International Research Journal of Medicine and Medical Sciences最新文献

{"title":"Deoxypyridinoline bone height after oral implant surgery in menopause women","authors":"Beatriz Cepeda De Romero, Carrera ª Bogotá D.C. Colombia, Diana Carolina Cañon Guarnizo, L. Herrera, Sofìa Cepeda Tarazona, Maria Alexandra Polo Pacheco, Cra Bogotá D.C. Colombia, Calle D Apto Bogotá D.C. Colombia","doi":"10.30918/IRJMMS.72.19.030","DOIUrl":"https://doi.org/10.30918/IRJMMS.72.19.030","url":null,"abstract":"The ratio Deoxypyridinoline / Creatinine measured in urine (DPD/Cr) is the most sensitive and specific marker of early metabolic breakdown of collagen I, and therefore, of osteopenia and bone resorption. The normal values change with age and gender; in male adults the normal range is 2.3 to 5.4 nmol/mmol and in women is 3.0 to 7.4 nmol/mmol. It has been shown that osteopenia can lead to osteoporosis and to failure of implant osseointegration. The objective of this study was to associate levels of DPD/Cr in urine with bone height measured by tomography before surgery and three months after oral implant surgery in menopausal women. 20 healthy or systemically controlled postmenopausal women who underwent surgery implants, were selected by convenience for the study. All implants were: Titanium SIS® Implants (CIEO Foundation, Colombia) customized according to the patient requirements indicated in the CBCT. The implant length varied in the range 5 to 15 mm, internal diameter: 3 to 5 mm, internal hexagon: 2.4 mm, and screw: 1.85 × 0.35 mm. DPD values in urine were measured by a Chemical Luminescence Immune test and bone height in mm was measured in a tomography on implant zone before the surgery and 3 months after implant surgery. The average age of the patients was 61.2 ± 17.31 years and the number of implants 1-4/patient. The ratio DPD/ Cr showed a high average of 9.594 ± 0.475 nmol/mmol. Average pre-surgery bone height was 15.23 ± 1.41 mm and post-surgery decreased to 13.78 ± 1.16 mm. This difference was significant (t paired, p = 0.001). The Pearson correlation test showed a high association (p = 1) between the elevation of DPD/Cr and the decrease in bone height. There is a significant association between the change in concentrations of urinary creatinine-corrected deoxypyridinoline and bone resorption in menopausal women, three months after oral implant surgery.","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127113673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level of patient’s satisfaction in gynaecological practice at a south west Nigerian specialist hospital","authors":"R. Omotayo, O. Akadiri, A. Akintan, S. Omotayo","doi":"10.30918/IRJMMS.72.19.033","DOIUrl":"https://doi.org/10.30918/IRJMMS.72.19.033","url":null,"abstract":"The health sector occupies an enormously important position in ensuring sustainable overall socio-economic advancement in developing countries. Healthy people make a healthy nation and also contribute to economic growth. Satisfaction is the contentment one feels when one has fulfilled a desire, need, or expectation. Poor quality is costly to clients, to programmes and to the society overall. People's perception about quality of care often determines whether they seek and continue to use services. This study evaluated the level of patient’s satisfaction in gynaecological practice at the state specialist hospital Akure. This study is a descriptive cross-sectional study. Questionnaires of the Likert-like form was used to obtain information from consenting patients on various factors that determines or have effect on their level of satisfaction while accessing gynaecological care services at the gynaecology clinic of State Specialist Hospital, Akure. Systematic sampling method was used to recruit patients by selecting every second patient serially as they present. Three hundred and eight consenting gynaecological patients were recruited into the study. Data was analysed with the Statistical Package for Social sciences (SPSS) 20.0. Majority of the respondents 295 (95.7%) were satisfied with the morning time clinic schedule. More percentage of respondents were very satisfied with attending doctor being male (52.9%) than if the attending doctor was female (26.3%). Most patients (53.3%) were not satisfied with having to go outside the hospital to get some of their investigations