Journal of Polymer Science最新文献_第3页

Synergistic Effect of Dual Additive System on Molecular Structure and Foaming Properties of Recycled PET

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-19 DOI: 10.1002/pol.20241141

Tae Hyeong Park, Hong Chan Jeon, Ji Eun Choo, Young Ho Ji, Sung Wook Hwang

{"title":"Synergistic Effect of Dual Additive System on Molecular Structure and Foaming Properties of Recycled PET","authors":"Tae Hyeong Park, Hong Chan Jeon, Ji Eun Choo, Young Ho Ji, Sung Wook Hwang","doi":"10.1002/pol.20241141","DOIUrl":"https://doi.org/10.1002/pol.20241141","url":null,"abstract":"<div>\u0000 \u0000 This study investigated the effect of chain extenders on molecular structure and foaming properties of poly (ethylene terephthalate) (PET) bottle flake (BF). To improve the melt strength of BF, two different chain extenders, pyromellitic dianhydride (PMDA) and BASF Joncryl ADR4468, were introduced, and the optimized composition was determined based on the melt viscosity of BF, which resulted in improvements in both the storage modulus and the complex viscosity. The foaming was achieved by applying a chemical blowing agent to the compositions of BF_p and BF_d3 samples which is required for the minimum intrinsic viscosity for the possible chemical foaming process. The formation of small and uniform cells within virgin PET (vPET) and BF was confirmed through the field emission scanning electron microscopy (FE-SEM). The vPET and BF using recipe R3, optimized chain extender composition, was found to be formed the lower density PET foam. In addition, the formation of a long-chain branched (LCB) structure was observed from the rheological behavior, therefore, it could be suggested that a dual additive system successfully proved a synergistic effect in PET foaming performance.\u0000 </div>","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1727-1738"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Synthesis of Acrylate-Based Macromonomers and Structured Copolymers by High-Temperature Semi-Batch Radical Polymerization: The Impact of Acrylate vs. Methacrylate Monomer Choice

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-18 DOI: 10.1002/pol.20240980

Elizabeth G. Bygott, David Pahovnik, Ema Žagar, Robin A. Hutchinson

{"title":"The Synthesis of Acrylate-Based Macromonomers and Structured Copolymers by High-Temperature Semi-Batch Radical Polymerization: The Impact of Acrylate vs. Methacrylate Monomer Choice","authors":"Elizabeth G. Bygott, David Pahovnik, Ema Žagar, Robin A. Hutchinson","doi":"10.1002/pol.20240980","DOIUrl":"https://doi.org/10.1002/pol.20240980","url":null,"abstract":"High-temperature starved-feed semi-batch radical polymerization is used to produce an isobornyl acrylate (iBoA) polymer solution with high macromonomer content without a mediating agent. The p(iBoA) macromonomer solution serves as an addition-fragmentation agent to synthesize a blocky copolymer in a single-pot sequential feeding process, as has been demonstrated using n-butyl acrylate (BA) as the second monomer. The impact of monomer selection on the copolymer product is investigated by switching the second monomer to n-butyl methacrylate (BMA) while keeping all other aspects of the operating strategy unchanged. Methodologies developed to verify macromonomer incorporation are used to compare the iBoA-BA and iBoA-BMA systems, with two-dimensional liquid chromatography providing a clear contrast between the acrylate and methacrylate (co)polymer products. The comparison demonstrates the effect of monomer structure on the macromonomer addition-fragmentation kinetics, with a blocky copolymer produced using the acrylate macromonomer only when an acrylate is used as the second monomer feed.","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1717-1726"},"PeriodicalIF":3.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pol.20240980","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of EPU Composite Cooling Coating With Environmental Suitability

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-13 DOI: 10.1002/pol.20240960

