{"title":"Pearl Sign: Enhanced Visualization of Molluscum Contagiosum Henderson-Patterson Bodies Under UV Dermoscopy.","authors":"Ece Gokyayla","doi":"10.1016/j.jaad.2025.07.015","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.015","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Genevieve Ho, Joanna Ludzik, Cristian Navarrete-Dechent, Christian Gronbeck, Virginia Velasco-Temariz, Manu Jain, Bruna Gallo, Peter Friedman, Melissa Gill, Andrea L Smith, Salvador Gonzalez, Jane M Grant-Kels, Linda K Martin, Pascale Guitera
{"title":"Testing the international expert recommendations on image capture for reflectance/cutaneous confocal microscopy: an international mixed methods study.","authors":"Genevieve Ho, Joanna Ludzik, Cristian Navarrete-Dechent, Christian Gronbeck, Virginia Velasco-Temariz, Manu Jain, Bruna Gallo, Peter Friedman, Melissa Gill, Andrea L Smith, Salvador Gonzalez, Jane M Grant-Kels, Linda K Martin, Pascale Guitera","doi":"10.1016/j.jaad.2025.07.019","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.019","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Ribeiro Vaz de Faria, Maria Cecília da Matta Rivitti Machado, Neusa Yuriko Sakai Valente, Julia Diva Zavariz, Isabella Doche
{"title":"Forehead atrophy in frontal fibrosing alopecia: an ultrasonographic and histopathological study of 10 patients.","authors":"Julia Ribeiro Vaz de Faria, Maria Cecília da Matta Rivitti Machado, Neusa Yuriko Sakai Valente, Julia Diva Zavariz, Isabella Doche","doi":"10.1016/j.jaad.2025.07.011","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.011","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and validation of prognostic models using novel inflammatory markers for drug reactions with eosinophilia and systemic symptoms: An international multicenter cohort study.","authors":"Tyng-Shiuan Hsieh, Haur Yueh Lee, Riichiro Abe, Shingo Takei, Ryota Hayashi, Natsumi Hama, Yung-Tsu Cho, Po-Wei Huang, Chia-Yu Chu","doi":"10.1016/j.jaad.2025.06.051","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.06.051","url":null,"abstract":"<p><strong>Background: </strong>Drug reaction with eosinophilia and systemic symptoms (DRESS) is a life-threatening disease that has received little attention focusing on its prognostic markers.</p><p><strong>Objective: </strong>We evaluated the association between novel inflammatory markers and in-hospital mortality. We also proposed and validated a risk stratification model to aid early intervention.</p><p><strong>Methods: </strong>This international multicenter, retrospective cohort study included 169 patients diagnosed with DRESS from Taiwan, Singapore, and Japan, collecting demographics and laboratory markers within 3 days of diagnosing DRESS. Inflammatory markers were calculated, and statistical analyses, including logistic regression and receiver operating characteristic curve analysis. Predictive models were developed with internal validation using leave-one-out cross-validation.</p><p><strong>Results: </strong>Lower hemoglobin-to-red blood cell distribution width ratio, higher platelet-to-lymphocyte ratio, and lower monocyte count are identified as significant predictors of mortality in a multivariate analysis. A predictive model for DRESS-related mortality, incorporating the significant inflammatory markers and underlying disease (malignancy, autoimmune disease, and cardiovascular disease), demonstrated good discrimination ability and acceptable accuracy.</p><p><strong>Limitation: </strong>The retrospective design, along with factors like interhospital transfers, and underlying malignancies are limitations.</p><p><strong>Conclusion: </strong>The presence of these novel inflammatory markers and the development of risk stratification model may be of value to stratification of the severity of DRESS.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yvonne Deng, Sunil Kalia, Jeffrey Toy, Chaocheng Liu, Laura Payant, Richard Liu, Kimberly Montague, Gary Garber, Tashmeeta Ahad
{"title":"Medico-legal Risks associated with Laser Therapy: A Cross-sectional Descriptive Analysis of Closed Cases over a 10-year Period in Canada.","authors":"Yvonne Deng, Sunil Kalia, Jeffrey Toy, Chaocheng Liu, Laura Payant, Richard Liu, Kimberly Montague, Gary Garber, Tashmeeta Ahad","doi":"10.1016/j.jaad.2025.07.020","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.020","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ching-Ting Ting, Brian Shiian Chen, James Cheng-Chung Wei