done. Most patients (44.6%) were not satisfied with the level of availability of drugs in the hospital as they still go out to buy drugs. Vast majority of the respondents (89.2%) were either satisfied or very satisfied with the behavior and competence of the attending doctors and nurses. In conclusion, client's satisfaction is reflected by their happy expression about the care they receive, where and how they access the care. There is need for health care givers to continue and improve on aspects of care that gives patients satisfaction and discourage those that make the patients dissatisfied.","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126714565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxicity analysis of etoposide and cisplatin on cell lines from human lung cancer and normal human lung","authors":"G. Davou, Nj Chuwang, U. Essien, T. Choji, B. Echeonwu, M. Lugos","doi":"10.30918/IRJMMS.72.19.022","DOIUrl":"https://doi.org/10.30918/IRJMMS.72.19.022","url":null,"abstract":"Lung cancer is the leading cause of cancer-related deaths in the world with non-small cell lung cancer (NSCLC) making up a large majority of all cases. Despite advancement and discoveries in cancer therapy, treatment of this disease has been less successful due to serious side effects and drug resistance. Therefore, there is a need to research into new therapeutic approaches for this disease. This study, therefore, evaluated the effect of two common cytotoxic lung cancer drugs, the etoposide and cisplatin on two lung cell lines, A549 (lung cancer cell line) and BEAS-2B (normal lung virus-transformed cell line). Our study was aimed at testing the response of normal lung and lung cancer cells to different concentrations of etoposide and cisplatin over a period of time in order to determine the cytotoxic effect of these drugs. The cells were grown in culture plates and MTT assays were performed on both cell lines in order to determine each cell line’s IC50 in response to various concentrations of cisplatin and etoposide over a maximum period of 72 hrs. Our results showed a cytotoxic effect on both cell lines. Unexpectedly, higher drug toxicity was observed on BEAS-2B compared to A549 cell lines. Consequently, this data highlights the necessity for further search of a more selective and effective drug that has minimal toxicity on the normal cells for effective treatment of NSCLC and lung cancer in general.","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128675399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effect of aerobic dance exercise on blood pressure of normotensive pregnant Nigerian women","authors":"J. A. Daniel, E. I. Nwaogu, S. Okoli, E. Nzeribe","doi":"10.30918/IRJMMS.71.19.013","DOIUrl":"https://doi.org/10.30918/IRJMMS.71.19.013","url":null,"abstract":"","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"263 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116063234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception and practice of Ramadan fasting among patients with type I diabetes mellitus in the view of the practical guidelines","authors":"Inass Taha, I. Sultan, A. Al-Harby, Randa Alharizi, Lama Ghandoura","doi":"10.30918/IRJMMS.71.18.070","DOIUrl":"https://doi.org/10.30918/IRJMMS.71.18.070","url":null,"abstract":"Many type 1 diabetes patients (T1DM) choose to fast during Ramadan despite having an increased risk according to guidelines. Their fasting perception and practice need to be explored. The objective of this study is to examine the fasting perception and practice among T1DM patients in relation to their risk categories, metabolic conditions and in the view of practical guidelines. This cross sectional study included 113 adolescent and young Saudis with T1DM on basal bolus regimen from the diabetic center in Madinah. Data on fasting perception and practice were collected from patients 2 weeks after the end of Ramadan 2017 together with reviewing medical records. Risk categorization was performed according to Diabetes and Ramadan (DAR) 2016. The very high risk group included 78.8%. Fasting was safe by 85.5%, obligatory by 67.8%, exempted by 2.5%, and not indicated for pregnant by 6.8%. Compensation for non-fasting days was obligatory by 81.4% with 16.8% used to fast extra days outside Ramadan. Among the 113 patients, 86.7% experienced fasting (70.8% full