Pharmacovigilance in the Long-Term use of Medications and the Alternative Based on the Combination of Drugs to Reduce Adverse Effects

Some demographic changes such as increased life expectancy and increased chronic degenerative diseases make pharmacovigilance is an important opportunity to clarify aspects of drug safety in patients with long-term treatment. A pharmacological alternative which seeks to improve these aspects of safety of using drugs, it is the combination of drugs with different mechanisms of action are analyzed through mathematical models to reduce the therapeutic doses but maintaining and even improving the therapeutic effect and thus reducing the adverse effects to avoid toxicity.