{"title":"Commentary on \"Hormone Therapy and Increased Risk of Psoriasis in Women\".","authors":"Ching-Ting Ting, Brian Shiian Chen, James Cheng-Chung Wei","doi":"10.1016/j.jaad.2025.07.016","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.016","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jundong Huang, Jia Jian, Min Li, Ruxin Ji, Tian Tian, Xiaobing Liang, Zhixiang Zhao, Yan Tang, Fangfen Liu, Ji Li, Wei Shi
{"title":"Real-world efficacy of ritlecitinib in treating alopecia areata across various anatomical sites: Potential rapid response predictors.","authors":"Jundong Huang, Jia Jian, Min Li, Ruxin Ji, Tian Tian, Xiaobing Liang, Zhixiang Zhao, Yan Tang, Fangfen Liu, Ji Li, Wei Shi","doi":"10.1016/j.jaad.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.008","url":null,"abstract":"<p><strong>Background: </strong>Effectiveness of ritlecitinib for alopecia areata (AA) is unknown in real-world practice.</p><p><strong>Objective: </strong>This real-world study aimed to evaluate the effectiveness and safety of ritlecitinib in a heterogeneous cohort of AA patients and identify response in scalp as well as lashes, brows and nails, and clinical predictors of early treatment response.</p><p><strong>Methods: </strong>We conducted a single-center retrospective cohort study of consecutive patients receiving ritlecitinib 50 mg daily for ≥12 weeks. Disease severity was assessed at baseline and weeks 4, 8, 12, 24, and 36. Treatment-emergent adverse events (AEs) were systematically recorded. Multivariate logistic regression models assessed the link between treatment response and clinical predictors.</p><p><strong>Results: </strong>The cohort comprised 89 patients (mean age 25.6 ± 13.9 years; 69.7% female). Efficacy outcomes demonstrated temporal progression. The therapeutic efficacy observed in eyelashes, eyebrows, and nails paralleled that of the scalp. Multivariate analysis identified prior JAK inhibitor exposure as an independent predictor of reduced early response. Ritlecitinib demonstrated a favorable safety profile, with no serious AEs reported throughout the study period.</p><p><strong>Limitations: </strong>Single-center and Chinese-limited cohort.</p><p><strong>Conclusion: </strong>Prior JAK inhibitor exposure as a significant factor influencing early treatment response. Responses of lashes, brows and nails were similar to scalp.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leila Shayegan, Arjun Mahajan, Yoo Jung Kim, Katharina Shaw, Kimberly Hashemi, David Fiorentino, Ellen Anshelevich, Lorena Acevedo Fontanez, Rochelle Castillo, Neda Shahriari, Ruth Ann Vleugels
{"title":"Risk of Head and Neck Cancer in Dermatomyositis: Findings from a Retrospective U.S.-based Cohort Study.","authors":"Leila Shayegan, Arjun Mahajan, Yoo Jung Kim, Katharina Shaw, Kimberly Hashemi, David Fiorentino, Ellen Anshelevich, Lorena Acevedo Fontanez, Rochelle Castillo, Neda Shahriari, Ruth Ann Vleugels","doi":"10.1016/j.jaad.2025.07.022","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.022","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui Sun MD PhD, Wei Shen MD, Yue-Hua Yao BSN, Ying-Ming Ma MD, Hui-Qiong Nie MD, Hua-Jie Zhong MD
{"title":"New Strategy for Liquid Nitrogen Treatment: Dual Cotton Swab Combined Cryotherapy","authors":"Hui Sun MD PhD, Wei Shen MD, Yue-Hua Yao BSN, Ying-Ming Ma MD, Hui-Qiong Nie MD, Hua-Jie Zhong MD","doi":"10.1016/j.jaad.2025.07.012","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.012","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":"1 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew Blauvelt, Petr Arenberger, Maxwell B. Sauder, Megan Couvillion, Roman G. Rubio, Nicholas E. Vlahakis, Sibel Ucpinar, Grace Ma, Elena Hitraya, Mera K. Tilley, Kim A. Papp, STRIDE investigators
{"title":"Highly selective, allosteric inhibition of TYK2 with oral ESK-001 in patients with moderate-to-severe plaque psoriasis: Results from STRIDE, a 12-week, randomized, double-blinded, placebo-controlled, dose-ranging Phase 2 study","authors":"Andrew Blauvelt, Petr Arenberger, Maxwell B. Sauder, Megan Couvillion, Roman G. Rubio, Nicholas E. Vlahakis, Sibel Ucpinar, Grace Ma, Elena Hitraya, Mera K. Tilley, Kim A. Papp, STRIDE investigators","doi":"10.1016/j.jaad.2025.07.013","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.013","url":null,"abstract":"ESK-001, a novel allosteric, highly selective oral TYK2 inhibitor in development for treatment of immune-mediated disorders, was well-tolerated, and achieved high levels of target inhibition in Phase 1 studies with healthy volunteers.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":"19 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}