Chengcheng Miao, Yanni Lv, Yan Wu, Xuejuan Cao, Boming Tang

{"title":"Optimization of EPU Composite Cooling Coating With Environmental Suitability","authors":"Chengcheng Miao, Yanni Lv, Yan Wu, Xuejuan Cao, Boming Tang","doi":"10.1002/pol.20240960","DOIUrl":"https://doi.org/10.1002/pol.20240960","url":null,"abstract":"<div>\u0000 \u0000 Thermal reflective cooling materials offer zero-energy cooling under sunlight but face durability challenges in complex environments. While improvements for single factors are well-documented, further studies on durability under multiple environmental factors are needed for large-scale application. In this study, a polyurethane-modified epoxy (EPU) resin was first synthesized, followed by the fabrication of a composite cooling coating (EPURC) using TiO2 and radiative powders. The optical properties and cooling performance confirmed that the optimized proportion of cooling fillers realized the maximum synergistic cooling effect of solar reflection and infrared emission. Therefore, when the temperature of the controlled black iron plate reached 60°C, EPURC achieved a temperature reduction of 13.8°C. Based on this, the comprehensive durability evaluation including shear resistance, water resistance, acid resistance, alkali resistance and UV resistance was further explored through cooling performance. Except for abrasion for 60 min, EPURC influenced by multiple factors could all achieve a strong cooling ability above 10°C. Although a heavy abrasion could weaken cooling performance to a certain extent, EPURC still showed a shear resistance due to the excellent toughness of EPU binder. These findings proved that EPURC could be applied in complicated work conditions and satisfied the need for practical applications.\u0000 </div>","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1707-1716"},"PeriodicalIF":3.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pH and Temperature Dependence of Low-Core T g Micellar Structures Formed by PDMAEMA-b-PLMA Diblock Copolymers in Aqueous Solution

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-12 DOI: 10.1002/pol.20241120

Varvara Chrysostomou, Stefano Da Vela, Stergios Pispas, Christine M. Papadakis

{"title":"pH and Temperature Dependence of Low-Core T\u0000 g Micellar Structures Formed by PDMAEMA-b-PLMA Diblock Copolymers in Aqueous Solution","authors":"Varvara Chrysostomou, Stefano Da Vela, Stergios Pispas, Christine M. Papadakis","doi":"10.1002/pol.20241120","DOIUrl":"https://doi.org/10.1002/pol.20241120","url":null,"abstract":"A diblock copolymer featuring a hydrophobic block with a low glass transition temperature and a pH-responsive, cationic block is synthesized and investigated with respect to its self-assembly behavior in aqueous solution. The synthesis of the poly(lauryl methacrylate)-block-poly(2-(N,N-dimethylamino) ethyl methacrylate) diblock copolymer PDMAEMA60-b-PLMA40 is carried out using reversible addition fragmentation chain transfer (RAFT) polymerization. Its self-assembly in dilute aqueous solution at pH 7 is investigated using various light scattering methods. Micelles with a positive zeta potential are identified. Synchrotron small-angle X-ray scattering reveals changes in the inner structure of the micelles as a function of temperature and at pH values above, below and close to the pKa value of PDMAEMA (ca. 7.5). At all pH values, cigar-shaped core–shell micelles are found. While the micellar size and shape hardly change with temperature at pH 5, temperature responsivity is observed at pH 7 and 10, resulting in, among others, a change of the core size. These structural changes are facilitated by the softness of the PLMA core. Such systems may be suitable for the co-delivery of hydrophobic drugs and nucleic acids.","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1684-1694"},"PeriodicalIF":3.9,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pol.20241120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Properties and Mechanism of Flame Retardant Poly(Lactic Acid) Composites Containing Phosphaphenanthrene-Hydroxyl Phenyl Maleimide Derivative

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-12 DOI: 10.1002/pol.20241098

Lijuan Long, Xiang Nie, Xin Wang, Chunyan Shan, Shuhao Qin, Wei Gong, Fu Hai, Jie Yu

