracnose (Colletotrichum gloeosporioides (Penz) Penz. & Sacc.) 基于uplc - qtof - mse的矮秆腰果无性系抗、感炭疽病生物标志物筛选& Sacc。)

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-23 DOI: 10.21577/0103-5053.20230097

P. Alves, Jhonyson Guedes, L. Serrano, M. Martins, Debora Bezerra de Sousa, G. Silva, Paulo Ribeiro, D. Zampieri, G. Zocolo

{"title":"UPLC-QTOF-MSE-Based Metabolic Profile to Screening Candidates of Biomarkers of Dwarf-Cashew Clones Resistant and Susceptible to Anthracnose (Colletotrichum gloeosporioides (Penz) Penz. & Sacc.)","authors":"P. Alves, Jhonyson Guedes, L. Serrano, M. Martins, Debora Bezerra de Sousa, G. Silva, Paulo Ribeiro, D. Zampieri, G. Zocolo","doi":"10.21577/0103-5053.20230097","DOIUrl":"https://doi.org/10.21577/0103-5053.20230097","url":null,"abstract":"Investigating specialized plant metabolites, traditionally referred to as ‘secondary metabolites’ present in leaf extracts of cashew trees (Anacardium occidentale) resistant and susceptible to anthracnose disease was carried out using metabolomics combined with chemometric tools. We used clones of dwarf-cashew with the following variations of characteristics: resistant and healthy (CCP 76, BRS 226, BRS 189), susceptible and healthy (BRS 265), and another clone also susceptible but affected by the disease (BRS 265). The UPLC-QTOF-MSE (ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry) analysis of the leaves of Anacardium clones allowed us annotation a total of 39 metabolites. The multiple orthogonal partial discriminant analysis of the least-squares (OPLS-DA) allowed twelve metabolites to be potential biomarkers of differentiation among the clones studied. Namely, the triene-(17:3)-anacardic acid found on CCP 76 and BRS 189 clones, respectively, is the main candidate for biomarker of resistance. While catechin, B-type procyanidin isomers, and procyanidin dimer monogallate identified in BRS 265 are significant potential biomarkers of susceptibility.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Versatility of Two-Dimensional Liquid Chromatography 二维液相色谱的多功能性

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-23 DOI: 10.21577/0103-5053.20230118

Carmen Cardoso, M. D. de Moraes, Q. Cass

引用次数: 1