Journal of Research in Applied and Basic Medical Sciences最新文献

{"title":"Assessment of immune response in ICU admitted SARS-CoV-2 patients from Kashmir, North India","authors":"Iqra Farooq, Rafiqa Eachkoti, Saleem Hussain, Inaamul Haq, Masood Tanvir, Shajrul Amin, Sanah Farooq, Sadaf Saleem, Sabhiya Majid","doi":"10.61186/rabms.11.1.1","DOIUrl":"https://doi.org/10.61186/rabms.11.1.1","url":null,"abstract":"Background & Aims:The present study aimed to investigate the lymphocyte subpopulation counts (Th, Tc, B-cell, and NK cell) in SARS-CoV-2 patients (admitted to the ICU) to gain greater insight into the dysregulated immune response found in COVID-19. Materials & Methods:A total of 30 SARS-CoV-2 patients recruited in the intensive care unit (ICU) of Chest Disease (CD) and DRDO hospitals in Srinagar were investigated for lymphocyte subpopulation counts (T cell, B cell, and NK cell) by FACS analysis of blood samples (using the Beckman Coulter (Navios) and FACS Diva software).Results: Correlation analysis of lymphocyte subpopulation counts revealed, in comparison to normal healthy controls, an overall decreased mean T cell subset count, i.e., T-helper (CD3+, CD4+) (1422.5 cell/ul vs 662.4 cell/ul); T-cytotoxic (CD3+CD8+) (973.7 cell/ul Vs 629.2 cell/ul) and B cell count (CD45+CD19+) (442.1 cell/ul Vs. 144.4 cell/ul) with CD4+/CD8+ ratio (1.4 Vs. 1) in SARS-CoV-2 patients.On comparison, Stage 3 Vs Stage 2 patients, the mean T cytotoxic lymphocyte count i.e.CD3+CD8+, was lower (518.9cells/ul Vs. 849.9 cell/ul) and the T-helper cell count, i.e.CD3+CD4+, was higher (764.9cell/ul Vs. 457.3 cell/ul) with CD4+/CD8+ = 1.4 Vs. 0.5.Furthermore, the antibody immune response reflected by B-cell count was lower (i.e., CD19+131.9cell/ul) in Stage 3 patients compared to Stage 2 patients (i.e., CD19+=162.9cell/ul).ROC analysis with disease outcome revealed raised CD3+CD4+ count (T-helper cell response: AUC = 0.70) and decreased CD19+ count (humoral immune response: AUC = 0.80) and increased NLR (AUC = 0.65) as predictors of poor disease outcome. Conclusion: In conclusion, the study identified increased NLR, T-cell activation (increased T-helper cells), T-cytotoxic exhaustion(decreased T cytotoxic cells), and decreased humoral immune response (decreased CD19+ B cells) as predictive markers of severity and poor disease outcome in ICU-admitted patients with SARS-CoV-2.","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"11 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://ijrabms.umsu.ac.ir/files/site1/user_files_683166/rafiqa-A-10-402-1-ebd02fd.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147907763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effect of eight weeks of moderate-intensity aerobic exercise and taking curcumin supplement alone and in combination, on leptin levels and hepatic enzymes in older rats","authors":"Minoo Shirpoor, A. Tofighi, Alireza Shirpoor, L. Chodari, M. Pourjabali","doi":"10.61186/rabms.9.4.263","DOIUrl":"https://doi.org/10.61186/rabms.9.4.263","url":null,"abstract":"","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139328273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ethanolic fruit extract of solanum aethiopicum (L.) on saccharin induced hyperlipidemia and sperm abnormalities in male wistar rats","authors":"Mishael Atukpa, Aruchi Wekhe, Al-amin Idris, Richard Recab","doi":"10.61186/rabms.9.4.215","DOIUrl":"https://doi.org/10.61186/rabms.9.4.215","url":null,"abstract":"","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139331471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of fetal autopsy and its importance in intrauterine fetal death: Histopathological diagnosis","authors":"Rasheed Fatima, Shilpa Karamchedu, Haricharan B.V, Tejeswari Jana, Suresh K, F. K","doi":"10.61186/rabms.9.4.233","DOIUrl":"https://doi.org/10.61186/rabms.9.4.233","url":null,"abstract":"","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"67 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139326616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of cytomegalovirus infection in the patients with chronic lymphocytic leukemia","authors":"Z. Rostamzadeh khameneh, Nasim Valizadeh, Mohaddeseh Nemati, A. Eishi","doi":"10.61186/rabms.9.4.223","DOIUrl":"https://doi.org/10.61186/rabms.9.4.223","url":null,"abstract":"","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139327411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of histomorphological spectrum of leprosy and its correlation with bacteriological index at a tertiary care center","authors":"Bhagyesh Shah, Nisha Chavda, Khyati Padhiyar, Yogita Kareliya, Roopam Gidwani","doi":"10.61186/rabms.9.4.280","DOIUrl":"https://doi.org/10.61186/rabms.9.4.280","url":null,"abstract":"","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139328332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An observational study on effect of breathing exercise on quality of recovery among postoperative patients","authors":"Anuradha Chaudhary, Samir Shukla, Devanand Sairker, Mohit Sharma, Siddharth Singh, Nitin Patta, Mayank Kandpal, M. L. Soni","doi":"10.61186/rabms.9.4.254","DOIUrl":"https://doi.org/10.61186/rabms.9.4.254","url":null,"abstract":"","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Patient with Brucella with initial Manifestations similar to Crimean Congo Fever","authors":"Mohammad Amin Abbasi, E. Rikhtegar, Shahin Keshtkar Rajabi","doi":"10.61186/rabms.9.4.229","DOIUrl":"https://doi.org/10.61186/rabms.9.4.229","url":null,"abstract":"","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of Serum Liver Enzymes in the Patients with Type 2 Diabetes Mellitus","authors":"Manila Makaju, Pritika Luitel, Rupa Nepal, S. Kunwar, Ram Krishna Shrestha, Govinda Akela, Suresh Jaiswal, Rajesh Kumar Thakur","doi":"10.61186/rabms.9.4.272","DOIUrl":"https://doi.org/10.61186/rabms.9.4.272","url":null,"abstract":"","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139328103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long duration of diabetes is associated with inadequate glycemic control and lipid profile","authors":"R. Bharti","doi":"10.61186/rabms.9.4.210","DOIUrl":"https://doi.org/10.61186/rabms.9.4.210","url":null,"abstract":"","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139329993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}