fasters) with no significant difference in risk categories. Some patients followed the recommendations during fasting (proper meals in 26.5% at sunset , 73.5% at pre-dawn, 72.4% decreased activity, 60.1% increased fluid intake, 75.5% had inverted sleep pattern, 37.8% decreased insulin doses, 75.5% performed regular SMBG and 5.1% had professional supervision). Severe complications were 5.1% DKA and 1% severe hypoglycemia. Significant predictors for non-fasting were adolescence (p=0.036), recurrent hypoglycemia (p=0.013), harm perception (p=0.006), non-compensation (p=0.000) and comorbidities (p=0.039). In conclusion, most T1DM patients chose to fast during Ramadan without adequate support or following strict guidelines. Most of them do not experience any adversities and if they break fasting (mostly due to hypoglycemia), they are able to compensate later. Adolescent patients with harm perception, recurrent hypoglycemia, and no tendency to compensate for non-fasting showed less positive attitude towards fasting. More specific guidelines, education, and professional supervision are needed for these patients during Ramadan.","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131932070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative medicine review","authors":"C. M. Pérez-Alvarado, Col. Industrial-Animas Xalapa Ver. C.P. Mexico n, E. Vargas‐Madrazo, E. Montes-Villaseñor, A. Valdez-Betanzos, G. E. Aranda, M. Hernández-Aguilar","doi":"10.30918/IRJMMS.64.18.062","DOIUrl":"https://doi.org/10.30918/IRJMMS.64.18.062","url":null,"abstract":"Integrative Medicine is a growing branch of medicine which integrates the best aspects of conventional (allopathic) and complementary and alternative medicines. This kind of medicine recognizes that the mechanistic, fragmentary and linear view of science, i.e. reductionism, has many limitations, particularly in biological and medical sciences. Moreover, Integrative Medicine provides a particular care to each patient, orienting its practices towards healing and emphasizing the therapeutic relationship. Its principles harmonize with the proposals of Systemic Biology which acknowledges the complexity, integrality and holistic nature of living beings. Based on the aforementioned postulates integrate our Five-Spheres Model for patient care.","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131849732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional ventricular tachycardia in rheumatic fever reactivation","authors":"Mohammad Iqbal, Andy Sukmadja, Rosa Syafitri, G. Karwiky, C. Achmad","doi":"10.30918/IRJMMS.64.18.059","DOIUrl":"https://doi.org/10.30918/IRJMMS.64.18.059","url":null,"abstract":"Bidirectional ventricular tachycardia (VT) is a rare rhythm disorder, usually described in digitalis intoxication, fulminant myocarditis, familial catecholaminergic polymorphic VT, familial hypokalemic periodic paralysis, and aconitine poisoning. This case describes a young male with rheumatic fever reactivation (RFR) with manifestation of myocarditis and bidirectional ventricular tachycardia (BVT). A myocarditis with BVT in RFR had not been reported before.","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"453 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116763707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of body mass index on quantitative ultrasound measurements of bone mineral density in Saudi women","authors":"Tahani O. Alkahtani, H. Almohammad, H. Hawesa, Arwa H. Alhulwah, Hind Qasem","doi":"10.30918/IRJMMS.64.18.060","DOIUrl":"https://doi.org/10.30918/IRJMMS.64.18.060","url":null,"abstract":"Osteoporosis is a bone density associated disease that causes fading of the bone structure and function, which thereby makes the bone fragile. This fragile bone can be easily fractured as a result of mechanical forces, or events that would otherwise not cause a fracture if the bones were healthy. Most previous studies have been conducted on postmenopausal females. The few studies that have been conducted on a Saudi population have primarily focused on risk factors for osteoporosis in women > 60 years of age or who are postmenopausal. This study aimed to evaluate younger, premenopausal Saudi females, <59 years old to investigate the impact of body mass index (BMI) on bone mineral density (BMD) using a quantitative ultrasound (QUS) machine. Cross-sectional