{"title":"Properties and Mechanism of Flame Retardant Poly(Lactic Acid) Composites Containing Phosphaphenanthrene-Hydroxyl Phenyl Maleimide Derivative","authors":"Lijuan Long, Xiang Nie, Xin Wang, Chunyan Shan, Shuhao Qin, Wei Gong, Fu Hai, Jie Yu","doi":"10.1002/pol.20241098","DOIUrl":"https://doi.org/10.1002/pol.20241098","url":null,"abstract":"<div>\u0000 \u0000 A derivative based on 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide and maleimide units with terminal hydroxyl group (DH) was synthesized and incorporated in poly(lactic acid) (PLA). The properties and mechanism of PLA/DH composites were investigated. The results showed that PLA composites under 10 wt% DH load achieved vertical combustion test (UL-94) V-0 rating with an increased limiting oxygen index (LOI) of 27.2% and a 15.8% decrease in peak heat release rate. The prominent flame retardant efficiency of DH in PLA was attributed to its excellent flame inhibition and diluting effects in gaseous phase as well as a certain cross-linked structure in the condensed phase. Specifically, the elongation at break of PLA/DH-7.5 was increased by 17.6% in comparison to that of pure PLA. DH with terminal hydroxyl group displayed enhanced interaction and good compatibility with PLA, thus endowing good comprehensive performances to PLA. As a result, the combination of phosphaphenanthrene and maleimide units with terminal hydroxyl group provides a facile and effective method to improve the flame retardancy and mechanical properties of PLA.\u0000 </div>","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1695-1706"},"PeriodicalIF":3.9,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Releasing Vanillin: An Eco-Friendly Self-Polishing Coating Designed for Marine Antifouling

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-10 DOI: 10.1002/pol.20241081

Xin Liu, Xiaojun Wang, Rongrong Chen, Qi Liu, Dalei Song, Gaohui Sun, Jing Yu, Jingyuan Liu, Jiahui Zhu, Shifeng Guo, Jun Wang

{"title":"Self-Releasing Vanillin: An Eco-Friendly Self-Polishing Coating Designed for Marine Antifouling","authors":"Xin Liu, Xiaojun Wang, Rongrong Chen, Qi Liu, Dalei Song, Gaohui Sun, Jing Yu, Jingyuan Liu, Jiahui Zhu, Shifeng Guo, Jun Wang","doi":"10.1002/pol.20241081","DOIUrl":"https://doi.org/10.1002/pol.20241081","url":null,"abstract":"<div>\u0000 \u0000 Biological fouling will cause severe damage to the functionality of marine underwater facilities, shorten their service life, impede their normal operation, and trigger a biological invasion event. The traditional marine antifouling coatings release heavy metal elements, which cause harm to the marine environment. To overcome this issue, a self-polishing antifouling resin based on vanillin methacrylate (VMA) was prepared via the free radical polymerization method. In seawater, the VMA-based coatings achieve self-polishing through the hydrolysis of the phenolic ester group. The hydrolysis mechanism of VMA was calculated using density functional theory by Cp2k software, and the results show that VMA achieves one-step hydrolysis by the SN2 mechanism. It exhibited antibacterial and environmentally friendly antifouling properties by releasing vanillin, which is a natural antifouling active substance. The antibacterial, diatom adhesion inhibition, and the 9-month marine field test demonstrated the excellent antifouling performance of VMA-based coatings. It provides a novel concept for environmentally friendly self-polishing coatings and has a promising application prospect.\u0000 </div>","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1662-1670"},"PeriodicalIF":3.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembled Micellar Aggregates From Star-Shaped Copolymers Decorated With Cholesterol

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-10 DOI: 10.1002/pol.20240898

