Journal of Pharmacovigilance最新文献_第7页

Importance of Pharmacovigilance and the Role of Healthcare Professionals 药物警戒的重要性和医疗保健专业人员的作用

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000252

S. Najafi

引用次数: 21

Adverse Effect of Unani Pharmacopeial Formulation Habb-E-Shifa 乌兰尼药厂制剂Habb-E-Shifa的不良反应

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000269

M. Azhar

引用次数: 1

Lichenoid Toxidermy with Antituberculosis 类地衣氧化法与抗结核

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000254

H. Hoummani

引用次数: 0

Pharmacovigilance in the Long-Term use of Medications and the Alternative Based on the Combination of Drugs to Reduce Adverse Effects 药物长期使用中的药物警戒和基于联合用药以减少不良反应的替代

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000265

Aguilera Martinez Maria Elena, Villafan Rodriguez Rodrigo

引用次数: 0

History, Epidemiology and Clinical Characteristic of Adverse Events 不良事件的历史、流行病学和临床特征

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000268

Kozulina Irina, Danilov Alexey, Andrianov Vladimir

{"title":"History, Epidemiology and Clinical Characteristic of Adverse Events","authors":"Kozulina Irina, Danilov Alexey, Andrianov Vladimir","doi":"10.4172/2329-6887.1000268","DOIUrl":"https://doi.org/10.4172/2329-6887.1000268","url":null,"abstract":"Rapid medicine and pharmacy progress bring new high-technology medical product to controlling and treating different diseases. Unfortunately, it does not correct a problem of drugs adverse events (ADE) from mild side effects till severe hyper sensitivity reactions, which can lead a new diseases and forming a temporary or total disability and death in some cases. There are about 17 thousand of different medicines in the world now, nearly 90% of them where done in last ten years. According to update data in last ten years mortality rate due to ADE takes 4-6 places in the world. In various ways the rate of hospitalization due to ADE is from 2%, 4% to 12%. As well as, ADE increases the volume of direct and indirect cost of patient treatment. In USA treatment of patients with ADE is about 30, 1 milliard dollars per year. According to Sultana, treatment cost for one person with one ADE averages about 2262$. According to Wester et al. most often ADE are gastrointestinal bleeding, cerebrospinal bleeding, cardiovascular accidents, and other bleeding and renal disorders. Primary ADE rate among medicines belong to nonsteroidal antiinflammatory drug. According to meta-analysis prospective studies of Lazarou et al. as a result of ADE there were more than 100000 death cases. Makary determined that most commonly ADE was because of medical error.","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"89 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72891595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Safety of Microneedles for Transdermal Drug Delivery 微针经皮给药的安全性

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000e172

Hiep X. Nguyen

{"title":"Safety of Microneedles for Transdermal Drug Delivery","authors":"Hiep X. Nguyen","doi":"10.4172/2329-6887.1000e172","DOIUrl":"https://doi.org/10.4172/2329-6887.1000e172","url":null,"abstract":"Volume 6 • Issue 2 • 1000e172 J Pharmacovigil, an open access journal ISSN: 2329-6887 Transdermal delivery is an attractive route of administration, allowing the therapeutic agents to bypass first pass-hepatic metabolism to minimize the drug toxicity and enhance the treatment efficacy, especially for drugs that are unstable in the acidic environment in the stomach or those cause irritation in the gastrointestinal tract [13]. Despite these advantages, a drawback is observed in skin delivery: numerous drugs have extremely low skin permeability due to the outermost lipophilic stratum corneum layer of skin. Passive diffusion is generally limited to small molecules (molecular weight less than 500 Da) with a low dose (highly potent), and moderate lipophilicity (log P 1-3) [2-5]. The drug delivery can be enhanced by optimizing the drug formulations or disrupting the skin barrier function using either chemical penetration enhancers or physical enhancement technologies including microneedles, laser, sonophoresis, iontophoresis, and thermal energy [6,7]. Microneedles application is a minimally invasive, cost-effective, and patient-compliant technique to significantly enhance the drug delivery into and across skin [8-10]. Upon being inserted into the skin, microneedles disrupt the stratum corneum and penetrate the epidermis layer to create interstitial fluid-filled and micronsized channels in skin. These microchannels allow the penetration of therapeutic agents of any size (monoclonal antibody, vaccines, proteins and peptides, microparticles, and cosmeceuticals) [8,11-13] without causing irreversible damage to skin, irritation, or infection [14-16]. The safety of microneedles could be evaluated on various factors including pore closure, potential infection, risk of bleeding, local reactions, needle breakage, biocompatibility of needle materials, concerns related to microneedles reuse, and safe disposal.","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"103 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80925381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Two Unexpected Cases of Rosacea during Fingolimod Therapy 芬戈莫德治疗中意外发生酒渣鼻2例

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000266

Simona Brusco, M. Bertini, C. Scavone, R. Docimo, A. Bisecco, A. Capuano, A. Gallo

引用次数: 0

Antibacterial Properties of Mixture Honey and Garlic (Allium sativum) Extracts Against Respiratory Tract Infection Causing Bacteria 蜂蜜与大蒜(Allium satium)提取物对呼吸道感染细菌的抑菌作用

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000267

M. Alemseged, Samuel Adugna, Ejigu Bayu

{"title":"Antibacterial Properties of Mixture Honey and Garlic (Allium sativum) Extracts Against Respiratory Tract Infection Causing Bacteria","authors":"M. Alemseged, Samuel Adugna, Ejigu Bayu","doi":"10.4172/2329-6887.1000267","DOIUrl":"https://doi.org/10.4172/2329-6887.1000267","url":null,"abstract":"In Ethiopia, different local communities use mixture of honey and garlic to treat coughing and other respiratory tract infections by traditional methods. Objective of the present study was to assess the antibacterial properties of mixture of honey and garlic extract against respiratory tract infection causing bacteria. The antibacterial activity of mixture of garlic extract and honey was evaluated by methods such as agar well diffusion method to observe zone of inhibition around the well as well as broth dilution method to evaluate the minimum inhibitory concentration of the extracts against the tested organisms. Five respiratory tract infection causing bacteria such as Pseudomonas aeruginosa, Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophilus influenza and Staphylococcus aureus were included in the study. Chloramphenicol was used as standard antibiotics. Mean inhibition zones of mixture of garlic extract and honey was significantly (P 0.05) greater than honey alone against the tested pathogens. The range of zone of inhibitions of mixture of garlic and honey against the tested bacteria was between 25 to 31 mm whereas the range of inhibition zone of chloramphenicol was from 9 to 30 mm. The inhibition capacity of mixture of garlic extract and honey was greater than the commercial antibiotics such as Co-trimoxazole, Cefoxitin and Erythromycin. Finally it may be possible to conclude that, mixture garlic extract and honey has the capacity to treat respiratory tract infection causing bacteria.","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"44 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81988741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Clinical Importance of Drug Monitoring: Methotrexate-Induced Acute Renal Failure 药物监测的临床重要性:甲氨蝶呤引起的急性肾功能衰竭

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000257

Arlette G Delgado, J. Vera, M. A. Moyano, M. Serrano

引用次数: 0

Pharmacovigilance within Technic Solutions 技术解决方案中的药物警戒

Journal of Pharmacovigilance Pub Date : 2018-01-01 DOI: 10.4172/2329-6887.1000262

Ludmila Schneider, Isabelle Laugel

引用次数: 1