observational study of 100 Saudi women aged 19 to 58 years. Body mass index (BMI) was calculated from each participant’s weight in kilograms divided by the square of her height in meters (kg/m). The DMS PEGASUS SMART Bone Densitometer, Mauguio, France, was used for portable quantitative ultrasound (QUS) with a Caucasian ethnicity setting and measurement of the right calcaneus bone. The mean age of the participants was 29.62 year (SD ± 10.25), range (19 to 58 years). A total of 5% exhibited evidence of osteoporosis and 64% had normal broadband ultrasound attenuation (BUA). The average BMI was 24.7268 kg/m2 and average SOS was 1,390.28 m/s. Spearman’s rho showed weak negative correlation between BMI and SOS (p = 0.001≤ 0.05 and r = -.331) and fairly positive correlation between BUA and SOS (p = .000 ≤ 0.05 and r = .463). Furthermore, none of the participants in the low and normal BMI category showed evidence of osteoporosis. A total of 6.9% of the participants in the overweight BMI category showed evidence of osteoporosis, and 17.6% of those in the obese BMI category had evidence of osteoporosis. In conclusion, low and high BMI were positively correlated with low BMD regardless of age. A BMD screening test using QUS should be considered as primary screening for BMD in preand postmenopausal females with low or high BMI, to prevent future development of osteoporosis. QUS should be used for primary screening because it is, portable, fast, efficient, user friendly, widely available and uses non-ionizing radiation.","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132442549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and management of fingertip amputations in a teaching hospital, South-South, Nigeria","authors":"M. Ozinko, O. Otei, R. Ekpo, G. Bassey","doi":"10.30918/IRJMMS.64.18.047","DOIUrl":"https://doi.org/10.30918/IRJMMS.64.18.047","url":null,"abstract":"Injuries to the fingertip are common in our Accident and Emergency Department. The goal of treatment is restoration of a painless, functional digit with protective sensation. In other words, it involves the provision of sensate and durable fingertip and bone support for nail growth. When selecting a treatment option the amount of soft-tissue loss, the integrity of the nail bed, the age and physical demands of the patient should be considered. The study seeks to evaluate the mechanisms and management of fingertip amputations including the treatment modalities used and its impact on patient outcomes. This is a prospective study of 37 patients with 43 cases of fingertip amputations. Patient ages ranged from 5 to 56 years. Data was collected from January, 2016 to December, 2017. Various reconstructive options were considered for the fingertip amputations such as skin grafting, cross finger flap, thenar flap, hypothenar flap, louvers flap and groin flap in multiple digital injuries. The total duration of treatment varied from two to seven weeks with follow-up of two to eight months. The results showed preservation of finger length and contour, retention of sensation and healing minimal complication. About 40% of the patients had well formed fingertip pulps which were aesthetically acceptable. In conclusion, fingertip amputation is a common injury. Treatment depends on how much skin, soft tissue, bone and nail were damaged and how much of the finger or thumb was cut off. A good knowledge of the mechanism of injury, type of injury, occupation of patient and hand dominance would help in deciding the surgical technique to use. A satisfactory reconstruction is ascertained if the patient has durable, sensate, fingertip length preservation and a fairly formed pulp.","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115154844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syed M. Hasnain, Alanoud A. AlQassim, Halima A. Alsini, Abdulrahman S. Al-Frayh, Futwan A. Almohanna, Mohamed M. Shoukri and Sultan T. Al-Sedairy","authors":"S. Hasnain, A. AlQassim, H. Alsini, A. Al-frayh, F. Al-Mohanna, M. Shoukri, S. Al-Sedairy","doi":"10.30918/irjmms.64.18.058","DOIUrl":"https://doi.org/10.30918/irjmms.64.18.058","url":null,"abstract":"","PeriodicalId":170316,"journal":{"name":"International Research Journal of Medicine and Medical Sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122342162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}