Isabel Morelos-Ramírez, Norma A. Cortez-Lemus

{"title":"Self-Assembled Micellar Aggregates From Star-Shaped Copolymers Decorated With Cholesterol","authors":"Isabel Morelos-Ramírez, Norma A. Cortez-Lemus","doi":"10.1002/pol.20240898","DOIUrl":"https://doi.org/10.1002/pol.20240898","url":null,"abstract":"<div>\u0000 \u0000 In this work, we synthesized star-shaped triblock copolymers based on poly(ε-caprolactone) (PCL), poly(2-hydroxyethyl acrylate) (PHEA), and poly(N-acryloyl D-glucosamine) (PAGA). PCL macro-RAFT agent was chain extended with 2-hydroxyethyl acrylate (HEA) via RAFT polymerization, followed by N-acryloyl D-glucosamine (AGA) to achieve the triblock. The length of the PHEA block was varied from DP = 2–59 per arm. The self-assembly behavior of PCL-b-PHEA diblock copolymer was studied in deionized water. By AFM, large semi-spherical micellar aggregates with a diameter of approximately 318–238 nm were observed. Some of these copolymers were decorated with cholesterol. PHEA block was mainly incorporated as a template to anchor cholesterol (Chol) and provide amphiphilic properties to the diblock, facilitating efficient extension of polymerization of AGA. The content of cholesterol conjugated in the PHEA block was 2.5%. It was found that the micellar aggregates prepared with the cholesterol-decorated diblock practically tripled their diameter. By introducing the PAGA block, the micellar aggregates reduced their size (111–136 nm in diameter), improved colloidal stability, and turned into a material with unique characteristics that can be used as nanocarriers of therapeutic agents.\u0000 </div>","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1650-1661"},"PeriodicalIF":3.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Responsive Nanogels Based on Sulfoxide Polymethacrylates for Biomedical Applications

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-10 DOI: 10.1002/pol.20241176

Hannah Elodie Stauber, Clara López-Iglesias, Sidra Kanwal, Elisa Quaas, Daniel Klinger

{"title":"Multi-Responsive Nanogels Based on Sulfoxide Polymethacrylates for Biomedical Applications","authors":"Hannah Elodie Stauber, Clara López-Iglesias, Sidra Kanwal, Elisa Quaas, Daniel Klinger","doi":"10.1002/pol.20241176","DOIUrl":"https://doi.org/10.1002/pol.20241176","url":null,"abstract":"Nanogels for biomedical applications require polymeric building blocks that show high hydrophilicity and (thermo-)responsive properties without immune response risks. Polysulfoxides offer these advantages but have not yet been translated to 3-dimensional colloidal materials. To examine their potential as alternatives to established systems, we developed a synthetic platform with synthetic control and chemical versatility. For this, we utilize the thermo-responsive properties of a polymethacrylate with propyl sulfoxide side groups, that is, poly(2-(n-propyl-sulfoxide)ethyl methacrylate) (P(nPr-SEMA)). Its phase transition near body temperature enables nanogel preparation via conventional precipitation polymerization in an all-aqueous system. To fully assess this approach's potential, we first demonstrate control over colloidal properties like size, size distribution, and crosslinking density. We examine the influence of these parameters on the temperature-dependent swelling profiles and develop a standard synthetic protocol. Second, we examine synthetic versatility to introduce additional stimuli-responsiveness. For this, we introduce methacrylic acid (MAA) as pH-responsive co-monomer and examine resulting double-sensitive swelling. Third, we add network degradability through reduction-cleavable crosslinker bis(2-methacryloyloxyethyl) disulfide (DSDMA). Fourth, we demonstrate that multi-responsive nanogels exhibit low cytotoxicity and high colloidal stability in biologically relevant media. Overall, this systematic study establishes P(nPr-SEMA)-based nanogels as versatile alternatives to established temperature-responsive nanogels for biomedical applications, for example, drug delivery.","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1671-1683"},"PeriodicalIF":3.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pol.20241176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfonated Fe-MOF Solid Acid Catalyst for High-Efficient Depolymerization of Polyamide 6

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-10 DOI: 10.1002/pol.20241149

Yang Liu, Guodong Cao, Xuelong Zhu, Yi Zhang, Chenglu Liang, Yukun Chen

{"title":"Sulfonated Fe-MOF Solid Acid Catalyst for High-Efficient Depolymerization of Polyamide 6","authors":"Yang Liu, Guodong Cao, Xuelong Zhu, Yi Zhang, Chenglu Liang, Yukun Chen","doi":"10.1002/pol.20241149","DOIUrl":"https://doi.org/10.1002/pol.20241149","url":null,"abstract":"<div>\u0000 \u0000 Upcycling the wasted polyamide 6 (PA6) to its monomer caprolactam via depolymerization is a promising way to build the resource cycling and alleviate the environmental pollution. High efficient catalyst for PA6 depolymerization is desirable and crucial. Herein, a sulfonated Fe-MOF catalyst was designed and performed as solid acid catalyst for the PA6 depolymerization for the first time. Results showed that a 100% conversion of PA6 solid to water-soluble liquid products can be achieved at temperatures of 250°C after only 1-h reaction. LC/MS results indicated that the water-soluble products were mainly composed of caprolactam and their oligomers. Without catalyst, nearly no water-soluble products can be obtained at the same condition. Moreover, a high selectivity of 90% caprolactam production in the water-soluble liquid products was achieved at 260°C, 5 h. The reaction rate constants at 240°C, 250°C, and 260°C were determined to be 0.024, 0.033, and 0.064, respectively, with a Ea value of 101.8 kJ/mol, showing positive temperature dependent relationship. The comparison of catalytic performances over sulfonated Fe-MOFs, FeCl3·6H2O and the pristine un-sulfonated Fe-MOF suggested the synergistic contribution of Fe sites (Lewis acid centers) and the sulfonic acid sites to the catalytic performances.\u0000 </div>","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1641-1649"},"PeriodicalIF":3.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart pH-Sensitive Biopolymeric Nanocarrier Enables Controlled Release of Curcumin Through Biomimetic Biological Barriers

IF 3.9 3区化学

Journal of Polymer Science Pub Date : 2025-02-07 DOI: 10.1002/pol.20240995

Gislaine G. Fonseca, Edileuza M. Vieira, Marcos V. S. Pereira, Tatianny de A. Andrade, Anamaria M. Santos, Amanda P. Gonçalves, Mairim R. Serafini, Anésia A. Santos, Eduardo Costa de Figueiredo, Jemmyson R. de Jesus

{"title":"Smart pH-Sensitive Biopolymeric Nanocarrier Enables Controlled Release of Curcumin Through Biomimetic Biological Barriers","authors":"Gislaine G. Fonseca, Edileuza M. Vieira, Marcos V. S. Pereira, Tatianny de A. Andrade, Anamaria M. Santos, Amanda P. Gonçalves, Mairim R. Serafini, Anésia A. Santos, Eduardo Costa de Figueiredo, Jemmyson R. de Jesus","doi":"10.1002/pol.20240995","DOIUrl":"https://doi.org/10.1002/pol.20240995","url":null,"abstract":"<div>\u0000 \u0000 Herein, the successful synthesis of a chitosan-iron nanosphere-based nanocarrier for smart delivery of curcumin (Cur) after penetration of the biomimetic barrier is reported. The synthesized nanocarrier displayed a spherical shape with an average size of 11 nm and a zeta potential value of −30.7 mV. The drug loading efficiency reached 64% ± 4% (n = 3). Infrared analysis confirmed the functionalization of the nanocarrier with Cur. Thermogravimetric analysis (TGA) demonstrated the nanocarrier's stability. The biopolymeric nanospheres exhibited a PCZ at pH 8.22. pH-responsive study indicated Cur satisfactory release (> 80%) at pH = 7.4. Cur release kinetics followed a pseudo-second order model (R\u0000 2 = 0.933), indicating a controlled release behavior. In vitro permeation studies revealed that the polymeric nanocarrier successfully penetrated the biomimetic barrier and delivered Cur to the receptor compartment. Cytotoxicity studies using VERO cells and \u0000 Artemia salina\u0000 demonstrated that the nanocarrier exhibits low toxicity. Fluorescence microscopy images suggest that the nanocarrier has cytocompatibility with VERO cells, maintaining cell viability. However, hemolysis was observed at concentrations higher than 54 μmol L−1 in the hemolytic activity study. Finally, through albumin fluorescence suppression analysis, it was observed that the nanocarrier exhibited significant interaction with albumin, indicating its potential for transport through the circulatory system when administered intravenously.\u0000 </div>","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 7","pages":"1628-1640"},"PeriodicalIF":3.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0